CN101167456A - Fenpyroximate water dispersible granule and preparation method thereof - Google Patents
Fenpyroximate water dispersible granule and preparation method thereof Download PDFInfo
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- CN101167456A CN101167456A CNA2007101952577A CN200710195257A CN101167456A CN 101167456 A CN101167456 A CN 101167456A CN A2007101952577 A CNA2007101952577 A CN A2007101952577A CN 200710195257 A CN200710195257 A CN 200710195257A CN 101167456 A CN101167456 A CN 101167456A
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- Prior art keywords
- agent
- water dispersible
- fenpyroximate
- filler
- dispersible granules
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- 239000004562 water dispersible granule Substances 0.000 title claims abstract description 30
- 239000005657 Fenpyroximate Substances 0.000 title claims abstract description 20
- YYJNOYZRYGDPNH-MFKUBSTISA-N fenpyroximate Chemical compound C=1C=C(C(=O)OC(C)(C)C)C=CC=1CO/N=C/C=1C(C)=NN(C)C=1OC1=CC=CC=C1 YYJNOYZRYGDPNH-MFKUBSTISA-N 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title description 3
- 239000000945 filler Substances 0.000 claims abstract description 16
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 9
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims abstract description 4
- 150000003851 azoles Chemical class 0.000 claims description 19
- 150000002148 esters Chemical class 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 16
- 239000002270 dispersing agent Substances 0.000 claims description 10
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 9
- 229940088417 precipitated calcium carbonate Drugs 0.000 claims description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- 239000000440 bentonite Substances 0.000 claims description 8
- 229910000278 bentonite Inorganic materials 0.000 claims description 8
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 8
- 239000007884 disintegrant Substances 0.000 claims description 8
- 239000000080 wetting agent Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 7
- 239000005995 Aluminium silicate Substances 0.000 claims description 6
- 235000012211 aluminium silicate Nutrition 0.000 claims description 6
- 239000011230 binding agent Substances 0.000 claims description 6
- 239000004927 clay Substances 0.000 claims description 6
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 6
- 239000003381 stabilizer Substances 0.000 claims description 6
- 244000215068 Acacia senegal Species 0.000 claims description 4
- 229920000084 Gum arabic Polymers 0.000 claims description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 4
- 229920002125 Sokalan® Polymers 0.000 claims description 4
- 239000000205 acacia gum Substances 0.000 claims description 4
- 235000010489 acacia gum Nutrition 0.000 claims description 4
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims description 4
- 229960000892 attapulgite Drugs 0.000 claims description 4
- 229940092782 bentonite Drugs 0.000 claims description 4
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 4
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 claims description 4
- 239000010445 mica Substances 0.000 claims description 4
- 229910052618 mica group Inorganic materials 0.000 claims description 4
- 229910052625 palygorskite Inorganic materials 0.000 claims description 4
- 239000004584 polyacrylic acid Substances 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 239000000853 adhesive Substances 0.000 claims description 3
- 230000001070 adhesive effect Effects 0.000 claims description 3
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 claims description 3
- 229940043264 dodecyl sulfate Drugs 0.000 claims description 3
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 claims description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 241000931143 Gleditsia sinensis Species 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 244000269722 Thea sinensis Species 0.000 claims description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 2
- 150000003863 ammonium salts Chemical class 0.000 claims description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 2
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 2
- 235000012216 bentonite Nutrition 0.000 claims description 2
- 239000001110 calcium chloride Substances 0.000 claims description 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
- 235000011148 calcium chloride Nutrition 0.000 claims description 2
- 239000004202 carbamide Substances 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 238000009792 diffusion process Methods 0.000 claims description 2
- 150000002170 ethers Chemical class 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 claims description 2
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 239000001488 sodium phosphate Substances 0.000 claims description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 2
- 235000011152 sodium sulphate Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 2
- 239000000454 talc Substances 0.000 claims description 2
- 235000012222 talc Nutrition 0.000 claims description 2
- 229910052623 talc Inorganic materials 0.000 claims description 2
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 claims description 2
- 239000013638 trimer Substances 0.000 claims description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- HVLLSGMXQDNUAL-UHFFFAOYSA-N triphenyl phosphite Chemical compound C=1C=CC=CC=1OP(OC=1C=CC=CC=1)OC1=CC=CC=C1 HVLLSGMXQDNUAL-UHFFFAOYSA-N 0.000 claims 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 1
- STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 8
- 238000000034 method Methods 0.000 abstract description 5
- 238000012545 processing Methods 0.000 abstract description 3
- 239000000428 dust Substances 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract description 2
- 239000000375 suspending agent Substances 0.000 abstract description 2
- 238000012856 packing Methods 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- 239000004563 wettable powder Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 description 12
- 239000003814 drug Substances 0.000 description 10
- 238000005469 granulation Methods 0.000 description 9
- 230000003179 granulation Effects 0.000 description 9
- 241001454293 Tetranychus urticae Species 0.000 description 7
- 230000003449 preventive effect Effects 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- 239000000575 pesticide Substances 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 241000238631 Hexapoda Species 0.000 description 3
- 241000607479 Yersinia pestis Species 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000009736 wetting Methods 0.000 description 3
- 235000006008 Brassica napus var napus Nutrition 0.000 description 2
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 2
- 241001674939 Caulanthus Species 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000003912 environmental pollution Methods 0.000 description 2
- -1 ester sodium lignin sulfonate Chemical class 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920002689 polyvinyl acetate Polymers 0.000 description 2
- 239000011118 polyvinyl acetate Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 238000005987 sulfurization reaction Methods 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- IJRKANNOPXMZSG-SSPAHAAFSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC(=O)CC(O)(C(O)=O)CC(O)=O IJRKANNOPXMZSG-SSPAHAAFSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- MUTCWUGBBPHCOV-UHFFFAOYSA-N N1N=CC=C1.[O].C1=CC=CC=C1 Chemical class N1N=CC=C1.[O].C1=CC=CC=C1 MUTCWUGBBPHCOV-UHFFFAOYSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 206010035148 Plague Diseases 0.000 description 1
- 241000382353 Pupa Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- ABUGVBRDFWGJRD-CHOYNLESSA-N [9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-methyloxolan-2-yl]-2-(2,4-dinitrophenyl)sulfanylpurin-6-yl] [hydroxy(phosphonooxy)phosphoryl] hydrogen phosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](C)O[C@H]1N1C2=NC(SC=3C(=CC(=CC=3)[N+]([O-])=O)[N+]([O-])=O)=NC(OP(O)(=O)OP(O)(=O)OP(O)(O)=O)=C2N=C1 ABUGVBRDFWGJRD-CHOYNLESSA-N 0.000 description 1
- 239000000642 acaricide Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 150000001875 compounds Chemical group 0.000 description 1
- 238000000205 computational method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 235000021110 pickles Nutrition 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000012958 reprocessing Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- LYDRKKWPKKEMNZ-UHFFFAOYSA-N tert-butyl benzoate Chemical compound CC(C)(C)OC(=O)C1=CC=CC=C1 LYDRKKWPKKEMNZ-UHFFFAOYSA-N 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Fenpyroximate water dispersible granule is granula made by mixing and processing fenpyroximate auxiliary agent and filler and can be rapidly disintegrated, dispersed in water to form a high-suspension stable disperse system. No floating dust exists in the producing, using and packing process of the agent, and thereby the agent is safe for operators and does not pollute environment. Compared with prior wettable powder and suspending agent, the agent is large in density, small in volume and able to substantially decrease costs of packing and transporting, and package can be conveniently reclaimed. The agent is good in dispersibility in water, high in suspension rate and able to improve prevention and cure effect.
Description
Technical field
The present invention relates to a kind of stable water dispersible granules and processing method thereof, its main component is an azoles mite ester, adds the formulations of pesticide that the part additive compound forms, and this formulation is easy to use, to user or environmentally friendly.
Background technology
Crops are owing to disease, insect pest, crop smothering, the plague of rats etc. can cause huge production loss, so annual applying pesticides in a large number just can be retrieved the loss of crop.A large amount of uses of agricultural chemicals have caused the pollution of environment: and because human more and more higher to the environmental ecology safe requirement, thereby make the formulations of pesticide develop to direction such as environmentally friendly, efficient.The so just novel formulation of water dispersible granules, its advantage and strong point are: the problem that no dust, organic solvent-free bring etc.Promote the use of widely through the America and Europe, fully demonstrate its unique charm, become each company and mainly studied one of formulation.Along with the development of pesticide industry, the appearance of high activity agricultural chemicals, the needs of market competition and environmental protection, the research and development water dispersible granules has become the urgent task of pesticide processing industry.
Azoles mite ester: (claiming to kill the mite king again) is benzene oxygen pyrazoles miticide.Can directly kill the mite class during high dose, can suppress mite class decortication during low dosage or lay eggs.Have knocking down and suppress decorticating, no systemic action.Various pests is had stomach toxicity and action of contace poison,, the control two spotted spider mite is had long, advantage such as dosage is low of preventive effect height, lasting period crop safety.English common name: fenpyroximate, chemical name: (E)-and 4[1,3-dimethyl-(5-phenoxy group-1H-pyrazolyl) methene ammonia oxygen methyl] benzoic acid-1,1 dimethyl ethyl ester.
Structural formula:
Though the suspending agent and the aqueous emulsion of existing relevant azoles mite ester yet there are no this formulation of water dispersible granules, and there are unsettled shortcoming in prior dosage form at present.The present invention is primarily aimed at this formulation, and highly active azoles mite ester is processed, and provides that a kind of environmental pollution is little, drug effect is high, easily transportation and stable novel form.
Summary of the invention
The purpose of this invention is to provide a kind of azoles mite ester that contains is the water dispersible granules of main component, and it has characteristics such as environmental pollution is little, drug effect is high, stability is strong.
Each weight percentages of components of fenpyroximate water dispersible granule is: azoles mite ester (0.1-50%) auxiliary agent (0.5-50%) filler (10-90%): described auxiliary agent is meant dispersant and/or wetting agent, disintegrant, stabilizing agent, binding agent; Described filler is the one or more kinds of mixed fillers in white carbon, potter's clay, bentonite, precipitated calcium carbonate, attapulgite, talcum powder, kaolin, the mica.
Preferred percentage by weight is: azoles mite ester (5-30%), auxiliary agent (10-30%), filler (30-70%): described auxiliary agent is meant dispersant and/or wetting agent, disintegrant, stabilizing agent, binding agent; Described filler is the one or more kinds of mixed fillers in white carbon, potter's clay, bentonite, precipitated calcium carbonate, attapulgite, talcum powder, kaolin, the mica.
Dispersant of the present invention can be one or more mixed dispersants among sodium lignin sulfonate, potassium and ammonium salt, polyacrylic acid, sodium phosphate trimer, diffusion agent N O, dispersing agent MF, naphthalene sulfonate, rope uncle SOPA, the NNO.
One or more hybrid adhesives in adhesive starch of the present invention, gum Arabic, polyvinyl alcohol, polyethylene glycol ethers, dextrin, sodium sulphate, rosin, the methylcellulose.
Wetting agent of the present invention is that alkylnaphthalene sulfonate, tea are withered, Chinese honey locust, sldium lauryl sulfate, draw back in powder, penetrant t, penetrating agent JFC, the neopelex one or more and mix wetting agents.
Filler of the present invention (carrier) is white carbon, diatomite, talcum, kaolin, clay, precipitated calcium carbonate.Can use separately also and can two or more mixing use.
The present invention is that in ammonium sulfate, carboxymethyl cellulose, calcium chloride, bentonite, aluminium chloride, the urea one or more mix disintegrants in described disintegrant.
Can make water dispersible granules of the present invention according to the method for well known to a person skilled in the art, as mist projection granulating, rotary table granulation, extruder grain and high strength mixing granulation etc.
Using method of the present invention is simple, can convert water spray by using dosage.
Embodiment
Example of formulations 1:10% fenpyroximate water dispersible granule
| Raw material | Consumption (weight portion) |
| Azoles mite ester sodium lignin sulfonate neopelex glucose bentonite precipitated calcium carbonate | 10.0 15.0 10.0 15.0 40.0 10.0 |
With precipitated calcium carbonate precomminution, then it is fully mixed with above-mentioned other composition earlier, adopt comminution by gas stream processing again, make 10% azoles mite ester wetting powder, carry out extruder grain again or wave granulation, promptly become 10% azoles mite ester water dispersion granule.
Example of formulations 2:15% fenpyroximate water dispersible granule
| Raw material | Consumption (weight portion) |
| The sodium sldium lauryl sulfate glucose bentonite polyvinyl acetate of azoles mite ester polyacrylic acid and carboxylic acid | 15.0 15.0 12.0 15.0 40.0 7.0 |
Adopt the rotary table granulation method, earlier above-mentioned raw materials (except that polyvinyl acetate) is carried out ultra-fine grinding, make the ultra-fine wetting powder of azoles mite ester, then in the rotating disc that tilts, the limit adds wetting powder, the aqueous solution that the limit spray has poly-vinegar vinyl acetate carries out granulation, promptly becomes 15% fenpyroximate water dispersible granule.
Example of formulations 3:5% acarid nitrile water dispersion granula
| Raw material | Consumption (weight portion) |
| The sodium sldium lauryl sulfate sulphur ammonium glucose precipitated calcium carbonate gum Arabic of azoles mite ester polyacrylic acid and carboxylic acid | 5.0 5.0 5.0 10.0 15.0 40.0 20.0 |
Adopt a sulfuration bed comminution granulation, earlier above-mentioned raw materials (except that polyvinyl alcohol) is pulverized, make superfine powder, this powder is kept under flow regime, the binder solution of spraying makes it the aggegation granulation, 5% fenpyroximate water dispersible granule.
Example of formulations 4:20% fenpyroximate water dispersible granule
| Raw material | Consumption (weight portion) |
| Azoles mite ester sodium lignin sulfonate sodium bicarbonate acid citrate dextrose | 20.0 10.0 27.0 23.0 10.0 |
| Gum Arabic | 10.0 |
Adopt a sulfuration bed comminution granulation, promptly earlier azoles mite ester, sodium lignin sulfonate, sodium bicarbonate, citric acid and glucose carried out ultra-fine grinding, and then the spraying polyvinyl alcohol, make it the granulation of condensing, 20% fenpyroximate water dispersible granule.
Biological Examples 15% fenpyroximate water dispersible granule is to the two spotted spider mite indoor virulence
At outdoor plantation wild cabbage, connect two spotted spider mite worm pupa mid-term in the wild cabbage growth, after breeding for 2 generations continuously, contain the phase of sending out at 3 ~ 4 instar larvaes, larva is adopted back indoor, get healthy and strong 4 the initial stage in age larva contain in the foster worm bottle that has gone to the end (6 centimetres of diameters, high 10 centimetres) respectively, bottle up and down two ends is respectively applied for 50 order nylon wires and tightens, every bottle contain larva about 25 standby.
Every kind of medicament is established 6 kinds of concentration gradients, and every kind of concentration is established 4 repetitions, about 25 4 instar larvaes of every reprocessing.The examination worm is immersed respectively in the soup of respective concentration, taken out after 8 seconds, inhale with blotting paper and remove unnecessary soup, worm is transferred to raised in the bottle (9 centimetres of diameters, high 10 centimetres) again.Place a filter paper in advance in the bottle, put into the fresh pickles leaf of 3 ~ 4 agreements that contracts a film or TV play to an actor or actress, 8 centimeter length, bottleneck is tightened with 60 order gauzes in case its escape is raised under the room temperature of insectary, places one little absorbent cotton in the bottle and drips the supernatant water insulation.Handle and checked each survival borer population and dead borer population of handling of record in back 48 hours.Death standard: with its overturning, the scrambler that can not normally reset is death with insect needle.Contrast is handled with clear water, establishes 4 repetitions.
Result of the test is as follows:
Its LC of Y=5.663+0.845X
50=2.29 R=0.9450
Hence one can see that, and 5% fenpyroximate water dispersible granule (example of formulations 3) is higher to the virulence of two spotted spider mite, and the lethal concentration of 50 is 2.29.
Biological embodiment 2 two spotted spider mite daejeon prevention tests
The results are shown in Table 1:
The drug effect computational methods:
" DMRT " method is adopted in b, significance of difference analysis.
In the formula: CK
0Pt before the medicine of-check plot
0Before-treatment region the medicine
CK
1Pt behind the medicine of-check plot
1Behind-treatment region the medicine
The field control effectiveness test of table 1 15% fenpyroximate water dispersible granule control two spotted spider mite
| Handle (g/ha) | Insect population radix (head) before the medicine | Behind the medicine 1 day | Behind the medicine 3 days | Behind the medicine 5 days | Behind the medicine 9 days | |||||
| Borer population (head) alive | Preventive effect (%) | Borer population (head) alive | Preventive effect (%) | Borer population (head) alive | Preventive effect (%) | Borer population (head) alive | Preventive effect (%) | |||
| The contrast of 15% fenpyroximate water dispersible granule clear water | 50 40 30 - | 40.75 35.45 30.23 20.35 | 8.00 9.05 11.25 19.23 | 78.56a 75.38b 68.34c - | 6.32 7.18 10.37 20.15 | 80.35a 76.59ab 70.26c - | 4.16 5.27 7.35 21.89 | 92.16a 85.64b 78.46c - | 1.59 2.67 4.57 29.00 | 98.61a 94.51ab 88.34c - |
Annotate: lowercase alphabet is shown in the significance of difference on 95% confidence interval in the table
As seen from the above table, 15% fenpyroximate water dispersible granule (preparation implements 2) has higher preventive effect to two spotted spider mite.
