CN109303976A - A kind of microneedle configuration that medicaments uniformity distribution imports - Google Patents
A kind of microneedle configuration that medicaments uniformity distribution imports Download PDFInfo
- Publication number
- CN109303976A CN109303976A CN201811320501.2A CN201811320501A CN109303976A CN 109303976 A CN109303976 A CN 109303976A CN 201811320501 A CN201811320501 A CN 201811320501A CN 109303976 A CN109303976 A CN 109303976A
- Authority
- CN
- China
- Prior art keywords
- pedestal
- essence
- needle body
- medicaments uniformity
- microneedle configuration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 23
- 230000008676 import Effects 0.000 title claims description 16
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims abstract description 36
- 230000000694 effects Effects 0.000 abstract description 6
- 210000003491 skin Anatomy 0.000 description 15
- 229940079593 drug Drugs 0.000 description 7
- 230000006872 improvement Effects 0.000 description 6
- 206010020649 Hyperkeratosis Diseases 0.000 description 3
- 208000001126 Keratosis Diseases 0.000 description 3
- 230000003796 beauty Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001835 salubrious effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The present invention relates to micropin technical fields, the microneedle configuration imported more particularly to a kind of distribution of medicaments uniformity, including pedestal, the pedestal is equipped with multiple needle bodies, the pedestal is equipped with multiple convex blocks, multiple convex blocks form criss-cross drainage trough, Essence can uniformly be flowed to each needle body by drainage trough, skin is uniformly input to along needle body, it clearly enhances Essence and uniformly introduces distribution assimilation effect, when in use, it can effectively and skin attachement, avoid the leakage of Essence, further, diversion trench is devised on needle body, quickly smoothly Essence can be inputted along diversion trench, and multiple diversion trenches can be designed, play the role of accelerating the importing of Essence.
Description
Technical field
The present invention relates to micropin technical fields, and in particular to a kind of microneedle configuration that medicaments uniformity distribution imports.
Background technique
In recent years, for needle body percutaneous dosing by common concern, the needle mode of applying by pressing needle body array being capable of moment
The duct of a large amount of micron dimension sizes is generated in keratoderma and epidermis, therefore the permeability of drug can be significantly improved,
Any drug including biopharmaceutical macromolecular drug theoretically be shall apply to without by molecular size range, polar drugs, molten
The limitation of point etc., to establish solid foundation using percutaneous dosing for these drugs.Before being pierced into skin, if
Drug is covered on the surface of needle body array especially needle point, then can be called needle body transdermal skin patches；In addition, can also be by needle body battle array
Column are removed after being directly pierced into skin, then apply drug again in applying at needle through its voluntarily diffusion drug delivery.Since needle body is sharp short
Small, medicine-feeding part does not touch nerve fiber and blood vessel in body surface, therefore will not generate pain and bleeding, and minimally invasive
Aperture can heal automatically within a very short time；It does not need professional using needle body administration to operate, using flexible side
Just, can interruption of the administration at any time, so being easier to be easily accepted by the patient.
Needle body importing is a kind of current common beauty means, i.e., punctures keratoderma by needle body and be not passed through corium
Layer, Essence is imported, and achievees the purpose that beauty, and traditional micropin is generally there are two types of mode, and one kind is injection-type, and another kind is
Puncture importing type.
For usual the latter because its substrate is plane, wafer surface Essence poor fluidity causes needle body to deposit when importing Essence
Big in local dose, the small problem of part dosage causes to absorb unevenness, influences using effect.
Summary of the invention
It is of the existing technology to solve the object of the present invention is to provide the microneedle configuration that a kind of distribution of medicaments uniformity imports
At least one of drawbacks described above.
To achieve the above object, the present invention provides the following technical scheme that the micropin knot that a kind of distribution of medicaments uniformity imports
Structure, including pedestal, the pedestal are equipped with multiple needle bodies, and the pedestal is equipped with multiple convex blocks, and multiple convex blocks form vertical
Horizontal staggered drainage trough.
Further improvement of the present invention, multiple convex blocks are evenly spaced on to form array.
Further improvement of the present invention, the needle body are polygon pyramidal structure.
Further improvement of the present invention, multiple needle bodies, which are uniformly arranged, forms array, and is arranged in the vertical of drainage trough
On horizontal staggered center.
Further improvement of the present invention, the needle body are equipped at least one diversion trench.
Further improvement of the present invention, the pedestal is rectangular or round.
The surrounding edge of further improvement of the present invention, the pedestal is equipped with enclosing.
In conclusion the invention has the following advantages:
The microneedle configuration that this kind of medicaments uniformity distribution imports, including pedestal, pedestal are equipped with multiple needle bodies, and pedestal is equipped with
Multiple convex blocks, multiple convex blocks form criss-cross drainage trough, Essence uniformly can be flowed to each needle by drainage trough
Body is uniformly input to skin along needle body, hence it is evident that enhances Essence and uniformly introduces distribution assimilation effect, when in use, Neng Gouyou
Imitate and skin attachement, avoids the leakage of Essence, further, diversion trench is devised on needle body, can quickly smoothly will
Essence is inputted along diversion trench, and can design multiple diversion trenches, plays the role of the importing for accelerating Essence.
The invention will be further described with specific embodiment with reference to the accompanying drawings of the specification.
Detailed description of the invention
Fig. 1 is overall structure diagram of the invention.
Fig. 2 is the partial structural diagram of needle body of the invention.
In attached drawing: 1, pedestal；2, needle body；3, enclosing；4, convex block；5, drainage trough；6, diversion trench.
Specific embodiment
In the description of the present invention, it is to be understood that, term " length ", " width ", "upper", "lower", "front", "rear",
The orientation or positional relationship of the instructions such as "left", "right", "vertical", "horizontal", "top", "bottom" "inner", "outside" is based on attached drawing institute
The orientation or positional relationship shown, is merely for convenience of description of the present invention and simplification of the description, rather than the dress of indication or suggestion meaning
It sets or element must have a particular orientation, be constructed and operated in a specific orientation, therefore should not be understood as to limit of the invention
System.
Referring to Fig. 1-2, a kind of microneedle configuration that medicaments uniformity distribution imports disclosed by the invention, including pedestal 1, pedestal 1
Multiple needle bodies 2 are equipped with, pedestal 1 is equipped with multiple convex blocks 4, and multiple convex blocks 4 form criss-cross drainage trough 5；Multiple convex blocks 4
It is evenly spaced on to form array；Needle body 2 is polygon pyramidal structure；Uniformly arrangement forms array to multiple needle bodies 2, and arranges
On the criss-cross center of drainage trough 5；Needle body 2 is equipped at least one diversion trench 6；Pedestal 1 is rectangular or round
Shape；The surrounding edge of pedestal 1 is equipped with enclosing 3.
Needle body 2 is polygon pyramidal structure；Uniformly arrangement forms array to multiple needle bodies 2, and is arranged in the vertical of drainage trough 5
On horizontal staggered center；Enclosing 3 is rectangular or round, and is integrally formed with pedestal 1；The height of enclosing 3 is less than needle
The height of body 2；Pedestal 1 is rectangular or round.
Wherein, by being equipped with multiple convex blocks 4 on pedestal 1, multiple convex blocks 4 are evenly spaced on to form array；It is multiple convex
Block 4 forms criss-cross drainage trough 5, Essence uniformly can be flowed to each needle body 2 by drainage trough 5, equal along needle body 2
It is even to be input to skin, hence it is evident that enhance Essence and uniformly introduce distribution assimilation effect.
Further, diversion trench 6 is devised on needle body 2, can quickly smoothly be inputted Essence along diversion trench 6, and
And can uniformly import Essence, and multiple diversion trenches 6 can be designed, play the role of the importing for accelerating Essence.
Wherein, the diversion trench 6 on needle body 2 of the present invention can be encountered liquid and melted at once, then be utilized needle body 2 with Tibetan medicine
Immediately by skin surface bolus skin permeation, the traditional micropin import volume of solution is few, solves vaccine polymer micro needle and beats
It puts skin and absorbs slow, the low problem of absorptivity.
Secondly, pedestal 1 is equipped with multiple tapered micropins, the surrounding edge of pedestal 1 is equipped with enclosing 3；Enclosing 3 is in rectangle
Shape or round, and be integrally formed with pedestal 1；The height of enclosing 3 is less than the height of micropin, is further conducive to the patch of skin
It closes；Pedestal 1 is rectangular or round；Micropin uniformly arranges and forms array, and is fixedly connected with pedestal 1.
In embodiment, by around pedestal 1 edge be equipped with enclosing 3, and the height of enclosing 3 be less than micropin height
Degree, and be integrally formed with pedestal 1；When in use, enclosing 3 effectively can stop Essence to leak around, and inside forms pressure,
Essence is set fast and efficiently to penetrate into skin.
Present invention process is simple, low in cost, can be widely used on the market.
In conclusion needle body 2 of the invention directly and skin contact can allow skin directly to absorb, beautifying liquid is allowed directly to seep
Thoroughly in skin, while keratoderma is only punctured when use of the present invention, painless and noninvasive, not bleeding, pro-skin is soft, sense of touch
Silk is sliding, can be close to skin, breathes freely salubrious.
In the present invention unless specifically defined or limited otherwise, term " installation ", " connected ", " connection ", " fixation " etc.
Term shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or integral；It can be mechanical connect
It connects, is also possible to be electrically connected；It can be directly connected, can also can be in two elements indirectly connected through an intermediary
The interaction relationship of the connection in portion or two elements.
It is carried out above by conjunction with the embodiments with technical effect of the attached drawing to design of the invention, specific structure and generation clear
Chu is fully described by, to be completely understood by the purpose of the present invention, feature and effect.Obviously, described embodiment is this hair
Bright a part of the embodiment, rather than whole embodiments, based on the embodiment of the present invention, those skilled in the art are not being paid
Other embodiments obtained, belong to the scope of protection of the invention under the premise of creative work.In addition, be previously mentioned in text
All connection/connection relationships not singly refer to that component directly connects, and referring to can be added deduct according to specific implementation situation by adding
Few couple auxiliary, to form more preferably coupling structure.
Above-described embodiment is served only for that invention is further explained to specific descriptions of the invention, should not be understood as
Limiting the scope of the present invention, the technician of this field make the present invention according to the content of foregoing invention some non-
The modifications and adaptations of essence are fallen within the scope of protection of the present invention.
Claims (7)
1. a kind of microneedle configuration that medicaments uniformity distribution imports, including pedestal (1), it is characterised in that: the pedestal (1) is equipped with
Multiple needle bodies (2), the pedestal (1) are equipped with multiple convex blocks (4), and multiple convex blocks (4) form criss-cross drainage trough
(5)。
2. a kind of microneedle configuration that medicaments uniformity distribution imports according to claim 1, it is characterised in that: multiple described convex
Block (4) is evenly spaced on to form array.
3. a kind of microneedle configuration that medicaments uniformity distribution imports according to claim 1, it is characterised in that: the needle body
It (2) is polygon pyramidal structure.
4. a kind of microneedle configuration that medicaments uniformity distribution imports according to claim 1, it is characterised in that: multiple needles
Uniformly arrangement forms array to body (2), and is arranged on the criss-cross center of drainage trough (5).
5. a kind of microneedle configuration that medicaments uniformity distribution imports according to claim 1, it is characterised in that: the needle body
(2) it is equipped at least one diversion trench (6).
6. a kind of microneedle configuration that medicaments uniformity distribution imports according to claim 1, it is characterised in that: the pedestal
(1) rectangular or round.
7. a kind of microneedle configuration that medicaments uniformity distribution imports according to claim 1, it is characterised in that: the pedestal
(1) surrounding edge is equipped with enclosing (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811320501.2A CN109303976A (en) | 2018-11-07 | 2018-11-07 | A kind of microneedle configuration that medicaments uniformity distribution imports |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811320501.2A CN109303976A (en) | 2018-11-07 | 2018-11-07 | A kind of microneedle configuration that medicaments uniformity distribution imports |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109303976A true CN109303976A (en) | 2019-02-05 |
Family
ID=65222684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811320501.2A Pending CN109303976A (en) | 2018-11-07 | 2018-11-07 | A kind of microneedle configuration that medicaments uniformity distribution imports |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109303976A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109125914A (en) * | 2018-11-07 | 2019-01-04 | 何坛明 | A kind of antiseep micropin gatherer |
| CN111675190A (en) * | 2020-06-18 | 2020-09-18 | 苏州恒之清生物科技有限公司 | A kind of preparation method of miniature solid silicon needle |
| JP2021007449A (en) * | 2019-06-28 | 2021-01-28 | 凸版印刷株式会社 | Microneedle |
| EP3772331A1 (en) * | 2019-08-08 | 2021-02-10 | PKvitality | Body monitoring system comprising a microneedle |
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| JP2013094530A (en) * | 2011-11-04 | 2013-05-20 | Asti Corp | Microneedle array and microneedle array device |
| CN103203072A (en) * | 2013-03-25 | 2013-07-17 | 清华大学 | Metal micro-needle array flexible patch, transdermal applicator and transdermal application patch |
| CN105126243A (en) * | 2015-09-06 | 2015-12-09 | 游学秋 | Microneedle injection bullet, manufacturing method thereof and mirconeedle injection device |
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| CN209751939U (en) * | 2018-11-07 | 2019-12-10 | 何坛明 | Microneedle structure with uniformly distributed and introduced drugs |
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2018
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| JP2013094530A (en) * | 2011-11-04 | 2013-05-20 | Asti Corp | Microneedle array and microneedle array device |
| CN103203072A (en) * | 2013-03-25 | 2013-07-17 | 清华大学 | Metal micro-needle array flexible patch, transdermal applicator and transdermal application patch |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109125914A (en) * | 2018-11-07 | 2019-01-04 | 何坛明 | A kind of antiseep micropin gatherer |
| JP2021007449A (en) * | 2019-06-28 | 2021-01-28 | 凸版印刷株式会社 | Microneedle |
| JP7459459B2 (en) | 2019-06-28 | 2024-04-02 | Ｔｏｐｐａｎホールディングス株式会社 | micro needle |
| EP3772331A1 (en) * | 2019-08-08 | 2021-02-10 | PKvitality | Body monitoring system comprising a microneedle |
| WO2021023884A1 (en) * | 2019-08-08 | 2021-02-11 | Pkvitality | Body monitoring system comprising a microneedle |
| CN111675190A (en) * | 2020-06-18 | 2020-09-18 | 苏州恒之清生物科技有限公司 | A kind of preparation method of miniature solid silicon needle |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190205 |