CN108844803A - A kind of chromosome with drymaster is automatically aobvious with device - Google Patents

Abstract

An automatic chromosome banding device with a dry film machine, comprising a first box and a second box, the first box and the second box are connected, and the first box is provided with a The second box is provided with a developing mechanism for developing the slides, a washing mechanism for rinsing the slides, a drying mechanism for drying the slides, and a movement for controlling the movement of the slides. mechanism, the moving mechanism is arranged above the second box body, the film display mechanism, the washing mechanism, and the drying mechanism are arranged in sequence, and the side of the second box body opposite to the film display mechanism is provided with Open first. By adopting the above-mentioned technical scheme, complex manual operations are solved, and the experimental environment for chromosome banding is uniformly controlled. Replace the manual operation with the automatic device, and set the most suitable experimental conditions to start banding and dyeing operations, saving labor and avoiding manual operation errors, and improving the efficiency of banding to achieve fast, efficient, and automatic.

Description

An automatic chromosome banding device with a dryer

technical field

The invention relates to the technical field of medical devices, in particular to an automatic chromosome banding device with a drying film machine.

Background technique

In recent years, medical genetics has developed rapidly. Chromosome examination is the most basic and common examination technique among many examination techniques of medical genetics. Over the years, in the process of chromosome preparation, G-banding technology has been widely used as a common technique, and it is also one of the decisive factors that determine the success of chromosome preparation. Now, when chromosome banding is mostly performed manually, personnel with a certain technical foundation are needed to control and adjust the experimental conditions. Therefore, the current chromosome banding technology has relatively complex manual operations and technical requirements, and the manual operation procedures are cumbersome and time-consuming.

Contents of the invention

To sum up, in order to overcome the deficiencies of the prior art, the present invention provides an automatic chromosome banding device with a drying machine.

In order to achieve the above object, the present invention provides the following technical solutions: an automatic chromosome banding device with a drying film machine, comprising a first box body and a second box body, and the first box body and the second box body are connected , the first box is provided with a baking mechanism for heating the slides, the second box is provided with a display mechanism for developing the slides, a washing mechanism for rinsing the slides, and a drying mechanism for drying the slides. A drying mechanism for glass slides and a moving mechanism for controlling the movement of glass slides. The moving mechanism is arranged above the second box body. The slide display mechanism, washing mechanism, and drying mechanism are arranged in sequence. The second A first opening is provided on a side of the box body opposite to the display mechanism.

By adopting the above technical scheme, first put the glass slide into the baking mechanism to heat, then put the heated glass slide into the second box, operate the moving mechanism to move the glass slide to the display mechanism to make the slide develop, and then operate The moving mechanism moves the slides to the washing mechanism, then operates the moving mechanism to move the slides to the drying mechanism to dry the slides, and finally operates the moving mechanism to move the slides to the exit. The invention solves the complicated manual operation and uniformly controls chromosomes Banded experimental environment. The automated device replaces the manual operation, put the slides to be processed into the device, and set the most suitable experimental conditions to start banding and dyeing operations, which saves labor and avoids manual operation errors, and can also improve banding. Efficiency, making the operating environment clean and pollution-free, realizing fast, efficient and automatic.

The present invention further provides that: the slice baking mechanism includes a first cylinder and a first storage table for placing slides, the first cylinder is arranged under the first storage table, and the first cylinder drives the first storage table The table moves up and down, and a second opening matching the first storage table is provided above the first box body, and a matching door panel is provided on the second opening.

By adopting the above-mentioned technical solution, when performing baking, the door panel is opened, and the first storage table is raised by operating the first cylinder, and the glass slides to be baked are placed on the first storage table, and multiple slides can be placed at the same time. Then the first air cylinder is operated to lower the first storage table, and the door panel is closed to bake slices. The operation is simple and efficient.

The present invention further provides that: the film display mechanism includes a second cylinder and a second storage table for placing containers, the second cylinder is arranged below the second storage table, and above the second storage table are respectively arranged A banding container, a termination reaction container, and a dyeing container, the banding container is provided with a solution for developing bands, the reaction container is provided with physiological saline, the dyeing container is provided with a dyeing solution, and the second storage A guide assembly is provided between the table and the second box, and the first cylinder drives the storage table to move up and down along the guide assembly.

By adopting the above-mentioned technical scheme, put the baked glass slides into the second box, operate the moving mechanism to move the glass slides to the top of the tape container, and then operate the second air cylinder to raise the second storage table so that the slides are completely submerged Put the solution in the band for 10s-20s, then operate the second air cylinder to lower the second object table, operate the moving mechanism to move the glass slide to the top of the termination reaction container, and then operate the second air cylinder to raise the second object table to make the glass slide completely Immerse in physiological saline to terminate the effect of the banding solution for 3 seconds, and then repeat the operation to completely immerse the slide in the staining solution to stain the slide.

The present invention further provides that: the guide assembly includes a first connecting portion arranged on the side of the second storage table, and the side of the second box opposite to the first connecting portion is provided with a The track groove is adapted, and the first connecting part is provided with a block clamped in the track groove.

By adopting the above technical solution, when the second cylinder is operated to raise or lower the second storage platform along the track groove, the guide assembly enhances the stability of the second storage platform.

The present invention further provides that: the flushing mechanism includes a water retaining assembly and a water spray gun, the water retaining assembly includes a first baffle and a second baffle arranged on the bottom surface of the second box, the first baffle, the second baffle The second baffle is vertically connected, the first baffle is provided with a first telescopic plate, the second baffle is provided with a second telescopic plate, the gap between the first telescopic plate and the second telescopic plate is A second connecting part is arranged between them, and a connecting rod is arranged on the other side of the first telescopic plate opposite to the second connecting part, and the connecting rod is connected with a third cylinder, and the third cylinder drives the connecting rod. The rod moves up and down,

By adopting the above-mentioned technical scheme, operate the moving mechanism to move the glass slides that have been developed to the washing mechanism, then operate the third cylinder to drive the connecting rod to make the first telescopic plate and the second telescopic plate rise at the same time, and then turn on the water spray gun to clean the glass slides. Perform flushing, then turn off the water spray gun, operate the third cylinder to drive the connecting rod to lower the first telescopic plate and the second telescopic plate at the same time, set the first baffle and the second baffle to prevent the water spray gun from splashing other mechanisms, The arrangement of the first telescopic plate and the second telescopic plate can make the movement of the glass slide unimpeded and make the structure more reasonable.

The present invention further provides that: the flushing mechanism further includes a drainage assembly, and the drainage assembly includes a water outlet that is arranged to match the sloping plate between the first baffle and the second baffle and the sloping plate, so The water outlet is provided with a drain pipe, and the drain pipe is provided with a drain port.

By adopting the above-mentioned technical scheme, a drainage assembly is installed to avoid water accumulation in the device, a sloping plate is provided to collect the accumulated water to the water outlet, and a drainage pipe is connected to the water outlet to discharge the box through the water outlet to avoid water accumulation.

The present invention further provides that: the drying mechanism includes an air delivery pipe for transporting hot air, the air delivery pipe includes a first pipeline, a second pipeline, and a third pipeline, the first pipeline is connected to the second pipeline, The interface between the first pipeline and the second pipeline is provided with an air outlet for drying glass slides, the other end of the second pipeline is connected to the third pipeline, and the lower part of the first baffle is connected to the A "U"-shaped pipe is arranged between the second baffles, and the third pipe is connected with the "U"-shaped pipe.

By adopting the above technical scheme, the moving mechanism is operated to move the rinsed slides to the blowing port, and the hot air is conveyed in the air duct, and the hot air passing through the blowing port dries the slides, and the excess hot air will enter along the second and third pipes The "U"-shaped pipe dries the water splashed on the first expansion plate and the second expansion plate during the previous flushing to prevent water accumulation, and at the same time uses hot air for the second time, which is energy-saving and environmentally friendly.

The present invention further provides that: the moving mechanism includes a track arranged on the second box body, a clamping assembly fixed in the track and moving along the track, and a power set above the track for controlling the movement of the clamping assembly component, the clamping component is connected with the power component.

By adopting the above technical solution, the power component drives the clamping component to move along the track, thereby enhancing the structural stability.

The present invention further provides that: the clamping assembly includes a fixing part used to connect with the power assembly, a sliding part clamped in the track, a third connecting part arranged under the sliding part, and a third connecting part Clamping part with detachable connection.