Though above the present invention is described in detail with a general description of the specific embodiments, on the invention basis, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, not departing from the these modifications or improvements basically of spirit of the present invention, all belong to the scope of protection of present invention.
Claims (9)
1. fenpyroximate water dispersible granule, it is characterized in that: its component and content (percentage by weight) are: azoles mite ester 1-80%, auxiliary agent 0.5-50%, filler 10-90%: described auxiliary agent is meant dispersant and/or wetting agent, disintegrant, stabilizing agent, binding agent; Described filler is the one or more kinds of mixed fillers in white carbon, potter's clay, bentonite, precipitated calcium carbonate, attapulgite, talcum powder, kaolin, the mica.
2. fenpyroximate water dispersible granule according to claim 1, it is characterized in that: the preferred content of each component is: azoles mite ester 5-30%, auxiliary agent 10-30%, filler 30-70%: described auxiliary agent is meant dispersant and/or wetting agent, disintegrant, stabilizing agent, binding agent; Described filler is the one or more kinds of mixed fillers in white carbon, potter's clay, bentonite, precipitated calcium carbonate, attapulgite, talcum powder, kaolin, the mica.
3. water dispersible granules according to claim 1 and 2 is characterized in that: described azoles mite ester can be azoles mite ester and kill the mite king.
4. fenpyroximate water dispersible granule according to claim 1 and 2 is characterized in that: described dispersant is one or more mixed dispersants among sodium lignin sulfonate, potassium and ammonium salt, polyacrylic acid, sodium phosphate trimer, diffusion agent N O, dispersing agent MF, naphthalene sulfonate, rope uncle SOPA, the NNO.
5. water dispersible granules according to claim 1 and 2 is characterized in that: described wetting agent is that alkylnaphthalene sulfonate, tea are withered, Chinese honey locust, sldium lauryl sulfate, draw back in powder, penetrant t, penetrating agent JFC, the neopelex one or more and mix wetting agents.
6. obtain 2 described water dispersible granules according to claim 1, it is characterized in that: described binding agent is one or more hybrid adhesives in starch, gum Arabic, polyvinyl alcohol, polyethylene glycol ethers, dextrin, sodium sulphate, rosin, the methylcellulose.
7. water dispersible granules according to claim 1 and 2 is characterized in that: described disintegrant is one or more mixing disintegrants in ammonium sulfate, carboxymethyl cellulose, calcium chloride, bentonite, aluminium chloride, the urea.
8. water dispersible granules according to claim 1 and 2 is characterized in that: described stabilizing agent is one or more mixed stabilizers of tributyl phosphate, triphenyl phosphite, BHT.
9. water dispersible granules according to claim 1 and 2 is characterized in that: described filler or carrier are one or more the mixed fillers in white carbon, diatomite, talcum, kaolin, clay, the precipitated calcium carbonate.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101953336A (en) * | 2010-10-26 | 2011-01-26 | 江苏七洲绿色化工股份有限公司 | Metribuzin water dispersible granules and preparation method thereof |
| CN101773115B (en) * | 2010-01-28 | 2012-02-01 | 惠州市银农科技有限公司 | Preparation method of pesticide water dispersible granules having fast disintegration property |
| CN101617660B (en) * | 2009-08-01 | 2012-05-02 | 深圳诺普信农化股份有限公司 | a pesticide composition |
| CN119278938A (en) * | 2024-10-09 | 2025-01-10 | 中国农业大学 | An emulsifiable microgranule for replacing pesticide droplet granulation, and its preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101617660B (en) * | 2009-08-01 | 2012-05-02 | 深圳诺普信农化股份有限公司 | a pesticide composition |
| CN101773115B (en) * | 2010-01-28 | 2012-02-01 | 惠州市银农科技有限公司 | Preparation method of pesticide water dispersible granules having fast disintegration property |
| CN101953336A (en) * | 2010-10-26 | 2011-01-26 | 江苏七洲绿色化工股份有限公司 | Metribuzin water dispersible granules and preparation method thereof |
| CN101953336B (en) * | 2010-10-26 | 2012-11-21 | 江苏七洲绿色化工股份有限公司 | Metribuzin water dispersible granules and preparation method thereof |
| CN119278938A (en) * | 2024-10-09 | 2025-01-10 | 中国农业大学 | An emulsifiable microgranule for replacing pesticide droplet granulation, and its preparation method and application |
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