CN108836897A - A kind of cosmetics and preparation method thereof containing Rosa Damascana - Google Patents
A kind of cosmetics and preparation method thereof containing Rosa Damascana Download PDFInfo
- Publication number
- CN108836897A CN108836897A CN201810950382.2A CN201810950382A CN108836897A CN 108836897 A CN108836897 A CN 108836897A CN 201810950382 A CN201810950382 A CN 201810950382A CN 108836897 A CN108836897 A CN 108836897A
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- CN
- China
- Prior art keywords
- parts
- rosa damascana
- modified
- cosmetics
- polyquaternium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 235000011449 Rosa Nutrition 0.000 title claims abstract description 51
- 239000002537 cosmetic Substances 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 40
- -1 glycyrrhizic acid surface-modified fullerenes Chemical class 0.000 claims abstract description 35
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 claims abstract description 27
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229960004949 glycyrrhizic acid Drugs 0.000 claims abstract description 27
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000001685 glycyrrhizic acid Substances 0.000 claims abstract description 27
- 235000019410 glycyrrhizin Nutrition 0.000 claims abstract description 27
- 239000000341 volatile oil Substances 0.000 claims abstract description 21
- 150000002254 galactosylceramides Chemical class 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000004615 ingredient Substances 0.000 claims abstract description 15
- 239000000284 extract Substances 0.000 claims abstract description 11
- 240000006497 Dianthus caryophyllus Species 0.000 claims abstract description 10
- 235000009355 Dianthus caryophyllus Nutrition 0.000 claims abstract description 10
- 235000019082 Osmanthus Nutrition 0.000 claims abstract description 9
- 241000333181 Osmanthus Species 0.000 claims abstract description 9
- FEPAFOYQTIEEIS-UHFFFAOYSA-N 2',5'-Bis(3,4,5-trihydroxybenzoyl)-beta-D-Furanose-2-C-Hydroxymethylribose Natural products OC1C(COC(=O)C=2C=C(O)C(O)=C(O)C=2)(O)C(O)OC1COC(=O)C1=CC(O)=C(O)C(O)=C1 FEPAFOYQTIEEIS-UHFFFAOYSA-N 0.000 claims abstract description 8
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims abstract description 8
- 241000605385 Ruscus Species 0.000 claims abstract description 8
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims abstract description 8
- FEPAFOYQTIEEIS-IZUGRSKYSA-N [(2r,3r,4r)-3,4,5-trihydroxy-4-[(3,4,5-trihydroxybenzoyl)oxymethyl]oxolan-2-yl]methyl 3,4,5-trihydroxybenzoate Chemical compound C([C@H]1OC([C@@]([C@@H]1O)(O)COC(=O)C=1C=C(O)C(O)=C(O)C=1)O)OC(=O)C1=CC(O)=C(O)C(O)=C1 FEPAFOYQTIEEIS-IZUGRSKYSA-N 0.000 claims abstract description 8
- 235000021283 resveratrol Nutrition 0.000 claims abstract description 8
- 229940016667 resveratrol Drugs 0.000 claims abstract description 8
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 7
- 239000002562 thickening agent Substances 0.000 claims abstract description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 32
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 29
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 28
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 claims description 18
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 16
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 15
- DDOVBCWVTOHGCU-QMXMISKISA-N n-[(e,2s,3r)-3-hydroxy-1-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxynonadec-4-en-2-yl]octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O DDOVBCWVTOHGCU-QMXMISKISA-N 0.000 claims description 15
- 210000003296 saliva Anatomy 0.000 claims description 15
- 239000002904 solvent Substances 0.000 claims description 15
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 12
- 235000019441 ethanol Nutrition 0.000 claims description 12
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 11
- ADNBOFQFSCPWBA-RJMJUYIDSA-N [Na].O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O Chemical compound [Na].O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O ADNBOFQFSCPWBA-RJMJUYIDSA-N 0.000 claims description 10
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 9
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 9
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 235000019155 vitamin A Nutrition 0.000 claims description 9
- 239000011719 vitamin A Substances 0.000 claims description 9
- 229940045997 vitamin a Drugs 0.000 claims description 9
- 238000009835 boiling Methods 0.000 claims description 8
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000003960 organic solvent Substances 0.000 claims description 8
- 238000010992 reflux Methods 0.000 claims description 8
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 7
- 238000013019 agitation Methods 0.000 claims description 7
- 150000001336 alkenes Chemical class 0.000 claims description 7
- 238000007599 discharging Methods 0.000 claims description 7