By adopting the above-mentioned technical scheme, the upper part of the clamping component is connected to the power component by the fixed part, the middle part is the sliding part which is clamped in the track, the lower part is the connecting part, and the lower end of the third connecting part is detachably connected to the clamping part. The holder can be replaced according to the number of slides.

The present invention further provides that: the clamping portion may be in the shape of a single hook, double hooks or multiple hooks.

By adopting the above technical solution, the clamping part can be in the shape of single hook, double hook or multiple hooks, and can be replaced according to the number of glass slides.

The specific implementation manner of the present invention will be described below in conjunction with the accompanying drawings and examples.

Description of drawings

Fig. 1 is a sectional view of the first use state of the embodiment of the present invention;

Figure 2 is an enlarged view of part A of Figure 1;

Fig. 3 is the sectional view of the second casing of the embodiment of the present invention;

4 is a perspective view of a second box body according to an embodiment of the present invention;

Fig. 5 is an enlarged view of part B of Fig. 4;

Fig. 6 is a cross-sectional view of the second use state of the embodiment of the present invention;

Fig. 7 is a cross-sectional view of the third use state of the embodiment of the present invention.

Reference signs: 1. The first cabinet, 11. The second opening, 12. The door panel, 2. The grill mechanism, 21. The first cylinder, 22. The first storage table, 3. The second cabinet, 31. The first One opening, 4. Film display mechanism, 41. The second cylinder, 42. The second storage table, 43. The tape display container, 44. The termination reaction container, 45. The dyeing container, 46. The guide assembly, 461. The first connection part . 515. Second connecting part, 516. Connecting rod, 517. Third cylinder, 52. Water spray gun, 53. Drain assembly, 531. Inclined plate, 532. Water outlet, 533. Drain pipe, 534. Drain outlet, 6 .Drying mechanism, 61. Air duct, 611. First pipeline, 612. Second pipeline, 613. Third pipeline, 614. Blowing port, 62. "U" shaped pipeline, 7. Moving mechanism, 71. Track , 72. Power assembly, 73. Clamping assembly, 731. Fixed part, 732. Sliding part, 733. Third connecting part, 734. Clamping part.

Detailed ways

This specific embodiment is only an explanation of the present invention, and it is not a limitation of the present invention. Those skilled in the art can make modifications to this embodiment without creative contribution as required after reading this specification, but as long as they are within the rights of the present invention All claims are protected by patent law.

Referring to accompanying drawings 1-6, an automatic chromosome banding device with a drying film machine disclosed in this embodiment includes a first box 1 and a second box 3, the first box 1 and the second box 3, the first box 1 is provided with a baking mechanism 2 for heating the glass slides, the second box 3 is provided with a display mechanism 4 for developing the glass slides, and is used for washing the glass slides. A flushing mechanism 5 for the slide, a drying mechanism 6 for drying the slide, and a moving mechanism 7 for controlling the movement of the slide, the moving mechanism 7 is arranged above the second box body 3, and the slide mechanism 4 , a washing mechanism 5 and a drying mechanism 6 are arranged in sequence, and a first opening 31 is arranged on a side of the second box body 3 opposite to the display mechanism 4 .

In this embodiment, it is further provided that: the slice baking mechanism 2 includes a first air cylinder 21 and a first storage table 22 for placing slides, the first air cylinder 21 is arranged under the first storage table 22, and the first air cylinder 21 is arranged below the first storage table 22. A cylinder 21 drives the first storage table 22 to move up and down, the top of the first box body 1 is provided with a second opening 11 compatible with the first storage table 22, and the second opening 11 is provided with a suitable Matching door panel 12.

In this embodiment, it is further provided that the display mechanism 4 includes a second cylinder 41 and a second storage table 42 for placing containers, the second cylinder 41 is arranged under the second storage table 42, and the second Above the object table 42, a banding container 43, a termination reaction container 44, and a dyeing container 45 are arranged respectively. The banding container 43 is provided with a solution for developing bands, the reaction container is provided with physiological saline, and the dyeing container 45 is provided with a dyeing solution, a guide assembly 46 is provided between the second storage table 42 and the second box body 3, and the second cylinder 41 drives the second storage table 42 along the guide assembly 46 Moving up and down.

In this embodiment, it is further provided that: the guide assembly 46 includes a first connecting part 461 arranged on the side of the second storage table 42, and the side of the second box 3 opposite to the first connecting part 461 is provided with a connection with the first connecting part 461. The first connecting portion 461 is fitted with a track groove 462 , and the first connecting portion 461 is provided with a locking block 463 that is locked in the track groove 462 .

In this embodiment, it is further provided that the flushing mechanism 5 includes a water blocking assembly 51 and a water spray gun 52, and the water blocking assembly 51 includes a first baffle 511 and a second baffle 512 arranged on the bottom surface of the second box body 3 , the first baffle plate 511 and the second baffle plate 512 are vertically connected, the first baffle plate 511 is provided with a first telescopic plate 513, and the second baffle plate 512 is provided with a second telescopic plate 514, A second connecting portion 515 is provided between the first telescopic plate 513 and the second telescopic plate 514, and a connecting rod 516 is provided on the other side of the first telescopic plate 513 opposite to the second connecting portion 515, The connecting rod 516 is connected with the third cylinder 517, and the third cylinder 517 drives the connecting rod 516 to move up and down,

In this embodiment, it is further provided that: the flushing mechanism 5 further includes a drainage assembly 53, and the drainage assembly 53 includes a sloping plate 531 and the sloping plate 531 arranged between the first baffle plate 511 and the second baffle plate 512 Compatible with the water outlet 532 , the water outlet 532 is provided with a drainage pipe 533 , and the drainage pipe 533 is provided with a water outlet 534 .

In this embodiment, it is further provided that: the drying mechanism 6 includes an air delivery pipe 61 for conveying hot air, and the air delivery pipe 61 includes a first pipeline 611, a second pipeline 612, and a third pipeline 613. The first pipeline 611 is connected with the second pipeline 612, the interface between the first pipeline 611 and the second pipeline 612 is provided with a blower port 614 for drying slides, the other end of the second pipeline 612 is connected with the third pipeline 613 are connected, a "U"-shaped pipe 62 is provided between the bottom of the first baffle 511 and the bottom of the second baffle 512 , and the third pipe 613 is connected to the "U"-shaped pipe 62 .

In this embodiment, it is further provided that the moving mechanism 7 includes a track 71 arranged on the second box body 3, a clamping assembly 73 which is clamped in the track 71 and moves along the track 71, and is arranged above the track 71 for controlling The clamping component 73 moves the power component 72 , and the clamping component 73 is connected with the power component 72 .

In this embodiment, it is further provided that: the clamping assembly 73 includes a fixing part 731 for connecting with the power assembly 72, a sliding part 732 clamped in the track 71, and a third part below the sliding part 732. The connecting part 733 and the clamping part 734 detachably connected with the third connecting part 733 .

In this embodiment, it is further provided that: the clamping portion 734 may be in the shape of a single hook, double hooks or multiple hooks.

Although this paper uses more: the first box body 1, the second opening 11, the baking sheet mechanism 2, the first cylinder 21, the first storage table 22, the second box body 3, the first opening 31, the door panel 12, the display Sheet mechanism 4, second cylinder 41, second storage table 42, developing tape container 43, termination reaction container 44, dyeing container 45, guide assembly 46, first connecting part 461, track groove 462, clamping block 463, flushing mechanism 5 , the water blocking assembly 51, the first baffle plate 511, the second baffle plate 512, the first telescopic plate 513, the second telescopic plate 514, the second connecting portion 515, the connecting rod 516, the third cylinder 517, the water spray gun 52, Drain assembly 53, inclined plate 531, water outlet 532, drainage pipe 533, water outlet 534, drying mechanism 6, air delivery pipe 61, first pipe 611, second pipe 612, third pipe 613, air outlet 614, " U"-shaped pipe 62, moving mechanism 7, track 71, power assembly 72, clamping assembly 73, fixed part 731, sliding part 732, third connecting part 733, clamping part 734 and other terms, but do not exclude the use of other terms possibility. These terms are used only for the purpose of describing and explaining the essence of the present invention more conveniently; interpreting them as any kind of additional limitation is against the spirit of the present invention.

Claims (10)

1. a kind of chromosome with drymaster shows band device automatically, it is characterised in that：It is described including the first cabinet, the second cabinet First cabinet and the second cabinet are connected, and are provided with the Kao Pian mechanism for heating slide in first cabinet, and described second The Xian Pian mechanism for making slide carry out aobvious band, the flushing machine for rinsing slide, the baking for drying slide are provided in cabinet Dry mechanism and the mobile mechanism for controlling slide movement, the mobile mechanism are set to the top of second cabinet, the aobvious piece Mechanism, flushing machine, drying mechanism are sequentially arranged, and the side of the relatively described Xian Pian mechanism of second cabinet is provided with first and opens Mouthful.

2. a kind of chromosome with drymaster according to claim 1 shows band device automatically, it is characterised in that：The roasting piece Mechanism includes the first cylinder, the first articles holding table for placing slide, and first cylinder is set under first articles holding table Side, first cylinder drive the first articles holding table to move up and down, are provided with above first cabinet and first glove Compatible second opening of platform, second opening are provided with compatible door-plate.

3. a kind of chromosome with drymaster according to claim 1 shows band device automatically, it is characterised in that：The aobvious piece Mechanism includes the second cylinder, the second articles holding table for placing container, and second cylinder is set under second articles holding table Side, the second articles holding table top is respectively arranged with aobvious band container, terminates reaction vessel, dyeing container, in the aobvious band container It is provided with the solution for showing band, physiological saline is provided in the reaction vessel, it is molten that dyeing is provided in the dyeing container Liquid, is provided with guidance set between second articles holding table and second cabinet, second cylinder drives second to set Object platform is moved up and down along the guidance set.

4. a kind of chromosome with drymaster according to claim 3 shows band device automatically, it is characterised in that：The guiding Component includes the first connecting portion for being set to second articles holding table side, the relatively described first connecting portion of the second cabinet Side is provided with track groove compatible with the first connecting portion, is provided in the first connecting portion and is arranged in the track The fixture block of slot.

5. a kind of chromosome with drymaster according to claim 1 shows band device automatically, it is characterised in that：The flushing Mechanism includes water blocking component and water pistol, and the water blocking component includes the first baffle being set in the second tank floor, second Baffle, the first baffle, second baffle are provided with the first expansion plate in the first baffle in conducting setting up and down, and second It is provided with the second expansion plate in baffle, is provided with second connecting portion between first expansion plate and second expansion plate, institute The other side for stating the relatively described second connecting portion of the first expansion plate is provided with connecting rod, and the connecting rod is connected with third cylinder It connects, the third cylinder drives the connecting rod to move up and down.

6. a kind of chromosome with drymaster according to claim 5 shows band device automatically, it is characterised in that：The flushing Mechanism further includes drain assembly, and the drain assembly includes setting and the inclined plate between the first baffle, second baffle and institute The compatible collector nozzle of inclined plate is stated, the collector nozzle is provided with drainage pipeline, and the drainage pipeline is provided with discharge outlet.

7. a kind of chromosome with drymaster according to claim 5 shows band device automatically, it is characterised in that：The drying Mechanism includes the wind conveying pipe for heat air delivery, and the wind conveying pipe includes first pipe, second pipe, third pipeline, and described One pipeline is connected with second pipe, and the first pipe is provided with the second pipe interface for drying blowing for slide Air port, the second pipe other end are connected with the third pipeline, below the first baffle and under the second baffle " u "-shaped pipeline is provided between side, the third pipeline is connected with the " u "-shaped pipeline.

8. a kind of chromosome with drymaster according to claim 1 shows band device automatically, it is characterised in that：The movement Mechanism includes the track being set on the second cabinet, is arranged in the clamp assemblies moved in track along track and is set to the rail For controlling the mobile Power Component of the clamp assemblies above road, the clamp assemblies are connected with the Power Component.

9. a kind of chromosome with drymaster according to claim 8 shows band device automatically, it is characterised in that：The clamping Component includes fixed part for being connected with the Power Component, the sliding part being arranged in track, is set to the sliding Third interconnecting piece below portion and the clamping part being detachably connected with third interconnecting piece.

10. a kind of chromosome with drymaster according to claim 9 shows band device automatically, it is characterised in that：The folder The portion of holding can be single hook shape, double hook shape or how hook-shaped.