CN109300569A - Large-scale photothermal particle aggregation and migration method based on tapered optical fibers - Google Patents
Large-scale photothermal particle aggregation and migration method based on tapered optical fibers Download PDFInfo
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Abstract
本发明公开了一种基于锥形光纤的大规模光热颗粒聚集和迁移方法，具体包括以下步骤：锥形光纤的制作、悬浮液的配备、锥形光纤和实验装置的安装、颗粒或细胞的聚集以及高效迁移；本发明所使用的装置简单、试验过程方便、易操作，对于微纳颗粒或细胞的聚集与迁移效率高，对微纳颗粒或细胞无损伤，易用广泛。
The invention discloses a large-scale photothermal particle aggregation and migration method based on a tapered optical fiber, which specifically includes the following steps: the production of the tapered optical fiber, the preparation of the suspension, the installation of the tapered optical fiber and the experimental device, the preparation of the particles or cells Aggregation and efficient migration; the device used in the present invention is simple, the test process is convenient and easy to operate, the aggregation and migration efficiency of micro-nano particles or cells is high, no damage to micro-nano particles or cells, and it is widely used.
Description
Technical field
The invention belongs to bio-photons and field of biomedicine technology, more particularly to a kind of based on the big of conical fiber
Scale photo-thermal particle aggregation and moving method.
Background technique
The progress such as micro-nano particle, biomolecule, biological cell are captured with aggregation and subsequent removal on a large scale, in biomedicine
Suffer from important role with many fields such as physical chemistry, for example, micro-nano structure assembling, drug screening, drug targeting treat,
Local Water warfare etc.；There are distinct methods to be used to that particle is assembled and assembled in the world at present, such as thermophoresis, electrophoresis, dielectric
Swimming, sound field etc.；In order to realize the aggregation capture of extensive particle, these methods are typically necessary more complicated device, simultaneously
Additional electrodes are also needed, in addition, these methods can not be directly realized by efficient particle targeting migration and remove.
In order to realize easy extensive particle aggregation and efficient migration, a kind of big rule based on conical fiber have been invented
Mould photo-thermal particle aggregation and moving method.
Summary of the invention
The purpose of the present invention is to provide a kind of extensive photo-thermal particle aggregation and moving method based on conical fiber, with
Realize extensive rapid aggregation, targeting migration micro-nano particle and biological cell, the equipment that this method uses is simple, easy to operate.
The technical scheme adopted by the invention is that extensive photo-thermal particle aggregation and moving method based on conical fiber,
Specifically includes the following steps:
Step 1: the production of conical fiber
The buffer layer of business single-mode fiber jumper and plastic wrapper are removed using optical fiber wire stripper, removal position length 20~
50cm protrudes into the optical fiber for removing housing in glass capillary, and after optical fiber passes through glass capillary, end is pulled out in alcolhol burner
After flame envelope heats 100~150s, with the speed of 1~3mm/s by 20~30s of optical fiber melt-pulling of flame upper end, experiment is obtained
Conical fiber；
Step 2: suspension is equipped with
By micro-nano particle or cellular invasion in deionization pure water, uniform suspension is formed, takes the suspension prepared
It is added drop-wise on micro slide, and micro slide is put in spare on microscopical two-dimensional shift platform；
Step 3: installation conical fiber and experimental provision
The conical fiber made is fixed on fine adjustment frame, conical fiber tip is protruded into suspension, and the other end is logical
It crosses erbium-doped fiber amplifier to be connected on laser, computer is connected on the microscope for being loaded with CCD, and experimentation can directly pass through
Computer display screen is observed；
Step 4: large-scale aggregating particle
Laser is opened, the photo-thermal that incident laser, micro-nano particle or cell are passed through into conical fiber in incident laser is made
Under, it is gathered in apart from the place at 100~500 μm of conical fiber tip；
Step 5: the particle of efficient migration aggregation
After particle is by large-scale aggregating, laser is kept to open, by adjusting the mobile conical fiber of fine adjustment frame to finger
The migration to aggregated particle or cell is realized in fixed position.
Further, conical fiber end diameter is 1~10 μm in step 1.
Further, for the size of micro-nano particle or cell at 1~5 μm, particle or cell is molten in suspension in step 2
Degree is 1.0 × 107~1.0 × 108A/mL；For the size of particle or cell at 5~10 μm, solubility is 2.0 × 106~2.0
×107A/mL.
Further, in step 4 incident power of incident laser be 100~170mW, wavelength 1550nm.
The beneficial effects of the present invention are: can quickly large-scale aggregating micro-nano particle and biological cell, and carried out
Targeting migration；The equipment used during aggregation micro-nano particle and biological cell is simple, at low cost, the harm to sample itself
The extremely low and process is simple and easy to operate, high to the transport efficiency of micro-nano particle or biological cell.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
It obtains other drawings based on these drawings.
Fig. 1 is the conical fiber figure of aggregation with migration.
Fig. 2 is the Experimental equipment for assembling and migrating.
Fig. 3 is the experimentation picture of aggregation with migration.
Fig. 4 be under different incident powers particle aggregation number and aggregation velocity with time variation diagram.
Fig. 5 is the experimental observation figure of extensive efficient migration particle.
In figure, 1. lasers, 2. erbium-doped fiber amplifiers, 3. fine adjustment framves, 4. conical fibers, 5. suspension, 6. is micro-
Mirror, 7.CCD, 8. computers.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Extensive photo-thermal particle aggregation and moving method based on conical fiber, specifically includes the following steps:
Step 1: the production of conical fiber 4
The buffer layer of business single-mode fiber jumper and plastic wrapper are removed using optical fiber wire stripper, removal position length 20~
50cm protrudes into the optical fiber for removing housing in glass capillary, and after optical fiber protrudes into glass capillary, end is pulled out in alcolhol burner
After flame envelope heats 100~150s, with the speed of 1~3mm/s by 20~30s of optical fiber melt-pulling of flame upper end, experiment is obtained
Conical fiber 4；
The core diameter of single mode optical fiber is 9 μm, and covering is 125 μm；The length of glass capillary be 120mm, internal diameter 0.9mm,
Thickness of pipe wall 0.1mm；4 end diameter of conical fiber is 1~10 μm；
4 structure of conical fiber is as shown in Figure 1；When 4 end diameter of conical fiber is greater than 10 μm, diameter is bigger, goes out accordingly
It penetrates light field more to dissipate, the region that can generate photo-thermal effect is bigger, and the particle that can be applied to is also more, but the aggregation to particle
Effect is deteriorated, and the particle of aggregation is compact, at compared with dispersed distribution, while migration effect is deteriorated；And fibre diameter is in 1~10 μm of model
When enclosing interior, optical output field is concentrated, and the region for generating photo-thermal effect is small, but more preferable to the congregational rate of particle, and aggregation is compact, is moved
It is also better to move effect；
Step 2: suspension 5 is equipped with
By micro-nano particle or cellular invasion in deionization pure water, uniform suspension 5 is formed, the suspension prepared is taken
5 are added drop-wise on micro slide, and micro slide are put in spare on the two-dimensional shift platform of microscope 6；
For the size of particle or cell at 1~5 μm, the solubility of particle and cell is 1.0 × 10 in suspension 57~1.0 ×
108A/mL；For the size of particle or cell at 5~10 μm, solubility is 2.0 × 106~2.0 × 107A/mL；
5 middle particle concentration of suspension is bigger, and the particle that conical fiber 4 is collected is more, to realize the time collected completely
It is longer, but since in transition process, particle or cell are easy to be deposited on sheet glass bottom, and migration effect can increase with concentration
Add and reduces；When the diameter of micro-nano particle or cell becomes larger, micro-nano particle or cell are easy, to stay in sheet glass table
Face is difficult to move, so that aggregation and migration effect can all be deteriorated；Micro-nano particle or cell size are too small, since Brownian movement is bright
It is aobvious, it collects and the effect of migration can also reduce；
Step 3: installation conical fiber 4 and experimental provision
As shown in Fig. 2, the conical fiber 4 made is fixed on fine adjustment frame 3, suspension is protruded at 4 tip of conical fiber
In liquid 5；4 other end of conical fiber is connected on laser 1 by erbium-doped fiber amplifier 2, and computer 8, which is connected to, is loaded with CCD7's
On microscope 6, experimentation can be directly observed by 8 display screen of computer；
Step 4: large-scale aggregating particle
Laser 1 is opened, the laser that incident power is 100~170mW, wavelength is 1550nm is passed through into conical fiber 4,
Deionized water is stronger to the absorption of laser, and micro-nano particle or biological cell are weaker to the absorption of laser, therefore micro-nano particle is in light
Under heat effect, it is gathered on a large scale apart from the place at 100~500 μm of 4 tip of conical fiber；
Step 5: the particle of efficient migration aggregation
After particle is by large-scale aggregating, laser 1 is kept to open, is arrived by adjusting the mobile conical fiber 4 of fine adjustment frame 3
Specified position, the particle of aggregation also carry out collective's targeting migration accordingly.
Extensive photo-thermal particle aggregation and moving method based on conical fiber, to the particle of different sizes, different materials
Or biological cell can realize large-scale aggregation and migration, aggregation and migration experiment behaviour to micro-nano particle and biological cell
Make simple, high-efficient, the equipment price used is cheap, at low cost.
The present invention can be used for microorganism-collecting, local Water warfare etc.；For various sizes of particle and microbiological specimens,
Due to its photo-thermal effect difference, can use the present invention can separating to particle and microorganism.
Embodiment 1
Extensive photo-thermal particle aggregation and moving method based on conical fiber, specifically includes the following steps:
Step 1: the production of conical fiber 4
The buffer layer of business single-mode fiber jumper and plastic wrapper are removed using optical fiber wire stripper, removal position length 20~
50cm protrudes into the optical fiber for removing housing in glass capillary, after optical fiber protrudes into glass capillary, end is pulled out and is added
Heat, with the speed of 1~3mm/s by 20~30s of optical fiber melt-pulling of flame upper end, is used after alcolhol burner flame envelope heats 100~150s
Scissors cuts optical fiber waist, obtains experiment conical fiber 4, and the end diameter of conical fiber 4 is 3.1 μm, structure such as Fig. 1 institute
Show；
Step 2: suspension 5 is equipped with
The silica dioxide granule that diameter is 2 μm is spread in deionized water, is spread under the auxiliary of Ultrasound Instrument uniformly, two
Silicon oxide particle concentration is 1.0 × 107~1.0 × 108A/mL；The suspension 5 for taking 500 μ L to prepare is added drop-wise on micro slide, and
Micro slide is put in spare on the two-dimensional shift platform of microscope 6；
Step 3: installation conical fiber 4 and experimental provision
As shown in Fig. 2, the conical fiber 4 made is fixed on fine adjustment frame 3, suspension is protruded at 4 tip of conical fiber
In liquid 5；4 other end of conical fiber is connected on laser 1 by erbium-doped fiber amplifier 2, and computer 8, which is connected to, is loaded with CCD7's
On microscope 6, experimentation can be observed directly by 8 display screen of computer in real time；
Step 4: large-scale aggregating particle
Open laser 1, the laser that incident power is 100mW, wavelength is 1550nm is passed through into conical fiber 4, go from
Sub- water is stronger to the absorption of laser, and silica dioxide granule is weaker to the absorption of laser, and silica dioxide granule is under photothermy, quilt
It is gathered on a large scale apart from the place at 100~500 μm of 4 tip of conical fiber；
Step 5: the particle of efficient migration aggregation
After particle is by large-scale aggregating, laser 1 is kept to open, is arrived by adjusting the mobile conical fiber 4 of fine adjustment frame 3
Specified position, the particle of aggregation also carry out collective's targeting migration accordingly.
Embodiment 2
150mW is set by the incident power of laser in 1 step 4 of embodiment, suspension 5 is observed by 8 display of computer
The aggregation and migration situation of middle silica dioxide granule.
Embodiment 3
170mW is set by the incident power of laser in 1 step 4 of embodiment, suspension 5 is observed by 8 display of computer
The aggregation and migration situation of middle silica dioxide granule.
The experimental result of 1~embodiment of embodiment 3 is as shown in figure 4, by Fig. 4 a it is found that silica dioxide granule in suspension 5
Aggregation number be presented growth trend at any time, increase early period more rapid, the later period increasess slowly, finally reach saturation state,
When power is 100,150,170mW, the numbers of particles assembled under saturation state is respectively 2600,6550,10150；By scheming
4b it is found that the aggregation velocity increase presentation at any time of particle first increases and subtracts trend afterwards, power be 100,150, under 170mW, reach
Time to maximum aggregation velocity is respectively 5.5,5.1 and 3.1min, and maximum aggregation velocity is respectively 7.4,14.8 and 22.1
A/second.
Particle in embodiment 3 in suspension 5 starts to assemble under photothermy；Result is observed by 8 display of computer
As shown in figure 3, experiment is shown in Fig. 3 a starts rear 5s, particle starts to be assembled；After experiment starts 2min in Fig. 3 b, about
There are 2100 particles to be assembled, forms a fusiform aggregation zone；As assemble index increases, the particle of aggregation is increasingly
It is more, when 5 minutes, probably there are 5150 particles to be assembled, as shown in Figure 3c；As more and more particles are assembled,
Spindle particle aggregation region is increasing, and the particle of outside is fewer and fewer, and aggregation velocity is also smaller and smaller, is 15 points when the time
When clock, aggregation reaches a saturation state, and about 10150 particles are assembled, as shown in Figure 3d, at this point, particle is poly-
Integrate 4 distance between two tips of centre distance conical fiber in region as d=380 μm.
After being continually fed into laser in embodiment 3, mobile conical fiber 4, the particle assembled is also moved, observed result
As shown in Figure 5；Conical fiber 4 is shown to after 112 μm of the direction-y moving fiber in Fig. 5 a~Fig. 5 e, and the particle of aggregation is also therewith
Mobile observation process, when mobile 65s, the particle of aggregation is nearly all moved to new position, only leave it is a small number of because
It can not be migrated on the glass sheet for particle precipitating；After being moved to new position, to 172 μm of the direction+y moving fiber, of aggregation
Grain is equally efficiently moved to new position, and for mobile observation process as shown in Fig. 5 f~Fig. 5 j, 95% or more particle is real
Migration is showed.
Each embodiment in this specification is all made of relevant mode and describes, same and similar portion between each embodiment
Dividing may refer to each other, and each embodiment focuses on the differences from other embodiments.Especially for system reality
For applying example, since it is substantially similar to the method embodiment, so being described relatively simple, related place is referring to embodiment of the method
Part explanation.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the scope of the present invention.It is all
Any modification, equivalent replacement, improvement and so within the spirit and principles in the present invention, are all contained in protection scope of the present invention
It is interior.
Claims (4)
1. extensive photo-thermal particle aggregation and moving method based on conical fiber, which is characterized in that specifically includes the following steps:
Step 1: the production of conical fiber (4)
The buffer layer of business single-mode fiber jumper and plastic wrapper are removed using optical fiber wire stripper, removal position length 20~
50cm protrudes into the optical fiber for removing housing in glass capillary, and after optical fiber passes through glass capillary, end is pulled out in alcolhol burner
After flame envelope heats 100~150s, with the speed of 1~3mm/s by 20~30s of optical fiber melt-pulling of flame upper end, experiment is obtained
Conical fiber (4)；
Step 2: suspension (5) is equipped with
By micro-nano particle or cellular invasion in deionization pure water, uniform suspension (5) are formed, the suspension prepared is taken
(5) it is added drop-wise on micro slide, and micro slide is put in spare on the two-dimensional shift platform of microscope (6)；
Step 3: installation conical fiber (4) and experimental provision
The conical fiber made (4) is fixed on fine adjustment frame (3), conical fiber (4) tip is protruded into suspension (5),
The other end is connected on laser (1) by erbium-doped fiber amplifier (2), and computer (8) is connected to the microscope for being loaded with (7) CCD
(6) on, experimentation can be directly observed by computer (8) display screen；
Step 4: large-scale aggregating particle
It opens laser (1), incident laser, micro-nano particle or cell is passed through into conical fiber (4) in the photo-thermal of incident laser
Under effect, it is gathered in apart from the place at 100~500 μm of conical fiber (4) tip；
Step 5: the particle of efficient migration aggregation
After particle is by large-scale aggregating, laser (1) is kept to open, it is mobile conical fiber (4) by adjusting fine adjustment frame (3)
To specified position, the migration to aggregated particle or cell is realized.
2. the extensive photo-thermal particle aggregation and moving method, feature according to claim 1 based on conical fiber exists
In conical fiber (4) end diameter is 1~10 μm in the step 1.
3. the extensive photo-thermal particle aggregation and moving method, feature according to claim 1 based on conical fiber exists
In for the size of micro-nano particle or cell at 1~5 μm, the solubility of particle or cell is 1.0 in suspension (5) in the step 2
×107~1.0 × 108A/mL；For the size of particle or cell at 5~10 μm, solubility is 2.0 × 106~2.0 × 107A/
mL。
4. the extensive photo-thermal particle aggregation and moving method, feature according to claim 1 based on conical fiber exists
In, in the step 4 incident power of incident laser be 100~170mW, wavelength 1550nm.
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Application publication date: 20190201 |