- 239000006185 dispersion Substances 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 238000004806 packaging method and process Methods 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 238000005406 washing Methods 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 6
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 4
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims description 4
- 239000012298 atmosphere Substances 0.000 claims description 4
- 150000002191 fatty alcohols Chemical class 0.000 claims description 4
- 150000008195 galaktosides Chemical class 0.000 claims description 4
- 210000005036 nerve Anatomy 0.000 claims description 4
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 4
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 150000001408 amides Chemical class 0.000 claims description 3
- 239000007789 gas Substances 0.000 claims description 3
- 239000001307 helium Substances 0.000 claims description 3
- 229910052734 helium Inorganic materials 0.000 claims description 3
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 3
- 239000011261 inert gas Substances 0.000 claims description 3
- 229910052754 neon Inorganic materials 0.000 claims description 3
- GKAOGPIIYCISHV-UHFFFAOYSA-N neon atom Chemical compound [Ne] GKAOGPIIYCISHV-UHFFFAOYSA-N 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical group [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 claims description 2
- 229910052786 argon Inorganic materials 0.000 claims description 2
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims 2
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 claims 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 2
- 230000003712 anti-aging effect Effects 0.000 abstract description 9
- 230000002087 whitening effect Effects 0.000 abstract description 5
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 4
- 230000003385 bacteriostatic effect Effects 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 description 14
- 238000006243 chemical reaction Methods 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 7
- 229930182478 glucoside Natural products 0.000 description 7
- 150000003863 ammonium salts Chemical class 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 241000220317 Rosa Species 0.000 description 5
- 239000006071 cream Substances 0.000 description 5
- 150000008131 glucosides Chemical class 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 159000000000 sodium salts Chemical class 0.000 description 5
- DCPMPXBYPZGNDC-UHFFFAOYSA-N hydron;methanediimine;chloride Chemical compound Cl.N=C=N DCPMPXBYPZGNDC-UHFFFAOYSA-N 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- XDQGMXYCBZNEAG-UHFFFAOYSA-N C(C)[C]CCCN(C)C Chemical compound C(C)[C]CCCN(C)C XDQGMXYCBZNEAG-UHFFFAOYSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000002500 effect on skin Effects 0.000 description 3
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- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical class C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 240000000353 Ruscus aculeatus Species 0.000 description 2
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- 206010023126 Jaundice Diseases 0.000 description 1
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- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 235000004789 Rosa xanthina Nutrition 0.000 description 1
- 241000220222 Rosaceae Species 0.000 description 1
- 102100038123 Teneurin-4 Human genes 0.000 description 1
- 101710122302 Teneurin-4 Proteins 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
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- 150000001298 alcohols Chemical class 0.000 description 1
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- 238000011031 large-scale manufacturing process Methods 0.000 description 1
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- 239000011707 mineral Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical group 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000036555 skin type Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of cosmetics containing Rosa Damascana, are made of the ingredient of following parts by weight：10-15 parts of galactosyl ceramide derivative, 1-5 parts of glycyrrhizic acid surface-modified fullerenes, modified Polyquaternium-10 10-15 parts, 0.1-0.3 parts of Rosa Damascana, 0.01-0.03 parts of Ruscus extract, 0.01-0.03 parts of carnation essential oil, 0.01-0.03 parts of osmanthus essential oil, 1-5 parts of hamameli tannin, 0.5-2 parts of resveratrol, 0.5-1 parts of thickener, 2-4 parts of emulsifier, 15-20 parts of water.The invention also discloses the preparation methods of the cosmetics containing Rosa Damascana.Cosmetics disclosed by the invention containing Rosa Damascana have good nourishing skin care, whitening anti-aging, crease-resistant, antibacterial bacteriostatic effect to skin, and performance is stablized, using safe and effective.
Description
Technical field
The present invention relates to cosmetic technical field more particularly to a kind of contain the cosmetics of Rosa Damascana and its preparation side
Method.
Background technique
With the sharp deterioration of modern society's air pollution, rhythm of life it is continuous accelerate, the day of life and work pressure
Benefit increases, and the free radical balance of the skin surface of more and more people is destroyed, and body will generate excessive free radical therewith, thus
Skin is caused the feature of the agings such as wrinkle, dry keratinization, tarnish and color spot excess deposition occur, so that originally honorable shine
People's gradually becomes obscure unglazed, colour of skin jaundice, long spot on the face, and the growth in particular with the age is even more so, these for
It is that one faced has to face and is difficult to solve for the modern society people tighter to quality of life and beautiful requirement
The problem of.
It is a kind of solve the above problems that the immunization barrier of this road human body of autologous skin is maintained and takeed good care of using cosmetics
Effective ways, this has become to know together.First barrier of the cosmetics as protection skin, it can play cleaning and mend to skin
The effect of water, moreover it is possible to play anti-aging, it is crease-resistant, adjust skin pH-value the effect of.However, existing commercially available cosmetic composition is multiple
Miscellaneous, primary raw material is mineral extract, such as hydro carbons, alcohols, and cooperation raw material is chemical products colorant, essence and preservative
Deng these ingredients contain to a certain extent to the harmful ingredient of skin, easily cause allergic reaction.Secondly, its moistening effect
It is not good enough, assimilation effect is poor, moisture preserving time is not lasting enough, anti-aging, crease-resistant effect are unobvious, and cost performance is low, do not reach consumption
Person is expected skin effect.
Rosa Damascana is a kind of natural rare spice extracted from rosaceae roseleaf, is known as " liquid Huang
Gold ".Its elegant fragrance is strong, quality is pure.It is medicinal to slow down fatigue, tranquilizing and allaying excitement, pressure of releiving, also have and adjusts in human body
Secretion balance makes the bright and clean moist beauty and health care functions of skin, the favor by consumer's especially female consumer.Therefore,
The multi-purpose auxiliary material for doing luxury food, cosmetics and daily chemical products of natural rose essential, has a vast market foreground.However, rose
Rare essential oil using when there are absorption rates it is low, irritating to stomach and intestine the disadvantages of.Further, since Rosa Damascana has good wave
Hair property, cannot keep rose scent for a long time, and many ingredients are easy loss and oxidation in production and storage and transport process, give its storage
Inconvenience is brought with using.
Therefore, select suitable ingredient, and Rosa Damascana reasonable compatibility, prepare a kind of performance stabilization, anti aging effect,
It is crease-resistant and performance of keeping humidity is excellent, is accorded with the demands of the market using safely and effectively cosmetics, there is extensive market value and application
Prospect.
Summary of the invention
In order to overcome the defects of the prior art, the present invention provides a kind of containing the cosmetics of Rosa Damascana and its preparation side
Method, the preparation method have good nourishing skin care, whitening anti-using suitable ingredient and Rosa Damascana reasonable compatibility, to skin
Aging, crease-resistant, antibacterial bacteriostatic effect, and performance is stablized, using safe and effective.
To achieve the above object of the invention, the technical solution adopted by the present invention is that, a kind of cosmetics containing Rosa Damascana, by
The ingredient of following parts by weight is made：10-15 parts of galactosyl ceramide derivative, 1-5 parts of glycyrrhizic acid surface-modified fullerenes,
Modified Polyquaternium-10 10-15 parts, 0.1-0.3 parts of Rosa Damascana, 0.01-0.03 parts of Ruscus extract, carnation essential oil
0.01-0.03 parts, 0.01-0.03 parts of osmanthus essential oil, 1-5 parts of hamameli tannin, 0.5-2 parts of resveratrol, thickener 0.5-1
Part, 2-4 parts of emulsifier, 15-20 parts of water.
Further, the galactosyl ceramide derivative is led to by raw material galactosyl ceramide, vitamin A
Diels-Alder reaction is crossed to be prepared；Modified Polyquaternium-10 is by poly- ammonium salt -10 by sending out with 6'- saliva lactose sodium salt
Raw ion-exchange reactions is prepared.
Preferably, the thickener is selected from least one of card wave 980, xanthan gum.
Preferably, the emulsifier in lauryl sodium sulfate, fatty alcohol polyoxyethylene ether, oliver1000 one
Kind or several combinations.
Preferably, the preparation method of the galactosyl ceramide derivative, includes the following steps：In nitrogen or inertia
Under atmosphere, galactosyl ceramide and vitamin A are added to the there-necked flask equipped with reflux condensing tube, electric mixer
In, then high boiling solvent is added into bottle, it flows back and is stirred to react 4-6 hours at 110-120 DEG C, solvent is evaporated off in back spin, obtains
To galactosyl ceramide derivative.
Preferably, the galactosyl ceramide, vitamin A, high boiling solvent mass ratio be 1.75:1:(10-
15)。
Preferably, the inert gas is selected from one or more of helium, neon, argon gas.
Preferably, the high boiling solvent is in dimethyl sulfoxide, N-Methyl pyrrolidone, n,N-Dimethylformamide
It is one or more of.
Preferably, the preparation method of the glycyrrhizic acid surface-modified fullerenes, includes the following steps：By amino modified fowler
Alkene, which is scattered in organic solvent, forms dispersion liquid, then glycyrrhizic acid, 1- ethyl-(3- dimethylaminopropyl) carbon two are added thereto
Inferior amine salt hydrochlorate, 4-dimethylaminopyridine are stirred to react 4-6 hours at 70-80 DEG C, rear to filter, and product 3-5 is washed with water
It is secondary, then with ethanol washing product 4-6 times, be placed on drying 10-15 hours at 80-90 DEG C of vacuum oven, obtain glycyrrhizic acid table
Face modified fullerenes.
Preferably, the amino modified fullerene, organic solvent, glycyrrhizic acid, 1- ethyl-(3- dimethylaminopropyl) carbon
Diimmonium salt hydrochlorate, 4-dimethylaminopyridine mass ratio be (3-5):(10-15):1:0.4:0.2.
Preferably, the organic solvent is selected from one or more of ethyl acetate, ethyl alcohol, methylene chloride.
Preferably, the preparation method of the modified Polyquaternium-10, includes the following steps：By Polyquaternium-10,6'- saliva
Liquid lactose sodium salt is added in tetrahydrofuran, is stirred to react at 50-70 DEG C 8-10 hours, and tetrahydrofuran is evaporated off in back spin, then
Acetone is added, by filtering, revolving removes acetone, obtains modified Polyquaternium-10.
Preferably, the mass ratio of the Polyquaternium-10,6'- saliva lactose sodium salt, tetrahydrofuran is (3-5):2:(15-
20)。
Preferably, the preparation method of the cosmetics containing Rosa Damascana, includes the following steps：By each components in certain proportion
Mixing, magnetic agitation 3-4 hour at 30-40 DEG C, after be cooled to room temperature, addition triethanolamine is neutralized to PH=7, stops stirring
It mixes, discharging packaging.
Generated beneficial effect is by adopting the above technical scheme：
1) cosmetics provided by the invention containing Rosa Damascana, preparation method is simple, and easy to operate, reaction condition is mild,
It is not high to consersion unit dependence, it is suitble to large-scale production.
2) cosmetics provided by the invention containing Rosa Damascana overcome Traditional makeup more or less existing cost
It is relatively high, allergic reaction is easily caused, moistening effect is not good enough, assimilation effect is poor, moisture preserving time is not lasting enough, anti-aging, crease-resistant
The technical issues of effect is unobvious, and cost performance is low, does not reach consumer anticipation skin effect, also overcomes single Rosa Damascana
Existing absorption rate is low when use, irritating to stomach and intestine, rose scent cannot be kept for a long time, in production and storage and transport process
In many ingredients the technical issues of being easy loss and oxidation, bringing inconvenience to its storage and use, have well to skin
Nourishing skin care, whitening anti-aging, crease-resistant, antibacterial bacteriostatic effect, and performance stablize, using safe and effective.
3) cosmetics provided by the invention containing Rosa Damascana, each ingredient synergistic effect, so that it is locked in skin moisturizing
There is remarkable efficacy in terms of water, anti-ageing flat wrinkle, activation epidermal cell, add galactosyl ceramide derivative, glycyrrhizic acid table
Face modified fullerenes, modified Polyquaternium-10 increase biocompatibility, improve anti-oxidant, anti-aging, raising immunity
The effect of, so that skin effect is more significant, stability is good, and the energy holding time is long；Quaternary ammonium salt structure is introduced, is further improved
Antibacterial ability；Ruscus extract, carnation essential oil, these plant extracts of osmanthus essential oil or essential oil are added simultaneously, is avoided
Single component cannot be suitble to the technical issues of a variety of skin types.
Specific embodiment
In order to make those skilled in the art more fully understand technical solution of the present invention, and make features described above of the invention,
Purpose and advantage are more clear understandable, and the present invention will be further explained with reference to the examples below.Embodiment is only used for
It is bright the present invention rather than limit the scope of the invention.
Present invention raw material as used in the following examples is purchased from upper Haiquan sunrise foreign trade Co., Ltd.
Embodiment 1
A kind of cosmetics containing Rosa Damascana, are made of the ingredient of following parts by weight：Galactosyl ceramide is derivative
10 parts of object, 1 part of glycyrrhizic acid surface-modified fullerenes, modified 10 parts of Polyquaternium-10,0.1 part of Rosa Damascana, Ruscus extract
0.01 part, 0.01 part of carnation essential oil, 0.01 part of osmanthus essential oil, 1 part of hamameli tannin, 0.5 part of resveratrol, card wave 9800.5
Part, 2 parts of lauryl sodium sulfate, 15 parts of water.
The galactosyl ceramide derivative is to pass through Diels- by raw material galactosyl ceramide, vitamin A
Alder reaction is prepared；Modified Polyquaternium-10 is to be handed over by poly- ammonium salt -10 by the way that ion occurs with 6'- saliva lactose sodium salt
Reaction is changed to be prepared.
The preparation method of the galactosyl ceramide derivative, includes the following steps：Under nitrogen atmosphere, by gala
Glucosides Cer EOS 7.5g and retinol1 0g be added to equipped with reflux condensing tube, electric mixer there-necked flask in, then to bottle
Middle addition dimethyl sulfoxide 100g flows back at 110 DEG C and is stirred to react 4 hours, and solvent is evaporated off in back spin, obtains galactoside nerve
Amide derivatives.
The preparation method of the glycyrrhizic acid surface-modified fullerenes, includes the following steps：By amino modified fullerene 30g points
It dissipates and forms dispersion liquid in ethyl acetate 100g, then glycyrrhizic acid 10g, 1- ethyl-(3- dimethylaminopropyl) is added thereto
Carbodiimide hydrochloride 4g, 4-dimethylaminopyridine 2g are stirred to react 4 hours at 70 DEG C, rear to filter, and product 3 is washed with water
It is secondary, then with ethanol washing product 4 times, drying 10 hours at 80 DEG C of vacuum oven are placed on, it is modified rich to obtain Radix Glycyrrhizae acid surfaces
Strangle alkene.
The preparation method of the modified Polyquaternium-10, includes the following steps：By Polyquaternium-10 30g, 6'- saliva cream
Sugared sodium salt 20g is added in tetrahydrofuran 150g, is stirred to react at 50 DEG C 8 hours, tetrahydrofuran is evaporated off in back spin, adds
Acetone, by filtering, revolving removes acetone, obtains modified Polyquaternium-10.
The preparation method of the cosmetics containing Rosa Damascana, includes the following steps：Each components in certain proportion is mixed,
Magnetic agitation 3 hours at 30 DEG C, after be cooled to room temperature, triethanolamine is added and is neutralized to PH=7, stops stirring, discharging packaging.
Embodiment 2
A kind of cosmetics containing Rosa Damascana, are made of the ingredient of following parts by weight：Galactosyl ceramide is derivative
11 parts of object, 2 parts of glycyrrhizic acid surface-modified fullerenes, modified 11 parts of Polyquaternium-10,0.15 part of Rosa Damascana, butcher's broom extract
0.015 part of object, 0.015 part of carnation essential oil, 0.015 part of osmanthus essential oil, 2 parts of hamameli tannin, 0.8 part of resveratrol, the Chinese are raw
0.6 part of glue, 2.5 parts of fatty alcohol polyoxyethylene ether, 16 parts of water.
The galactosyl ceramide derivative is to pass through Diels- by raw material galactosyl ceramide, vitamin A
Alder reaction is prepared；Modified Polyquaternium-10 is to be handed over by poly- ammonium salt -10 by the way that ion occurs with 6'- saliva lactose sodium salt
Reaction is changed to be prepared.
The preparation method of the galactosyl ceramide derivative, includes the following steps：Under helium atmosphere, by gala
Glucosides Cer EOS 7.5g and retinol1 0g be added to equipped with reflux condensing tube, electric mixer there-necked flask in, then to bottle
Middle addition N-Methyl pyrrolidone 110g flows back at 113 DEG C and is stirred to react 4.5 hours, and solvent is evaporated off in back spin, obtains gala
Glucosides ceramide derivatives.
The preparation method of the glycyrrhizic acid surface-modified fullerenes, includes the following steps：By amino modified fullerene 35g points
It dissipates and forms dispersion liquid in ethyl alcohol 112g, then glycyrrhizic acid 10g, 1- ethyl-(3- dimethylaminopropyl) carbon two is added thereto
Inferior amine salt hydrochlorate 4g, 4-dimethylaminopyridine 2g are stirred to react 4.5 hours at 73 DEG C, rear to filter, and are washed with water product 4 times,
It uses ethanol washing product 5 times again, is placed on drying 11.5 hours at 83 DEG C of vacuum oven, obtain the modified fowler of Radix Glycyrrhizae acid surfaces
Alkene.
The preparation method of the modified Polyquaternium-10, includes the following steps：By Polyquaternium-10 36g, 6'- saliva cream
Sugared sodium salt 20g is added in tetrahydrofuran 165g, is stirred to react at 56 DEG C 8.5 hours, and back spin is evaporated off tetrahydrofuran, then plus
Enter acetone, by filtering, revolving removes acetone, obtains modified Polyquaternium-10.
The preparation method of the cosmetics containing Rosa Damascana, includes the following steps：Each components in certain proportion is mixed,
Magnetic agitation 3.5 hours at 34 DEG C, after be cooled to room temperature, triethanolamine is added and is neutralized to PH=7, stops stirring, discharging packaging.
Embodiment 3
A kind of cosmetics containing Rosa Damascana, are made of the ingredient of following parts by weight：Galactosyl ceramide is derivative
13 parts of object, 3 parts of glycyrrhizic acid surface-modified fullerenes, modified 13 parts of Polyquaternium-10,0.2 part of Rosa Damascana, Ruscus extract
0.02 part, 0.02 part of carnation essential oil, 0.02 part of osmanthus essential oil, 3 parts of hamameli tannin, 1.3 parts of resveratrol, card wave 9800.7
Part, oliver10003 parts, 17 parts of water.
The galactosyl ceramide derivative is to pass through Diels- by raw material galactosyl ceramide, vitamin A
Alder reaction is prepared；Modified Polyquaternium-10 is to be handed over by poly- ammonium salt -10 by the way that ion occurs with 6'- saliva lactose sodium salt
Reaction is changed to be prepared.
The preparation method of the galactosyl ceramide derivative, includes the following steps：Under neon atmosphere, by gala
Glucosides Cer EOS 7.5g and retinol1 0g be added to equipped with reflux condensing tube, electric mixer there-necked flask in, then to bottle
Middle addition n,N-Dimethylformamide 125g flows back at 115 DEG C and is stirred to react 5 hours, and solvent is evaporated off in back spin, obtains gala
Glucosides ceramide derivatives.
The preparation method of the glycyrrhizic acid surface-modified fullerenes, includes the following steps：By amino modified fullerene 40g points
It dissipates and forms dispersion liquid in methylene chloride 133g, then glycyrrhizic acid 10g, 1- ethyl-(3- dimethylaminopropyl) is added thereto
Carbodiimide hydrochloride 4g, 4-dimethylaminopyridine 2g are stirred to react 5.2 hours at 75 DEG C, rear to filter, and product is washed with water
4 times, then with ethanol washing product 5 times, drying 13 hours at 85 DEG C of vacuum oven are placed on, it is modified rich to obtain Radix Glycyrrhizae acid surfaces
Strangle alkene.
The preparation method of the modified Polyquaternium-10, includes the following steps：By Polyquaternium-10 40g, 6'- saliva cream
Sugared sodium salt 20g is added in tetrahydrofuran 175g, is stirred to react at 60 DEG C 9 hours, tetrahydrofuran is evaporated off in back spin, adds
Acetone, by filtering, revolving removes acetone, obtains modified Polyquaternium-10.
The preparation method of the cosmetics containing Rosa Damascana, includes the following steps：Each components in certain proportion is mixed,
Magnetic agitation 3.7 hours at 37 DEG C, after be cooled to room temperature, triethanolamine is added and is neutralized to PH=7, stops stirring, discharging packaging.
Embodiment 4
A kind of cosmetics containing Rosa Damascana, are made of the ingredient of following parts by weight：Galactosyl ceramide is derivative
14 parts of object, 4 parts of glycyrrhizic acid surface-modified fullerenes, modified 14 parts of Polyquaternium-10,0.25 part of Rosa Damascana, butcher's broom extract
0.025 part of object, 0.025 part of carnation essential oil, 0.025 part of osmanthus essential oil, 4 parts of hamameli tannin, 1.8 parts of resveratrol, thickening
0.9 part of agent, 3 parts of emulsifier, 18 parts of water；The thickener is card wave 980, xanthan gum in mass ratio 2:3 mixing mixed
Object；The emulsifier is lauryl sodium sulfate, fatty alcohol polyoxyethylene ether, oliver1000 in mass ratio 2:3:2 mixing and
At mixture.
The galactosyl ceramide derivative is to pass through Diels- by raw material galactosyl ceramide, vitamin A
Alder reaction is prepared；Modified Polyquaternium-10 is to be handed over by poly- ammonium salt -10 by the way that ion occurs with 6'- saliva lactose sodium salt
Reaction is changed to be prepared.
The preparation method of the galactosyl ceramide derivative, includes the following steps：Under argon atmosphere, by gala
Glucosides Cer EOS 7.5g and retinol1 0g be added to equipped with reflux condensing tube, electric mixer there-necked flask in, then to bottle
Middle addition high boiling solvent 145g flows back at 118 DEG C and is stirred to react 5.8 hours, and solvent is evaporated off in back spin, obtains galactoside
Ceramide derivatives；The high boiling solvent is dimethyl sulfoxide, N-Methyl pyrrolidone, N,N-dimethylformamide by quality
Than 1:3:2 mixtures mixed.
The preparation method of the glycyrrhizic acid surface-modified fullerenes, includes the following steps：By amino modified fullerene 45g points
It dissipates and forms dispersion liquid in organic solvent 145g, then glycyrrhizic acid 10g, 1- ethyl-(3- dimethylaminopropyl) is added thereto
Carbodiimide hydrochloride 4g, 4-dimethylaminopyridine 2g are stirred to react 5.5 hours at 78 DEG C, rear to filter, and product is washed with water
5 times, then with ethanol washing product 6 times, drying 14 hours at 88 DEG C of vacuum oven are placed on, it is modified rich to obtain Radix Glycyrrhizae acid surfaces
Strangle alkene；The organic solvent is ethyl acetate, ethyl alcohol, methylene chloride in mass ratio 2:3:5 mixtures mixed.
The preparation method of the modified Polyquaternium-10, includes the following steps：By Polyquaternium-10 45g, 6'- saliva cream
Sugared sodium salt 20g is added in tetrahydrofuran 195g, is stirred to react at 66 DEG C 9.5 hours, and back spin is evaporated off tetrahydrofuran, then plus
Enter acetone, by filtering, revolving removes acetone, obtains modified Polyquaternium-10.
