CN109700436A - A kind of Dermal microvessel form and blood flow detection device - Google Patents
A kind of Dermal microvessel form and blood flow detection device Download PDFInfo
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- CN109700436A CN109700436A CN201910080286.1A CN201910080286A CN109700436A CN 109700436 A CN109700436 A CN 109700436A CN 201910080286 A CN201910080286 A CN 201910080286A CN 109700436 A CN109700436 A CN 109700436A
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Abstract
The present invention provides a kind of Dermal microvessel form and blood flow detection devices, the detection device includes swept light source, Michelson interference system and photoelectric detecting system, the light beam that the swept light source provides is scanned through Michelson interference System guides to sample, the light being reflected back is received through photoelectric detecting system and is imaged, and the wavelength of the swept light source is 1305nm, bandwidth length 110nm, output power > 40mW, scanning speed 50-100kHz.Detection device of the invention can accomplish in real time, monitor Dermal microvessel morphological change and Dermal microvessel blood stream rheology etc. to dynamic, high-resolution.
Description
Technical field
The invention belongs to Dermal microvessel technical field of imaging, and in particular to a kind of Dermal microvessel form and blood flow detection
Device.
Background technique
" everybody has a love of beauty ", " U.S.A is to recommend all strong reference than any ".Today's society is " a brush
The age of face ", " spelling face value ", beautifying skin technical ability can make sufferer seem young moving after diagnosis and treatment sufferer, therefore by
People's heat is held in both hands.
The injection of collagen egg is one kind of beautifying skin technical ability, and Major Epidemic is in many female friends, it is considered to be maintains blueness
The good medicine in spring.Really, collagen is implanted into subcutaneously by non-surgical way, increases the capacity of dermis layer tissue, can reaches and comfort
Flat wrinkle improves face's defect, the purpose of sculpture perfect skin.But many complication or pair below may also can be brought simultaneously
Effect, including injection portion is rubescent, part occurs that extravasated blood, injection volume be exceeded, injection site swelling.Local infection, retinal blood
Pipe occlusion etc..
Therefore, it is necessary to a kind of advanced technologies, immediately, Noninvasive, precisely assess the side effect of beautifying skin bring.
108309244 A of patent application document CN disclose a kind of novel pressure sensor skin capilary scanning means and
System and working method, by installing diaphragm pressure sensor in the light transmitting sheet that probe is contacted with skin surface, when pressure is super
Crossing certain zone of reasonableness (i.e. too large or too small) Times alarm device can then sound, and manually adjust probe to the pressure of skin surface
Size, to reach the consistency and accuracy of OCT scan depth.But the system is based on spectral domain OCT, and near infrared light is worn
Saturating ability is weak, and OCT image is only capable of displaying shallower Form form, imaging depth, sensitivity and detection accuracy still need into
One step improves；It must be by pressure sensor when accurately image；Although OCT image definition can reach micron order, there are optics
Signal transduction difference and motion artifacts etc. is controllable but not eliminable factor, so that the technology is not possible to replace histology biopsy.
Summary of the invention
It is an object of the present invention to provide a kind of Dermal microvessel form and blood flow detection device, which is based on SS-OCT
Technology provides better support consequently facilitating obtaining accurate Dermal microvessel shape information for clinical diagnosis and treatment.
In order to reach above-mentioned technical purpose, technical scheme is as follows: a kind of Dermal microvessel form and blood flow are visited
Device is surveyed, the detection device includes swept light source, Michelson interference system and photoelectric detecting system, and the swept light source mentions
The light beam of confession is scanned through Michelson interference System guides to sample, the light being reflected back through photoelectric detecting system receive at
Picture, the wavelength of the swept light source are 1305nm, bandwidth length 110nm, output power > 40mW, scanning speed 50-100kHz.
Preferably, the Michelson interference system includes the first fiber coupler, reference arm, sample arm, the second optical fiber
Coupler, circulator,
First fiber coupler is used for the incipient beam of light that receiving frequency-sweeping light source provides, and is classified as two parts, point
It Jin Ru not sample arm and reference arm；
The reference arm includes circulator, collimation lens and plane mirror, and the light beam of entrance is after circulator, collimated lens
Plane mirror reflection is focused on, then backtracking is directed into second fiber coupler through circulator；
The sample arm includes circulator and hand-held probe, into sample arm incipient beam of light by entering after circulator
Hand-held probe is scanned skin, then backtracking, then leads through circulator back into the second fiber coupler；
The photoelectric detecting system includes balanced detector and acquisition and processing card, and the balanced detector is for receiving second
The interference spectrum of fiber coupler output, and optical signal is converted to electric signal；The acquisition and processing card is visited for acquiring balance
It surveys the interference electric signal of device output and is imaged.
Preferably, sensitivity > 95dB of the detection device.
Preferably, areas imaging 6mm × 6mm of the detection device, imaging depth 2mm.
Preferably, the lateral resolution of the detection device is 7.5 μm, and axial resolution is 5 μm.
Preferably, first fiber coupler is 90/10 coupler, and 90% light enters sample arm, 10% light into
Enter reference arm.
Preferably, second fiber coupler is 50/50 fiber coupler.
Preferably, x-y scan-type galvanometer, diameter 12mm are provided in the hand-held probe.
Preferably, the image probe aperture of the hand-held probe is 1.2-1.4cm.
Preferably, the acquisition process rate of the acquisition and processing card is 50-200fps.
Dermal microvessel form and blood flow detection device provided by the invention based on SS-OCT have it is following the utility model has the advantages that
1, with spectral domain OCT (SD-OCT), frequency domain OCT (FD-OCT), SS-OCT there is more long wavelength, faster speed to sweep
Frequency light source and the balanced detector that can accurately detect point by point, therefore it has faster image taking speed, deeper imaging deep
Degree, higher signal-to-noise ratio, stronger sensitivity.
2, the additional background noise that the interferometer with circulator, balanced detector can generate to avoid light source.
3, SS-OCT system imaging process is friendly, noninvasive lossless, and time-consuming short, imaging resolution is high, and expense is cheap.
Detection device of the invention can accomplish in real time, monitor collagen injections to dynamic, high-resolution after skin it is micro-
Blood vessel morphology variation and Dermal microvessel blood stream rheology, diagnosis, the treatment of aid in skin beauty complication, are expected into
Successfully go beyond the important leverage tool of last one of barrier on the road Qiu Meizhi for sufferer.
Detailed description of the invention
Fig. 1 is the Dermal microvessel form of the embodiment of the present invention and the structural schematic diagram of blood flow detection device.
Specific embodiment
The technical solution that the present invention will be described in detail in the following with reference to the drawings and specific embodiments.
The present invention provides a kind of Dermal microvessel form and blood flow detection device, including swept light source, Michelson is dry
System and photoelectric detecting system are related to, the light beam that swept light source provides is scanned through Michelson interference System guides to sample,
The light being reflected back is received through photoelectric detecting system and is imaged, and the wavelength of swept light source is 1305nm, bandwidth length 110nm, output work
Rate > 40mW, scanning speed 50-100kHz.
Compared with traditional OCT, have longer scanning wavelength and scanning speed, therefore have faster image taking speed,
Deeper imaging depth, higher signal-to-noise ratio, stronger sensitivity.And all be it is noninvasive lossless, can in real time, high-resolution it is visual
Change skin internal structure image, imaging process is friendly, and expense is cheap.
Below with reference to preferred embodiment, it is described further.
Embodiment 1
Shown in referring to Fig.1, a kind of Dermal microvessel form and blood flow detection device, comprising:
Swept light source 1, the wavelength of swept light source are 1305nm, bandwidth length 110nm, output power > 40mW, scanning speed
It spends 50-100kHz (50000-100000A-lines/s)；First fiber coupler 2, the first fiber coupler 2 are 90/10 coupling
Device；Reference arm, including circulator 3, collimation lens 5 and plane mirror 6；Sample arm, including circulator 3 and hand-held probe 4 are held
X-y scan-type galvanometer is provided in formula probe 4, diameter 12mm, image probe aperture is 1.2-1.4cm, in order to fast implement
Two-dimensional scanning to sample to be tested；Second fiber coupler 7, the second fiber coupler are 50/50 fiber coupler；Photoelectricity balance
Detector 8 and acquisition and processing card 9, wherein the acquisition process rate of acquisition and processing card is 50-200fps.
In use, the light beam that swept light source 1 issues, enters the first fiber coupler 2 through fiber guides, is then divided into two
Part, 90% light enter sample arm, and 10% light enters reference arm, and the light into reference arm passes through collimation after circulator 3
Lens 5 focus on backtracking after plane mirror 6 reflects；Into the light of sample arm, hand-held probe 4 is entered after circulator 3
Sample is scanned, then backtracking；The light that reference arm and sample arm return backward is led by corresponding circulator 3 respectively
To, then import the second fiber coupler 7, be divided into the equicohesive interference spectrum of two beams, most afterwards through balanced detector 8 carry out light
Electrotransformation forms imaged interference signal；The collected processing card 9 of imaged interference signal receives imaging, and acquisition and processing card 9 can be selected
The product of NI PCIe-1433 model.
Sensitivity > 95dB of entire detection device；Areas imaging 6mm × 6mm, imaging depth 2mm；Lateral resolution is
7.5 μm, axial resolution is 5 μm.
The Dermal microvessel form and blood flow detection device that embodiment 1 provides have it is following the utility model has the advantages that
1, compared with the existing device for being based on spectral domain OCT (SD-OCT), frequency domain OCT (FD-OCT), this detection device
With more long wavelength, the swept light source of faster speed and the balanced detector that can accurately detect point by point, therefore it has more
Fast image taking speed, deeper imaging depth, higher signal-to-noise ratio, stronger sensitivity.
2, the additional background noise that the interferometer with circulator, balanced detector can generate to avoid light source.
3, imaging process is friendly, noninvasive lossless, and time-consuming short, imaging resolution is high, and expense is cheap.
Dermal microvessel form and blood flow detection device of the invention further may be used by obtaining Dermal microvessel form
There is the distance of organized layer, by extracting blood vessel morphology and blood flow information to measure skin epidermis layer surface to first blood vessel
Daily assessment skin inflammation situation before and after collagen injections.Blood vessel morphology can be from dermovascular radius, density etc.
Set about, vascular flow information can start with from quantization blood flow, oxygen content of blood etc..Detection device of the invention can be combined with making
Blood flow spirogram is drawn with Doppler mapping technology, and estimates blood flow velocity.Its principle is similar with ultrasonic wave, but resolution ratio is more
It is high.
Therefore, the Dermal microvessel form and blood flow detection device of noninvasive noninvasive imaging of the invention, can further comment
Estimate living body to extract and quantify dermal layer of the skin capilary, to disclose Healthy People tectology and blood vessel before and after beautifying skin
The difference of disease guarantees exclusion while beautifying, becoming handsome to instruct the timely screening and diagnosis and treatment of beautifying skin complication
The trouble and worry of complication.
In addition, first important physiology defence line of the skin as protection human body, moment participate in the functional activity of body.Machine
Any abnormal conditions of body are likely to reflect in skin surface, the external table of many skin diseases itself or viscera disease
It is existing.For this purpose, promptly and accurately being diagnosed to skin, giving immunotherapy targeted autoantibody just seems of crucial importance.The disease of previous skin disease
Reason, which checks, to be needed to obtain sample from human body, is either cut sample and can all be caused to patient using cutting method, trepan method and still perform the operation
Injury is also possible to that there are scars after the skin materials of the exposure portions such as face.Therefore the device of the invention can be also used for
Assess skin disease.
According to the disclosure and teachings of the above specification, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula is changed and is modified.Therefore, the invention is not limited to the specific embodiments disclosed and described above, to of the invention
Some modifications and changes should also be as falling into the scope of the claims of the present invention.In addition, although being used in this specification
Some specific terms, these terms are merely for convenience of description, does not limit the present invention in any way.
Claims (10)
1. a kind of Dermal microvessel form and blood flow detection device, the detection device includes swept light source, Michelson interference
System and photoelectric detecting system, the light beam that the swept light source provides are swept through Michelson interference System guides to sample
It retouches, the light being reflected back is received through photoelectric detecting system and is imaged, which is characterized in that the wavelength of the swept light source is 1305nm, band
Wide length 110nm, output power > 40mW, scanning speed 50-100kHz.
2. Dermal microvessel form according to claim 1 and blood flow detection device, which is characterized in that the Michelson
Interference system includes the first fiber coupler, reference arm, sample arm, the second fiber coupler, circulator, photoelectricity balance detection
Device,
First fiber coupler is used for the incipient beam of light that receiving frequency-sweeping light source provides, and is classified as two parts, respectively into
Enter sample arm and reference arm；
The reference arm includes circulator, collimation lens and plane mirror, and the light beam of entrance is after circulator, collimated lens focus
It is reflected to plane mirror, then backtracking is led through circulator back into second fiber coupler；
The sample arm includes circulator and hand-held probe, and the incipient beam of light into sample arm is hand-held by entering after circulator
Formula probe is scanned skin, then backtracking, then is directed into the second fiber coupler through circulator；
The photoelectric detecting system includes balanced detector and acquisition and processing card, and the balanced detector is for receiving the second optical fiber
The interference spectrum of coupler output, and optical signal is converted to electric signal；The acquisition and processing card is for acquiring balanced detector
The interference electric signal of output is simultaneously imaged.
3. Dermal microvessel form according to claim 1 and blood flow detection device, which is characterized in that the detection device
Sensitivity > 95dB.
4. Dermal microvessel form according to claim 1 and blood flow detection device, which is characterized in that the detection device
Areas imaging 6mm × 6mm, imaging depth 2mm.
5. Dermal microvessel form according to claim 1 and blood flow detection device, which is characterized in that the detection device
Lateral resolution be 7.5 μm, axial resolution be 5 μm.
6. Dermal microvessel form according to claim 1 and blood flow detection device, which is characterized in that first optical fiber
Coupler is 90/10 coupler, and 90% light enters sample arm, and 10% light enters reference arm.
7. Dermal microvessel form according to claim 1 and blood flow detection device, which is characterized in that second optical fiber
Coupler is 50/50 fiber coupler.
8. Dermal microvessel form according to claim 1 and blood flow detection device, which is characterized in that the hand-held is visited
X-y scan-type galvanometer, diameter 12mm are provided in head.
9. Dermal microvessel form according to claim 1 and blood flow detection device, which is characterized in that the hand-held is visited
The image probe aperture of head is 1.2-1.4cm.
10. Dermal microvessel form according to claim 1 and blood flow detection device, which is characterized in that at the acquisition
The acquisition process rate of reason card is 50-200fps.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111436907A (en) * | 2020-04-17 | 2020-07-24 | 佛山科学技术学院 | A cerebral vascular imaging device based on swept-frequency adaptive optics OCT |
| CN111701118A (en) * | 2020-06-24 | 2020-09-25 | 郭中华 | Blood vessel developing device for injection of hyaluronic acid |
| CN112120685A (en) * | 2020-08-21 | 2020-12-25 | 中国人民解放军总医院第一医学中心 | Blood flow imaging device and method based on optical clearing agent |
| CN115251853A (en) * | 2022-07-26 | 2022-11-01 | 中国科学院深圳先进技术研究院 | Method, device and system for detecting position of microvascular and storage medium |
| CN115444372A (en) * | 2022-09-29 | 2022-12-09 | 山东探微医疗技术有限公司 | Skin avulsion injury blood circulation detection method and system and OCT blood circulation detection system |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130301000A1 (en) * | 2012-05-10 | 2013-11-14 | Carl Zeiss Meditec, Inc. | Systems and methods for faster optical coherence tomography acquisition and processing |
| CN104768446A (en) * | 2012-09-10 | 2015-07-08 | 俄勒冈健康科学大学 | Quantification of regional circulation with optical coherence tomography angiography |
| CN106166058A (en) * | 2016-08-04 | 2016-11-30 | 温州医科大学 | One is applied to optical coherence tomography blood vessel imaging method and OCT system |
| CN108245130A (en) * | 2016-12-28 | 2018-07-06 | 南京理工大学 | A kind of optical coherence tomography angiographic apparatus and method |
| CN108523852A (en) * | 2018-05-10 | 2018-09-14 | 视微影像(河南)科技有限公司 | A kind of optical interference imaging system of frequency sweep OCT |
| CN210130816U (en) * | 2019-01-28 | 2020-03-10 | 广东唯仁医疗科技有限公司 | Skin micro-vessel shape and blood flow detection device |
-
2019
- 2019-01-28 CN CN201910080286.1A patent/CN109700436A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130301000A1 (en) * | 2012-05-10 | 2013-11-14 | Carl Zeiss Meditec, Inc. | Systems and methods for faster optical coherence tomography acquisition and processing |
| CN104768446A (en) * | 2012-09-10 | 2015-07-08 | 俄勒冈健康科学大学 | Quantification of regional circulation with optical coherence tomography angiography |
| CN106166058A (en) * | 2016-08-04 | 2016-11-30 | 温州医科大学 | One is applied to optical coherence tomography blood vessel imaging method and OCT system |
| CN108245130A (en) * | 2016-12-28 | 2018-07-06 | 南京理工大学 | A kind of optical coherence tomography angiographic apparatus and method |
| CN108523852A (en) * | 2018-05-10 | 2018-09-14 | 视微影像(河南)科技有限公司 | A kind of optical interference imaging system of frequency sweep OCT |
| CN210130816U (en) * | 2019-01-28 | 2020-03-10 | 广东唯仁医疗科技有限公司 | Skin micro-vessel shape and blood flow detection device |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111436907A (en) * | 2020-04-17 | 2020-07-24 | 佛山科学技术学院 | A cerebral vascular imaging device based on swept-frequency adaptive optics OCT |
| CN111701118A (en) * | 2020-06-24 | 2020-09-25 | 郭中华 | Blood vessel developing device for injection of hyaluronic acid |
| CN112120685A (en) * | 2020-08-21 | 2020-12-25 | 中国人民解放军总医院第一医学中心 | Blood flow imaging device and method based on optical clearing agent |
| CN112120685B (en) * | 2020-08-21 | 2024-01-30 | 中国人民解放军总医院第一医学中心 | Device and method for blood flow imaging based on optical transparency agent |
| CN115251853A (en) * | 2022-07-26 | 2022-11-01 | 中国科学院深圳先进技术研究院 | Method, device and system for detecting position of microvascular and storage medium |
| WO2024021373A1 (en) * | 2022-07-26 | 2024-02-01 | 中国科学院深圳先进技术研究院 | Microvascular position detection method, apparatus and system, and storage medium |
| CN115444372A (en) * | 2022-09-29 | 2022-12-09 | 山东探微医疗技术有限公司 | Skin avulsion injury blood circulation detection method and system and OCT blood circulation detection system |
| CN115444372B (en) * | 2022-09-29 | 2024-04-23 | 山东探微医疗技术有限公司 | Skin avulsion blood transport detection method, system and OCT blood transport detection system |
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