CN1093920A - Zhichuang gao - Google Patents
Zhichuang gao Download PDFInfo
- Publication number
- CN1093920A CN1093920A CN 93114622 CN93114622A CN1093920A CN 1093920 A CN1093920 A CN 1093920A CN 93114622 CN93114622 CN 93114622 CN 93114622 A CN93114622 A CN 93114622A CN 1093920 A CN1093920 A CN 1093920A
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- CN
- China
- Prior art keywords
- anal
- medicine
- chinese
- western medicine
- zhichuang gao
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- PLHJDBGFXBMTGZ-WEVVVXLNSA-N furazolidone Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)OCC1 PLHJDBGFXBMTGZ-WEVVVXLNSA-N 0.000 claims abstract description 5
- 229960001625 furazolidone Drugs 0.000 claims abstract description 5
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229960000905 indomethacin Drugs 0.000 claims abstract description 5
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229960000282 metronidazole Drugs 0.000 claims abstract description 5
- 238000003756 stirring Methods 0.000 claims description 5
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 4
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims description 3
- 229940070384 ventolin Drugs 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 19
- 230000000694 effects Effects 0.000 abstract description 12
- 208000014617 hemorrhoid Diseases 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 4
- 206010052428 Wound Diseases 0.000 abstract description 3
- 208000027418 Wounds and injury Diseases 0.000 abstract description 3
- 231100000957 no side effect Toxicity 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 abstract description 3
- 206010048946 Anal abscess Diseases 0.000 abstract description 2
- 206010002153 Anal fissure Diseases 0.000 abstract description 2
- 208000016583 Anus disease Diseases 0.000 abstract description 2
- 208000009531 Fissure in Ano Diseases 0.000 abstract description 2
- 206010036774 Proctitis Diseases 0.000 abstract description 2
- 208000004680 Rectal Fistula Diseases 0.000 abstract description 2
- 208000015815 Rectal disease Diseases 0.000 abstract description 2
- 210000002255 anal canal Anatomy 0.000 abstract description 2
- 206010002156 anal fistula Diseases 0.000 abstract description 2
- 201000009890 sinusitis Diseases 0.000 abstract description 2
- 241000972155 Moschus Species 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 210000000436 anus Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- QMGVPVSNSZLJIA-FVWCLLPLSA-N strychnine Chemical compound O([C@H]1CC(N([C@H]2[C@H]1[C@H]1C3)C=4C5=CC=CC=4)=O)CC=C1CN1[C@@H]3[C@]25CC1 QMGVPVSNSZLJIA-FVWCLLPLSA-N 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010054787 Haemorrhoidal haemorrhage Diseases 0.000 description 1
- 229920000057 Mannan Polymers 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- ALHUZKCOMYUFRB-OAHLLOKOSA-N Muscone Chemical compound C[C@@H]1CCCCCCCCCCCCC(=O)C1 ALHUZKCOMYUFRB-OAHLLOKOSA-N 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- QMGVPVSNSZLJIA-UHFFFAOYSA-N Nux Vomica Natural products C1C2C3C4N(C=5C6=CC=CC=5)C(=O)CC3OCC=C2CN2C1C46CC2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241001279009 Strychnos toxifera Species 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 208000005448 Trichomonas Infections Diseases 0.000 description 1
- 206010044620 Trichomoniasis Diseases 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003103 anti-anaerobic effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 239000003907 antipyretic analgesic agent Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000009969 fructus bruceae Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- LUEWUZLMQUOBSB-GFVSVBBRSA-N mannan Chemical class O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-GFVSVBBRSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- ALHUZKCOMYUFRB-UHFFFAOYSA-N muskone Natural products CC1CCCCCCCCCCCCC(=O)C1 ALHUZKCOMYUFRB-UHFFFAOYSA-N 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000032696 parturition Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 229960005453 strychnine Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000001550 time effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 210000001113 umbilicus Anatomy 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention adopts the method for the combination of Chinese and Western medicine to provide a kind of Chinese medicine and western medicine of being made up of Radix Sanguisorbae, the Pseudobulbus Bletillae (Rhizoma Bletillae), indometacin, furazolidone, metronidazole etc. to merge preparation " ZHICHUANG GAO ", on probation to anorectal diseases such as mixed hemorrhoids, anal fistula, anal fissure, anal sinusitis, anal canal phlegmasia, perianal abscess, proctitis, wound surface disunion of a specified duration example surplus 4000, three hours produce effects after the medication, five days (ten times) can fully recover, no longer recurrence has no side effect.
Description
The present invention relates to a kind of Chinese medicine and western medicine and merge preparation " ZHICHUANG GAO ".
The method and the medicine of treatment hemorrhoid are many at present, but seldom can thoroughly effect a radical cure, and curative effect is low, the side effect in addition that has.Disclosed two patents of invention, wherein one is " chemicals curing piles " (application number: 89103672.5), with Moschus, Semen Strychni is principal agent, and Moschus (containing muscone) has the effect of hastening parturition of excited uterus, and with Semen Strychni (containing strychnine) nervus centralis is had excitation, breathing palpitating speed, blood pressure are increased, so contraindication in pregnancy, the careful usefulness of hyperpietic, its therapeutic domain also only is confined to hemorrhoid, and Moschus is a valuable medicinal, and is expensive, cost is high; Another is " Llaemorrhoids pills and production method thereof " (application number: 91103302.5), its principal agent Fructus Bruceae contains multiple Ramulus Et Folium Picrasmae, bitter principle class composition, overt toxicity is arranged, orally often cause nausea, vomit, suffer from abdominal pain, suffer from diarrhoea and dizzy side effect such as unable, Ying Shenyong.
The objective of the invention is to adopt the method for the combination of Chinese and Western medicine to provide a kind of to have no side effect, " ZHICHUANG GAO " Chinese medicine and western medicine with low cost, that therapeutic domain is wide, curative effect is high merges preparation.
The present invention's " ZHICHUANG GAO " is mainly made through grinding, sieve, heat, stirring by Radix Sanguisorbae 15-30%, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-30%, indometacin 10-20%, furazolidone 10-20%, metronidazole 10-15%, an amount of Borneolum Syntheticum and medical ventolin etc.
According to " Chinese pharmacopoeia nineteen ninety version and interrelated data record: " Radix Sanguisorbae " property hardship, acid, puckery, be slightly cold, return liver, large intestine channel, skin ulcer, convergence reducing internal heat are held back in function removing heat from blood, hemostasis, detoxifcation, have shorten, clotting time, hemostatic and antibacterial effect, can be used for all kinds of hemorrhage disease, diseases such as having blood in stool due to the outstanding suitable part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels heat in blood, hemorrhoidal bleeding, metrorrhagia: " Pseudobulbus Bletillae (Rhizoma Bletillae) " property hardship, sweet, puckery, be slightly cold, return lung, liver, stomach warp, the merit that astringing to arrest bleeding, detumescence and promoting granulation, wound repairing are arranged contains a large amount of mannans (gluey hemostasis composition), and hemostasis is stronger than sponge, starch sponge effect; " indometacin " is non-steroid antiinflammatory antipyretic analgesic medicine, and prostaglandin is synthetic to be produced by suppressing in its effect, and anti-inflammatory analgesic is stronger 12 times than aspirin during topical application, and long action time; " furazolidone " is antibiotics class medicine, and its antimicrbial power is not subjected to pus and tissue to decompose the influence that produces, and is difficult for absorbing, and can reduce wound infection, promotes wound healing; " metronidazole " is the good medicine of killing ameba and treatment trichomoniasis, and pathogenic anaerobic infection is had good effect, confirmed as the choice drug of anti anaerobic bacteria infection in 1978 by World Health Organization (WHO); " Borneolum Syntheticum " property suffering, hardship, be slightly cold, GUIXIN, spleen, lung meridian, the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain, anticorrosion antipruritic, in vitro tests has antibacterial action, and patient is had comfortable cooling feeling; " medical ventolin " plays lubricated and mediation effect.
Its specific embodiment is as follows: get Radix Sanguisorbae 15-30 gram, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-30 gram, indometacin 10-20 gram, furazolidone 10-20 gram, metronidazole 10-15 gram is pulverization altogether, crosses 120 mesh sieves, pour into and heat in the 500 gram medical ventolins that dissolve, stir evenly when putting to tepor, go into interior stirring with Borneolum Syntheticum 5-10 gram pulverize again, it is standby that the cream bottling is received in the back that cools.With the anus syringe ointment is injected in the anus during use, or the cream of getting it filled divides in right amount on aseptic dressing, cover the affected part,, also ointment can be made suppository, for the treatment use with immobilization with adhesive tape.
The present invention is owing to adopted the prescription of Chinese and Western medicine combination, it all is the common drug composition, the medicine source is wide, process easy, low price, this " acne cream " compared with existing medicine for treaching hemorrhoie, except treating the hemorrhoid, all effective in cure to anorectal diseases such as anal fistula, anal fissure, anal sinusitis, anal canal phlegmasia, perianal abscess, rectitis, surface of a wound disunion of a specified duration, example surplus the clinic trial 4000, three hours produce effects, medicine-feeding five days (ten times) can be fully recovered after the medication, and no longer recurrence has that therapeutic domain is wide, no pain, the advantage such as have no side effect.
Claims (1)
1, a kind of ZHICHUANG GAO, it is characterized in that: stir evenly through grinding, sieve, pour into to have heated in the medical ventolin that dissolves with the Radix Sanguisorbae of 15-30%, the Pseudobulbus Bletillae (Rhizoma Bletillae) of 15-30%, the indometacin of 10-20%, the furazolidone of 10-20%, the metronidazole of 10-15%, go into interior stirring with the powder of an amount of Borneolum Syntheticum again, cool back is received cream and is formed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93114622 CN1093920A (en) | 1993-11-18 | 1993-11-18 | Zhichuang gao |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93114622 CN1093920A (en) | 1993-11-18 | 1993-11-18 | Zhichuang gao |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1093920A true CN1093920A (en) | 1994-10-26 |
Family
ID=4990574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93114622 Pending CN1093920A (en) | 1993-11-18 | 1993-11-18 | Zhichuang gao |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1093920A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002074290A3 (en) * | 2001-03-15 | 2004-02-19 | Agis Ind 1983 Ltd | Dermatological preparations containing a nsaid |
-
1993
- 1993-11-18 CN CN 93114622 patent/CN1093920A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002074290A3 (en) * | 2001-03-15 | 2004-02-19 | Agis Ind 1983 Ltd | Dermatological preparations containing a nsaid |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |