CN109172481A - Women stern treats hip pad essence dew - Google Patents
Women stern treats hip pad essence dew Download PDFInfo
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- CN109172481A CN109172481A CN201811242083.XA CN201811242083A CN109172481A CN 109172481 A CN109172481 A CN 109172481A CN 201811242083 A CN201811242083 A CN 201811242083A CN 109172481 A CN109172481 A CN 109172481A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
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Abstract
The invention discloses women sterns to treat hip pad essence dew, including following components: water, extract from maize plumule, ferulic acid, glycerol, honey, ostrich oil, carbomer, Hijiki polysaccharide, glucosides.Women stern of the present invention, which treats hip pad essence dew, has good stability, and moisturizing of releiving improves the elasticity and smoothness of skin, maintains skin health, defends the various stimulations being subject to from the external world, achievees the purpose that moist beauty treatment skin.Furthermore it is also possible to which anti-oxidant, adjusting immune function, promotes collagen to generate, improves skin repair environment, have significant facilitation to the epicuticle cell of buttocks.
Description
Technical field
The present invention relates to skin care implement technical fields, treat hip pad essence dew more particularly to women stern.
Background technique
With advancing age, the aging speed of skin is getting faster, and skin will be in now at 25 years old by general women
Sliding trend, skin starts to become loose and pigmentation, basic moisturiser are unable to satisfy the demand of skin, can only pass through supplement
Essence improves skin.And existing Essence is to reach good effect, using a variety of anti-aging substances, although can be one
It fixes time the interior promotion colour of skin, but is used for a long time and can bring damage to skin even body.
The beautiful flesh essence dew of the disclosure of the invention of application number 201610858160.9, by below according to the raw material group of parts by weight
At: 65-80 parts of deionized water, 0.01-0.1 parts of EDETATE SODIUM, 941 0.2-0.8 parts of card wave, 1-10 parts of glycerol, propylene glycol 1-10
Part, 0.05-0.3 parts of Sodium Hyaluronate, 0.2-0.8 parts of triethanolamine, 3-8 parts of licorice extract, soluble pearl powder 0.5-2
Part, 0.5-2 parts of motherwort extracting solution, 0.5-2 parts of asarum extracting solution, 1.0-5.0 parts of root of Dahurain angelica extracting solution, bletilla striata extract 0.8-4
Part, 0.1-0.8 parts of anti-anaphylaxis agent, 0.1-0.8 parts of preservative.With nourishing skin of face, comprehensive conditioning skin nutrition and moisture, beauty
The effect of pale skin, especially to facial colour spot, it is dark and gloomy, withered and yellow, loose, dry, there is peculiar improvement to imitate without symptoms such as expressions
Fruit.
The invention of application number 201510900305.2 is described more particularly to a kind of cutin maintenance essence dew and preparation method thereof
Essence dew includes Artemisia capillaris flower extract, satsuma orange pericarp extract, fragrant citrus berry extract, cloves flower extract, Mei Guoti
Take object.Its moisturizing ingredient is obtained by screening, and above-mentioned moisturizing ingredient is added in cosmetic base, is had to skin fine
Moisture-keeping efficacy；In addition, arginine is added in essence dew, guarantee the stability of essence dew.
A kind of maintenance spy of the disclosure of the invention of application number 201510490348.8 moistens essence dew, including by following raw materials by weight
Amount portion rate is prepared: 30~50 parts of deionized water, 3~6 parts of butanediol, 2~5 parts of lactobacillus fermentation, saualane 2~6
Part, 2~4 parts of camomile extract, 1~2 part of caffeine, 0.2~0.8 part of hydrolecithin, 0.2~0.6 part of hyaluronic acid, benzene
0.1~0.5 part of oxyethanol.Maintenance spy is moistened essence dew by preferred a variety of skin care substances and is matched, and essence is not added, and leads to
Nutrition needed for crossing moisturizer and extract guarantee skin；In addition caffeine plays the role of accelerating skin blood circulation；Saualane
Play the role of good moisturizing；Hydrolecithin does emulsifier and emollient, non-stimulated；Phenoxyethanol is as mild anti-corrosion
Agent, it is small to skin irritatin.
The invention of application number 201711013365.8 is specifically related to a kind of essence that moisturizing is releived dew and preparation method thereof, by
Following raw materials are prepared: purslane extract, dried tremella extract and glycine betaine, the purslane containing high-content in the cosmetics
Extract, to guarantee that there is cosmetics moisturizing to releive effect.
Summary of the invention
The first object of the present invention is to provide a kind of women stern treatment hip pad essence dew.
The present invention discloses a kind of women stern treatment hip pad essence dew, including following components: water, extract from maize plumule, asafoetide
Acid, glycerol, honey, ostrich oil, carbomer, Hijiki polysaccharide, glucosides.
As one of technical solution of the present invention, the women stern treats hip pad essence dew, the raw material including following weight parts:
50~80 parts by weight of water, 2~4 parts by weight of extract from maize plumule, 0.01~0.05 parts by weight of ferulic acid, 1~10 weight of glycerol
Part, 0.5~2.5 parts by weight of honey, 1~3 parts by weight of ostrich oil, 0.2~0.6 parts by weight of carbomer, Hijiki polysaccharide 0.2~
0.8 parts by weight, 2~3 parts by weight of glucosides, 0.003~0.006 parts by weight of hyaluronic acid.
As the two of technical solution of the present invention, the women stern treats hip pad essence dew, the raw material including following weight parts:
50~80 parts by weight of water, 2~4 parts by weight of extract from maize plumule, 0.01~0.05 parts by weight of ferulic acid, 1~10 weight of glycerol
Part, 0.5~2.5 parts by weight of honey, 1~3 parts by weight of ostrich oil, 0.2~0.6 parts by weight of carbomer, Hijiki polysaccharide 0.2~
0.8 parts by weight, 2~3 parts by weight of glucosides, 0.003~0.006 parts by weight of agarose graft modification hyaluronic acid.
As the three of technical solution of the present invention, the women stern treats hip pad essence dew, by the raw material system of following parts by weight
It is standby to form: 50~80 parts by weight of water, 2~7 parts by weight of astaxanthin nano-complex, 2~4 parts by weight of extract from maize plumule, Ah
0.01~0.05 parts by weight of Wei's acid, 1~10 parts by weight of glycerol, 0.5~2.5 parts by weight of honey, 1~3 parts by weight of ostrich oil, card wave
0.2~0.6 parts by weight of nurse, 0.2~0.8 parts by weight of Hijiki polysaccharide, 2~3 parts by weight of glucosides, agarose graft modification hyalomitome
Sour 0.003~0.006 parts by weight.
Hyaluronic acid is the important bracket ingredient in skin connective tissue, has the ability in conjunction with water and good biofacies
Capacitive.But hyaluronic acid is easy degradation, by the present invention in that the hyaluronic acid modified with agarose, reduces the degradation of hyaluronic acid
Speed promotes the generation of fibroblastic proliferation and collagen, promotes the seamless reparation of skin and wound reparation.Therefore, originally
Invent the women stern and treat hip pad essence dew and can go deep into skin epidermis even intradermal and work, the water absorbing capacity of Stratum Corneum and
Barrier function plays the role of maintenance and reinforcement, maintains the water content of cuticula, to prevent from having dry skin.
The agarose graft modification hyaluronic acid obtains by the following method: 5~15g agarose is dissolved into 500~
In the water that 50~60 DEG C of 1500g temperature, after mixing well, 30~40 DEG C are naturally cooling to, is placed 1~3 hour；Addition 2.5~
6g sodium hydroxide and 12~40g epoxychloropropane stir 2~5 hours at 30~40 DEG C；It is dried under reduced pressure 30~60 minutes, removes
Extra epoxychloropropane obtains concentrate；1~2 times of the volume of the concentrated liquid of water is added into concentrate to be centrifuged 10~25 minutes,
Collect supernatant liquor；5~15g hyaluronic acid is added into supernatant liquor, is stirred to react at 30~40 DEG C 48~60 hours, is collected
Reaction solution；It is small with the bag filter dialysis 48~72 for the molecular weight 8000~12000 that shuts off after reaction solution is dried under reduced pressure 2~4 hours
When, it obtains and retains liquid；Liquid vacuum freeze drying will be retained, obtain the agarose graft modification hyaluronic acid.
Further, the astaxanthin nano-complex be chitosan/lecithin/astaxanthin nano-complex, by with
Lower section method is prepared: 500~1000mg astaxanthin is dissolved in the lecithin ethyl alcohol of 200~400mL concentration, 20~30mg/mL
In solution, as A liquid；250~500mg chitosan is dissolved into the hydrochloric acid solution of 25~50mL concentration, 0.2~0.3mol/L,
As B liquid；B liquid is injected into A liquid, the Tween-80 aqueous solution conduct of 2000~4000mL mass fraction 1.5~2% is then added
Emulsifier, after being sufficiently stirred, ultrasound is after 15~30 minutes, as C liquid；By C liquid in 2~4 DEG C stand 4~6 hours after, using cut
It stays the bag filter of 8000~14000Da of molecular weight to dialyse 3~6 hours, goes bail for and stay liquid；Liquid vacuum freeze drying will be retained, obtained
Chitosan/lecithin/astaxanthin the nano-complex.
Chitosan belongs to linear macromolecule, can be fully absorbed by organism, and lecithin then has good skin phase
Capacitive, astaxanthin and the progress of chitosan and lecithin is compound, the stability of astaxanthin can not only be improved, people is more advantageous to
Body is absorbed and is utilized.The hydrophobic grouping of lecithin is introduced into chitosan hydrophilic chain by the present invention under the action of ultrasonic wave added,
Being formed by the driving forces self aggregation such as hydrophobic, electrostatic interaction has the shell of the core-shell structure of hydrophily shell and hydrophobic cores poly-
Sugar/lecithin/astaxanthin nano-complex.
Further, the astaxanthin nano-complex is chitosan/astaxanthin/DNA nano-complex, by with lower section
Method is prepared: 500~1000mg chitosan being dissolved into 40~80mL deionized water, stirs 2~3 hours, obtains shell
Glycan hydration solution；40~80mL pH hydrochloric acid solution for being 2 is added in chitosan hydration solution, after stirring 2~3 hours,
PH to 7 is adjusted using the sodium hydrate aqueous solution that pH is 13；Be eventually adding deionized water, obtain chitosan concentration 0.02~
The chitosan mother liquor of 0.04mg/mL, as A liquid；100~200mg astaxanthin is dissolved into 150~300mL dehydrated alcohol,
It stirs 24~36 hours, is centrifuged 5~10 minutes in light protected environment, take supernatant liquor, astaxanthin ethanol solution is obtained, as B liquid；
Salmon sperm dna is dissolved into deionized water, preparation obtains the salmon sperm dna solution of 0.02~0.32mg/mL of concentration, as C
Liquid；A liquid and B liquid are uniformly mixed under the conditions of being protected from light, and C liquid is added, the volume ratio of A liquid, B liquid and C liquid is 2:(0.5~3):
1, it mixes well, vacuum freeze drying, obtains the chitosan/astaxanthin/DNA nano-complex.
The concentration of the salmon sperm dna solution is preferably 0.02~0.04mg/mL.
The present invention, by being self-assembly of nanoparticle, is deposited by chitosan and DNA macromolecular in the space structure of nanoparticle
In hydrophobic microcell, hydrophobic microcell and fat-soluble and astaxanthin are combined, and are wrapped up astaxanthin, are further increased astaxanthin
Water-soluble and stability, so that its activity and biological utilisation degree improve.Wherein, when salmon sperm dna solution 0.02mg/mL, shell
It is combined the most closely between glycan/astaxanthin/each molecule of DNA nano-complex, inoxidizability and stability are most strong.
The deacetylated degree of the chitosan is 90~95%.
The glucosides is polyethylene glycol starch glucosides and/or polyethylene glycol glucoside.Preferably, the glucosides is poly- second
The mixture that glycol starch glucosides and polyethylene glycol glucoside are formed with mass ratio 1:1.
The honey is acacia honey, honey of various flowers, winter honey, clover honey, honey of lychee flowers, eucalyptus honey, sophorae honey, osmanthus honey, Huang
Even one of honey, Chinese gall honey, Radix Salviae Miltiorrhizae honey, Radix Astragali honey, Chinese gall honey, motherwort honey, fructus lycii honey or a variety of.
Women stern of the present invention, which treats hip pad essence dew, has good stability, and moisturizing of releiving improves the elasticity of skin
And smoothness, skin health is maintained, the various stimulations being subject to from the external world is defendd, achievees the purpose that moist beauty treatment skin.In addition, also
Can it is anti-oxidant, adjust immune function, promote collagen generate, improve skin repair environment, to the epicuticle cell of buttocks
There is significant facilitation.
Specific embodiment
Raw material is described below in embodiment:
Extract from maize plumule, Shaanxi Pa Nier Biotechnology Co., Ltd provide, and 20g Western corn is mentioned with dehydrated alcohol
Obtain 1g extract from maize plumule.
Ferulic acid, No. CAS: 1135-24-6, cosmetics-stage, Shanghai Shi Feng Biotechnology Co., Ltd provides.
Glycerol, Guangdong Sui Xin Chemical Co., Ltd. provide, cosmetics-stage.
Acacia honey, Hubei Xin Yang apiculture Co., Ltd provide.
Ostrich oil, Ji'an City Qingyuan District magnificent natural perfume material oil refinery provide.
Carbomer, specifically used Acritamer 940, Hangzhou Ka Boka Import and Export Co., Ltd. provide, cosmetics-stage.
Hijiki polysaccharide, Xi'an Sen Ran bioengineering Co., Ltd provide.
Polyethylene glycol starch glucosides, with reference to " synthesis of polyethylene glycol starch glucosides and its moisture retention " (fine chemistry industry, Wang Qing
Rather, the 05th phase in 2012) preparation, reaction condition is as follows: 118 DEG C of reaction temperature, the reaction time 4.5 hours, starch, to toluene sulphur
The mass ratio of acid, ethylene glycol and polyethylene glycol-800 is 1:0.025:4:2.
Hyaluronic acid, Guangzhou Hua Yu Chemical Co., Ltd. provide, molecular weight 5000.
Astaxanthin, Shandong Ju Rong bioengineering Co., Ltd provide.
Lecithin, Yu Lu international trade (Shanghai) Co., Ltd. provide, food-grade.
Dehydrated alcohol, food-grade, Zhengzhou E-BANG Industrial Co., Ltd. provide.
Tween-80, No. CAS: 9005-65-6, food-grade.
Chitosan, the Shandong biotech inc land-sea Lan Sheng provide, deacetylated degree 90%.
The hydrochloric acid solution that pH is 2, is settled to 1000mL with deionized water for the hydrochloric acid of 0.96mL mass fraction 38% and obtains
The hydrochloric acid solution that pH is 2.
The sodium hydrate aqueous solution that pH is 13, the hydrochloric acid of specifically used molar concentration 0.125mol/L.
Salmon sperm dna is bought from Sigma company.
Polyethylene glycol glucoside is with reference to " the glucosidic synthesis of polyethylene glycol and moisturizing Journal of Sex Research " (household chemicals work
Industry, Jin Xin, the 4th phase in 2000) it is prepared, reaction condition is as follows: 120 DEG C of reaction temperature, catalyst amount 0.1%, alcohol sugar
Compare 1:1.
Agarose, Zhengzhou Yu Zheng food additives Co., Ltd provide, food-grade.
Sodium hydroxide, No. CAS: 1310-73-2.
Epoxychloropropane, No. CAS: 106-89-8.
In the case where embodiment does not illustrate, the concrete technology condition of vacuum freeze drying are as follows: pre-freezing temperature -80
DEG C, pre-freeze time 2 h, -60 DEG C of cryogenic temperature, cooling time 48 hours, absolute pressure 100Pa.
Embodiment 1
Women stern treats hip pad essence dew, is prepared by the raw material of following parts by weight: 70 parts by weight of deionized water, corn children
4 parts by weight of bud extract, 0.02 parts by weight of ferulic acid, 10 parts by weight of glycerol, 2 parts by weight of acacia honey, 3 parts by weight of ostrich oil, card
0.5 parts by weight of wave nurse, 0.2 parts by weight of Hijiki polysaccharide, 3 parts by weight of polyethylene glycol starch glucosides, 0.004 weight of hyaluronic acid
Part.
Women stern treat hip pad essence dew the preparation method comprises the following steps: removing ionized water, glycerol, carbomer, polyethylene glycol starch sugar
Glycosides is added water-bath, is heated to 80 DEG C, is stirred 30 minutes with 800 revs/min；Stop stirring, is cooled to 40 DEG C, sequentially adds
Extract from maize plumule, ferulic acid, acacia honey, ostrich oil, Hijiki polysaccharide, hyaluronic acid continue to stir with 300 revs/min
20 minutes；Finally, being cooled to 30 DEG C, obtains the women stern and treat hip pad essence dew.
Embodiment 2
Women stern treats hip pad essence dew, is prepared by the raw material of following parts by weight: 70 parts by weight of deionized water, corn children
4 parts by weight of bud extract, 0.02 parts by weight of ferulic acid, 10 parts by weight of glycerol, 2 parts by weight of acacia honey, 3 parts by weight of ostrich oil, card
0.5 parts by weight of wave nurse, 0.2 parts by weight of Hijiki polysaccharide, 3 parts by weight of polyethylene glycol starch glucosides, agarose graft modification are transparent
Matter 0.004 parts by weight of acid.
Women stern treat hip pad essence dew the preparation method comprises the following steps: removing ionized water, glycerol, carbomer, polyethylene glycol starch sugar
Glycosides is added water-bath, is heated to 80 DEG C, is stirred 30 minutes with 800 revs/min；Stop stirring, is cooled to 40 DEG C, sequentially adds
Extract from maize plumule, ferulic acid, acacia honey, ostrich oil, Hijiki polysaccharide, agarose graft modification hyaluronic acid, continue with
300 revs/min are stirred 20 minutes；Finally, being cooled to 30 DEG C, obtains the women stern and treat hip pad essence dew.
The agarose graft modification hyaluronic acid obtains by the following method: 5g agarose is dissolved into 500g temperature 60
DEG C water in, after mixing well, be naturally cooling to 30 DEG C, place 1 hour；2.5g sodium hydroxide and 12g epoxychloropropane is added,
It is stirred 3 hours at 30 DEG C with 80 revs/min；It is dried under reduced pressure 30 minutes, removes under conditions of 55 DEG C, absolute pressure 0.04MPa
Extra epoxychloropropane obtains concentrate；The isometric deionized water of concentrate is added into concentrate, at 4000 revs/min
Zhongli's heart 10 minutes, collect supernatant liquor；5g hyaluronic acid is added into supernatant liquor, it is anti-with 80 revs/min of stirrings at 30 DEG C
It answers 48 hours, collects reaction solution；After reaction solution is dried under reduced pressure 4 hours under conditions of 60 DEG C, absolute pressure 0.04MPa, use
Shut off molecular weight 12000 bag filter dialyse 72 hours, obtain retain liquid；Liquid vacuum freeze drying will be retained, obtain the fine jade
Lipolysaccharide graft modification hyaluronic acid.
Embodiment 3
Women stern treats hip pad essence dew, is prepared by the raw material of following parts by weight: 70 parts by weight of deionized water, astaxanthin
5 parts by weight of nano-complex, 4 parts by weight of extract from maize plumule, 0.02 parts by weight of ferulic acid, 10 parts by weight of glycerol, acacia honey 2
Parts by weight, 3 parts by weight of ostrich oil, 0.5 parts by weight of carbomer, 0.2 parts by weight of Hijiki polysaccharide, 3 weight of polyethylene glycol starch glucosides
Measure part, 0.004 parts by weight of agarose graft modification hyaluronic acid.
Women stern treat hip pad essence dew the preparation method comprises the following steps: removing ionized water, glycerol, carbomer, polyethylene glycol starch sugar
Glycosides is added water-bath, is heated to 80 DEG C, is stirred 30 minutes with 800 revs/min；Stop stirring, is cooled to 40 DEG C, sequentially adds
Astaxanthin nano-complex, extract from maize plumule, ferulic acid, acacia honey, ostrich oil, Hijiki polysaccharide, agarose grafting change
Property hyaluronic acid, continue with 300 revs/min stir 20 minutes；Finally, being cooled to 30 DEG C, obtains the women stern and treat hip pad essence
Hua Lu.
The agarose graft modification hyaluronic acid obtains by the following method: 5g agarose is dissolved into 500g temperature 60
DEG C water in, after mixing well, be naturally cooling to 30 DEG C, place 1 hour；2.5g sodium hydroxide and 12g epoxychloropropane is added,
It is stirred 3 hours at 30 DEG C with 80 revs/min；It is dried under reduced pressure 30 minutes, removes under conditions of 55 DEG C, absolute pressure 0.04MPa
Extra epoxychloropropane obtains concentrate；The isometric deionized water of concentrate is added into concentrate, at 4000 revs/min
Zhongli's heart 10 minutes, collect supernatant liquor；5g hyaluronic acid is added into supernatant liquor, it is anti-with 80 revs/min of stirrings at 30 DEG C
It answers 48 hours, collects reaction solution；After reaction solution is dried under reduced pressure 4 hours under conditions of 60 DEG C, absolute pressure 0.04MPa, use
Shut off molecular weight 12000 bag filter dialyse 72 hours, obtain retain liquid；Liquid vacuum freeze drying will be retained, obtain the fine jade
Lipolysaccharide graft modification hyaluronic acid.
The astaxanthin nano-complex is chitosan/lecithin/astaxanthin nano-complex, is prepared by the following method
It obtains: 500mg astaxanthin being dissolved in the lecithin ethanol solution of 200mL concentration 25mg/mL, as A liquid；By 250mg shell
Glycan is dissolved into the hydrochloric acid solution of 25mL concentration 0.27mol/L, as B liquid；Utilize the asepsis injector of needle diameter 0.7mm
B liquid is injected into A liquid, then the Tween-80 aqueous solution of addition 2000mL mass fraction 1.8% is as emulsifier, after being sufficiently stirred,
Ultrasound is after 16 minutes under conditions of ultrasonic power 300W, as C liquid；By C liquid in 4 DEG C stand 6 when after, utilize molecular cut off
The bag filter of 12000Da is dialysed 4 hours, is gone bail for and is stayed liquid；Will retain liquid vacuum freeze drying, obtain the chitosan/lecithin/
Astaxanthin nano-complex.
Embodiment 4
Women stern treats hip pad essence dew, is prepared by the raw material of following parts by weight: 70 parts by weight of deionized water, astaxanthin
5 parts by weight of nano-complex, 4 parts by weight of extract from maize plumule, 0.02 parts by weight of ferulic acid, 10 parts by weight of glycerol, acacia honey 2
Parts by weight, 3 parts by weight of ostrich oil, 0.5 parts by weight of carbomer, 0.2 parts by weight of Hijiki polysaccharide, 3 weight of polyethylene glycol starch glucosides
Measure part, 0.004 parts by weight of agarose graft modification hyaluronic acid.
Women stern treat hip pad essence dew the preparation method comprises the following steps: removing ionized water, glycerol, carbomer, polyethylene glycol starch sugar
Glycosides is added water-bath, is heated to 80 DEG C, is stirred 30 minutes with 800 revs/min；Stop stirring, is cooled to 40 DEG C, sequentially adds
Astaxanthin nano-complex, extract from maize plumule, ferulic acid, acacia honey, ostrich oil, Hijiki polysaccharide, agarose grafting change
Property hyaluronic acid, continue with 300 revs/min stir 20 minutes；Finally, being cooled to 30 DEG C, obtains the women stern and treat hip pad essence
Hua Lu.
The agarose graft modification hyaluronic acid obtains by the following method: 5g agarose is dissolved into 500g temperature 60
DEG C water in, after mixing well, be naturally cooling to 30 DEG C, place 1 hour；2.5g sodium hydroxide and 12g epoxychloropropane is added,
It is stirred 3 hours at 30 DEG C with 80 revs/min；It is dried under reduced pressure 30 minutes, removes under conditions of 55 DEG C, absolute pressure 0.04MPa
Extra epoxychloropropane obtains concentrate；The isometric deionized water of concentrate is added into concentrate, at 4000 revs/min
Zhongli's heart 10 minutes, collect supernatant liquor；5g hyaluronic acid is added into supernatant liquor, it is anti-with 80 revs/min of stirrings at 30 DEG C
It answers 48 hours, collects reaction solution；After reaction solution is dried under reduced pressure 4 hours under conditions of 60 DEG C, absolute pressure 0.04MPa, use
Shut off molecular weight 12000 bag filter dialyse 72 hours, obtain retain liquid；Liquid vacuum freeze drying will be retained, obtain the fine jade
Lipolysaccharide graft modification hyaluronic acid.
The astaxanthin nano-complex is chitosan/astaxanthin/DNA nano-complex, is prepared by the following method
To: 500mg chitosan is dissolved into 40mL deionized water, is stirred 2 hours with 300 revs/min, it is molten to obtain chitosan hydration
Liquid；The 40mL pH hydrochloric acid solution for being 2 is added drop-wise in chitosan hydration solution with the speed of 50mL/h, is stirred with 500 revs/min
After mixing 2 hours, pH to 7 is adjusted using the sodium hydrate aqueous solution that pH is 13；It is eventually adding deionized water, obtains chitosan concentration
The chitosan mother liquor of 0.02mg/mL, as A liquid；100mg astaxanthin is dissolved into 180mL dehydrated alcohol, in light protected environment
Stirred 24 hours with 500 revs/min, with 12000 revs/min high speed centrifugation 5 minutes, take supernatant liquor, obtain astaxanthin ethyl alcohol
Solution, as B liquid；Salmon sperm dna is dissolved into deionized water, the salmon sperm dna that preparation obtains concentration 0.02mg/mL is molten
Liquid, as C liquid；A liquid and B liquid are uniformly mixed under the conditions of being protected from light, and C liquid, A liquid, B liquid are added dropwise with the speed of 50mL/h dropwise
Volume ratio with C liquid is 2:1:1, mixes well, vacuum freeze drying, it is nano combined to obtain the chitosan/astaxanthin/DNA
Object.
Embodiment 5
Women stern treats hip pad essence dew, is prepared by the raw material of following parts by weight: 70 parts by weight of deionized water, astaxanthin
5 parts by weight of nano-complex, 4 parts by weight of extract from maize plumule, 0.02 parts by weight of ferulic acid, 10 parts by weight of glycerol, acacia honey 2
Parts by weight, 3 parts by weight of ostrich oil, 0.5 parts by weight of carbomer, 0.2 parts by weight of Hijiki polysaccharide, 3 weight of polyethylene glycol starch glucosides
Measure part, 0.004 parts by weight of agarose graft modification hyaluronic acid.
Women stern treat hip pad essence dew the preparation method comprises the following steps: removing ionized water, glycerol, carbomer, polyethylene glycol starch sugar
Glycosides is added water-bath, is heated to 80 DEG C, is stirred 30 minutes with 800 revs/min；Stop stirring, is cooled to 40 DEG C, sequentially adds
Astaxanthin nano-complex, extract from maize plumule, ferulic acid, acacia honey, ostrich oil, Hijiki polysaccharide, agarose grafting change
Property hyaluronic acid, continue with 300 revs/min stir 20 minutes；Finally, being cooled to 30 DEG C, obtains the women stern and treat hip pad essence
Hua Lu.
The agarose graft modification hyaluronic acid obtains by the following method: 5g agarose is dissolved into 500g temperature 60
DEG C water in, after mixing well, be naturally cooling to 30 DEG C, place 1 hour；2.5g sodium hydroxide and 12g epoxychloropropane is added,
It is stirred 3 hours at 30 DEG C with 80 revs/min；It is dried under reduced pressure 30 minutes, removes under conditions of 55 DEG C, absolute pressure 0.04MPa
Extra epoxychloropropane obtains concentrate；The isometric deionized water of concentrate is added into concentrate, at 4000 revs/min
Zhongli's heart 10 minutes, collect supernatant liquor；5g hyaluronic acid is added into supernatant liquor, it is anti-with 80 revs/min of stirrings at 30 DEG C
It answers 48 hours, collects reaction solution；After reaction solution is dried under reduced pressure 4 hours under conditions of 60 DEG C, absolute pressure 0.04MPa, use
Shut off molecular weight 12000 bag filter dialyse 72 hours, obtain retain liquid；Liquid vacuum freeze drying will be retained, obtain the fine jade
Lipolysaccharide graft modification hyaluronic acid.
The astaxanthin nano-complex is chitosan/astaxanthin/DNA nano-complex, is prepared by the following method
To: 500mg chitosan is dissolved into 40mL deionized water, is stirred 2 hours with 300 revs/min, it is molten to obtain chitosan hydration
Liquid；The 40mL pH hydrochloric acid solution for being 2 is added drop-wise in chitosan hydration solution with the speed of 50mL/h, is stirred with 500 revs/min
After mixing 2 hours, pH to 7 is adjusted using the sodium hydrate aqueous solution that pH is 13；It is eventually adding deionized water, obtains chitosan concentration
The chitosan mother liquor of 0.02mg/mL, as A liquid；100mg astaxanthin is dissolved into 180mL dehydrated alcohol, in light protected environment
Stirred 24 hours with 500 revs/min, with 12000 revs/min high speed centrifugation 5 minutes, take supernatant liquor, obtain astaxanthin ethyl alcohol
Solution, as B liquid；Salmon sperm dna is dissolved into deionized water, the salmon sperm dna that preparation obtains concentration 0.08mg/mL is molten
Liquid, as C liquid；A liquid and B liquid are uniformly mixed under the conditions of being protected from light, and C liquid, A liquid, B liquid are added dropwise with the speed of 50mL/h dropwise
Volume ratio with C liquid is 2:1:1, mixes well, vacuum freeze drying, it is nano combined to obtain the chitosan/astaxanthin/DNA
Object.
Embodiment 6
Women stern treats hip pad essence dew, is prepared by the raw material of following parts by weight: 70 parts by weight of deionized water, astaxanthin
5 parts by weight of nano-complex, 4 parts by weight of extract from maize plumule, 0.02 parts by weight of ferulic acid, 10 parts by weight of glycerol, acacia honey 2
Parts by weight, 3 parts by weight of ostrich oil, 0.5 parts by weight of carbomer, 0.2 parts by weight of Hijiki polysaccharide, 3 weight of polyethylene glycol starch glucosides
Measure part, 0.004 parts by weight of agarose graft modification hyaluronic acid.
Women stern treat hip pad essence dew the preparation method comprises the following steps: removing ionized water, glycerol, carbomer, polyethylene glycol starch sugar
Glycosides is added water-bath, is heated to 80 DEG C, is stirred 30 minutes with 800 revs/min；Stop stirring, is cooled to 40 DEG C, sequentially adds
Astaxanthin nano-complex, extract from maize plumule, ferulic acid, acacia honey, ostrich oil, Hijiki polysaccharide, agarose grafting change
Property hyaluronic acid, continue with 300 revs/min stir 20 minutes；Finally, being cooled to 30 DEG C, obtains the women stern and treat hip pad essence
Hua Lu.
The agarose graft modification hyaluronic acid obtains by the following method: 5g agarose is dissolved into 500g temperature 60
DEG C water in, after mixing well, be naturally cooling to 30 DEG C, place 1 hour；2.5g sodium hydroxide and 12g epoxychloropropane is added,
It is stirred 3 hours at 30 DEG C with 80 revs/min；It is dried under reduced pressure 30 minutes, removes under conditions of 55 DEG C, absolute pressure 0.04MPa
Extra epoxychloropropane obtains concentrate；The isometric deionized water of concentrate is added into concentrate, at 4000 revs/min
Zhongli's heart 10 minutes, collect supernatant liquor；5g hyaluronic acid is added into supernatant liquor, it is anti-with 80 revs/min of stirrings at 30 DEG C
It answers 48 hours, collects reaction solution；After reaction solution is dried under reduced pressure 4 hours under conditions of 60 DEG C, absolute pressure 0.04MPa, use
Shut off molecular weight 12000 bag filter dialyse 72 hours, obtain retain liquid；Liquid vacuum freeze drying will be retained, obtain the fine jade
Lipolysaccharide graft modification hyaluronic acid.
The astaxanthin nano-complex is chitosan/astaxanthin/DNA nano-complex, is prepared by the following method
To: 500mg chitosan is dissolved into 40mL deionized water, is stirred 2 hours with 300 revs/min, it is molten to obtain chitosan hydration
Liquid；The 40mL pH hydrochloric acid solution for being 2 is added drop-wise in chitosan hydration solution with the speed of 50mL/h, is stirred with 500 revs/min
After mixing 2 hours, pH to 7 is adjusted using the sodium hydrate aqueous solution that pH is 13；It is eventually adding deionized water, obtains chitosan concentration
The chitosan mother liquor of 0.02mg/mL, as A liquid；100mg astaxanthin is dissolved into 180mL dehydrated alcohol, in light protected environment
Stirred 24 hours with 500 revs/min, with 12000 revs/min high speed centrifugation 5 minutes, take supernatant liquor, obtain astaxanthin ethyl alcohol
Solution, as B liquid；Salmon sperm dna is dissolved into deionized water, the salmon sperm dna that preparation obtains concentration 0.16mg/mL is molten
Liquid, as C liquid；A liquid and B liquid are uniformly mixed under the conditions of being protected from light, and C liquid, A liquid, B liquid are added dropwise with the speed of 50mL/h dropwise
Volume ratio with C liquid is 2:1:1, mixes well, vacuum freeze drying, it is nano combined to obtain the chitosan/astaxanthin/DNA
Object.
Embodiment 7
Women stern treats hip pad essence dew, is prepared by the raw material of following parts by weight: 70 parts by weight of deionized water, astaxanthin
5 parts by weight of nano-complex, 4 parts by weight of extract from maize plumule, 0.02 parts by weight of ferulic acid, 10 parts by weight of glycerol, acacia honey 2
Parts by weight, 3 parts by weight of ostrich oil, 0.5 parts by weight of carbomer, 0.2 parts by weight of Hijiki polysaccharide, 3 weight of polyethylene glycol glucoside
Measure part, 0.004 parts by weight of agarose graft modification hyaluronic acid.
Women stern treat hip pad essence dew the preparation method comprises the following steps: removing ionized water, glycerol, carbomer, polyethylene glycol glucose
Glycosides is added water-bath, is heated to 80 DEG C, is stirred 30 minutes with 800 revs/min；Stop stirring, is cooled to 40 DEG C, sequentially adds
Astaxanthin nano-complex, extract from maize plumule, ferulic acid, acacia honey, ostrich oil, Hijiki polysaccharide, agarose grafting change
Property hyaluronic acid, continue with 300 revs/min stir 20 minutes；Finally, being cooled to 30 DEG C, obtains the women stern and treat hip pad essence
Hua Lu.
The agarose graft modification hyaluronic acid obtains by the following method: 5g agarose is dissolved into 500g temperature 60
DEG C water in, after mixing well, be naturally cooling to 30 DEG C, place 1 hour；2.5g sodium hydroxide and 12g epoxychloropropane is added,
It is stirred 3 hours at 30 DEG C with 80 revs/min；It is dried under reduced pressure 30 minutes, removes under conditions of 55 DEG C, absolute pressure 0.04MPa
Extra epoxychloropropane obtains concentrate；The isometric deionized water of concentrate is added into concentrate, at 4000 revs/min
Zhongli's heart 10 minutes, collect supernatant liquor；5g hyaluronic acid is added into supernatant liquor, it is anti-with 80 revs/min of stirrings at 30 DEG C
It answers 48 hours, collects reaction solution；After reaction solution is dried under reduced pressure 4 hours under conditions of 60 DEG C, absolute pressure 0.04MPa, use
Shut off molecular weight 12000 bag filter dialyse 72 hours, obtain retain liquid；Liquid vacuum freeze drying will be retained, obtain the fine jade
Lipolysaccharide graft modification hyaluronic acid.
The astaxanthin nano-complex is chitosan/astaxanthin/DNA nano-complex, is prepared by the following method
To: 500mg chitosan is dissolved into 40mL deionized water, is stirred 2 hours with 300 revs/min, it is molten to obtain chitosan hydration
Liquid；The 40mL pH hydrochloric acid solution for being 2 is added drop-wise in chitosan hydration solution with the speed of 50mL/h, is stirred with 500 revs/min
After mixing 2 hours, pH to 7 is adjusted using the sodium hydrate aqueous solution that pH is 13；It is eventually adding deionized water, obtains chitosan concentration
The chitosan mother liquor of 0.02mg/mL, as A liquid；100mg astaxanthin is dissolved into 180mL dehydrated alcohol, in light protected environment
Stirred 24 hours with 500 revs/min, with 12000 revs/min high speed centrifugation 5 minutes, take supernatant liquor, obtain astaxanthin ethyl alcohol
Solution, as B liquid；Salmon sperm dna is dissolved into deionized water, the salmon sperm dna that preparation obtains concentration 0.02mg/mL is molten
Liquid, as C liquid；A liquid and B liquid are uniformly mixed under the conditions of being protected from light, and C liquid, A liquid, B liquid are added dropwise with the speed of 50mL/h dropwise
Volume ratio with C liquid is 2:1:1, mixes well, vacuum freeze drying, it is nano combined to obtain the chitosan/astaxanthin/DNA
Object.
Embodiment 8
Women stern treats hip pad essence dew, is prepared by the raw material of following parts by weight: 70 parts by weight of deionized water, astaxanthin
5 parts by weight of nano-complex, 4 parts by weight of extract from maize plumule, 0.02 parts by weight of ferulic acid, 10 parts by weight of glycerol, acacia honey 2
Parts by weight, 3 parts by weight of ostrich oil, 0.5 parts by weight of carbomer, 0.2 parts by weight of Hijiki polysaccharide, polyethylene glycol starch glucosides 1.5
Parts by weight, 1.5 parts by weight of polyethylene glycol glucoside, 0.004 parts by weight of agarose graft modification hyaluronic acid.
Women stern treat hip pad essence dew the preparation method comprises the following steps: removing ionized water, glycerol, carbomer, polyethylene glycol starch sugar
Glycosides, polyethylene glycol glucoside are added water-bath, are heated to 80 DEG C, are stirred 30 minutes with 800 revs/min；Stop stirring, drop
Temperature sequentially adds astaxanthin nano-complex, extract from maize plumule, ferulic acid, acacia honey, ostrich oil, sargassum fusifome to 40 DEG C
Polysaccharide, agarose graft modification hyaluronic acid continue to stir 20 minutes with 300 revs/min；Finally, being cooled to 30 DEG C, institute is obtained
It states women stern and treats hip pad essence dew.
The agarose graft modification hyaluronic acid obtains by the following method: 5g agarose is dissolved into 500g temperature 60
DEG C water in, after mixing well, be naturally cooling to 30 DEG C, place 1 hour；2.5g sodium hydroxide and 12g epoxychloropropane is added,
It is stirred 3 hours at 30 DEG C with 80 revs/min；It is dried under reduced pressure 30 minutes, removes under conditions of 55 DEG C, absolute pressure 0.04MPa
Extra epoxychloropropane obtains concentrate；The isometric deionized water of concentrate is added into concentrate, at 4000 revs/min
Zhongli's heart 10 minutes, collect supernatant liquor；5g hyaluronic acid is added into supernatant liquor, it is anti-with 80 revs/min of stirrings at 30 DEG C
It answers 48 hours, collects reaction solution；After reaction solution is dried under reduced pressure 4 hours under conditions of 60 DEG C, absolute pressure 0.04MPa, use
Shut off molecular weight 12000 bag filter dialyse 72 hours, obtain retain liquid；Liquid vacuum freeze drying will be retained, obtain the fine jade
Lipolysaccharide graft modification hyaluronic acid.
The astaxanthin nano-complex is chitosan/astaxanthin/DNA nano-complex, is prepared by the following method
To: 500mg chitosan is dissolved into 40mL deionized water, is stirred 2 hours with 300 revs/min, it is molten to obtain chitosan hydration
Liquid；The 40mL pH hydrochloric acid solution for being 2 is added drop-wise in chitosan hydration solution with the speed of 50mL/h, is stirred with 500 revs/min
After mixing 2 hours, pH to 7 is adjusted using the sodium hydrate aqueous solution that pH is 13；It is eventually adding deionized water, obtains chitosan concentration
The chitosan mother liquor of 0.02mg/mL, as A liquid；100mg astaxanthin is dissolved into 180mL dehydrated alcohol, in light protected environment
Stirred 24 hours with 500 revs/min, with 12000 revs/min high speed centrifugation 5 minutes, take supernatant liquor, obtain astaxanthin ethyl alcohol
Solution, as B liquid；Salmon sperm dna is dissolved into deionized water, the salmon sperm dna that preparation obtains concentration 0.02mg/mL is molten
Liquid, as C liquid；A liquid and B liquid are uniformly mixed under the conditions of being protected from light, and C liquid, A liquid, B liquid are added dropwise with the speed of 50mL/h dropwise
Volume ratio with C liquid is 2:1:1, mixes well, vacuum freeze drying, it is nano combined to obtain the chitosan/astaxanthin/DNA
Object.
Effect example 1
The security performance for treating hip pad essence dew to Examples 1 to 8 women stern is evaluated.
Experimental animal: New Zealand White Rabbit, regular grade, 2.4~3.0kg of weight, half male and half female.
(1) acute skin irritation test method
New Zealand White Rabbit is taken, is divided to two groups, i.e. intact skin group and damaged skin group, half male and half female at random.It is small to test preceding 24
When, from left to right divide 2 pieces for New Zealand White Rabbit back backbone two sides, every piece of unhairing range 3cm × 6cm can not damage skin.It is broken
The # font scar that skin group draws 2cm × 2cm at depilation position with disinfection syringe needle is damaged, pays attention to only scratching epidermis, does not hurt corium, with
Slight oozing of blood is degree.Test is compareed using itself left and right sides.Hair-fields is gone to medicinal alcohol disinfection before coating, tested material 3mL is taken to apply
On the skin, left survey applies tested material, and right side applies same amount of normal saline as control.Every New Zealand White Rabbit single cage word is supported, the topical application of drug
Residual tested material is removed with warm water after 24 hours.Observation in 1 hour, 24 hours and 48 hours after removing tested material is smeared
The dermoreaction at position carries out dermoreaction integral according to document and stimulus intensity is evaluated.Concrete operations and evaluation reference
GB7919-87 safety evaluation of cosmetics program and method, and " toxicology basis " (gold Thailand granary, Fudan University in Shanghai publication
Society, 2003:248-260 are carried out).
The specific test result of acute skin irritation test is shown in Table 1.
1 acute skin irritation test result of table
According to GB7919-87 stimulus intensity grade scale: integrated value 0~0.4 is nonirritant, 0.5~1.9 subexcite,
2.0~5.9 medium irritations, 6.0~8.0 strong and stimulatings it is found that women stern of the present invention treat hip pad essence dew to skin without
Irritation.
(2) multiple Skin Irritation Test method
Take New Zealand White Rabbit, grouping and skin treatment with a dermal application test.Tested material 3mL is taken to be applied to a skin left side
Hair-fields is gone in side, is covered with one layer of oilpaper, then fixed with nonirritant adhesive plaster and bandage.Right side respectively goes to hair-fields to smear physiology
Salt water is smeared 2 times daily as control, is repeated 14 days.Cropping is answered before each coating, skin must not be damaged.Observation skin daily
Reaction carries out dermoreaction integral by document.Concrete operations and evaluation with reference to GB7919-87 safety evaluation of cosmetics program and
Method, and " toxicology basis " (gold Thailand granary, Fudan University in Shanghai publishing house, 2003:248-260 are carried out).
The multiple specific test result of Skin Irritation Test is shown in Table 2.
More than 2 Skin Irritation Test results of table
According to GB7919-87 stimulus intensity grade scale: integrated value 0~0.4 is nonirritant, 0.5~1.9 subexcite,
2.0~5.9 medium irritations, 6.0~8.0 strong and stimulatings.It is non-stimulated to skin that women stern of the present invention treats hip pad essence dew
Property.And by it has been observed that the new zealand rabbit of intact skin group is smeared after stern of the present invention treats hip pad essence dew, skin without
Red and swollen oedema phenomenon, weight diet are normal.
Effect example 2
The promotion skin healing performance for treating hip pad essence dew to Examples 1 to 8 women stern is evaluated.
Experimental animal: kunming mice, 6~8 weeks, spf grades, Beijing was tieed up experimental animal Co., Ltd of tonneau China and is provided.
It is at random respectively experimental group and blank control group by kunming mice.3% yellow Jackets (80mg/kg) is injected intraperitoneally
Physiological saline anesthesia.After skin of back iodine disinfection, clip back whole process skin and deep fascia reach muscle layer, form diameter 1.5cm
The round surface of a wound of size.After hemostasis, experimental group wound surface smearing 3mL women's stern is treated hip pad essence dew film and is fixed using bandage,
The physiological saline of blank control group smearing equivalent.
After 3 weeks, each group mouse is put to death with excess diethyl ether, counts wounds in mice skin histology Type I collagen albumen and III type glue
The secretory volume of former albumen.
The secretory volume of Type I collagen albumen and III collagen type is with reference to " Gelatin hydrolysate is to rat dermal fibroblast
The influence of proliferation and Type I collagen protein secretion " (side Jing is big perhaps, Chinese minimally invasive surgery magazine, 08 phase in 2007) progress.
Statistical data is with group I collagen type secretory volume and III collagen type secretory volume relative to I type of control group
The multiple of collagen secretion amount and III collagen type secretory volume indicates.
Specific test result is shown in Table 3.
3 I type of table and III collagen type secretory volume statistical form
Chitosan belongs to linear macromolecule, can be fully absorbed by organism, and lecithin then has good skin phase
Capacitive, astaxanthin and the progress of chitosan and lecithin is compound, the stability of astaxanthin can not only be improved, people is more advantageous to
Body is absorbed and is utilized.The hydrophobic grouping of lecithin is introduced into chitosan parent under the action of ultrasonic wave added by the embodiment of the present invention 3
In water chain, the driving forces self aggregation such as hydrophobic, electrostatic interaction of dependence forms the nucleocapsid knot with hydrophily shell and hydrophobic cores
Chitosan/lecithin/astaxanthin nano-complex of structure.
It is different from embodiment 3, embodiment 4~6, by being self-assembly of nanoparticle, is received by chitosan and DNA macromolecular
There are hydrophobic microcell, hydrophobic microcell and fat-soluble and astaxanthins to combine in the space structure of the grain of rice, wraps up astaxanthin,
The water solubility and stability of astaxanthin are further increased, so that its activity and biological utilisation degree improve.Wherein, embodiment 4~6
It is combined when middle salmon sperm dna solution 0.02mg/mL, between chitosan/astaxanthin/each molecule of DNA nano-complex the most closely,
Inoxidizability and stability are most strong.
Effect example 3
The shield bullet of hip pad essence dew is treated to Examples 1 to 8 women stern and performance of keeping humidity is evaluated.
(1) experimental method: selection health, skin is normal, without the tested crowd of cosmetic allergic contact dermatitis history, and the age 20-45 years old,
Middle men and women is fifty-fifty.One week is as a treatment course, totally four courses for the treatment of, is every time cleaned buttocks using preceding, and cleaning time is identical every time,
Corresponding product is used after skin dries, each group uses corresponding product 1 time daily, and 10g is taken uniformly to be applied to tested region.
Measurement: select buttocks as test zone, product to be used is tested after ten minutes.It is tested using skin elasticity
Instrument measures skin elasticity curve, and according to the amount of tension of skin and resilience data, the shield elasticity of hip pad essence dew is treated to women stern
It can be carried out assessment.
Experimental result: skin elasticity test is to be based on suction and stretch principle, generates one on the surface of tested skin and bears
Pressure, by skin inspiration one special test probe, skin is inhaled into depth and is surveyed by a non-contact optical detection system
, measurement result usually indicates that unit 1, numerical value is bigger with an index, illustrates that skin elasticity is stronger.
Specific test result is shown in Table 4.
Table 4 protects elastic energy test value table
| Group | 0 week | 1 week | 2 weeks | 3 weeks | 4 weeks |
| Embodiment 1 | 0.491 | 0.530 | 0.617 | 0.647 | 0.675 |
| Embodiment 2 | 0.489 | 0.533 | 0.625 | 0.651 | 0.684 |
| Embodiment 3 | 0.494 | 0.558 | 0.658 | 0.691 | 0.726 |
| Embodiment 4 | 0.490 | 0.540 | 0.630 | 0.669 | 0.691 |
| Embodiment 5 | 0.497 | 0.544 | 0.637 | 0.672 | 0.698 |
| Embodiment 6 | 0.496 | 0.565 | 0.671 | 0.695 | 0.737 |
| Embodiment 7 | 0.487 | 0.560 | 0.665 | 0.690 | 0.733 |
| Embodiment 8 | 0.501 | 0.572 | 0.685 | 0.721 | 0.755 |
Note: statistical analysis is carried out more afterwards, the results showed that P < 0.05, difference have statistical significance.
(2) experimental method: selection healthy skin, no tested crowd of cosmetic allergic contact dermatitis history, the age 20-45 years old, wherein men and women
It is fifty-fifty.25 DEG C ± 1 DEG C of room temperature；Humidity 50% ± 5%.Buttocks is cleaned when test, and everyone cleaning time is identical, dries to skin
It selects buttocks 4cm × 4cm skin as test zone afterwards, 0.8g is taken uniformly to be applied to buttocks.
It is tested within 10 minutes after buttocks (4cm × 4cm) test zone, product to be used.
(1) water content of skin of buttock is measured with digital skin moisture detector.It is small using after corresponding product 1
When, 2 hours, 4 hours, after 6 hours, survey face skin of buttock water content, measurement be averaged three times.
(2) water loss amount of skin of buttock is measured with percutaneous moisture loss measuring instrument.Use after corresponding product 1
Hour, 2 hours, 4 hours after 6 hours, survey skin of buttock water loss amount, and measurement is averaged three times.
Experimental result: water content of stratum corneum is measured by testing using the variation of keratoderma capacitance before and after product
Variation to come evaluate women stern treat hip pad essence dew moisture-keeping efficacy.The method quantifies skin keratin moisture content
Change, can delicately react the variation of skin moisture content, and favorable reproducibility, be that current moisturizing cosmetic efficacy assessments are common
One of method.
Specific test result is shown in Table 5.
5 performance of keeping humidity test value list position of table: %
| Group | 0 hour | 1 hour | 2 hours | 4 hours | 6 hours |
| Embodiment 1 | 30.52 | 62.41 | 60.22 | 57.46 | 56.39 |
| Embodiment 2 | 30.56 | 62.52 | 60.37 | 57.54 | 56.48 |
| Embodiment 3 | 30.49 | 62.79 | 60.52 | 57.85 | 56.87 |
| Embodiment 4 | 30.61 | 63.63 | 60.44 | 57.61 | 56.51 |
| Embodiment 5 | 30.47 | 62.65 | 60.49 | 57.74 | 56.69 |
| Embodiment 6 | 30.72 | 62.96 | 60.74 | 58.06 | 57.17 |
| Embodiment 7 | 30.64 | 62.93 | 60.63 | 57.99 | 56.98 |
| Embodiment 8 | 30.57 | 63.09 | 60.82 | 58.18 | 57.29 |
Note: statistical analysis is carried out more afterwards, the results showed that P < 0.05, difference have statistical significance.
Hyaluronic acid is the important bracket ingredient in skin connective tissue, has the ability in conjunction with water and good biofacies
Capacitive.But hyaluronic acid is easy degradation, from test case 2 and test case 3 it is found that by the present invention in that being modified with agarose saturating
Bright acid reduces the degradation speed of hyaluronic acid, promotes the generation of fibroblastic proliferation and collagen, promotes skin seamless
It repairs and wound reparation.Therefore, women stern treatment hip pad essence dew of the present invention can go deep into skin epidermis or even intradermal acts as
With the water absorbing capacity and barrier function of Stratum Corneum play the role of maintenance and reinforcement, the water content of cuticula are maintained, thus anti-
Only have dry skin.
Although this specification is described in terms of embodiments, but not each embodiment only includes an independent skill
Art scheme, this narrating mode of specification just for the sake of for the sake of clear, those skilled in the art should using specification as
One entirety, the technical solutions in the various embodiments may also be suitably combined, formed it will be appreciated by those skilled in the art that its
His embodiment.
Claims (10)
1. women stern treats hip pad essence dew, which is characterized in that including following components: water, extract from maize plumule, ferulic acid are sweet
Oil, honey, ostrich oil, carbomer, Hijiki polysaccharide, glucosides.
2. women stern according to claim 1 treats hip pad essence dew, which is characterized in that the raw material including following weight parts:
50~80 parts by weight of water, 2~4 parts by weight of extract from maize plumule, 0.01~0.05 parts by weight of ferulic acid, 1~10 weight of glycerol
Part, 0.5~2.5 parts by weight of honey, 1~3 parts by weight of ostrich oil, 0.2~0.6 parts by weight of carbomer, Hijiki polysaccharide 0.2~
0.8 parts by weight, 2~3 parts by weight of glucosides, 0.003~0.006 parts by weight of hyaluronic acid.
3. women stern according to claim 1 treats hip pad essence dew, which is characterized in that the raw material including following weight parts:
50~80 parts by weight of water, 2~4 parts by weight of extract from maize plumule, 0.01~0.05 parts by weight of ferulic acid, 1~10 weight of glycerol
Part, 0.5~2.5 parts by weight of honey, 1~3 parts by weight of ostrich oil, 0.2~0.6 parts by weight of carbomer, Hijiki polysaccharide 0.2~
0.8 parts by weight, 2~3 parts by weight of glucosides, 0.003~0.006 parts by weight of agarose graft modification hyaluronic acid.
4. women stern according to claim 3 treats hip pad essence dew, which is characterized in that prepared by the raw material of following parts by weight
It forms: 50~80 parts by weight of water, 2~7 parts by weight of astaxanthin nano-complex, 2~4 parts by weight of extract from maize plumule, asafoetide
Sour 0.01~0.05 parts by weight, 1~10 parts by weight of glycerol, 0.5~2.5 parts by weight of honey, 1~3 parts by weight of ostrich oil, carbomer
0.2~0.6 parts by weight, 0.2~0.8 parts by weight of Hijiki polysaccharide, 2~3 parts by weight of glucosides, agarose graft modification hyaluronic acid
0.003~0.006 parts by weight.
5. women stern according to claim 4 treats hip pad essence dew, which is characterized in that the astaxanthin nano-complex is
Chitosan/lecithin/astaxanthin nano-complex, is prepared by the following method to obtain: 500~1000mg astaxanthin is dissolved in
In the lecithin ethanol solution of 200~400mL concentration, 20~30mg/mL, as A liquid；250~500mg chitosan is dissolved into
In the hydrochloric acid solution of 25~50mL concentration, 0.2~0.3mol/L, as B liquid；By B liquid inject A liquid, then be added 2000~
The Tween-80 aqueous solution of 4000mL mass fraction 1.5~2% is as emulsifier, after being sufficiently stirred, after 15~30 minutes ultrasonic,
As C liquid；By C liquid after 2~4 DEG C stand 4~6 hours, the bag filter dialysis 3 of 8000~14000Da of molecular cut off is utilized
It~6 hours, goes bail for and stays liquid；Liquid vacuum freeze drying will be retained, obtain the chitosan/lecithin/astaxanthin nano-complex.
6. women stern according to claim 4 treats hip pad essence dew, which is characterized in that the astaxanthin nano-complex is
Chitosan/astaxanthin/DNA nano-complex, is prepared by the following method to obtain: by 500~1000mg chitosan be dissolved into
In 40~80mL deionized water, stirs 2~3 hours, obtain chitosan hydration solution；The hydrochloric acid solution for being 2 by 40~80mL pH
It is added in chitosan hydration solution, after stirring 2~3 hours, adjusts pH to 7 using the sodium hydrate aqueous solution that pH is 13；Most
After be added deionized water, the chitosan mother liquor of 0.02~0.04mg/mL of chitosan concentration is obtained, as A liquid；By 100~200mg
Astaxanthin is dissolved into 150~300mL dehydrated alcohol, is stirred 24~36 hours in light protected environment, is centrifuged 5~10 minutes, is taken
Supernatant liquor obtains astaxanthin ethanol solution, as B liquid；Salmon sperm dna is dissolved into deionized water, preparation obtains concentration
The salmon sperm dna solution of 0.02~0.32mg/mL, as C liquid；A liquid and B liquid are uniformly mixed under the conditions of being protected from light, and C is added
Liquid, the volume ratio of A liquid, B liquid and C liquid are 2:(0.5~3): 1, it mixes well, vacuum freeze drying, obtains the chitosan/shrimp
Green element/DNA nano-complex.
7. women stern according to claim 6 treats hip pad essence dew, which is characterized in that the salmon sperm dna solution it is dense
Degree is preferably 0.02~0.04mg/mL.
8. women stern according to claim 5 or 6 treats hip pad essence dew, which is characterized in that the chitosan it is deacetylated
Degree is 90~95%.
9. women stern according to any one of claims 1 to 4 treats hip pad essence dew, which is characterized in that the glucosides is
Polyethylene glycol starch glucosides and/or polyethylene glycol glucoside.
10. women stern according to any one of claims 1 to 4 treats hip pad essence dew, which is characterized in that the honey is
Acacia honey, honey of various flowers, winter honey, clover honey, honey of lychee flowers, eucalyptus honey, sophorae honey, osmanthus honey, coptis honey, Chinese gall honey, Radix Salviae Miltiorrhizae
One of honey, Radix Astragali honey, Chinese gall honey, motherwort honey, fructus lycii honey are a variety of.
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