CN1090026C - Novel medicine for stopping narcotic taking and preparation process thereof - Google Patents

Abstract

The present invention relates to a new medicine for stopping drug addiction, which is a medicament prepared by that raw materials of Biebersteinia heterostemon Maxim., Tangut henbane, falcate crazyweed herb, notopterygium root and pinellia tuber are processed by using a conventional ethanol abstraction and extraction technology and then processed by using a conventional preparation method. In the present invention the stereo combination of effective substances with morphine receptors is utilized to eliminate the symptoms in the central pivot and the periphery through the functions of resisting choline and histamine of the medicine to control abstinence syndromes but not form new dependency. The medicine has the advantages of rapid effect, safety, and effective therapeutic rate of 100%.

Description

Novel detoxification drug and preparation method thereof

The invention relates to a novel drug for detoxification prepared with Tibetan medicine and a preparation method thereof.

The drug problem is seriously perplexing the governments of various countries, and it seriously threatens human health and social security.

The problem of drug rehabilitation is actually a systematic project including the fields of addiction withdrawal, rehabilitation, psychotherapy, community control and complete medical care. In terms of drugs for treatment, there are two main categories, namely opioid drugs and non-opioid drugs. Methadone, which belongs to the former category, is firstly synthesized in Germany. It is a less addictive opioid receptor agonist that can be taken orally and has a longer duration of action. In the second category are Clonidine and Fukang Tablets, which relieve withdrawal symptoms in heroin addicts. However, Chinese medicine detoxification is still in the initial stage of exploration, and the traditional Chinese medicine preparations and methods that can really control withdrawal symptoms well have not yet been seen.

Modern medicine believes that the pathological basis of drug abuse is the receptor theory, and withdrawal symptoms are mainly manifested in the excitation of central and peripheral biliary receptors. Morphine drug addiction is mainly caused by the combination of exogenous morphine-like substances and the body's morphine receptors, resulting in the reduction of endogenous morphine-like substances or the increase of the body's morphine receptor tolerance. In the past, it was believed that morphine-like substances exert their effects through the central nervous system. The latest research shows that, in addition to central effects, morphine-like substances also have considerable effects on peripheral afferent nerves. This means that addicts not only have mental symptoms such as extreme anxiety, but also have quite serious physical symptoms, such as catarrh, joint pain, myalgia, chills and other symptoms.

The object of the present invention is to provide a kind of active substance that can be combined stereoscopically with morphine receptors, through which it has anticholinergic and antihistamine effects, so that central and peripheral symptoms can be eliminated, so as to control withdrawal symptoms without forming new Dependence, fast-acting, safe, and 100% effective treatment of new drug detoxification drugs.

The object of the present invention is also to provide a preparation method of a novel detoxification drug.

Another object of the present invention is to provide a new type of detoxification drug that avoids the disadvantages of vomiting and non-absorption of drugs by addicts after taking the drug, and uses injections to facilitate the comprehensive absorption of drugs.

The purpose of the present invention can be achieved through the following measures:

A new type of drug detoxification drug is made from the following raw materials in the following weight percentages according to the conventional preparation method: 1-100% smoked beef, 0-50% scopolamine tangutate, 0-50% Oxytropis falciparum, 0-50% notopterygium -20%, pinellia 0-20%.

The object of the present invention can also be achieved by the following measures:

A preparation method of a new drug detoxification drug comprises the following steps: (1) After pulverizing tangutate scorpion, Oxytropis falciparum and pinellia, extracting by conventional alcohol extraction process to obtain the extract; adding hydrochloric acid to the extract to concentrate After filtering, the filtrate is adjusted to a pH value of 8-11, and then mixed with chloroform and the above filtrate for extraction, and then the alkaloid is extracted from the chloroform with hydrochloric acid, then the acid solution is neutralized, and then extracted with ether, and the ether is recovered Obtain the alkaloid mixture A; (2) grind the smoked cow and notopterygium and extract by boiling with ethanol for 3 times, the extraction time is 3, 2, and 1 hour successively, and the weight ratio of each raw material to ethanol is 1:8, 1 : 6, 1: 4, combine the extracts for 3 times, take the supernatant to reclaim ethanol, dissolve the extract in water, pass it through the macroporous adsorption resin, then elute with water, evaporate the eluent to get lavonine; wash with alcohol Remove macroporous adsorption resin to obtain eluent, recover alcohol to obtain notopterygium effective part; mix funidoxine and notopterygium effective part to obtain extract B; (3) mix extract A and B with conventional preparation process to make medicament.

Another object of the present invention can also be achieved through the following measures:

A new type of detoxification drug can be an injection.

Compared with the prior art, the present invention has the following advantages:

1. The present invention adopts the Tibetan medicine lavaniubine (Tibetan is called "Mingjian Saibao") as main, and utilizes lavenderine to combine with morphine receptors stereoscopically and its effects such as anticholinergic and antihistamine, which can make The central and peripheral symptoms are eliminated, and the therapeutic purpose of controlling withdrawal symptoms is fully achieved.

2. Scopolamine tangutate can also be added to the compatibility of the present invention, and its active ingredient is hyoscyamine, so the present invention has good receptor blocking and analgesic effects. In addition, the present invention also adds Oxytropis falciparum, Notopterygium and Pinellia, so the present invention has evacuation, pain relief and antispasmodic effects.

3. The present invention does not contain morphine-like substances, is a non-opioid non-addictive drug, and does not form new dependence on patients.

4, the present invention is through clinical observation of 108 cases, can play drug effect after intramuscular injection 10 minutes, can remove withdrawal symptom completely after three days, and does not form new dependence, completely withdraw from addiction (urine test morphine turns negative) after five days, thus The invention relieves withdrawal symptoms completely, quickly and safely.

5. The present invention is preferably prepared as an injection. This preparation can help the drug to be absorbed comprehensively and rapidly. For addicts with nausea, vomiting, diarrhea and abdominal distension withdrawal symptoms, it can avoid vomiting after oral administration of the drug and the drug cannot be absorbed. ills. It has been clinically verified that its injection has a short course of treatment, and the treatment period is 3-4 days, and the effective rate is 100%. After the treatment, the withdrawal symptoms basically disappeared, the physical health improved, the total score of the three major symptoms of craving, anxiety, and insomnia was less than 10, and the urine trace morphine test was negative, which indicated a significant curative effect. 70% of the patients turned negative within 5 days, and 30% of the patients It turned cloudy in 7 days, which was obviously better than that of the Keerding control group (turned cloudy in 10 days).

The present invention will also be described in further detail in conjunction with embodiment:

Embodiment one:

A new type of detoxification drug is made from the following raw materials according to the conventional preparation method: 50% smoked cow, 25% scopolamine tangutate, 10% Oxytropis falciparum, 7% notopterygium, 8% pinellia .

The preparation method of the novel detoxification drug comprises the following steps: (1) weighing and pulverizing scopolamine tangutata, Oxytropis falciparum and pinellia according to the weight percentage in the formula, adding an equal amount of 90% ethanol to moisten, Place it in the percolation cylinder overnight, and percolate with 90% ethanol the next day. When the percolation liquid is 10 times that of the raw material, combine the percolation liquid, recover ethanol, and obtain the extract; add 90% hydrochloric acid to the extract Dissolve the concentrate, filter and adjust the pH value of the filtrate to 9, then mix the filtrate with chloroform and extract, then use 5% hydrochloric acid to extract the alkaloid from the chloroform, neutralize the acid solution, and then extract with ether , reclaim ether to obtain alkaloid mixture A; (2) grind the smoked cow and notopterygium and extract by boiling with ethanol 3 times, the extraction time is 3, 2, and 1 hour successively, and the weight ratio of each raw material to ethanol is 1: 8, 1:6, 1:4, combine the extracts for 3 times, take the supernatant to recover ethanol, dissolve the extract in water, pass through the macroporous resin, and then elute with water. liquid to obtain fubaniuine; then elute the macroporous adsorption resin with alcohol to obtain the eluent, and recover the alcohol to obtain the effective part of notopterygium; mix furnadoxine and the effective part of notopterygium to obtain extract B; (3) extract A and B are mixed with conventional preparation technology to make medicament. It is preferably prepared as an injection. The medicament of the present invention takes danidine N-3-methyl-2-butenyl urea as the quality control standard, and the dose of danidine contained in each dose is 15-40 mg, 3 times a day.

Embodiment two:

A new type of detoxification drug is made of raw materials containing the following weight percentages according to a conventional preparation method: 100% smoked cattle.

Its preparation method is the same as the example, and its raw material is only smoked beef.

Embodiment three:

A novel detoxification drug is prepared from raw materials containing the following percentages by weight according to a conventional preparation method: 50% smoked bull and 50% scopolamine tangut.

Its preparation method is the same as the example, and its raw materials are only smoked beef and tangut scopolamine.

Embodiment four:

A new drug detoxification drug is made of raw materials containing the following weight percentages according to a conventional preparation method: 75% of smoked beef and 25% of Oxytropis falciparum.

Its preparation method is the same as the example, and its raw materials are only smoked beef and Oxytropis falciparum.

Embodiment five:

A new type of detoxification drug is made from raw materials containing the following weight percentages according to a conventional preparation method: 40% smoked beef, 40% Oxytropis falciparum and 20% notopterygium.

Its preparation method is the same as in the example, and its raw materials are only smoked cattle, Oxytropis falciparum and notopterygium.

Embodiment six:

A new type of detoxification drug is made from the following raw materials in the following weight percentages according to the conventional preparation method: 4% smoked cow, 6% Oxytropis falciparum, 50% scopolamine tangutate, 20% notopterygium, 20% pinellia .

Its preparation method is the same as the examples.

Claims (4)

1, a kind of novel detoxification drug, is characterized in that by the raw material of following percentage by weight, is made into medicament by conventional preparation method: Smoked Beef 1-100% Tangut Scopolamine 0-50% Oxytropis Sickle 0-50% Notopterygium 0-20% Pinellia 0-20%. 2. The new drug detoxification drug as claimed in claim 1, characterized in that the drug is any dosage form described in pharmacy. 3. The new drug detoxification drug according to claim 1, characterized in that the drug is an injection. 4. The preparation method of the novel detoxification drug as claimed in claim 1, which is characterized in that it comprises the following steps: (1) After pulverizing Scopolamine tangutata, Oxytropis falciparum and Pinellia chinensis, extracting by conventional alcohol extraction process to obtain the extracted Add hydrochloric acid to the extract to dissolve the concentrate, filter the filtrate to adjust the pH value to 8-11, then mix the above filtrate with chloroform and extract, then use hydrochloric acid to extract the alkaloid from the chloroform, and then put it in the acid solution and, then extract with ether, recover the ether to obtain alkaloid mixture A; (2) grind the smoked cow and notopterygium and extract by boiling with ethanol for 3 times, the extraction time is 3, 2, and 1 hour in sequence, and the raw materials and The weight ratio of ethanol is 1:8, 1:6, 1:4, combine the extracts for 3 times, take the supernatant to recover ethanol, dissolve the extract in water, pass it through the macroporous adsorption resin, then elute with water, and evaporate the eluent Obtain fubaniuine; then elute the macroporous resin with alcohol to obtain the eluent, and recover the alcohol to obtain the effective part of notopterygium; mix funiuine and the effective part of notopterygium to obtain extract B: (3) extract A , and B are mixed to make medicaments according to the conventional preparation process.