CN1092992A - 提高脑功能的药物及其制备方法 - Google Patents
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Abstract
提高脑功能的药物，可以治疗遗尿症、智力低下
和痴呆症等由于脑功能低下所引起的病症，其特征在
于所述药物为文冠果子的提取物。文冠果种仁的脱
脂粉，含有粗脂肪，由17种氨基酸(如谷氨酸、赖氨
酸、精氨酸、酪氨酸等)组成的粗蛋白、皂甙、水、醣、微
量元素，具体含量为：
粗脂肪 粗蛋白 皂甙 水 其他
1～10 55～65 2～4 7～20 余
提高脑功能药物可全面提高脑神经系统功能，对
小儿智力低下和中老年性痴呆等病症具有明显疗
效。
Description
本发明涉及中药，特别是一种以文冠果子提取物制得的提高脑功能的药物。
文冠果系无患子科文冠果属植物，又名崖木瓜，属落叶灌木或小乔木、奇数羽状复叶、总状花序、花白色、蒴果三瓣型，种子多数，经过对文冠果的子化学成份分析表明，它含有约60%的油脂，约26%的蛋白质，约1.2%的粗皂甙，2.4%的水份及4.9%的其它成份，过去为野生植物，近来北方部分地区有栽培，其适应性强，耐寒、耐旱、耐贫瘠，一般对文冠果的利用多为两方面，其一是防风固沙，其二是用其种子榨取食用油，经查阅国内外有关文献，发现《中国药典》和历代药用本草中对文冠果均无药用记载。
本发明的目的在于提供一种提高脑功能的药物。
本发明所提供的提高脑功能的药物，可以治疗遗尿症、智力低下和痴呆症等由于脑功能低下所引起的病症，其特征在于所述药物为文冠果子的提取物。
其中之一为文冠果种仁的脱脂粉，含有粗脂肪，由17种氨基酸（如谷氨酸、赖氨酸、精氨酸、酪氨酸等）组成的粗蛋白、皂甙、水、
具体含量为：
粗脂肪 粗蛋白 皂甙 水 其他
1～10 55～65 2～4 7～10 余
生产过程依下述步骤进行：
-预榨种仁饼粉;
-萃取脱脂;
-干燥，粉碎，过筛，灭菌得脱脂粉。
其中萃取脱脂可以采用下述方式：
-用弱极性有机溶剂如石油醚、苯、正已烷等于室温下或加热＜90℃情况下，萃取;
-收集萃取液，除去溶剂得脱脂粗粉。
或者采用超临界CO2。
用文冠果种仁脱脂粉可以制成治疗遗尿症的胶囊或颗粒剂。
文冠果子和遗尿停胶囊及颗粒剂对遗尿症的疗效显著治愈率75%，好转率18%，总有效率达93%，是目前此类药物中最为理想的一种。同时，遗尿停胶囊或颗粒剂还可以治疗智力低下和痴呆症。
本发明还提供了一种提高脑功能的药物可治疗智力低下和痴呆症及遗尿症，所述药物为文冠果子的醇提取物，具体含量为：
粗脂肪 粗蛋白 皂甙 醣 水 其他
1～10 15～20 10～20 20～30 10～15 余
工艺过程如下：
-压榨后的文冠果子或文冠果脱脂粉用醇类有机溶剂如乙醇、甲醇、正丁醇等浸提;
-收集浸提液，除去溶剂，灭菌得醇提取物清膏。用所述提取物清膏可以制成冲剂或片剂。提高脑功能药物可全面提高脑神经系统功能，对小儿智力低下和中老年性痴呆等病症具有明显疗效。本发明以文冠果子为原料提取药物，经各种药理试验表明，无任何毒副作用，文冠果种仁脱脂粉制备工艺简单，皂甙收率高、造价低、果子里含有60%的油脂，含有17种氨基酸，脱下的油脂可以作为食用油和高级油漆等。下面通过实施例详细叙述本发明。
实施例1
采收1kg文冠果种子，清选，干燥，剥去种皮得440g种仁，预榨种仁得饼粉，用正己烷在室温下按正己烷∶饼粉＝1∶1浸提4到5次，每次24～48小时，收集浸提液，用减压蒸馏法除去溶剂，干燥粉碎过筛灭菌得176g脱脂粉，成份为：
粗脂肪 粗蛋白 皂甙 水 其它
5.4 61 3.3 7.5 22.8
实施例2
将实例1所述脱脂粉76g加适量乙醇成软材，过筛制粒，加热干燥过筛整粒，装2号胶囊380粒。本胶囊即为治疗遗尿症的遗尿停胶囊。
实施例3
用实例1所述脱脂粉100g，加400g蔗糖粉混均，制粒，干燥，灭菌，装10g袋50个，即为一种遗尿停颗粒剂。
实施例4
采收1kg文冠果种子，按实例1所述步骤得170g脱脂粉，成份为：
粗脂肪 粗蛋白 皂甙 水 其它
6.2 59 3.5 8.2 23.1
实施例5
用实例4所得脱脂粉，按乙醇∶脱脂粉＝2∶1浸提3～4次，每次16到32小时，收集浸提液，除去溶剂，灭菌消毒得乙醇提取物25.5g，成分为：
粗脂肪 粗蛋白 皂甙 醣 水 其他
8.0 15.6 19.2 23.5 14.1 19.6
实施例6
采收与实施例4质量相同的文冠果种子1kg，清选干燥，压榨除油，得750g饼，用2倍的甲醇浸提3～4次，每次20～40小时，收集浸提液除去溶剂，灭菌得甲醇提取物80g，成份：
粗脂肪 粗蛋白 皂甙 醣 水 其他
6.1 17.1 12.3 20.5 12.6 31.4
实施例7
将实例5所得乙醇提取物清膏10g，加0.2g干淀粉、0.06g50%乙醇和0.1g滑石粉，混匀，压片，灭菌消毒，得200mg片60个片剂。可以治疗遗尿症、智力低下和痴呆症。
实施例8
将实例6所得甲醇提取物清膏10g加32g蔗糖粉，混匀制粒干燥，灭菌，装10g袋4个，可治疗遗尿症，智力低下及痴呆症。
Claims (7)
1、一种提高脑功能的药物，可以治疗遗尿症、智力低下和痴呆症，其特征在于所述药物为文冠果子的提取物。
2、按权利要求1所述提高脑功能药物，其特征是：所述药物为文冠果种仁的脱脂粉，含有粗脂肪，由17种氨基酸（如谷氨酸、赖氨酸、精氨酸、酪氨酸等）组成的粗蛋白质、皂甙、水、醣、微量元素，
具体含量为：
粗脂肪 粗蛋白 皂甙 水 其他
1～10 55～65 2～4 7～10 余
3、一种生产权利要求2所述提高脑功能药物的方法，其特征是，生产依下述步骤：
-预榨种仁饼粉;
-萃取脱脂;
-干燥，粉碎，过筛，灭菌得脱脂粉。
4、按权利要求3所述生产提高脑功能药物的方法，其特征是，萃取脱脂采用下述方式：
-用弱极性有机溶剂如石油醚、苯、正已烷等于室温下或加热＜90°情况下，萃取;
-收集萃取液，除去溶剂得脱脂粗粉。
5、按权利要求3所述生产提高脑功能药物的方法，其特征是，萃取脱脂采用超临界CO2萃取。
6、按权利要求2所述提高脑功能药物，其特征在于可将脱脂粉制成胶囊用于治疗遗尿症。
7、按权利要求2所述提高脑功能药物，其特征在于可将脱脂粉制成颗粒剂，用于治疗遗尿症。
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93111011 CN1092992A (zh) | 1993-03-29 | 1993-03-29 | 提高脑功能的药物及其制备方法 |
Applications Claiming Priority (1)
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|---|---|---|---|
| CN 93111011 CN1092992A (zh) | 1993-03-29 | 1993-03-29 | 提高脑功能的药物及其制备方法 |
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| Publication Number | Publication Date |
|---|---|
| CN1092992A true CN1092992A (zh) | 1994-10-05 |
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ID=4988821
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| CN (1) | CN1092992A (zh) |
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| GB2335599A (en) * | 1998-03-26 | 1999-09-29 | Phytopharm Plc | Treatment of conditions characterised by a deficiency in the number and function of membrane bound receptors using saponins and sapogenins |
| CN1055217C (zh) * | 1995-07-28 | 2000-08-09 | 黄斌 | 一种治疗小儿痴呆症、发育不良及智能低下的中药及其制备方法 |
| US6391310B1 (en) * | 1996-03-13 | 2002-05-21 | Archer Daniels Midland Company | Method of preparing and using isoflavones for the treatment of neurological symptoms |
| WO2003017919A2 (en) | 2001-08-31 | 2003-03-06 | Fountain Silver Limited | Composition comprising wenguanguo extracts, methods for preparing same and uses therof |
| US7138427B2 (en) | 1999-03-26 | 2006-11-21 | Phytopharm Plc. | 5-β-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia |
| WO2007079695A1 (fr) * | 2006-01-12 | 2007-07-19 | Liu Shujun | Extrait de xanthoceras sorbifolia bunge et extraction et utilisation |
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| US7727561B2 (en) | 2001-08-31 | 2010-06-01 | Pacific Arrow Limited | Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof |
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| CN102151305A (zh) * | 2010-02-10 | 2011-08-17 | 哈尔滨三乐生物工程有限公司 | 文冠果提取物、其提取方法及其用途 |
| WO2012094785A1 (zh) * | 2011-01-14 | 2012-07-19 | 哈尔滨三乐生物工程有限公司 | 一种文冠果油、其提取方法及检测方法 |
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- 1993-03-29 CN CN 93111011 patent/CN1092992A/zh active Pending
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| US6391310B1 (en) * | 1996-03-13 | 2002-05-21 | Archer Daniels Midland Company | Method of preparing and using isoflavones for the treatment of neurological symptoms |
| US7507720B2 (en) | 1998-03-26 | 2009-03-24 | Phytopharm Plc | 5-Beta-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia |
| GB2335599B (en) * | 1998-03-26 | 2001-08-01 | Phytopharm Plc | Membrane-bound receptors and their function; cognitive disfunction; treatments therefor; and compositions for use in such treatments |
| GB2335599A (en) * | 1998-03-26 | 1999-09-29 | Phytopharm Plc | Treatment of conditions characterised by a deficiency in the number and function of membrane bound receptors using saponins and sapogenins |
| US7138427B2 (en) | 1999-03-26 | 2006-11-21 | Phytopharm Plc. | 5-β-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia |
| WO2003017919A2 (en) | 2001-08-31 | 2003-03-06 | Fountain Silver Limited | Composition comprising wenguanguo extracts, methods for preparing same and uses therof |
| US6616943B2 (en) * | 2001-08-31 | 2003-09-09 | Fountain Silver Limited | Composition comprising Wenguanguo extracts and methods for preparing same |
| WO2003017919A3 (en) * | 2001-08-31 | 2004-07-22 | Fountain Silver Ltd | Composition comprising wenguanguo extracts, methods for preparing same and uses therof |
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