CN108837174A - A kind of preparation method of medical dressing - Google Patents
A kind of preparation method of medical dressing Download PDFInfo
- Publication number
- CN108837174A CN108837174A CN201810808268.6A CN201810808268A CN108837174A CN 108837174 A CN108837174 A CN 108837174A CN 201810808268 A CN201810808268 A CN 201810808268A CN 108837174 A CN108837174 A CN 108837174A
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- China
- Prior art keywords
- dressing
- impregnated
- hospital gauze
- preparation
- liquid
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 229920002907 Guar gum Polymers 0.000 claims abstract description 26
- 239000000665 guar gum Substances 0.000 claims abstract description 26
- 229960002154 guar gum Drugs 0.000 claims abstract description 26
- 235000010417 guar gum Nutrition 0.000 claims abstract description 26
- 239000007788 liquid Substances 0.000 claims abstract description 25
- 229920001661 Chitosan Polymers 0.000 claims abstract description 15
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229920002472 Starch Polymers 0.000 claims abstract description 15
- ZRALSGWEFCBTJO-UHFFFAOYSA-N anhydrous guanidine Natural products NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000013078 crystal Substances 0.000 claims abstract description 15
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000008107 starch Substances 0.000 claims abstract description 15
- 235000019698 starch Nutrition 0.000 claims abstract description 15
- 229920001046 Nanocellulose Polymers 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000008367 deionised water Substances 0.000 claims abstract description 10
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 10
- 238000004090 dissolution Methods 0.000 claims abstract description 10
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 abstract description 6
- 230000035699 permeability Effects 0.000 abstract description 5
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 4
- 208000027418 Wounds and injury Diseases 0.000 description 10
- 206010052428 Wound Diseases 0.000 description 9
- 238000002604 ultrasonography Methods 0.000 description 7
- 238000000034 method Methods 0.000 description 4
- 239000000654 additive Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 239000000084 colloidal system Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- -1 safety It is high Substances 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of preparation methods of medical dressing, include the following steps：S1, by guar gum, starch, nano cellulose crystal and guanidine radicals chitosan, heat ultrasonic dissolution in deionized water in ultrasonic oscillator, obtain dressing and be impregnated with liquid；S2, it hospital gauze is impregnated with is impregnated in liquid in the dressing that S1 is obtained, after ultrasonic a period of time, take out hospital gauze；S3, hospital gauze in S2 is freeze-dried, obtains medical dressing.The medical dressing obtained using preparation method of the present invention solves the problems, such as the absorption of diffusate while maintaining antibacterial functions and gas permeability.
Description
Technical field
The present invention relates to medical care technical fields, and in particular to a kind of preparation method of medical dressing.
Background technique
General patient wound position is easy to happen sepage, and wound cannot be exposed in air for a long time, otherwise be held
Easily cause infection, conventional wound dressing is short using the time, and poor air permeability, absorption is limited, wound be easy to cause it is red, swollen,
The adverse reactions such as exudation, influence the healing of wound.At present clinically for surgical incision filling use gauze dressing,
Netted dressing and antiseptic dressing, but comprehensive ventilative, absorption of diffusate and the surface of a wound scar of wound cannot be solved simultaneously, cause
Therapeutic effect is poor.And common gauze dressing filling is relatively difficult, is not easy to operate, certain pain is brought to patient.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of preparation method of medical dressing, is obtained using this method
Medical dressing solves the problems, such as the absorption of diffusate while maintaining antibacterial functions and gas permeability.
To achieve the goals above, the present invention uses following technical scheme：
A kind of preparation method of medical dressing, includes the following steps：
S1, by guar gum, starch, nano cellulose crystal and guanidine radicals chitosan, ultrasonic dissolution is heated in ultrasonic oscillator
In deionized water, it obtains dressing and is impregnated with liquid；
S2, it hospital gauze is impregnated with is impregnated in liquid in the dressing that S1 is obtained, after ultrasonic a period of time, take out hospital gauze；
S3, hospital gauze in S2 is freeze-dried, obtains medical dressing.
The effect of guar gum is macromolecular Natural hydrophilic colloid, forms colloid substance after chance water, reaches rapid thickening.This
Invention is impregnated in liquid in dressing is added guar gum, absorption of the medical dressing to diffusate can be enhanced, while playing adhesive
Effect, enables dressing to be impregnated with liquid and is firmly combined with hospital gauze.Starch is widely used in conventional medical material, safety
It is high, and glue can be become after absorbing penetrating fluid, starch is added, guar gum is regulated and controled, diffusate is most preferably inhaled with reaching
It receives.Nano cellulose crystal diameter is the fiber of Nano grade, while having biocompatibility, and nano cellulose crystal is added can
It is firmly wound so that dressing is impregnated with the additive in liquid and is attached on hospital gauze.Guanidine radicals chitosan has antibacterial effect, energy
It is enough that medical dressing keeps effective anti-microbial property.The above different materials all have biocompatibility, will not be to patient wound's skin
Bring additional injury.
And medical dressing of the invention is prepared using impregnating method, so that dressing is impregnated with the additive in liquid and is evenly affixed to
On the cable of hospital gauze, the gas permeability of gauze is maintained.
The hospital gauze being impregnated with is dried using the method for freeze-drying, effectively prevents being impregnated in liquid dressing
The destruction of additive maintains the bioactivity of guar gum Yu guanidine radicals chitosan.
Preferably, the mass ratio of the guar gum, starch, nano cellulose crystal and guanidine radicals chitosan is 1：（0.5-
0.6）：（0.1-0.5）：（0.01-0.05）.
Preferably, the dissolved concentration of the guar gum is 1g/mL.
Preferably, heating temperature is 50-60 DEG C in S1.It can make guar gum, starch, nano-cellulose under this temperature range
Crystal and guanidine radicals chitosan sufficiently dissolve, and will not destroy its bioactivity.
Preferably, the time ultrasonic in S2 is 12-24 h.
Another aspect of the present invention also provides the medical dressing that above-mentioned preparation method obtains.
Beneficial effects of the present invention
Using the preparation method of medical dressing provided by the invention, obtained medical dressing is maintaining antibacterial functions and gas permeability
While, solve the problems, such as the absorption of diffusate.
Specific embodiment
The present invention is specifically described below by embodiment, it is necessary to which indicated herein is that the present embodiment is served only for pair
The present invention is further described, and should not be understood as limiting the scope of the invention, and the person skilled in the art in the field can
To make some nonessential modifications and adaptations according to the content invented above.In the absence of conflict, the reality in the present invention
The feature applied in example and embodiment can be combined with each other.
Embodiment 1
S1, by guar gum, starch, nano cellulose crystal and guanidine radicals chitosan according to 1：0.5：0.1：0.01 mass ratio claims
It takes, 50 DEG C of ultrasonic dissolutions is heated in ultrasonic oscillator in deionized water, so that the dissolved concentration of guar gum is 1g/
ML obtains dressing and is impregnated with liquid；
S2, it hospital gauze is impregnated with is impregnated in liquid in the dressing that S1 is obtained, after 12 h of ultrasound, take out hospital gauze；
S3, hospital gauze in S2 is freeze-dried, obtains medical dressing.
Embodiment 2
S1, by guar gum, starch, nano cellulose crystal and guanidine radicals chitosan according to 1：0.6：0.1：0.01 mass ratio claims
It takes, 50 DEG C of ultrasonic dissolutions is heated in ultrasonic oscillator in deionized water, so that the dissolved concentration of guar gum is 1g/
ML obtains dressing and is impregnated with liquid；
S2, it hospital gauze is impregnated with is impregnated in liquid in the dressing that S1 is obtained, after 12 h of ultrasound, take out hospital gauze；
S3, hospital gauze in S2 is freeze-dried, obtains medical dressing.
Embodiment 3
S1, by guar gum, starch, nano cellulose crystal and guanidine radicals chitosan according to 1：0.5：0.3：0.01 mass ratio claims
It takes, 50 DEG C of ultrasonic dissolutions is heated in ultrasonic oscillator in deionized water, so that the dissolved concentration of guar gum is 1g/
ML obtains dressing and is impregnated with liquid；
S2, it hospital gauze is impregnated with is impregnated in liquid in the dressing that S1 is obtained, after 12 h of ultrasound, take out hospital gauze；
S3, hospital gauze in S2 is freeze-dried, obtains medical dressing.
Embodiment 4
S1, by guar gum, starch, nano cellulose crystal and guanidine radicals chitosan according to 1：0.5：0.5：0.01 mass ratio claims
It takes, 50 DEG C of ultrasonic dissolutions is heated in ultrasonic oscillator in deionized water, so that the dissolved concentration of guar gum is 1g/
ML obtains dressing and is impregnated with liquid；
S2, it hospital gauze is impregnated with is impregnated in liquid in the dressing that S1 is obtained, after 12 h of ultrasound, take out hospital gauze；
S3, hospital gauze in S2 is freeze-dried, obtains medical dressing.
Embodiment 5
S1, by guar gum, starch, nano cellulose crystal and guanidine radicals chitosan according to 1：0.5：0.1：0.03 mass ratio claims
It takes, 50 DEG C of ultrasonic dissolutions is heated in ultrasonic oscillator in deionized water, so that the dissolved concentration of guar gum is 1g/
ML obtains dressing and is impregnated with liquid；
S2, it hospital gauze is impregnated with is impregnated in liquid in the dressing that S1 is obtained, after 12 h of ultrasound, take out hospital gauze；
S3, hospital gauze in S2 is freeze-dried, obtains medical dressing.
Embodiment 6
S1, by guar gum, starch, nano cellulose crystal and guanidine radicals chitosan according to 1：0.5：0.1：0.05 mass ratio claims
It takes, 50 DEG C of ultrasonic dissolutions is heated in ultrasonic oscillator in deionized water, so that the dissolved concentration of guar gum is 1g/
ML obtains dressing and is impregnated with liquid；
S2, it hospital gauze is impregnated with is impregnated in liquid in the dressing that S1 is obtained, after 12 h of ultrasound, take out hospital gauze；
S3, hospital gauze in S2 is freeze-dried, obtains medical dressing.
Embodiment 7
S1, by guar gum, starch, nano cellulose crystal and guanidine radicals chitosan according to 1：0.5：0.1：0.05 mass ratio claims
It takes, 60 DEG C of ultrasonic dissolutions is heated in ultrasonic oscillator in deionized water, so that the dissolved concentration of guar gum is 1g/
ML obtains dressing and is impregnated with liquid；
S2, it hospital gauze is impregnated with is impregnated in liquid in the dressing that S1 is obtained, after 24 h of ultrasound, take out hospital gauze；
S3, hospital gauze in S2 is freeze-dried, obtains medical dressing.
Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on this
Embodiment in invention, every other reality obtained by those of ordinary skill in the art without making creative efforts
Example is applied, the scope of the present invention is belonged to.
Claims (6)
1. a kind of preparation method of medical dressing, which is characterized in that include the following steps：
S1, by guar gum, starch, nano cellulose crystal and guanidine radicals chitosan, ultrasonic dissolution is heated in ultrasonic oscillator
In deionized water, it obtains dressing and is impregnated with liquid；
S2, it hospital gauze is impregnated with is impregnated in liquid in the dressing that S1 is obtained, after ultrasonic a period of time, take out hospital gauze；
S3, hospital gauze in S2 is freeze-dried, obtains medical dressing.
2. preparation method according to claim 1, which is characterized in that the guar gum, starch, nano cellulose crystal and
The mass ratio of guanidine radicals chitosan is 1：（0.5-0.6）：（0.1-0.5）：（0.01-0.05）.
3. preparation method according to claim 2, which is characterized in that the dissolved concentration of guar gum is 1g/mL.
4. preparation method according to claim 1, which is characterized in that heating temperature is 50-60 DEG C in S1.
5. preparation method according to claim 1, which is characterized in that the ultrasonic time is 12-24 h in S2.
6. a kind of medical dressing obtained by any preparation method of claim 1-5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810808268.6A CN108837174A (en) | 2018-07-22 | 2018-07-22 | A kind of preparation method of medical dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810808268.6A CN108837174A (en) | 2018-07-22 | 2018-07-22 | A kind of preparation method of medical dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108837174A true CN108837174A (en) | 2018-11-20 |
Family
ID=64197763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810808268.6A Pending CN108837174A (en) | 2018-07-22 | 2018-07-22 | A kind of preparation method of medical dressing |
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| Country | Link |
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| CN (1) | CN108837174A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005021057A1 (en) * | 2003-08-29 | 2005-03-10 | Ethicon, Inc. | Impregnated charcoal cloth as wound dressing |
| EP1679086A2 (en) * | 2004-12-27 | 2006-07-12 | Bristol-Myers Squibb Company | Enzyme inhibiting adhesives |
| CN1944495A (en) * | 2006-09-29 | 2007-04-11 | 北京大学 | Water gel containing natural high molecule and its radiation preparing method |
| CN101224310A (en) * | 2008-01-18 | 2008-07-23 | 中国人民解放军第四军医大学 | A medical wound dressing loaded with antibacterial drug nanoparticles |
| US20160213808A1 (en) * | 2006-05-26 | 2016-07-28 | Z-Medica, Llc | Clay-based hemostatic agents |
| CN106075556A (en) * | 2016-06-02 | 2016-11-09 | 四川奎星医用高分子制品有限责任公司 | Containing the medical recombination chitosan gel promoting wound healing medicine |
-
2018
- 2018-07-22 CN CN201810808268.6A patent/CN108837174A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005021057A1 (en) * | 2003-08-29 | 2005-03-10 | Ethicon, Inc. | Impregnated charcoal cloth as wound dressing |
| EP1679086A2 (en) * | 2004-12-27 | 2006-07-12 | Bristol-Myers Squibb Company | Enzyme inhibiting adhesives |
| US20160213808A1 (en) * | 2006-05-26 | 2016-07-28 | Z-Medica, Llc | Clay-based hemostatic agents |
| CN1944495A (en) * | 2006-09-29 | 2007-04-11 | 北京大学 | Water gel containing natural high molecule and its radiation preparing method |
| CN101224310A (en) * | 2008-01-18 | 2008-07-23 | 中国人民解放军第四军医大学 | A medical wound dressing loaded with antibacterial drug nanoparticles |
| CN106075556A (en) * | 2016-06-02 | 2016-11-09 | 四川奎星医用高分子制品有限责任公司 | Containing the medical recombination chitosan gel promoting wound healing medicine |
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