CN1012941B - Alkali water process for plumula Nelumbinis - Google Patents
Alkali water process for plumula NelumbinisInfo
- Publication number
- CN1012941B CN1012941B CN 89106311 CN89106311A CN1012941B CN 1012941 B CN1012941 B CN 1012941B CN 89106311 CN89106311 CN 89106311 CN 89106311 A CN89106311 A CN 89106311A CN 1012941 B CN1012941 B CN 1012941B
- Authority
- CN
- China
- Prior art keywords
- sodium carbonate
- andrographis
- herba andrographis
- water
- boiled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 20
- 239000003513 alkali Substances 0.000 title abstract description 3
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims abstract description 44
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 22
- 229910000029 sodium carbonate Inorganic materials 0.000 claims abstract description 22
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000011780 sodium chloride Substances 0.000 claims abstract description 11
- 238000001035 drying Methods 0.000 claims abstract description 10
- 238000006386 neutralization reaction Methods 0.000 claims abstract description 3
- 241000746375 Andrographis Species 0.000 claims description 33
- 239000000843 powder Substances 0.000 claims description 14
- 230000029087 digestion Effects 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 7
- 239000012141 concentrate Substances 0.000 claims description 6
- 238000009495 sugar coating Methods 0.000 claims description 6
- 238000002419 base digestion Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 244000118350 Andrographis paniculata Species 0.000 abstract description 6
- 230000008901 benefit Effects 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 238000000605 extraction Methods 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 238000000227 grinding Methods 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 21
- 239000000047 product Substances 0.000 description 8
- 239000003814 drug Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 229930003944 flavone Natural products 0.000 description 4
- 150000002213 flavones Chemical class 0.000 description 4
- 235000011949 flavones Nutrition 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000010298 pulverizing process Methods 0.000 description 4
- BOJKULTULYSRAS-OTESTREVSA-N Andrographolide Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)\C=C1/[C@H](O)COC1=O BOJKULTULYSRAS-OTESTREVSA-N 0.000 description 3
- 206010013786 Dry skin Diseases 0.000 description 3
- ASLUCFFROXVMFL-UHFFFAOYSA-N andrographolide Natural products CC1(CO)C(O)CCC2(C)C(CC=C3/C(O)OCC3=O)C(=C)CCC12 ASLUCFFROXVMFL-UHFFFAOYSA-N 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000000470 constituent Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- 150000002596 lactones Chemical class 0.000 description 2
- GVRNTWSGBWPJGS-YSDSKTICSA-N 4-[2-[(1r,4as,5r,6r,8as)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1h-naphthalen-1-yl]ethyl]-2h-furan-5-one Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)CC1=CCOC1=O GVRNTWSGBWPJGS-YSDSKTICSA-N 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- GVRNTWSGBWPJGS-UHFFFAOYSA-N deoxyandrographolide Natural products C=C1CCC2C(C)(CO)C(O)CCC2(C)C1CCC1=CCOC1=O GVRNTWSGBWPJGS-UHFFFAOYSA-N 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002481 ethanol extraction Methods 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000006317 isomerization reaction Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 229940071462 oralone Drugs 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a novel andrographis paniculata alkali water method process, which is characterized in that andrographis paniculata is soaked and boiled in water by using sodium carbonate which accounts for 1-6% of the weight of andrographis paniculata, then the effective components are extracted through the procedures of neutralization by hydrochloric acid, concentration, drying, grinding, sodium chloride removal and the like, and the andrographis paniculata tablets are prepared by tabletting and coating sugar. Compared with the prior art, the method has the advantages of high extraction rate, good production benefit and high curative effect.
Description
The invention discloses a kind of patent medicine " andrographis tablet " and make new technology.
Herba Andrographis (formal name used at school Andrographis paniculata(Burm.f) Nees) be acanthaceous plant, another name Herba Andrographitis, ZHANSHEJIAN, Radix Gentianae etc.Have heat-clearing and toxic substances removing, anti-inflammation function, it mainly contains effective constituent and is: total andrographolides (comprises andrographolide, Neoandrographolium, deshydroxy andrographolide, deoxyandrographolide ...), Herba Andrographis total flavones or the like.Utilization to this product has several stages.
1. YANDEPING: in the fifties later stage, with Folium Andrographis pulverizing, dress soft gelatin capsule, every ball weighs 0.25 gram, obeys the 4-6 ball at every turn.These method medicinal residues all take orally, and side effect such as cause nausea, tell.Superseded.
2. andrographis tablet: with Herba Andrographis herb decocting, the decocting fluid through concentrate, dry, tabletting (sugar coating), every 0.4g obeys the 4-6 sheet at every turn.Since Herba Andrographis mainly contain the effective constituent total andrographolides, water insoluble, so the finished product curative effect is not good enough.Also superseded.
3. andrographolide: according to 1974 " Shanghai City drug standard ", with Herba Andrographis herb decocting 2 times, 2 hours for the first time, 1 hour 30 minutes for the second time, medical filtration, being concentrated into proportion is that 1.06(heat is surveyed), wait to be chilled to below 40 ℃, add isopyknic 95% ethanol and stir, precipitation reclaims ethanol with supernatant.Being concentrated into proportion 1.38～1.40(heat surveys), this extractum 35kg adds Folium Andrographis powder 14kg, stirs and spares, and 60～70 ℃ of dryings, makes granule, tabletting, the heavy 0.37g of sheet, sugar coating is promptly obeyed 4～6 at every turn, and is also superseded.
4. Chinese Pharmacopoeia method; 85 years versions " the Chinese pharmacopoeia regulation is got the Herba Andrographis coarse powder and is carried secondary with 85% ethanol hot dipping, and each 2 hours, merge extractive liquid,, filtration, filtrate recycling ethanol are condensed into thick shape, are dried to dry extract, add appropriate amount of auxiliary materials, make granule, and tabletting, sugar coating are promptly.Every contains Herba Andrographis dry extractum 0.105g, oral one time 5,3-4 time on the one.This law needs to make extractant with ethanol under heating condition, though curative effect is good, cost is too high, and deficiency in economic performance is produced relatively danger, and dose is big again.Domestic more than 100 pharmaceutical factories have stopped production about 10 years.
The objective of the invention is: a kind of extraction ratio height is provided, eutherapeutic andrographis tablet new process, without ethanol, its production cost is than using the also cheap of water extraction at main abstraction process for this process.
The main effective ingredient of Herba Andrographis: total andrographolides is water insoluble, and is soluble in ethanol, but is dissolvable in water thermokalite water.This is the main contents of invention.Because in suitable alkaline solution, become then water soluble of sodium salt after the lactone open loop, reaction equation is as follows:
(general formula is seen the literary composition back)
But, if alkalescence too a little less than, imperfection is extracted in not open loop of lactone, if alkalescence is too strong, just might makes total andrographolides isomerization even resinification and loses the property of medicine.Herba Andrographis total flavones dissolubility in aqueous alkali also increases.Based on this principle, the method that the present invention proposes is: the sodium carbonate liquor digestion that Herba Andrographis is placed debita spissitudo, the sodium carbonate amount be Herba Andrographis heavy 1～6%, the open loop of original water-fast composition total andrographolides is dissolved in the water, total flavones also dissolves.With the concentrated hydrochloric acid neutralization, reheat makes its closed loop recover original structure, removes sodium chloride through washing then, after ethanol extraction reclaims total flavones, and drying.Promptly get the heavy 0.2g of new product " andrographis tablet " sheet behind tabletting, the sugar coating.
Adopt the benefit of this process to be that technology is easy, can avoid a large amount of under heating condition and use the ethanol inflammable, explosive, that valency is high, and good extraction effect is arranged.Another benefit be in acid and the time use hydrochloric acid, product is a sodium chloride, and is residual on a small quantity in tablet after removing the sodium chloride operation, harmless to health after the food.The andrographis tablet of producing with this method began flu, influenza, tonsillitis from 83 years, pharyngitis, enteritis, bacillary dysentery, etc. clinical trial 836 examples, total effective rate 92.23%, prove a kind of effective, safe, inexpensive, new drug that economic benefit is big, code is produced, criticized to central authorities' Ministry of Public Health in January, 89 approval: (89) are defended the accurate word Z-01 of medicine number, and the andrographis tablet that this law is produced is shown compared with the prior art:
(seeing literary composition back table)
Hereinafter give several embodiment of this process
1, Herba Andrographis 100kg inserts in the still, adds water to not have the about 10cm of powder, adds carbon ester sodium 6kg digestion and boils half an hour, leaches digestion liquid, is neutralized to neutrality, concentrates, wears into 60 order fine powders after 90～100 ℃ of following dryings with concentrated hydrochloric acid, waits to remove sodium chloride.
2, Herba Andrographis 100kg inserts in the still, adds water to not have the about 10cm of powder, add the sodium carbonate person of soaking 2 times, use sodium carbonate 4kg for the first time, uses sodium carbonate 2kg the second time.Boiled 1 hour at every turn, and merged 2 digestion filtrate, be neutralized to neutrality, concentrate, after 90-100 ℃ of following drying, wear into 60 order fine powders, wait to remove sodium chloride with concentrated hydrochloric acid.
3, Herba Andrographis 100kg inserts in the still, adds water to not have the about 10cm of powder, add the sodium carbonate digestion three times.Add for the first time sodium carbonate 2kg, add sodium carbonate 2kg for the second time, add sodium carbonate 2kg for the third time, boiled 1.5 hours at every turn, merge three times digestion liquid, to neutral, concentrated, after 90～100 ℃ of following dryings, wear into 60 order fine powders, wait to remove sodium chloride with concentrated hydrochloric acid.
4, Herba Andrographis 100kg places in the still, adds water to not have the about 10cm of powder, add the sodium carbonate digestion three times.Add for the first time sodium carbonate 3kg, add sodium carbonate 2.5kg for the second time, add sodium carbonate 2.5kg for the third time, boiled 1 hour at every turn, merge three times digestion liquid, add concentrated hydrochloric acid and be neutralized to neutrality, concentrate, after 90-100 ℃ of drying, wear into 60 order fine powders, wait to remove sodium chloride.
5, Herba Andrographis 100kg places in the still, adds water to not have the about 10cm of powder, add the sodium carbonate digestion three times.Add for the first time sodium carbonate 2kg, add sodium carbonate 1kg for the second time, add sodium carbonate 1kg for the third time, boiled 2 hours at every turn, merge three times digestion liquid, be neutralized to neutrality, concentrate, after 90-100 ℃ of drying, wear into 60 order fine powders, wait to remove sodium chloride with concentrated hydrochloric acid.
In present described embodiment, all adopt following method to remove sodium chloride; 60 order fine powders are added its weight 6-10 distilled water doubly, stir, placed 6 hours, per hour stir once.Filter, precipitate is at 90-100 ℃ of drying, pulverizing, get finished product (1), the filtrate heating is concentrated into syrupy shape, adds 95% ethanol of 10 times of volumes, stir, ethanol extract is told in placement, recovery of alcohol distillation, and medicinal liquid is dry down at 90～100 ℃, pulverizing, get product (2), with finished product (1), (2) mix homogeneously, tabletting, sugar coating promptly get new product " andrographis tablet ".
The name of an article technology extraction ratio dosage price remarks that take medicine once
YANDEPING leaf pulverizing/4-6 sheet/time 5.2-7.8 divides the price by 80 years
Andrographis tablet water-boiling method 20% ± 4-6 sheet/time 6-9 branch
17% ± 5 slice/time 12.5-15 branch of andrographis tablet ethanol method
28% ± 2～3 slices/time 3.0-4.5 branches of andrographis tablet this law
General formula:
Example:
Claims (5)
1, a kind of by adding the alkali digestion, neutralization, concentrate, dry, the preparation method of removing the andrographis tablet that operations such as sodium chloride, drying, tabletting, sugar coating form, it is characterized in that: each sodium carbonate that accounts for Herba Andrographis weight 1～6% that adds during digestion adds water and did not have powder to boil 0.5～2 hour.
2, the method for claim 1, its feature also are, use concentrated hydrochloric acid that digestion liquid is neutralized to neutrality.
3, the method for claim 1, its feature also be, Herba Andrographis added sodium carbonate and water logging is boiled once.
4, the method for claim 1, its feature also be, Herba Andrographis added sodium carbonate and secondary is boiled in water logging.
5, the method for claim 1, its feature also be, Herba Andrographis added sodium carbonate and water logging is boiled three times.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89106311 CN1012941B (en) | 1989-07-29 | 1989-07-29 | Alkali water process for plumula Nelumbinis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89106311 CN1012941B (en) | 1989-07-29 | 1989-07-29 | Alkali water process for plumula Nelumbinis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1042077A CN1042077A (en) | 1990-05-16 |
| CN1012941B true CN1012941B (en) | 1991-06-26 |
Family
ID=4856709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 89106311 Expired CN1012941B (en) | 1989-07-29 | 1989-07-29 | Alkali water process for plumula Nelumbinis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1012941B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1747008E (en) | 2004-04-28 | 2015-03-31 | Nutrition Science Partners Ltd | Crude extracts from andrographis paniculata |
| US20070160696A1 (en) * | 2006-01-11 | 2007-07-12 | The Procter & Gamble Company | Compositions and methods useful for prevention or treatment of respiratory illness |
| US20090117209A1 (en) | 2007-11-02 | 2009-05-07 | Hutchison Medipharma Enterprises Limited | Andrographis paniculata extract |
-
1989
- 1989-07-29 CN CN 89106311 patent/CN1012941B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CN1042077A (en) | 1990-05-16 |
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| C13 | Decision | ||
| GR02 | Examined patent application | ||
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| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |