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CN109922806A - 氢溴酸沃替西汀长效注射制剂 - Google Patents

氢溴酸沃替西汀长效注射制剂 Download PDF

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Publication number
CN109922806A
CN109922806A CN201780066679.6A CN201780066679A CN109922806A CN 109922806 A CN109922806 A CN 109922806A CN 201780066679 A CN201780066679 A CN 201780066679A CN 109922806 A CN109922806 A CN 109922806A
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CN
China
Prior art keywords
hydrobromic acid
injection
long acting
acid vortioxetine
preparation
Prior art date
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CN201780066679.6A
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English (en)
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CN109922806B (zh
Inventor
宋平
朱思琪
赵步文
游劲松
黄芳芳
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Guangdong HEC Pharmaceutical Co Ltd
Original Assignee
Ruyuan Yongxing Technical Service Co ltd
Sunshine Lake Pharma Co Ltd
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Publication of CN109922806A publication Critical patent/CN109922806A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

本发明涉及一种氢溴酸沃替西汀长效注射制剂。所述制剂包含氢溴酸沃替西汀、助悬剂、稳定剂、缓冲剂、pH调节剂、溶剂，所述制剂可以为即用型液体注射剂，也可以为冻干粉针剂，所述制剂注射后具有明显缓释效果，可减少给药次数，延长药物作用时间，提高患者依从性，提高生物利用度。同时，本发明还提供了制备上述氢溴酸沃替西汀长效注射制剂的方法，该方法简单经济，适用于工业化生产。

Description

PCT国内申请，说明书已公开。

Claims (17)

  1. PCT国内申请，权利要求书已公开。
CN201780066679.6A 2016-11-09 2017-11-08 氢溴酸沃替西汀长效注射制剂 Active CN109922806B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2016109936425 2016-11-09
CN201610993642 2016-11-09
PCT/CN2017/109941 WO2018086534A1 (zh) 2016-11-09 2017-11-08 氢溴酸沃替西汀长效注射制剂

Publications (2)

Publication Number Publication Date
CN109922806A true CN109922806A (zh) 2019-06-21
CN109922806B CN109922806B (zh) 2021-11-05

Family

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Country Status (2)

Country Link
CN (1) CN109922806B (zh)
WO (1) WO2018086534A1 (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114366714A (zh) * 2021-04-29 2022-04-19 山东京卫制药有限公司 一种阿戈美拉汀混悬鼻喷剂及其应用
CN115052601A (zh) * 2020-03-13 2022-09-13 广东东阳光药业有限公司 一种哌嗪基类药物的组合物
WO2024183192A1 (zh) * 2023-06-30 2024-09-12 山东泰合医药科技有限公司 昔萘酸伏硫西汀长效缓释微球组合物及其制备方法和应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114222565B (zh) * 2019-10-16 2023-10-20 广东东阳光药业股份有限公司 一种药物组合物
JP2024528732A (ja) * 2021-08-05 2024-07-30 浙江華海薬業股▲フン▼有限公司 ボルチオキセチンパモ酸塩の凍結乾燥粉末注射剤およびその調製方法
CN118201600A (zh) * 2021-11-10 2024-06-14 广东东阳光药业股份有限公司 一种喹啉类药物的组合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015035802A1 (zh) * 2013-09-12 2015-03-19 杭州普晒医药科技有限公司 沃替西汀盐及其晶体、它们的制备方法、药物组合物和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104146953A (zh) * 2014-07-24 2014-11-19 李雪梅 一种氢溴酸沃替西汀注射液
US20170196802A1 (en) * 2016-01-08 2017-07-13 Abon Pharmaceuticals, Llc Long Acting Injectable Formulations
AU2017242867B9 (en) * 2016-03-29 2019-07-04 Shanghai Synergy Pharmaceutical Sciences Co., Ltd Vortioxetine pamoic acid salt and crystal form thereof
CN106265498A (zh) * 2016-08-31 2017-01-04 安徽省润生医药股份有限公司 一种新型氢溴酸沃替西汀注射液及其制备方法
CN109010261B (zh) * 2017-06-22 2020-11-06 四川大学 一种小分子药物原位相变凝胶缓释系统及其制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015035802A1 (zh) * 2013-09-12 2015-03-19 杭州普晒医药科技有限公司 沃替西汀盐及其晶体、它们的制备方法、药物组合物和用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
潘卫三主编: "《工业药剂学》", 31 August 2015, 中国医药科技出版社 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115052601A (zh) * 2020-03-13 2022-09-13 广东东阳光药业有限公司 一种哌嗪基类药物的组合物
CN114366714A (zh) * 2021-04-29 2022-04-19 山东京卫制药有限公司 一种阿戈美拉汀混悬鼻喷剂及其应用
CN114366714B (zh) * 2021-04-29 2022-10-11 山东京卫制药有限公司 一种阿戈美拉汀混悬鼻喷剂及其应用
WO2024183192A1 (zh) * 2023-06-30 2024-09-12 山东泰合医药科技有限公司 昔萘酸伏硫西汀长效缓释微球组合物及其制备方法和应用

Also Published As

Publication number Publication date
WO2018086534A1 (zh) 2018-05-17
CN109922806B (zh) 2021-11-05

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Effective date of registration: 20200429

Address after: 523808 Guangdong city of Dongguan province Hubei Songshan Industrial Park Industrial Road No. 1

Applicant after: SUNSHINE LAKE PHARMA Co.,Ltd.

Address before: 523808 Guangdong city of Dongguan province Hubei Songshan Industrial Park Industrial Road No. 1

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Applicant before: Ruyuan Yongxing Technical Service Co.,Ltd.

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Address after: 523808 No.1, Gongye North Road, Songshanhu Park, Dongguan City, Guangdong Province

Patentee after: Guangdong Dongyangguang Pharmaceutical Co.,Ltd.

Address before: 523808 No. 1 Industrial North Road, Songshan Industrial Park, Songshan, Guangdong, Dongguan, Hubei

Patentee before: SUNSHINE LAKE PHARMA Co.,Ltd.