CN109953819A - A multipolar plasma ablation catheter - Google Patents

Abstract

The present invention relates to ablation device field, especially a kind of multipole Inferior turbinate hypertrophy conduit comprising: have the tube body of distal ports, the distal ports have free end；Electrode, the electrode are set on the free end of the distal ports；Control handle, the distal ports are installed on the control handle and can be controlled by the control handle and are bent；It is provided with plasma on the free end and generates medium delivery outlet；The electrode includes: head end electrode, and the head end number of electrodes is set to the free end for more than two and mutually insulated, and centered on the axis of the distal ports, the head end electrode is arranged towards more than two directions；Ring electrode, around distal ports at least one week the free end is arranged in the ring electrode, and be located at the rear of the head end electrode, goal of the invention of the invention be to provide a kind of Collation surgery direction is controllable, reduce health tissues near target tissue damage multipole Inferior turbinate hypertrophy conduit.

Description

A multipolar plasma ablation catheter

technical field

The invention relates to the field of ablation treatment devices, in particular to a multipolar plasma ablation catheter.

Background technique

Under the action of the electric field, the particles of different electrical properties inside the material will be subjected to the electric field force in the opposite direction. When the electric field is strong enough, the positive and negative particles cannot be assembled together, and eventually become ions that can move freely, and the material is transformed into an ionic state. This transformation can be transformed at room temperature, that is, low temperature plasma.

The working principle of low-temperature plasma ablation is to excite a medium (NaCl) with a specific 100kHz ultra-low frequency electric energy to generate plasma, and in the temperature range of 40-70 °C, the sound waves generated by the "plasma" break the molecular bonds of the target tissue. , which directly splits biological macromolecules such as proteins into O ₂ , CO ₂ , N ₂ and other gases, thereby completing tissue ablation in a "minimally invasive" form.

Under the low-frequency stable electric field of 100kHz, the particles will obtain a longer acceleration time, and finally form high-speed charged particles (plasma) with greater kinetic energy, which directly break the molecular bonds. Intermolecular friction generates heat, enabling ablation to be performed at low temperatures (temperatures that do not denature cells), thereby achieving a minimally invasive effect.

Usually, under a low-frequency stable electric field of 100KHz, exciting a molecule of NaCl (plasma generating medium) will generate 8 electron volts of kinetic energy, while the kinetic energy required to break a peptide bond is 4 electron volts, so that the target tissue cells are disintegrated in molecular units. Cleavage and vaporize tissues such as proteins into low-molecular-weight gases such as H ₂ , O ₂ , CO ₂ , N ₂ and methane, and form cutting and ablation effects at low temperatures. Organizations work very differently.

At present, low-temperature plasma ablation is used in many parts outside the human body, such as the nasal cavity and tonsils. The target tissue in this case is generally a part of the inner wall of a larger cavity in the human body, and low-temperature plasma ablation is used However, if the target tissue is located in some small space deep in the human body, when the electrode tip for low temperature plasma ablation extends into the target tissue When the target tissue is completely surrounded by tissue, when the target tissue is only located on one side of the electrode head, this is a low-temperature plasma ablation, which will destroy healthy tissue and cause irreversible damage to the human body.

SUMMARY OF THE INVENTION

In view of the problems existing in the prior art, the purpose of the present invention is to provide a multipolar plasma ablation catheter that can control the direction of low temperature plasma ablation and reduce the damage of healthy tissue next to the target tissue.

In order to achieve the above object, the technical scheme adopted in the present invention is:

A multipolar plasma ablation catheter comprising:

a pipe body with a distal section, the distal section has a free end, and the free end is provided with a plasma generating medium output hole;

an electrode, the electrode is disposed on the free end of the distal segment;

a control handle, the pipe body is mounted on the control handle and can be controlled to bend by the control handle;

The electrodes include:

a tip electrode, wherein the number of the tip electrodes is two or more and is provided on the free end in an insulated manner, and the tip electrodes are arranged in more than two directions with the axis of the distal segment as the center;

A ring electrode is disposed at the free end at least once around the distal segment and behind the tip electrode.

The free end is provided with a plasma generating medium output hole, so that the free end can output a plasma generating medium (usually liquid), and in the case of this solution, the target tissue (disease tissue) is located deep in the human body. Some places with small spaces (generally not including blood vessels, because the flowing blood will wash away the plasma generating medium, but this solution can also be used in special cases, such as temporarily blocking the blood flow in the target blood vessels for surgery), When the plasma generating medium is output from the output hole of the plasma generating medium, due to the narrow space, there are tissues around the free end, and the plasma generating medium will soon fill around the free end, including the target tissue position, so that the space between the target tissue and the electrode will be filled. There is a plasma generating medium, which satisfies the conditions for low temperature plasma ablation.

The electrodes are divided into tip electrodes and ring electrodes. There are more than two tip electrodes. When two or more tip electrodes contact the target tissue at the same time, they discharge together to form a current in some or all of the target tissue, and finally When an electric field with a stable frequency is formed, the plasma generating medium corresponding to part or all of the target _tissue is _separated , and _plasma is _generated . Molecular weight gas to achieve plasma ablation. At the same time, if the ring electrode is matched with more than two head electrodes, for example, the ring electrode cooperates with a head electrode to discharge, the head electrode and the target tissue can be made through the above-mentioned plasma ablation principle. The plasma generating medium between them is separated, and the target tissue corresponding to this part is ablated by plasma, which has the controllability of the low-temperature plasma ablation direction. Plasma ablates the target tissue on one side of the free end, reducing damage to healthy tissue next to the target tissue.

As a preferred solution of the present invention, a single head-end electrode can discharge independently, and some target tissues (disease tissues) are not always affected. Stimulate the target tissue, induce disease, and facilitate the more precise search for the target tissue.

As a preferred solution of the present invention, the ring electrode can discharge independently, and the principle is as described above, so that the release range of the stimulation voltage is wider and the adaptability is stronger.

As a preferred solution of the present invention, the number of the head-end electrodes is two, and the two head-end electrodes are distributed on both sides of the free end.

As a preferred solution of the present invention, the two head-end electrodes are symmetrically arranged around the axis of the distal end segment, which is more convenient for the doctor to operate and judge, because after the ablation catheter is inserted into the human body, the doctor is based on external instruments (such as Mapping signal or 3D modeling, etc.) to judge the position of the electrode and the position of the target tissue, so as to make adjustments. The two head-end electrodes are symmetrically arranged, which is easier to help under the condition that the direction of low-temperature plasma ablation can be controlled. Doctors operate and judge.

As a preferred solution of the present invention, the output hole of the plasma generating medium is used for outputting NaCl solution, which is less harmful to the human body. For example, there are many trace elements in the human body, such as K and Mg. If these elements are injected into the human body Too much will cause adverse effects, and NaCl has a relatively large threshold for the acceptable amount of the human body. We usually use NaCl solution for infusion, which is what we call normal saline. Therefore, our plasma generation medium uses NaCl. The solution can not only meet the conditions for low-temperature plasma ablation, but also minimize the harm to the human body, and at the same time, the cost is relatively low and the economic performance is better.

As a preferred solution of the present invention, a temperature sensor is arranged in the free end to detect the temperature of the tissue during ablation, so that the ablation treatment is controllable and safety is improved.

As a preferred solution of the present invention, the temperature sensor is located in the tip electrode, so that the temperature detection of the tissue is more accurate, and the ablation treatment is more controllable and safer.

The beneficial effects of the present invention are:

The free end is provided with a plasma generating medium output hole, so that the free end can output a plasma generating medium (usually liquid), and in the case of this solution, the target tissue is located in some narrow places deep in the human body. (Intravascular is generally not included, because the flowing blood will wash away the plasma-generating medium, but this solution can also be used in special cases, such as surgery to temporarily block the blood flow in the target blood vessel), when the plasma-generating medium is removed from the After the output hole of the plasma generating medium is output, due to the narrow space, there are tissues around the free end, and the plasma generating medium will soon be filled around the free end, including the position of the target tissue, so that there is plasma generation between the target tissue and the electrode. medium, meeting the conditions for low temperature plasma ablation.

The electrodes are divided into tip electrodes and ring electrodes. There are more than two tip electrodes. When two or more tip electrodes contact the target tissue at the same time, they discharge together to form a current in some or all of the target tissue, and finally When an electric field with a stable frequency is formed, the plasma generating medium corresponding to part or all of the target tissue is separated to realize plasma ablation. Then the plasma generating medium between the tip electrode and the target tissue can be separated by the above-mentioned plasma ablation principle, and the target tissue corresponding to this part is ablated by plasma, which has the controllability of the low-temperature plasma ablation direction. The ring electrode is selected to work with one or more different tip electrodes, and the low-temperature plasma ablates the target tissue on one side of the free end to reduce the damage to the healthy tissue next to the target tissue.

Description of drawings

Fig. 1 is the structural representation of the distal section of the present invention;

Figure 2 is a cross-sectional view of a distal segment of the present invention;

3 is a schematic diagram of the ablation of the present invention;

Fig. 4 is the structural representation of the present invention;

Marked in the figure: 1-distal segment, 2-ring electrode, 21-ring electrode lead, 3-electrode A, 31-electrode A lead, 4-electrode B, 41-electrode B lead, 5-insulation block, 51- Plasma generation medium output hole, 6-temperature sensor, 7-target tissue, 8-control handle, 15-plasma generation medium interface, 16-wire interface.

Detailed ways

The present invention will be further described in detail below with reference to the examples and specific implementation manners. However, it should not be construed that the scope of the above-mentioned subject matter of the present invention is limited to the following embodiments, and all technologies realized based on the content of the present invention belong to the scope of the present invention.

Example 1

As shown in Figures 1, 2 and 4, a multipolar plasma ablation catheter comprising:

A pipe body with a distal section 1, the distal section 1 has a free end, and the free end is provided with a plasma generating medium output hole 51, and the plasma generating medium output hole 51 is used to output a NaCl solution, that is, a plasma generating medium. The medium is NaCl solution;

an electrode, the electrode is arranged on the free end of the distal end segment 1, and a temperature sensor 6 is arranged in the free end;

a control handle 8, the pipe body is mounted on the control handle 8 and can be controlled to bend by the control handle 8;

The electrodes include:

The head-end electrode, the number of the head-end electrodes is two or more and is provided at the free end insulated from each other (insulation is achieved by the insulating block 5 arranged between the head-end electrodes, the opening of the plasma generating medium output hole 51 is It is arranged in the middle position of the distal end of the insulating block 5, ), with the axis of the distal end segment 1 as the center, and the tip electrode is arranged in more than two directions;

The ring electrode 2 is disposed at the free end at least one circle around the distal end segment 1, and is located behind the tip electrode.

Among the above electrodes, a single tip electrode can discharge independently, and the ring electrode 2 can discharge independently.

Specifically, in this embodiment, the distal segment 1 is provided with a ring electrode lead 21, one end of which is connected to the ring electrode 2 for power supply and data transmission, and the other end is connected to a wire capable of supplying energy to it and transmitting data. In the ablation instrument for control, the number of the head electrodes is two, the two head electrodes are distributed on both sides of the free end, and the two head electrodes are symmetrically arranged around the axis of the distal section 1, and the The temperature sensor 6 is located in the head-end electrode, the two head-end electrodes are electrode A3 and electrode B4, respectively, and the distal section 1 is provided with corresponding electrode A wire 31 and electrode B wire 41, one end of which is respectively connected to the electrode A3 and electrode B4 are used to supply energy and transmit data, and the other end is connected to the ablation instrument that can supply energy and control it. The outward end of electrode A3 and electrode B4 is rounded to better adhere to the tissue And to prevent tissue from being scratched, the end of the control handle 8 opposite to the distal segment is provided with a plasma generating medium interface 15 and a wire interface 16. The plasma generating medium output hole 51 is in communication, the plasma generating medium interface 15 is used to connect an external plasma generating medium output source, and the wire interface 16 is finally connected to the electrode A wire 31 respectively through the connecting line provided in the control handle 8 . , the electrode B wire 41 , the ring electrode wire 21 and the temperature sensor 6 are connected, and the wire interface 16 is used to connect the ablation instrument.

The number of the ring electrodes 2 is one, which is located behind the tip electrode, between electrode A3 and electrode B4, or between electrode A3 and ring electrode 2, or between electrode B4 and ring electrode 2, and can be stimulated (two The current and voltage required to form the corresponding "stimulation" between the electrodes), stimulate the disease during the treatment, help to find the lesion tissue, after the ablation is completed, between the electrode A3 and the electrode B4, or between the electrode A3 and the ring electrode 2, or Between electrode B4 and ring electrode 2, impedance detection can be performed (the current and voltage required to form the corresponding "impedance detection" between the two electrodes) to judge the ablation effect and improve the safety of ablation. The impedance will decrease after normal ablation is successful. , but excessive ablation will lead to a sharp rise in tissue impedance, from which the effect of ablation can be determined.

At the same time, a certain voltage can be applied between the electrode A3 and the electrode B4, or between the electrode A3 and the ring electrode 2, or between the electrode B4 and the ring electrode 2, so that a 100kHz low-frequency stable electric field is formed between the two electrodes, and the 100kHz ultra-low frequency electric energy excites the dielectric NaCl solution Plasma is generated, and the sound wave generated by the plasma breaks the molecular bonds of the target tissue, and directly splits biological macromolecules such as proteins into O ₂ , CO ₂ , N ₂ and other gases, so as to complete the target tissue in a low-temperature and minimally invasive form7 Ablation (Figure 3).

Claims (8)

1. A multipolar plasma ablation catheter comprising: a tubular body having a distal segment, the distal segment having a free end; an electrode, the electrode is disposed on the free end of the distal segment; It is characterized in that it also includes a control handle, and the pipe body is mounted on the control handle and can be controlled to bend by the control handle; The free end is provided with a plasma generating medium output hole; The electrodes include: a tip electrode, wherein the number of the tip electrodes is two or more and is provided on the free end in an insulated manner, and the tip electrodes are arranged in more than two directions with the axis of the distal segment as the center; A ring electrode is disposed at the free end at least once around the distal segment and behind the tip electrode. 2 . The multipolar plasma ablation catheter according to claim 1 , wherein the single tip electrode can discharge independently. 3 . 3 . The multipolar plasma ablation catheter according to claim 1 , wherein the ring electrode can discharge independently. 4 . The multipolar plasma ablation catheter according to claim 2 or 3, wherein the number of the head electrodes is two, and the two head electrodes are distributed on both sides of the free end. 5 . The multipolar plasma ablation catheter according to claim 4 , wherein the two tip electrodes are symmetrically arranged around the axis of the distal end segment. 6 . 6 . The multi-pole plasma ablation catheter according to claim 1 , wherein the plasma generating medium output hole is used for outputting NaCl solution. 7 . 7 . The multi-pole plasma ablation catheter according to claim 1 , wherein a temperature sensor is arranged in the free end. 8 . 8. The multi-pole plasma ablation catheter according to claim 7, wherein the temperature sensor is located in the tip electrode.