[go: up one dir, main page]

CN109540881A - A kind of analoids - Google Patents

A kind of analoids Download PDF

Info

Publication number
CN109540881A
CN109540881A CN201811485828.5A CN201811485828A CN109540881A CN 109540881 A CN109540881 A CN 109540881A CN 201811485828 A CN201811485828 A CN 201811485828A CN 109540881 A CN109540881 A CN 109540881A
Authority
CN
China
Prior art keywords
substrate
analoids
film
supporting layer
pasted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201811485828.5A
Other languages
Chinese (zh)
Other versions
CN109540881B (en
Inventor
刘军
廖达翠
苏明龙
李秋平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Urit Medical Electronic Co Ltd
Original Assignee
Urit Medical Electronic Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Urit Medical Electronic Co Ltd filed Critical Urit Medical Electronic Co Ltd
Priority to CN201811485828.5A priority Critical patent/CN109540881B/en
Publication of CN109540881A publication Critical patent/CN109540881A/en
Application granted granted Critical
Publication of CN109540881B publication Critical patent/CN109540881B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7756Sensor type
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769Measurement method of reaction-produced change in sensor
    • G01N2021/7773Reflection

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention discloses a kind of analoids, it is related to medical treatment consumptive materials technical field, including substrate, one end of substrate offers locating slot, location hole and instrument connection are also provided on substrate, reaction film is pasted on substrate above instrument connection, there is syphon structure on reaction film, syphon structure is made of supporting layer and hydrophilic film, hydrophilic film is pasted on supporting layer, and supporting layer is pasted on reaction film, there is partial disconnection on substrate, partial disconnection leans on handle side close to reaction film, is equipped on close relative's moisture film close to partial disconnection side and assists mouth of sucking blood.The present invention is in the detection system by needing to be added dropwise blood sample originally by increasing new syphon structure on reaction film, it may be implemented not having to the sample that sample injector quantitatively sucks constant volume, the design and use of partial disconnection, substrate is bent in which can be convenient before inhaling sample, facilitate tip blood sample to pass through the mouth that assists sucking blood quantitatively to suck full of reaction chamber, siphon path is significantly shortened, keeps testing result more accurate, accurate.

Description

A kind of analoids
Technical field
The present invention relates to medical treatment consumptive materials technical field more particularly to a kind of analoids.
Background technique
Hemoglobin (Hemoglobin, Hb) is the main ingredient of red blood cell, is had in conjunction with being in invertibity with oxygen molecule Function is the main carriers of transport and the exchange of oxygen in human body.The pathophysiological change of many diseases is directed to Hb matter or amount Change.Its function is to combine oxygen in lung, is sent to whole body and respectively organizes and the carbon dioxide in tissue is sent to lung and is breathed out In vitro.Accurate detection hemoglobin parameters have the diagnosing and treating of anaemia and other disease of hematopoietic system important meaning Justice is also highly important for understanding blood donor whether there is or not anaemia, medical examiner's physical condition.
There are many kinds of the detection methods of hemoglobin, and the clinical labororatories such as hospital, inspection and quarantine mechanism mostly use haemocyte Analyzer, but equipment is not portable, be unfavorable for quickly detecting and bedside diagnoses (POCT), detects speed relative to Dry chemistry Slowly.It is wider in the examples of hemoglobin detection system application of the medical fields such as base, scene and emergency treatment, miniature portable.
But the examples of hemoglobin detection system of the prior art is in use, needs blood sample to be directly added dropwise or used capillary It is added dropwise on reaction film again after absorption, in fact it could happen that operator makes mistakes and leads to hemoglobin sample complicated for operation and being added Amount inaccuracy, to influence to detect quality, detection effect accuracy and repeatability are deteriorated.
Summary of the invention
In view of this, of the invention provides a kind of analoids, increase siphon sampling structure, makes with the cooperation of mating analyzer With to solve the technical issues of proposing in background technique.
Siphon sampling structure generally uses in electric pole type detection system, but realization is had no in optical reflection type system With a kind of innovation structure used, solves sample by design folding line and siphon channel and suck distance and optical texture volume Conflicting contradiction bigger than normal will be only capable of the siphon sample introduction being just able to achieve in electric pole type POCT detection system originally, anti-in optics It penetrates on formula instrument and realizes.
The present invention solves above-mentioned technical problem by following technological means:
A kind of analoids, including substrate, one end of the substrate offer locating slot, positioning are also provided on the substrate Hole and instrument connection are pasted with reaction film on the substrate above instrument connection, syphon structure, institute are pasted on the reaction film It states syphon structure to be made of supporting layer and hydrophilic film, the hydrophilic film is pasted on pad level, and the supporting layer is pasted onto reaction On film.
Further, the supporting layer is made of double-sided adhesive, and the channel for entering blood is offered on the supporting layer. In order to make siphon sample volume meet test needs, the thickness of supporting layer is within the scope of 0.05~0.35mm, and more preferably thickness exists In the range of 0.1~0.2mm.
Further, the hydrophilic film is made of water wetted material, and the hydrophilic film offers auxiliary above the open end of channel Help mouth of sucking blood, the hydrophilic film offers exhaust outlet above the tail end of channel, the diameter of gas vent within the scope of 0.1~5mm, For more preferably diameter in the range of 0.5~4mm, optimal diameter range is in 0.8~3.4mm.
Blood sample mobility is fast on water wetted material, and blood sample to be measured can quickly fill with reaction chamber;Exhaust outlet is for arranging Air in reaction chamber out is conducive to blood sample sucking;Auxiliary suck blood mouth be conducive to blood sample import channel in.
Further, the auxiliary sucks blood mouth as semicircle or half elliptic.Semicircle or half elliptic is conducive to increase auxiliary The area for helping mouth of sucking blood is more advantageous to blood sample sucking, and outer openings size is in the range of 0.1~10mm, more preferably ruler It is very little in the range of 0.5~5mm, optimal size range is in 2.5~3.8mm.
Further, adhesion has layers of two-sided between the reaction film and substrate.
Further, partial disconnection is offered on the substrate, the partial disconnection is located on the outside of reaction film, and the partial disconnection is close Hydrophilic film is equipped with the side for the mouth that assists sucking blood.Partial disconnection facilitates substrate bending, shortens siphon path, and siphon is avoided to import road Electrical path length influences the repeatability and accuracy of analoids, rapidly enters blood sample in channel, detects in time.
Further, through-hole is offered in location hole corresponding position in the supporting layer and hydrophilic film.
Further, the substrate is printed on dark coating in reaction film bottom corresponding position.
Further, the dark coating is that the printing of ink material is made.The dark unglazed reflection of coating, prevents the light of analyzer The detection light for learning detector is irradiated on substrate, causes the result of mistake.
Beneficial effects of the present invention:
(1) present invention joins together syphon structure and reaction film on the basis of conventional examples of hemoglobin detection system, blood Liquid sample is full of after channel, and syphon structure stopping continues to suck blood sample, is kept the sample volume of blood sample constant, is avoided The situation that operator makes mistakes and causes the hemoglobin being added inaccurate occurs;Also, sample introduction convenience when in order to improve test, Sample volume is reduced, increasing before partial disconnection makes substrate suck sample can bend, and shorten siphon path, inhale blood sample quickly Enter in channel, avoid the too long repeatability and accuracy for influencing analoids of siphon lead-in path, keeps detection more accurate, quick.
(2) this analoids accurate positioning has locating slot on substrate, positions at location hole two, both can guarantee that analoids were accurate Movement when being inserted into analyzer, and can prevent analoids half are disconnected to bend, it is ensured that detection quality reduces personnel in test process and operates The error and uncertainty that may cause, improve the experience of user.
(3) this reagent chip architecture can be used for hemoglobin, blood glucose, uric acid, cholesterol, high density cholesterol, low-density gallbladder Sterol, triglycerides, transaminase etc. are using in the various tests of whole blood sample, since substrate is bent, the analoids tested It can be taken out easily from instrument by the bending end of substrate, avoid sample contamination instrument and operator, it is special that instrument does not have to setting Move back a structure, the cost of reduced test equipment.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of analoids of the present invention;
Fig. 2 is a kind of front view of analoids of the present invention;
Fig. 3 is a kind of structural schematic diagram of the analoids of the present invention under substrate bending state;
Wherein, substrate 1, locating slot 2, location hole 3, working hole 4, reaction film 5, supporting layer 6, channel 61, hydrophilic film 7, double Face glue-line 8 assists suck blood mouth 71, exhaust outlet 72, partial disconnection 9, dark coating 10.
Specific embodiment
Below with reference to the drawings and specific embodiments, the present invention is described in detail:
As shown in Figure 1-Figure 3, a kind of analoids of the invention can be used for hemoglobin, blood glucose, uric acid, cholesterol, highly dense It spends cholesterol, low density cholesterol, triglycerides, transaminase etc. to use in the various tests of whole blood sample, the present embodiment institute Detection of the analoids for hemoglobin is stated as detailed description.
The analoids of the present embodiment include substrate 1, and the plastic materials such as PET, PVC, PP, one end of substrate 1 can be selected in substrate 1 Offer locating slot 2, locating slot 2 is also provided with location hole 3 and test on substrate 1 along the longitudinal centre line bilateral symmetry of substrate 1 The center of circle of hole 4, location hole 3 and instrument connection 4 on the longitudinal centre line of substrate 1, location hole 3 be conducive to production when to substrate 1 into Row positioning, while location hole 3 cooperates locating slot 2, and analoids can be made fast and accurately to be positioned at hydrocone type hemoglobin analyser On, it avoids analoids movement from impacting test result, is pasted with reaction film 5 in the top of instrument connection 4 on substrate 1, react Adhesion has layers of two-sided 8 between film 5 and substrate 1, is pasted with syphon structure on reaction film 5, and syphon structure is by supporting layer 6 and hydrophilic Film 7 forms, and hydrophilic film 7 is pasted on supporting layer 6, and supporting layer 6 is pasted on reaction film 5, in fixed on supporting layer 6 and hydrophilic film 7 3 corresponding position of position hole offers through-hole, and supporting layer 6 is made of double-sided adhesive, and one is offered on supporting layer 6 enters blood Channel 61.
Hydrophilic film 7 is made of water wetted material, such as the hydrophilic material of hydrophilic plastic film, and hydrophilic film 7 is in the opening of channel 61 End top offers auxiliary and sucks blood mouth 71, and auxiliary sucks blood mouth 71 as semicircle or semiellipse, and hydrophilic film 7 is on the tail end of channel 61 Side is provided with exhaust outlet 72, and exhaust outlet 72 is circle or rectangular, and auxiliary sucks blood mouth 71 as semicircle or half elliptic.
In the present embodiment, be also provided with partial disconnection 9 on substrate 1, partial disconnection 9 close to 5 outside of reaction film, hydrophilic film 7 close to 9 side of partial disconnection, which is equipped with, assists mouth 71 of sucking blood, and partial disconnection 9 and the longitudinal centre line of substrate 1 are perpendicular, and 1 bottom of substrate is in anti- 5 corresponding position of film is answered to be printed on dark coating 10, dark coating 10 is that the printing of ink material is made, the unglazed reflection of dark coating 10, It prevents the detection light of the optical detecting head of analyzer to be irradiated on substrate, causes the result of mistake.
Partial disconnection 9 can process formation with the common method of cutlery, punch die, laser cutting on the specified position of substrate 1, It keeps straight and upright when production packaging, after inserting instrument, is bent before sucking sample, sufficiently expose auxiliary and suck blood mouth 71, be convenient for sample This sucking.
Working principle:
Hydrocone type analoids are based on made of dry chemical colorimetric method principle.Analoids include substrate 1, are arranged on substrate 1 There are reaction film 5, syphon structure, reaction film 5 contains chemical reagent, and syphon structure is made of supporting layer 6 and hydrophilic film 7, siphon knot Structure is located at 5 top of reaction film, when blood sample to be measured is after hydrophilic film 7 is drawn into channel 61, on blood sample ingredient to be measured and reaction film 5 Chemical reagent reacts, the variation of the intensity of optical reflection on the optical detecting head detection reaction film 5 of analyzer, light reflection Intensity is inversely proportional with hemoglobin concentration, to achieve the purpose that detect hemoglobin concentration.
The above examples are only used to illustrate the technical scheme of the present invention and are not limiting, although referring to preferred embodiment to this hair It is bright to be described in detail, those skilled in the art should understand that, it can modify to technical solution of the present invention Or equivalent replacement should all cover without departing from the objective and range of technical solution of the present invention in claim of the invention In range.Technology not described in detail in the present invention, shape, construction portion are well-known technique.

Claims (9)

1. one end of a kind of analoids, including substrate (1), the substrate (1) offers locating slot (2), on the substrate (1) also Location hole (3) and instrument connection (4) are offered, is pasted with above working hole (4) reaction film (5) on the substrate (1), is invented Syphon structure is pasted on reaction film described in content (5), the syphon structure is made of supporting layer (6) and hydrophilic film (7), described Hydrophilic film (7) is pasted on supporting layer (6), and the supporting layer (6) is pasted on reaction film (5).
2. a kind of analoids according to claim 1, it is characterised in that: the supporting layer (6) is by specific thicknesses range Double-sided adhesive is made, and the supporting layer (6) is equipped with the channel (61) for entering blood.
3. a kind of analoids according to claim 2, it is characterised in that: the hydrophilic film (7) is made of water wetted material, institute It states hydrophilic film (7) to suck blood mouth (71) above the open end of channel (61) equipped with auxiliary, the hydrophilic film (7) is in channel (61) Exhaust outlet (72) are equipped with above tail end.
4. a kind of analoids according to claim 3, it is characterised in that: the auxiliary sucks blood mouth (71) as semicircle or half Ellipse.
5. a kind of analoids according to claim 1, it is characterised in that: adhesion between the reaction film (5) and substrate (1) There are layers of two-sided (8).
6. -5 any a kind of analoids according to claim 1, it is characterised in that: it is disconnected to offer half on the substrate (1) Line (9), close to reaction film (5) outside, the hydrophilic film (7) is equipped with auxiliary close to partial disconnection side and inhales the partial disconnection (9) Blood mouth (71).
7. a kind of analoids according to claim 1, it is characterised in that: in fixed on the supporting layer (6) and hydrophilic film (7) Position hole (3) corresponding position is equipped with through-hole.
8. a kind of analoids according to claim 1, it is characterised in that: substrate (1) bottom is corresponding in reaction film (5) Position is printed on dark coating (10).
9. a kind of analoids according to claim 8, it is characterised in that: the dark color coating (10) is black ink material Printing is made.
CN201811485828.5A 2018-12-06 2018-12-06 Reagent tablet Active CN109540881B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811485828.5A CN109540881B (en) 2018-12-06 2018-12-06 Reagent tablet

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811485828.5A CN109540881B (en) 2018-12-06 2018-12-06 Reagent tablet

Publications (2)

Publication Number Publication Date
CN109540881A true CN109540881A (en) 2019-03-29
CN109540881B CN109540881B (en) 2024-07-30

Family

ID=65853874

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201811485828.5A Active CN109540881B (en) 2018-12-06 2018-12-06 Reagent tablet

Country Status (1)

Country Link
CN (1) CN109540881B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110632331A (en) * 2019-10-31 2019-12-31 无锡锦帛诚医疗器械科技有限公司 Dry tablet reagent for quantitative detection of total cholesterol
CN115290602A (en) * 2022-07-07 2022-11-04 量准(上海)医疗器械有限公司 Chip test strips, test cards and molecular detection analysis systems for nanoplasmon resonance detection

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2788184Y (en) * 2005-04-22 2006-06-14 北京怡成生物电子技术有限公司 Biological testing bar
CN1952653A (en) * 2006-10-01 2007-04-25 中南大学 Disposable whole blood uric acid testing electrode indicator bar and manufacturing method thereof
CN201518028U (en) * 2009-10-22 2010-06-30 桂林优利特医疗电子有限公司 Hemoglobin analoids
CN106706891A (en) * 2017-01-03 2017-05-24 长沙中生众捷生物技术有限公司 Hemoglobin detection reagent and hemoglobin detection paper
CN107918031A (en) * 2016-10-11 2018-04-17 赵天贤 A kind of liquid sample guiding device and the detection device containing the guiding device
CN209624397U (en) * 2018-12-06 2019-11-12 桂林优利特医疗电子有限公司 A kind of analoids

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2788184Y (en) * 2005-04-22 2006-06-14 北京怡成生物电子技术有限公司 Biological testing bar
CN1952653A (en) * 2006-10-01 2007-04-25 中南大学 Disposable whole blood uric acid testing electrode indicator bar and manufacturing method thereof
CN201518028U (en) * 2009-10-22 2010-06-30 桂林优利特医疗电子有限公司 Hemoglobin analoids
CN107918031A (en) * 2016-10-11 2018-04-17 赵天贤 A kind of liquid sample guiding device and the detection device containing the guiding device
CN106706891A (en) * 2017-01-03 2017-05-24 长沙中生众捷生物技术有限公司 Hemoglobin detection reagent and hemoglobin detection paper
CN209624397U (en) * 2018-12-06 2019-11-12 桂林优利特医疗电子有限公司 A kind of analoids

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110632331A (en) * 2019-10-31 2019-12-31 无锡锦帛诚医疗器械科技有限公司 Dry tablet reagent for quantitative detection of total cholesterol
CN115290602A (en) * 2022-07-07 2022-11-04 量准(上海)医疗器械有限公司 Chip test strips, test cards and molecular detection analysis systems for nanoplasmon resonance detection

Also Published As

Publication number Publication date
CN109540881B (en) 2024-07-30

Similar Documents

Publication Publication Date Title
US8399259B2 (en) Measuring device, measuring apparatus and method of measuring
US7811276B2 (en) Medical sensor and technique for using the same
US7347973B2 (en) Synchronized analyte testing system
US11883012B1 (en) Breath analysis cartridge with components for dispensing developer solution
CN111213060B (en) Microfluidic metering and delivery systems
JPH04194660A (en) Device for measuring concentration of component in blood
US20120325658A1 (en) Detection device
CN109540881A (en) A kind of analoids
CN209624397U (en) A kind of analoids
US20070078307A1 (en) Sensor for tissue gas detection and technique for using the same
CN101865851A (en) A rapid lactic acid detection card
CN101233408B (en) Measuring instrument, measuring device, and measuring method
CN221612871U (en) Hemoglobin measurement test paper
Niculescu et al. Reagent-free Hemoglobin Portable Analyzer Using Image Processing
US8501111B2 (en) Small volume and fast acting optical analyte sensor

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant