CN1093421C - Process for preparing snuff to treat hepatitis B - Google Patents
Process for preparing snuff to treat hepatitis B Download PDFInfo
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- CN1093421C CN1093421C CN99126394A CN99126394A CN1093421C CN 1093421 C CN1093421 C CN 1093421C CN 99126394 A CN99126394 A CN 99126394A CN 99126394 A CN99126394 A CN 99126394A CN 1093421 C CN1093421 C CN 1093421C
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- hepatitis
- snuff
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- 208000002672 hepatitis B Diseases 0.000 title claims abstract description 18
- 238000004519 manufacturing process Methods 0.000 title abstract description 4
- 239000003814 drug Substances 0.000 claims abstract description 37
- 239000000843 powder Substances 0.000 claims abstract description 13
- 239000002795 scorpion venom Substances 0.000 claims abstract description 9
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 4
- 206010028748 Nasal obstruction Diseases 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 241000628997 Flos Species 0.000 claims description 5
- 241000972155 Moschus Species 0.000 claims description 4
- 150000002333 glycines Chemical class 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 210000000582 semen Anatomy 0.000 claims description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 abstract description 10
- 201000010099 disease Diseases 0.000 abstract description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 7
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 244000144619 Abrus precatorius Species 0.000 abstract 1
- 235000000832 Ayote Nutrition 0.000 abstract 1
- 241001164374 Calyx Species 0.000 abstract 1
- 235000007516 Chrysanthemum Nutrition 0.000 abstract 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 abstract 1
- 240000004244 Cucurbita moschata Species 0.000 abstract 1
- 235000009854 Cucurbita moschata Nutrition 0.000 abstract 1
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 abstract 1
- 241000402754 Erythranthe moschata Species 0.000 abstract 1
- 241000202807 Glycyrrhiza Species 0.000 abstract 1
- 244000299790 Rheum rhabarbarum Species 0.000 abstract 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 1
- 240000008042 Zea mays Species 0.000 abstract 1
- 235000007244 Zea mays Nutrition 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 229940089639 cornsilk Drugs 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 abstract 1
- 230000003950 pathogenic mechanism Effects 0.000 abstract 1
- 235000015136 pumpkin Nutrition 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 239000001231 zea mays silk Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 12
- 210000003494 hepatocyte Anatomy 0.000 description 9
- 231100000614 poison Toxicity 0.000 description 9
- 241000700721 Hepatitis B virus Species 0.000 description 8
- 230000007096 poisonous effect Effects 0.000 description 8
- 210000004185 liver Anatomy 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 210000001331 nose Anatomy 0.000 description 5
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 210000003928 nasal cavity Anatomy 0.000 description 4
- 102000014150 Interferons Human genes 0.000 description 3
- 108010050904 Interferons Proteins 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000036737 immune function Effects 0.000 description 3
- 229940079322 interferon Drugs 0.000 description 3
- 230000029812 viral genome replication Effects 0.000 description 3
- 206010023126 Jaundice Diseases 0.000 description 2
- 241000590428 Panacea Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 230000009545 invasion Effects 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 210000002751 lymph Anatomy 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 210000002850 nasal mucosa Anatomy 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 206010003445 Ascites Diseases 0.000 description 1
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- 230000004543 DNA replication Effects 0.000 description 1
- 241000201295 Euphrasia Species 0.000 description 1
- 206010019837 Hepatocellular injury Diseases 0.000 description 1
- 241001608711 Melo Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 239000008923 Qingkailing Substances 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000002895 emetic Substances 0.000 description 1
- 230000000095 emetic effect Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 208000018191 liver inflammation Diseases 0.000 description 1
- 229940078979 liver therapy drug Drugs 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 231100000189 neurotoxic Toxicity 0.000 description 1
- 230000002887 neurotoxic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
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- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000003998 snake venom Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000001457 vasomotor Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a process for preparing snuffing medicaments for treating hepatitis B. According to pathogenic mechanisms and pharmacology, traditional Chinese medicines of raw pumpkin stalk, rhubarb, calyx meto, jequirity, scorpion venom powder paste, musk, chrysanthemum, corn silk, radix glycyrrhiza filament and borneol are carefully selected for diseases and are reasonably compounded to obtain snuffing medicines and snuffling medicines, namely the snuffing medicaments.
Description
What the present invention relates to is a kind of method for preparing treatment hepatitis B snuff with Chinese medicine.
After American physician Blume uncle outstanding person in 1967 finds that hepatitis B " Australia antigen " obtains Nobel Prize, the countries in the world doctor is for capturing the hepatitis B unremitting effort, but it is little to produce effects so far, and makes it to transfer to chronic hepatitis, liver cirrhosis, hepatic ascites, hepatocarcinoma and then bring misery and burden to patient and family.The method of traditional treatment hepatitis B, normally with have an injection, transfusion and oral in, the mode such as the oral liver of Western medicine must answer, all curative effect is very little for instant particles for treating hepatitis B, MIEAOLING, QINGKAILING, interferon, anti-hepatitis B ribonucleic acid etc.
