CN1095615A - Externally-used agent for treatment of psoriasis - Google Patents
Externally-used agent for treatment of psoriasis Download PDFInfo
- Publication number
- CN1095615A CN1095615A CN 93118088 CN93118088A CN1095615A CN 1095615 A CN1095615 A CN 1095615A CN 93118088 CN93118088 CN 93118088 CN 93118088 A CN93118088 A CN 93118088A CN 1095615 A CN1095615 A CN 1095615A
- Authority
- CN
- China
- Prior art keywords
- psoriasis
- external agent
- substrate
- good
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 201000004681 Psoriasis Diseases 0.000 title claims abstract description 27
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 18
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims abstract description 14
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000000758 substrate Substances 0.000 claims abstract description 14
- 241001161070 Calomela Species 0.000 claims abstract description 7
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims abstract description 7
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229960000890 hydrocortisone Drugs 0.000 claims abstract description 7
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 7
- 239000011593 sulfur Substances 0.000 claims abstract description 7
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 7
- 239000004480 active ingredient Substances 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 5
- 229940099259 vaseline Drugs 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 4
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 3
- 229940025250 camphora Drugs 0.000 claims description 3
- 239000010238 camphora Substances 0.000 claims description 3
- LSPHULWDVZXLIL-UHFFFAOYSA-N (+/-)-Camphoric acid Chemical compound CC1(C)C(C(O)=O)CCC1(C)C(O)=O LSPHULWDVZXLIL-UHFFFAOYSA-N 0.000 claims description 2
- 239000008157 edible vegetable oil Substances 0.000 claims description 2
- 239000012188 paraffin wax Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 16
- 239000012567 medical material Substances 0.000 abstract description 6
- 238000002360 preparation method Methods 0.000 abstract description 5
- 230000008901 benefit Effects 0.000 abstract description 3
- 239000000470 constituent Substances 0.000 abstract description 3
- 231100000957 no side effect Toxicity 0.000 abstract description 3
- 239000000047 product Substances 0.000 abstract description 3
- 239000000843 powder Substances 0.000 abstract description 2
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000006071 cream Substances 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000010298 pulverizing process Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 241000863032 Trieres Species 0.000 description 1
- HXELGNKCCDGMMN-UHFFFAOYSA-N [F].[Cl] Chemical compound [F].[Cl] HXELGNKCCDGMMN-UHFFFAOYSA-N 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- NUZWLKWWNNJHPT-UHFFFAOYSA-N anthralin Chemical compound C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O NUZWLKWWNNJHPT-UHFFFAOYSA-N 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229960002311 dithranol Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 206010033898 parapsoriasis Diseases 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
What the present invention relates to is a kind of medicine that is used for the treatment of refractory skins such as psoriasis.Its basic effective constituents is: Chinese and Western medical materials such as Radix Panacis Quinquefolii, hydrocortisone, Calomelas, Os Draconis, Calamina, salicylic acid, sulfur, phenol, with their powder and substrate, make various external agent products.The present invention offers medicine simply, fills a prescription unique, makes easily; Good effect, safe and reliable, have no side effect effective percentage 100%, cure rate is more than 90%, and the scope of application is wide, good economy performance, whatsoever this preparation of psoriasis of type all has good effectiveness, can alleviate significantly the patient pain and if financial burden, obvious social benefit.
Description
What the present invention relates to is a kind of medicine that is used for the treatment of refractory skins such as psoriasis.
Psoriasis is one of four big pertinacious diseases of being known as world's end solution still.This refractory skin makes the patient taste varieties of misery, extremely decocts torment.Be used for the treatment of the effective medicine for external use of refractory skin such as psoriasis at present, as anthralin Ointment, chlorine fluorine Shu Shuan etc., generally all formed by substrate and active ingredient modulation, select for use different substrate to can be formulated into different cream, frost (breast) dosage form, chemical substance is almost adopted in active ingredient entirely.The weak point of these existing common drugs mainly is: curative effect is all not ideal enough, easily recurrence after the drug withdrawal, and Western medicine, the side effect of chemicals life-time service are big, and what have contains a large amount of hormones; In addition, also there is narrow application range in the medicine that has, and what have is only effective to certain several types in the psoriasis, not suitable to other type, not only invalid, increases the weight of on the contrary sometimes after the use; Though have effectively curative effect is slow, the course of treatment long, need just can manifest effect more than half a year to one year, these certainly will make patient economy burden overweight.
The objective of the invention is to avoid the deficiencies in the prior art part, and a kind of good effect is provided, short treating period is in having no side effect, the psoriasis external agent product formed of Western medicine.
Can take following technical scheme to realize purpose, it is also formed by substrate and effective ingredient allotment, but active ingredient is made up of Radix Panacis Quinquefolii, hydrocortisone, Calomelas, Os Draconis, Calamina, salicylic acid, sulfur, phenol substantially, and the consumption of every component can be selected as one sees fit.Medical material through clean, dry, pulverization process becomes 80-120 order fine powdered, active ingredient and substrate are mixed in proportion promptly can be made into to the specific various external agent products of refractory skins such as psoriasis.
Be described in further detail in conjunction with the content of embodiment the technical program.
During Chinese and Western medical material in this psoriasis external agent can be pressed, the conventional amount used of doctor trained in Western medicine is selected, or suitably increase and decrease contains the external agent of these basic effective constituents, all has heat clearing away, removing heat from blood, invigorates blood circulation, nourishes blood, the circulation of qi promoting skin moistening; The obvious effect of desensitization antiinflammatory, antipruritic, desquamation, this is the unique distinction of this preparation just.As for substrate, can adopt vaseline or ethanol or edible oil or Mel or paraffin etc. to make different dosage forms routinely, as cream, water ...Also can mix lanoline in substrate on a small quantity increases the medicine penetration power, play soften, effect such as suction.No matter make which kind of dosage form, basic active ingredient wherein is constant, just refractory skins such as psoriasis is had obvious curative effects.
When the consumption of basic effective constituents is respectively by total weight:
Radix Panacis Quinquefolii 2-3% hydrocortisone 0.1-0.2%
Calomelas 0.1-0.2% Os Draconis 5-20%
Calamina 5-20% salicylic acid 3-5%
Sulfur 3-5% phenol 1-2%;
Made cream during with substrate 50-70% weight, water ..., be good through the clinic trial curative effect.
Also can in above-mentioned effective ingredient, camphorate, Borneolum Syntheticum or other Chinese crude drug adapt to the state of an illness, improves curative effect.Their consumption is Camphora 1-2% by weight, the best during Borneolum Syntheticum 9.8-9.9%.
Used medical material all can be bought from pharmaceuticals or pharmaceutical factory.What wherein Radix Panacis Quinquefolii employing life in 3 years was above is good.The external agent can evenly be coated with one deck by 3 times/day or doctor's advice and get final product in the affected part.
Can prepare psoriasis external agent by the following method:
A, washing: the medical material that will need to wash is removed earth impurity, is cleaned up.To can directly buy, satisfactory powder then need not to carry out other processing.
B, drying: washed medical material is carried out dried, but to degree of grinding.But artificial drying or natural air drying.
C, pulverizing: will be through the pulverizing medicinal materials of above-mentioned processing to the 80-120 order.
D, mixing: due active ingredient and substrate are concerned mix homogeneously in proportion, promptly get psoriasis external agent.Should do different processing routinely to different substrate during mixing, as when adopting vaseline and lanoline,, put after the fusing when being chilled to 40 ℃ of left and right sides earlier with vaseline, lanoline Hybrid Heating as substrate, slowly add each effective ingredient, stirring is psoriasis paster.
Adopt medical general drying plant during preparation, pulverizer, blender, pack, bottle filling machine just can meet the demands, and need not other special installation.
Example 1:(presses % weight)
Radix Panacis Quinquefolii 3
Hydrocortisone 0.2
Calomelas 0.1
Os Draconis 6.8
Calamina 5
Salicylic acid 4
Sulfur 5
Phenol 1
Camphora 1
Borneolum Syntheticum 9.8
70% ethanol 64.1
The water preparation that makes except that to each parapsoriasis effectively, to controlling the head psoriasis specially good effect is arranged.
Example 2:(presses % weight)
Radix Panacis Quinquefolii 3
Hydrocortisone 0.2
Calomelas 0.2
Os Draconis 6.8
Calamina 10.8
Salicylic acid 5
Sulfur 5
Phenol 1
Vaseline 6.8
The unguentum that makes has specially good effect to the refractory skins of locating beyond the head such as psoriasis.
The relatively existing topical drug of the present invention has following advantage:
1, dispensing is simple, and prescription is unique, the Chinese and Western medicine combination, and take Chinese medicine as main, technology is simple, makes easily.
2, good effect, safe and reliable has no side effect: the fast short treating period of curative effect, and general medication 10-20 days can take effect, and with the same usefulness of psoriasis oral agents, recovery from illness 1-3 month course of treatment can not recurred substantially, effective percentage 100%, cure rate is more than 90%.The patient of more than ten years tries out psoriasis external agent, the recovery from illness in two months of psoriasis oral agents, and not recurrence in 5 years is described as the psoriasis specific drug by the trier so far.
3, wide, the good economy performance of the scope of application: the homeliness type of types such as this external agent is dry to heat in blood, the blood of the traditional Chinese medical science, blood stasis, doctor trained in Western medicine, joint type, pustular type etc., whatsoever this preparation of psoriasis of type all has good effectiveness, can significantly alleviate patient's misery and financial burden, obvious social benefit.
Claims (5)
1, a kind of psoriasis external agent is formed by substrate and effective ingredient allotment, it is characterized in that its basic active ingredient is: Radix Panacis Quinquefolii, hydrocortisone, Calomelas, Os Draconis, Calamina, salicylic acid, sulfur, phenol.
2, psoriasis external agent as claimed in claim 1 is characterized in that it also can camphorate, the Borneolum Syntheticum active ingredient.
3, psoriasis external agent as claimed in claim 1 is characterized in that the consumption of active ingredient is respectively by total weight:
Radix Panacis Quinquefolii 2-3% hydrocortisone 0.1-0.2%
Calomelas 0.1-0.2% Os Draconis 5-20%
Calamina 5-20% salicylic acid 3-5%
Sulfur 3-5% phenol 1-2%
Substrate 50-70% weight.
4, psoriasis external agent as claimed in claim 2 is characterized in that by weight: Camphora 1-2%, Borneolum Syntheticum 9.8-9.9%.
5, as claim 1,2 described psoriasis external agent, it is characterized in that its substrate can adopt vaseline, ethanol, edible oil, Mel, paraffin etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93118088 CN1095615A (en) | 1993-09-30 | 1993-09-30 | Externally-used agent for treatment of psoriasis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93118088 CN1095615A (en) | 1993-09-30 | 1993-09-30 | Externally-used agent for treatment of psoriasis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1095615A true CN1095615A (en) | 1994-11-30 |
Family
ID=4992332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93118088 Pending CN1095615A (en) | 1993-09-30 | 1993-09-30 | Externally-used agent for treatment of psoriasis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1095615A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6479058B1 (en) * | 1999-09-02 | 2002-11-12 | Mccadden Michael E. | Composition for the topical treatment of poison ivy and other forms of contact dermatitis |
| US6656928B1 (en) * | 1999-09-02 | 2003-12-02 | Mccadden Michael E. | Composition for the topical treatment of rashes, dermatoses and lesions |
| CN104173396A (en) * | 2014-07-25 | 2014-12-03 | 中国人民解放军第三0二医院 | Dracontomelon duperreanum leaf extract suspension, as well as preparation method and application thereof |
| CN111773356A (en) * | 2020-08-06 | 2020-10-16 | 辽宁宝一堂科技发展有限公司 | Preparation method of plaster for treating psoriasis |
-
1993
- 1993-09-30 CN CN 93118088 patent/CN1095615A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6479058B1 (en) * | 1999-09-02 | 2002-11-12 | Mccadden Michael E. | Composition for the topical treatment of poison ivy and other forms of contact dermatitis |
| US6656928B1 (en) * | 1999-09-02 | 2003-12-02 | Mccadden Michael E. | Composition for the topical treatment of rashes, dermatoses and lesions |
| US6890544B2 (en) | 1999-09-02 | 2005-05-10 | Mccadden Michael E. | Gel composition for the topical treatment of poison ivy and other forms of contact dermatitis |
| CN104173396A (en) * | 2014-07-25 | 2014-12-03 | 中国人民解放军第三0二医院 | Dracontomelon duperreanum leaf extract suspension, as well as preparation method and application thereof |
| CN104173396B (en) * | 2014-07-25 | 2017-09-26 | 中国人民解放军第三0二医院 | Dracontomelon duperreanum leaf extract supensoid agent and preparation method and application |
| CN111773356A (en) * | 2020-08-06 | 2020-10-16 | 辽宁宝一堂科技发展有限公司 | Preparation method of plaster for treating psoriasis |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |