CN109006849A - A kind of bactericidal composition containing rosickyite azoles and its application - Google Patents
A kind of bactericidal composition containing rosickyite azoles and its application Download PDFInfo
- Publication number
- CN109006849A CN109006849A CN201811201406.0A CN201811201406A CN109006849A CN 109006849 A CN109006849 A CN 109006849A CN 201811201406 A CN201811201406 A CN 201811201406A CN 109006849 A CN109006849 A CN 109006849A
- Authority
- CN
- China
- Prior art keywords
- trifloxystrobin
- rosickyite azoles
- bactericidal composition
- azoles
- rosickyite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003851 azoles Chemical class 0.000 title claims abstract description 69
- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 25
- 239000005857 Trifloxystrobin Substances 0.000 claims abstract description 66
- ONCZDRURRATYFI-TVJDWZFNSA-N trifloxystrobin Chemical compound CO\N=C(\C(=O)OC)C1=CC=CC=C1CO\N=C(/C)C1=CC=CC(C(F)(F)F)=C1 ONCZDRURRATYFI-TVJDWZFNSA-N 0.000 claims abstract description 66
- 239000004530 micro-emulsion Substances 0.000 claims abstract description 10
- 230000002265 prevention Effects 0.000 claims abstract description 10
- 239000004563 wettable powder Substances 0.000 claims abstract description 10
- 239000000839 emulsion Substances 0.000 claims abstract description 9
- 239000000375 suspending agent Substances 0.000 claims abstract description 9
- 241001530056 Athelia rolfsii Species 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 239000002552 dosage form Substances 0.000 claims description 5
- 239000006185 dispersion Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 10
- 239000004562 water dispersible granule Substances 0.000 abstract description 9
- 241000209140 Triticum Species 0.000 abstract description 8
- 235000021307 Triticum Nutrition 0.000 abstract description 8
- 230000002195 synergetic effect Effects 0.000 abstract description 6
- 241000223218 Fusarium Species 0.000 abstract description 4
- 240000005979 Hordeum vulgare Species 0.000 abstract description 4
- 235000007340 Hordeum vulgare Nutrition 0.000 abstract description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 19
- -1 diffusant Substances 0.000 description 19
- 238000000034 method Methods 0.000 description 17
- 238000002156 mixing Methods 0.000 description 13
- 239000003921 oil Substances 0.000 description 13
- 235000019198 oils Nutrition 0.000 description 13
- 239000002994 raw material Substances 0.000 description 12
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 11
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 11
- 239000003795 chemical substances by application Substances 0.000 description 11
- 239000002904 solvent Substances 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 10
- 229920000056 polyoxyethylene ether Polymers 0.000 description 10
- 229940051841 polyoxyethylene ether Drugs 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 239000003995 emulsifying agent Substances 0.000 description 9
- 239000003814 drug Substances 0.000 description 8
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 7
- 239000002270 dispersing agent Substances 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 6
- 230000000295 complement effect Effects 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 6
- 239000010452 phosphate Substances 0.000 description 6
- 230000001988 toxicity Effects 0.000 description 6
- 231100000419 toxicity Toxicity 0.000 description 6
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 5
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 5
- 210000000481 breast Anatomy 0.000 description 5
- 239000006229 carbon black Substances 0.000 description 5
- 239000000575 pesticide Substances 0.000 description 5
- 230000003449 preventive effect Effects 0.000 description 5
- 241001290235 Ceratobasidium cereale Species 0.000 description 4
- 206010059866 Drug resistance Diseases 0.000 description 4
- 241000233866 Fungi Species 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 208000031888 Mycoses Diseases 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 4
- 238000004166 bioassay Methods 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 239000005995 Aluminium silicate Substances 0.000 description 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 3
- 241000221785 Erysiphales Species 0.000 description 3
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 3
- 241000233679 Peronosporaceae Species 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 3
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 3
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 3
- 235000011130 ammonium sulphate Nutrition 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
- 239000012752 auxiliary agent Substances 0.000 description 3
- 229910021538 borax Inorganic materials 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 229920005610 lignin Polymers 0.000 description 3
- 230000001590 oxidative effect Effects 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 3
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 3
- 239000004576 sand Substances 0.000 description 3
- 229910052710 silicon Inorganic materials 0.000 description 3
- 239000010703 silicon Substances 0.000 description 3
- 239000004328 sodium tetraborate Substances 0.000 description 3
- 235000010339 sodium tetraborate Nutrition 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- 239000000230 xanthan gum Substances 0.000 description 3
- 229940082509 xanthan gum Drugs 0.000 description 3
- 235000010493 xanthan gum Nutrition 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 244000241235 Citrullus lanatus Species 0.000 description 2
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 244000061176 Nicotiana tabacum Species 0.000 description 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
- 206010039509 Scab Diseases 0.000 description 2
- FSXPZSJEXMUNIU-UHFFFAOYSA-N [S].C=1C=CNC=1 Chemical class [S].C=1C=CNC=1 FSXPZSJEXMUNIU-UHFFFAOYSA-N 0.000 description 2
- HXHWSAZORRCQMX-UHFFFAOYSA-N albendazole Chemical compound CCCSC1=CC=C2NC(NC(=O)OC)=NC2=C1 HXHWSAZORRCQMX-UHFFFAOYSA-N 0.000 description 2
- 229960002669 albendazole Drugs 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000000593 microemulsion method Methods 0.000 description 2
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical class C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- CDMGNVWZXRKJNS-UHFFFAOYSA-N 2-benzylphenol Chemical compound OC1=CC=CC=C1CC1=CC=CC=C1 CDMGNVWZXRKJNS-UHFFFAOYSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- 241000193738 Bacillus anthracis Species 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 235000010149 Brassica rapa subsp chinensis Nutrition 0.000 description 1
- 235000000536 Brassica rapa subsp pekinensis Nutrition 0.000 description 1
- 241000499436 Brassica rapa subsp. pekinensis Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- 240000008790 Musa x paradisiaca Species 0.000 description 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 1
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 241000918585 Pythium aphanidermatum Species 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940054066 benzamide antipsychotics Drugs 0.000 description 1
- 150000003936 benzamides Chemical class 0.000 description 1
- 150000001556 benzimidazoles Chemical class 0.000 description 1
- SMLHHBQGIJMAIM-UHFFFAOYSA-N calcium;2-dodecylbenzenesulfonic acid Chemical compound [Ca].CCCCCCCCCCCCC1=CC=CC=C1S(O)(=O)=O SMLHHBQGIJMAIM-UHFFFAOYSA-N 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 150000002085 enols Chemical class 0.000 description 1
- 229940125532 enzyme inhibitor Drugs 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- SLGWESQGEUXWJQ-UHFFFAOYSA-N formaldehyde;phenol Chemical compound O=C.OC1=CC=CC=C1 SLGWESQGEUXWJQ-UHFFFAOYSA-N 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- LCRMGUFGEDUSOG-UHFFFAOYSA-N naphthalen-1-ylsulfonyloxymethyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(OCOS(=O)(=O)C=3C4=CC=CC=C4C=CC=3)=O)=CC=CC2=C1 LCRMGUFGEDUSOG-UHFFFAOYSA-N 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- VSXGXPNADZQTGQ-UHFFFAOYSA-N oxirane;phenol Chemical compound C1CO1.OC1=CC=CC=C1 VSXGXPNADZQTGQ-UHFFFAOYSA-N 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- MZSDGDXXBZSFTG-UHFFFAOYSA-M sodium;benzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC=C1 MZSDGDXXBZSFTG-UHFFFAOYSA-M 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/50—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids the nitrogen atom being doubly bound to the carbon skeleton
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition containing rosickyite azoles, which contains effective component rosickyite azoles and trifloxystrobin, and the mass ratio of the two is 1:50~70:1.The present composition can be configured to missible oil, suspending agent, aqueous emulsion, microemulsion, wettable powder or water dispersible granules.Instant component is reasonable, has significant bactericidal effect and synergistic effect, good to crop safety.The present composition is suitable for the diseases such as prevention and treatment gray mold, gibberella zeaze petch of wheat and barley, banded sclerotial blight.
Description
Technical field
The present invention relates to a kind of bactericidal composition, especially a kind of bactericidal composition containing rosickyite azoles and its prevention and treatment farming
The application of object disease, belongs to technical field of pesticide compounding.
Background technique
Rosickyite azoles, english common name: albendazole also known as albendazole belong to benzimidazoles derivative, tool
There are protection, treatment and infiltration conduction.Wide sterilization spectrum, to rice blast, wheat scab, watermelon anthrax, Banana Leaf
Pinta, tobacco virus, Powdery Mildew in Tobacco, Chinese cabbage downy mildew, watermelon blight etc. have good control efficiency.
Trifloxystrobin, english common name: trifloxystrobin belongs to methoxy acrylic bactericide.With height
Effect wide spectrum, protection, is treated, is rooted out, permeating, the characteristics such as systemic activity, resistance of rainwater washing against, lasting period are long.To 1,4- demethylation
The bacterial strain that enzyme inhibitor, benzamides, dicarboxyl amine and benzimidazole generate resistance is effective, with it is current have fungicide without
Cross resistance.To nearly all Mycophytes (sac fungus, basidiomycetes, oomycetes and Fungi Imperfecti) disease, such as powdery mildew, rust, Ying are withered
Disease, net blotch, downy mildew, rice blast etc. have good activity.In addition to having special efficacy to powdery mildew, leaf spot, to rust, downy mildew
Disease, damping-off, scab have good activity.To crop safety, because it is capable of being fast degraded in soil, water, therefore to environment
Safety.
It after the long-term single use of pesticide, is easy that disease is made to develop drug resistance, causes dosage to increase, preventive effect reduces, holding effect
The problems such as phase shortens, is unfavorable for resistance management and environment sustainable development.And the effective component of different role mechanism is compounded,
It is the common method for delaying disease to develop drug resistance, and according to the effect in production application, to judge that this compounding is synergy
Effect or antagonism.Compound synergic effect is significantly formulated, and can be significantly improved preventive effect, be substantially reduced the medication of pesticide
Amount can also expand prevention spectrum, improve control efficiency.Inventor has been surprisingly found that through a large number of experiments, by the different rosickyite of the mechanism of action
Azoles is compounded with trifloxystrobin, and applied to gray mold, the prevention and treatment of gibberella zeaze petch of wheat and barley, banded sclerotial blight, synergistic effect is significant.
Summary of the invention
It is an object of the invention to: a kind of bactericidal composition containing rosickyite azoles is provided, helps that pathogen is delayed to generate
Resistance improves control efficiency and reduces effective ingredient consumption.
It is a further object to provide application of the bactericidal composition on prevention and treatment fungal diseases of plants, especially
Application on the fungal diseases such as prevention and treatment gray mold, gibberella zeaze petch of wheat and barley, banded sclerotial blight.
In order to achieve the above-mentioned object of the invention, the present invention is achieved through the following technical solutions:
A kind of bactericidal composition containing rosickyite azoles, it is characterised in that: contain effective component third in the bactericidal composition
Sulphur azoles and trifloxystrobin, the mass ratio of the two are 1:50~70:1, and preferred mass ratio is 1:10~20:1；More preferable mass ratio is 1:
4~10:1, most preferably mass ratio are 1:2~5:1.
The gross mass percentage composition of effective component is 6%~70% in the bactericidal composition.
The bactericidal composition can be configured on pesticide to allow using any one dosage form, dosage form is missible oil, outstanding
Floating agent, aqueous emulsion, microemulsion, wettable powder or water dispersible granules.
The bactericidal composition further includes known auxiliary agent and excipient in addition to effective component rosickyite azoles and trifloxystrobin.?
Auxiliary agent, the excipients known have dispersing agent, diffusant, defoaming agent, wetting agent, disintegrating agent etc., can use dodecyl benzene sulfonic acid
Calcium, alkyl phenol polyoxyethylene ether, Ben-zylphenol Polyoxyethyl Ether, phenethyl phenol polyethenoxy ether, fatty alcohol polyoxyethylene ether and its
Similar products, aliphatic amine polyoxyethylene ether, fatty acid ethylene oxide addition product, polyoxyethylene polyoxy propylene block compound, castor
Sesame oil polyoxyethylene ether, nonylphenol polyoxyethylene ether, TWEEN Series, fatty alcohol polyoxyethylene ether, polyethylene glycol series, sulfonate
Class, carboxylate, sulfate, phosphate, phosphite, lignosulfonates, xanthan gum, phenol formaldehyde condensate, ammonium salt, quaternary ammonium salt
Combination more than one or two of type, excipient include cyclohexanone, dimethylbenzene, various solvent naphthas, water, antifreezing agent (such as third
Glycol), deionized water etc..The above auxiliary agent, excipient and other auxiliary materials can be applied alone or use with.
Application of the bactericidal composition on prevention and treatment fungal diseases of plants, especially in prevention and treatment Cereal, fruit tree, vegetable
The application of gray mold, head blight, banded sclerotial blight on dish crop.
Compared with prior art, the present invention the beneficial effects are as follows:
(1) compared with single dose, the fungies such as the composition antagonism fungal disease such as gray mold, gibberella zeaze petch of wheat and barley, banded sclerotial blight
Disease has obvious synergistic function, improves control efficiency；(2) reduce prevention and treatment recruitment, drug cost；(3) composition by
The effective component of different role mechanism forms, and action site increases, and helps to overcome and pathogen is delayed to develop drug resistance；(4)
Compared with single dose, production and application cost is reduced；(5) inhibit the generation of fungi drug resistance, effect, which is apparently higher than its single dose, to be made
With.
Specific embodiment
In order to which technical problems, technical solutions and advantageous effects to be solved by the present invention are more clearly understood, below in conjunction with
The present invention will be described in further detail for specific embodiment.It should be appreciated that specific embodiment described herein is only used to
It explains the present invention, is not intended to limit the present invention.
The invention will be further described with reference to embodiments, and the preparation method of dosage form is conventional side in embodiment
Method, " % " of the present invention is mass percent.
Embodiment 1:15% rosickyite azoles trifloxystrobin wettable powder (1:2)
By rosickyite azoles 5g, trifloxystrobin 10g, detergent LS (to methoxyl group fatty acid amido benzene sulfonic acid sodium salt) 2g, dispersing agent NNO
(sodium methylene bis-naphthalene sulfonate) 4g, dispersing agent white carbon black 5g, filler kaolin carry out air-flow crushing after adding to 100g mixing, are made
15% rosickyite azoles trifloxystrobin wettable powder.
Embodiment 2:15% rosickyite azoles trifloxystrobin wettable powder (1:4)
By rosickyite azoles 3g, trifloxystrobin 12g, wetting agent lauryl sodium sulfate 3g, dispersing agent NNO (di-2-ethylhexylphosphine oxide naphthalene sulfonic acids
Sodium) 4g, dispersing agent white carbon black 5g, filler kaolin add to 100g mixing after carry out air-flow crushing, be made 15% rosickyite azoles oxime
Bacterium ester wettable powder.
Embodiment 3:16% rosickyite azoles trifloxystrobin wettable powder (1:7)
By rosickyite azoles 2g, trifloxystrobin 14g, wetting agent lauryl sodium sulfate 3g, dispersing agent NNO (di-2-ethylhexylphosphine oxide naphthalene sulfonic acids
Sodium) 4g, dispersing agent white carbon black 5g, filler kaolin add to 100g mixing after carry out air-flow crushing, be made 16% rosickyite azoles oxime
Bacterium ester wettable powder.
Embodiment 4:20% rosickyite azoles trifloxystrobin suspending agent (1:1)
Weigh 10g rosickyite azoles, 10g trifloxystrobin, lignin 2g, polyoxyethylene poly-oxygen propylene aether and its sulfate 4g, xanthan
Glue 0.15g, ethylene glycol 5g, silicon oxidative ethane 0.10g, aluminium-magnesium silicate 0.5g complement to 100g with water, in sand mill under the action of system
Obtain 20% rosickyite azoles trifloxystrobin suspending agent.
Embodiment 5:55% rosickyite azoles trifloxystrobin water emulsion (1:10)
It is poly- to weigh 5g rosickyite azoles, 50g trifloxystrobin, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkyl phenol
Ethylene oxide ether 1g, solvent naphtha 13g add water to 100g.The above raw material is routinely prepared in the method investment mixing kettle of aqueous emulsion
55% rosickyite azoles trifloxystrobin water emulsion is made in mixed at high speed.
Embodiment 6:42% rosickyite azoles trifloxystrobin missible oil (1:20)
2g rosickyite azoles, 40g trifloxystrobin are weighed, emulsifier: calcium dodecyl benzene sulfonate 8g, emulsifier: phenethyl phenol polyoxy
Vinethene 5g, solvent: solvent naphtha to 100g.The above raw material is routinely prepared and is mixed in the method investment mixing kettle of missible oil, is made
Obtain 42% rosickyite azoles trifloxystrobin missible oil.
Embodiment 7:70% rosickyite azoles trifloxystrobin missible oil (2.5:1)
50g rosickyite azoles, 20g trifloxystrobin are weighed, emulsifier: calcium dodecyl benzene sulfonate 5g, emulsifier: phenethyl phenol polyoxy
Vinethene 2g, emulsifier: castor oil polyoxyethylene ether 2g, solvent: solvent naphtha to 100g.The above raw material is routinely prepared into missible oil
Method investment mixing kettle in mix, be made 70% rosickyite azoles trifloxystrobin missible oil.
Embodiment 8:18% rosickyite azoles trifloxystrobin water dispersible granule (5:1)
Weigh 15g rosickyite azoles, 3g trifloxystrobin, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, poly- second
Enol 5g, borax 2g, diatomite 28g complement to 100g, and 18% rosickyite is made by water dispersible granules processing method in the above raw material
Azoles trifloxystrobin water dispersible granule.
Embodiment 9:11% rosickyite azoles trifloxystrobin missible oil (10:1)
10g rosickyite azoles, 1g trifloxystrobin are weighed, emulsifier: calcium dodecyl benzene sulfonate 6g, emulsifier: phenethyl phenol polyoxy
Vinethene 7g, solvent: solvent naphtha to 100g.The above raw material is routinely prepared and is mixed in the method investment mixing kettle of missible oil, is made
Obtain 11% rosickyite azoles trifloxystrobin missible oil.
Embodiment 10:31.5% rosickyite azoles trifloxystrobin microemulsion (20:1)
Weigh 30g rosickyite azoles, 1.5g trifloxystrobin, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate
3g, agriculture breast 33#2g, alkyl phenol polyoxyethylene ether 1g, isopropanol 10g add water to 100g.The above raw material is routinely prepared into micro emulsion
It is mixed in the method investment mixing kettle of agent, 31.5% rosickyite azoles trifloxystrobin microemulsion is made.
Embodiment 11:31% rosickyite azoles trifloxystrobin missible oil (30:1)
30g rosickyite azoles, 1g trifloxystrobin are weighed, emulsifier: calcium dodecyl benzene sulfonate 4g, emulsifier: phenethyl phenol polyoxy
Vinethene 4g, solvent: solvent naphtha to 100g.The above raw material is routinely prepared and is mixed in the method investment mixing kettle of missible oil, is made
Obtain 31% rosickyite azoles trifloxystrobin missible oil.
Embodiment 12:51% rosickyite azoles trifloxystrobin suspending agent (50:1)
Weigh 50g rosickyite azoles, 1g trifloxystrobin, lignin 2g, polyoxyethylene poly-oxygen propylene aether and its sulfate 4g, xanthan gum
0.15g, ethylene glycol 5g, silicon oxidative ethane 0.10g, aluminium-magnesium silicate 0.5g complement to 100g with water, are made under the action of sand mill
51% rosickyite azoles trifloxystrobin suspending agent.
Embodiment 13:32% rosickyite azoles trifloxystrobin microemulsion (1:15)
Weigh 2g rosickyite azoles, 30g trifloxystrobin, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g,
Agriculture breast 33#2g, alkyl phenol polyoxyethylene ether 1g, isopropanol 10g add water to 100g.The above raw material is routinely prepared into microemulsion
Method investment mixing kettle in mix, be made 32% rosickyite azoles trifloxystrobin microemulsion.
Embodiment 14:6% rosickyite azoles trifloxystrobin water emulsion (1:5)
Weigh 1g rosickyite azoles, 5g trifloxystrobin, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkyl phenol polyoxy
Vinethene 1g, solvent naphtha 13g, adds water to 100g.The above raw material is routinely prepared high in the method investment mixing kettle of aqueous emulsion
Speed mixing, is made 6% rosickyite azoles trifloxystrobin water emulsion.
Embodiment 15:62% rosickyite azoles trifloxystrobin microemulsion (1:30)
Weigh 2g rosickyite azoles, 60g trifloxystrobin, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g,
Agriculture breast 33#2g, alkyl phenol polyoxyethylene ether 1g, isopropanol 10g add water to 100g.The above raw material is routinely prepared into microemulsion
Method investment mixing kettle in mix, be made 62% rosickyite azoles trifloxystrobin microemulsion.
Embodiment 16:51% rosickyite azoles trifloxystrobin suspending agent (1:50)
Weigh 1g rosickyite azoles, 50g trifloxystrobin, lignin 2g, polyoxyethylene poly-oxygen propylene aether and its sulfate 4g, xanthan gum
0.15g, ethylene glycol 5g, silicon oxidative ethane 0.10g, aluminium-magnesium silicate 0.5g complement to 100g with water, are made under the action of sand mill
51% rosickyite azoles trifloxystrobin suspending agent.
Embodiment 17:7% rosickyite azoles trifloxystrobin water dispersible granule (1:2.5)
Weigh 2g rosickyite azoles, 5g trifloxystrobin, wooden sodium sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol
5g, borax 2g, white carbon black 3g, diatomite complement to 100g, and 7% rosickyite is made by water dispersible granular agent method in the above raw material
Azoles trifloxystrobin water dispersible granule.
Embodiment 18:71% rosickyite azoles trifloxystrobin water dispersible granule (70:1)
Weigh 1g rosickyite azoles, 70g trifloxystrobin, wooden sodium sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyethylene
Alcohol 5g, borax 2g, white carbon black 3g, diatomite complement to 100g, and the above raw material is made 71% the third by water dispersible granular agent method
Sulphur azoles trifloxystrobin water dispersible granule.
Indoor bioassay test: composition tests the indoor bioassay of rhizoctonia cerealis
Subjects: rhizoctonia cerealis (Rhizoctonia cerealis)
Test uses mycelial growth rate method.Different agents are measured to the EC of bacterial strain50Value, using co-toxicity coefficient calculating side
Method calculates the co-toxicity coefficient (CTC) of mixture, determines the building performance of mixture, circular is as follows:
Survey toxicity index (ATI)=standard agent EC50/ reagent agent EC50×100
Percentage composition+B the medicament toxicity index of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture × mixed
The percentage composition of B in agent
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI)/mixtures theoretical toxicity index (TTI)] × 100
Co-toxicity coefficient classification: mixture has synergetic when CTC>=120, is antagonism, 80<CTC<120 when CTC≤80
For summation action.
According to effective component rosickyite azoles (A): the mass ratio of trifloxystrobin (B) are as follows: 70:1,50:1,30:1,20:1,10:1,5:
1,2.5:1,1:1,1:2,1:4,1:7,1:10,1:20,1:30,1:50 are tested, and measure its total poison to wheat sharp eyespot
Coefficient.
1 rosickyite azoles of table, trifloxystrobin different ratio are to the indoor bioassay test result of rhizoctonia cerealis
Field control effectiveness test:
Composition for preventing and controlling wheat sharp eyespot field control effectiveness test
1, test process: this test medicine dosage sets two concentration for the treatment of, comparison medicine according to the difference of each ingredient respectively
Agent is 50% trifloxystrobin wettable powder and 200g/L rosickyite azole suspending agent and clean water experiment respectively.
2, test method: each plot area is 66.7m2, it is repeated 3 times；Disease index is investigated before application, is investigated after medicine anti-
Control effect.Investigation method are as follows: 5 points of grab sample in test process area carry out disease according to " pesticide field efficacy medicine test criterion "
Mutual affection grade calculates preventive effect.Test result is shown in Table 2:
2 composition for preventing and controlling wheat sharp eyespot field control effectiveness test result of table
Indoor bioassay test and field control effectiveness test result show that rosickyite azoles and trifloxystrobin are mixed in a certain ratio tool
There is apparent synergistic function.The control efficiency of composition is excellent, and preventive effect is better than control single dose, and preventive effect phase is long, in agriculture
There is application value in industry application.
Claims (7)
1. a kind of bactericidal composition containing rosickyite azoles, it is characterised in that: the bactericidal composition contains effective component rosickyite azoles
And trifloxystrobin, the mass ratio of the two are 1:50~70:1.
2. bactericidal composition according to claim 1, it is characterised in that: the mass ratio of effective component rosickyite azoles and trifloxystrobin
For 1:10~20:1.
3. bactericidal composition according to claim 2, it is characterised in that: the mass ratio of effective component rosickyite azoles and trifloxystrobin
For 1:4~10:1.
4. bactericidal composition according to claim 3, it is characterised in that: the mass ratio of effective component rosickyite azoles and trifloxystrobin
For 1:2~5:1.
5. bactericidal composition according to any one of claims 1 to 4, it is characterised in that: in the bactericidal composition effectively at
The gross mass percentage composition divided is 6%~70%.
6. bactericidal composition according to claim 5, it is characterised in that: the bactericidal composition can be configured to any one
Kind dosage form, dosage form is missible oil, suspending agent, aqueous emulsion, microemulsion, wettable powder or water dispersion granule.
7. the application of bactericidal composition described in claim 1 gray mold, head blight, banded sclerotial blight on prevention and treatment crops.
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| CN113287621A (en) * | 2021-05-07 | 2021-08-24 | 广东省农业科学院果树研究所 | Application of imidazole derivative A in preparation of pesticide bactericide for preventing and treating banana fusarium wilt |
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| CN105407721A (en) * | 2013-07-31 | 2016-03-16 | 龙灯农业化工国际有限公司 | Fungicidal compositions and their use |
| CN109042701A (en) * | 2018-09-21 | 2018-12-21 | 贵州道元生物技术有限公司 | A kind of rosickyite azoles and the bactericidal composition of trifloxystrobin and application thereof for preventing and treating Cucumber Target Leaf Spot |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105407721A (en) * | 2013-07-31 | 2016-03-16 | 龙灯农业化工国际有限公司 | Fungicidal compositions and their use |
| CN109042701A (en) * | 2018-09-21 | 2018-12-21 | 贵州道元生物技术有限公司 | A kind of rosickyite azoles and the bactericidal composition of trifloxystrobin and application thereof for preventing and treating Cucumber Target Leaf Spot |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113287621A (en) * | 2021-05-07 | 2021-08-24 | 广东省农业科学院果树研究所 | Application of imidazole derivative A in preparation of pesticide bactericide for preventing and treating banana fusarium wilt |
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