Just at present universally acknowledged to the medicable interferon of hepatitis B, though can suppress its lower cure rate of part patient virus replication and side effect and knock-on rate height, and price is high, and extensive patients is difficult to accept.
Add up present Beijing Hospital treatment hepatitis B according to authority and spend between ten thousand yuan of the 3-4, and the time is about 2-3.Cure rate is only about 25%, and what use is to protect the liver therapy.
My institute utilized theory of Chinese medical science in recent years, " the hepatitis B quick-acting panacea " that adopts pure Chinese medicinal preparation to develop, and definite effect, and have characteristics such as cost is low, quick and easy, solve the deficiency of its existing other medicines.
Purpose of the present invention just provides a kind of hepatitis B prepares snuff with pure Chinese medicine method for the treatment of.
Purpose of the present invention; take following scheme to realize: according to cause of disease mechanism and pharmacology; suit the medicine to the illness selected have eliminate stagnant, blood circulation promoting and blood stasis dispelling, antiviral invasion, repair the Chinese medicine of damage hepatocyte function, carry out compatibility; make nose news and nasal obstruction medicine; by nasal-cavity administration, treating the poisonous disease with poisonous drugs, anti-killing the virus, protection hepatocyte; strengthen cellular immune function, thereby make the patient reach rehabilitation.
Adopt the snuff of such scheme preparation, through clinical practice and contrast test: effective percentage reaches more than 90%, and cure rate reaches more than 70%; Needed cure in 24 months with traditional method treatment hepatitis B, only needed cure in 6 months with the snuff treatment; The patient is followed up a case by regular visits to 2-8, and 95% does not have recurrence.
Snuff divides snuff and nasal obstruction medicine two parts to form.
The prescription of snuff:
Give birth to Pedicellus Cucurbitae powder 10g, Radix Et Rhizoma Rhei powder 10g, Herba Lactucae formosanae XIANGFEN 10g, yearning between lovers Semen Glycines powder 15g, scorpion venom powder paste 200g, Moschus powder 0.05-0.1g.
The nasal obstruction pharmaceutical formulation:
Flos Chrysanthemi 10g, Stigma Maydis 10g, Radix Glycyrrhizae filament 10g, Borneolum Syntheticum 0.1g.
The manufacture method of snuff:
1. get living Pedicellus Cucurbitae, each 10g of Radix Et Rhizoma Rhei respectively, be soaked in the 200g scorpion venom powder paste, take out behind the first quarter moon, airing is pulverized standby.
2. get the yellow Herba Lactucae formosanae XIANGFEN 10g of roasting, yearning between lovers Semen Glycines powder 15g, Moschus powder 0.05-0.1g mix thoroughly with material mixing 1., snuff.
The manufacture method of nasal obstruction medicine:
1. the Flos Chrysanthemi of plucking, Stigma Maydis, Radix Glycyrrhizae filament are dried respectively slightly and pulverize.
2. get Flos Chrysanthemi 10g, Stigma Maydis 10g, the Radix Glycyrrhizae filament 10g mix homogeneously of pulverizing, add Borneolum Syntheticum 0.1g mix thoroughly the nasal obstruction medicine.
Cause of disease mechanism and pharmacology analysis:
In general, after hepatocyte was subjected to the hepatitis B virus invasion, hepatitis B virus itself did not directly cause hepatocellular pathological changes.The nutriment that hepatitis B virus just utilizes hepatocyte to absorb is depended on for existence and is duplicated in hepatocyte.The surface antigen of virus replication, antigen and cAg all are released on the liver plasma membrane immune system of exciting human and recognize, and react.This antigen antibody reaction that takes place on the liver cell membrane can cause hepatocellular damage and destruction, thereby produces a series of clinical symptoms.
Doctor trained in Western medicine does not have good medicine in the procreation of control hepatitis B virus duplication.Because the beneficial effect of Western medicine antiviral drugs also may be offseted by its simultaneous immunosuppressive action.Though interferon can suppress part patient virus replication, its cure rate is lower, side effect and knock-on rate height.The dialectical Chinese medicine liver protecting therapy of controlling of executing that the traditional Chinese medical science is traditional, though treatment abnormal liver function person there is definite curative effect, also very low to hepatitis B virus cure rate in the elimination body at present.
Nose is in facial centre, have another name called central scroll, the Central Mountain, nasal membrane is in the twelve regular channels and links to each other with the vital organs of the human body, blood vessel is very abundant, and tremulous pulse, vein, lymph and blood capillary interweave netted, and mucosa as thin as a wafer, irritant reaction sensitivity to external world, be very beneficial for infiltration, the absorption of medicine, medicine can be rapidly gone into systemic circulation through Nasal Mucosa Absorption is laggard, simultaneously during nasal administration, because of the nose larynx is ventilated mutually, have most of medicine to enter blood through alveolar, cause medicine to be had an effect soon from respiratory tract, infiltration rate can with quiet match in excellence or beauty, and dosage is little, and toxic and side effects is slight, safety.
And " hepatitis B quick-acting panacea " gives birth to the function that Pedicellus Cucurbitae has the subcutaneous ulcer of harnessing the Yellow River; Pedicellus Melo has emetic action, can improve body cell immunity, jaundice eliminating is arranged and improve the liver function effect; The yearning between lovers Semen Glycines powder: emetic also has heat-clearing and toxic substances removing, attacks the treating the liver inflammation, the anticancer performance of parasite killing; Flos Chrysanthemi: dispelling wind, the heat that disappears, make eye bright, detoxify, go into lung, Liver Channel; The Stigma Maydis diuresis, expel the heat-evil, suppressing the hyperactive liver, function of gallbladder promoting, treatment jaundice; Radix Glycyrrhizae is adjusted all medicines.Moschus has permeability, energy " priming reaches thoroughly ".Scorpion venom has " to be had blood pressure lowering and suppresses vasomotor center, blood vessel dilating, directly suppresses plain boosting on the heart antagonism kidney cardiovascular system.Scorpion venom system plays attack function by stimulating body to produce corresponding antibody after the Nasal Mucosa Absorption to hepatitis B virus like the Neurotoxic protein of snake venom, and also possibility scorpion venom itself plays inhibitory action to the dna replication dna of hepatitis B virus.
We think that by nasal-cavity administration, Chinese medicines such as scorpion venom have stimulated the twelve regular channels, tremulous pulse, vein, lymph and blood capillary.And the nasal cavity medicine, most of medicine enters blood from respiratory tract through alveolar and reaches liver again, and the efficacy of a drug is had an effect, and this is the treating the poisonous disease with poisonous drugs that Chinese medicine such as scorpion venom is risen in hepatocyte, anti-ly kills the main effect that hepatitis B virus DNA duplicates.Changing traditional medication channel is that nose is treated, and also is the very important key factor that the treatment hepatitis B makes it to take place basic curative effect.
More than all medicine compatibilities, treating the poisonous disease with poisonous drugs, anti-killing the virus, the protection hepatocyte strengthens cellular immune function, thereby makes the patient steadily, fast reach the purpose of rehabilitation.
Instructions of taking: nose is heard (man left and woman right), the 20-30 milligram of snuff is pushed away gently put into nasal cavity, encases the nasal obstruction medicine with senior filter paper and blocks, and hears getting final product in 1-2 hour.Take medicine weekly, 28 days is a course of treatment.
Function: antiviral, treating the poisonous disease with poisonous drugs, protection hepatocyte, enhance hepatocyte immunologic function.
Cure mainly: hepatitis B
Claims (1)
1, a kind of preparation method for the treatment of hepatitis B nose with medicament is characterized in that: (1) gets living Pedicellus Cucurbitae, each 10 gram of Radix Et Rhizoma Rhei respectively, is soaked in the 200 gram scorpion venom powder pastes, and the taking-up dried and crushed is standby behind the first quarter moon; (2) get the yellow Herba Lactucae formosanae XIANGFEN of roasting 10 grams, yearning between lovers Semen Glycines powder 15 grams, Moschus powder 0.05-0.1 gram and mix with the raw material of (1) and mix thoroughly, make snuff; (3) get Flos Chrysanthemi 10 gram, Stigma Maydis 10 grams, the Radix Glycyrrhizae filament 10 gram mix homogeneously of pulverizing, add Borneolum Syntheticum 0.1 gram and mix thoroughly, make the nasal obstruction medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99126394A CN1093421C (en) | 1999-12-21 | 1999-12-21 | Process for preparing snuff to treat hepatitis B |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99126394A CN1093421C (en) | 1999-12-21 | 1999-12-21 | Process for preparing snuff to treat hepatitis B |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1300620A CN1300620A (en) | 2001-06-27 |
| CN1093421C true CN1093421C (en) | 2002-10-30 |
Family
ID=5284434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99126394A Expired - Fee Related CN1093421C (en) | 1999-12-21 | 1999-12-21 | Process for preparing snuff to treat hepatitis B |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1093421C (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1181945A (en) * | 1996-11-11 | 1998-05-20 | 车利群 | Convalescence capsule for hepatosis patient |
| CN1182611A (en) * | 1997-09-04 | 1998-05-27 | 田丽华 | Yigan Powder |
| CN1200290A (en) * | 1997-05-24 | 1998-12-02 | 汪怀元 | Medicine recipe for treating liver disease |
-
1999
- 1999-12-21 CN CN99126394A patent/CN1093421C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1181945A (en) * | 1996-11-11 | 1998-05-20 | 车利群 | Convalescence capsule for hepatosis patient |
| CN1200290A (en) * | 1997-05-24 | 1998-12-02 | 汪怀元 | Medicine recipe for treating liver disease |
| CN1182611A (en) * | 1997-09-04 | 1998-05-27 | 田丽华 | Yigan Powder |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1300620A (en) | 2001-06-27 |
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