The preparation method of the cosmetics containing Rosa Damascana, includes the following steps：Each components in certain proportion is mixed,
Magnetic agitation 3.8 hours at 39 DEG C, after be cooled to room temperature, triethanolamine is added and is neutralized to PH=7, stops stirring, discharging packaging.
Embodiment 5
A kind of cosmetics containing Rosa Damascana, are made of the ingredient of following parts by weight：Galactosyl ceramide is derivative
15 parts of object, 5 parts of glycyrrhizic acid surface-modified fullerenes, modified 15 parts of Polyquaternium-10,0.3 part of Rosa Damascana, Ruscus extract
0.03 part, 0.03 part of carnation essential oil, 0.03 part of osmanthus essential oil, 5 parts of hamameli tannin, 2 parts of resveratrol, 1 part of xanthan gum, ten
4 parts of sodium dialkyl sulfate, 20 parts of water.
The galactosyl ceramide derivative is to pass through Diels- by raw material galactosyl ceramide, vitamin A
Alder reaction is prepared；Modified Polyquaternium-10 is to be handed over by poly- ammonium salt -10 by the way that ion occurs with 6'- saliva lactose sodium salt
Reaction is changed to be prepared.
The preparation method of the galactosyl ceramide derivative, includes the following steps：Under nitrogen atmosphere, by gala
Glucosides Cer EOS 7.5g and retinol1 0g be added to equipped with reflux condensing tube, electric mixer there-necked flask in, then to bottle
Middle addition dimethyl sulfoxide 150g flows back at 120 DEG C and is stirred to react 6 hours, and solvent is evaporated off in back spin, obtains galactoside nerve
Amide derivatives.
The preparation method of the glycyrrhizic acid surface-modified fullerenes, includes the following steps：By amino modified fullerene 50g points
It dissipates and forms dispersion liquid in ethyl acetate 150g, then glycyrrhizic acid 10g, 1- ethyl-(3- dimethylaminopropyl) is added thereto
Carbodiimide hydrochloride 4g, 4-dimethylaminopyridine 2g are stirred to react 6 hours at 80 DEG C, rear to filter, and product 5 is washed with water
It is secondary, then with ethanol washing product 6 times, drying 15 hours at 90 DEG C of vacuum oven are placed on, it is modified rich to obtain Radix Glycyrrhizae acid surfaces
Strangle alkene.
The preparation method of the modified Polyquaternium-10, includes the following steps：By Polyquaternium-10 50g, 6'- saliva cream
Sugared sodium salt 20g is added in tetrahydrofuran 200g, is stirred to react at 70 DEG C 10 hours, and back spin is evaporated off tetrahydrofuran, then plus
Enter acetone, by filtering, revolving removes acetone, obtains modified Polyquaternium-10.
Preferably, the preparation method of the cosmetics containing Rosa Damascana, includes the following steps：By each components in certain proportion
Mixing, magnetic agitation 4 hours at 40 DEG C, after be cooled to room temperature, triethanolamine is added and is neutralized to PH=7, stops stirring, discharging
Packaging.
Comparative example 1
This example provides a kind of cosmetics containing Rosa Damascana, and raw material and preparation method thereof is the same as embodiment 1, difference
It is not add galactosyl ceramide derivative.
Comparative example 2
This example provides a kind of cosmetics containing Rosa Damascana, and raw material and preparation method thereof is the same as embodiment 1, difference
It is not add glycyrrhizic acid surface-modified fullerenes.
Comparative example 3
This example provides a kind of cosmetics containing Rosa Damascana, and raw material and preparation method thereof is the same as embodiment 1, difference
It is not add modified Polyquaternium-10.
Comparative example 4
This example provides a kind of cosmetics containing Rosa Damascana, and raw material and preparation method thereof is the same as embodiment 1, difference
It is not add Ruscus extract.
Comparative example 5
This example provides a kind of cosmetics containing Rosa Damascana, and raw material and preparation method thereof is the same as embodiment 1, difference
It is not add carnation essential oil.
Comparative example 6
Certain commercially available rose cosmetics.
Skin integrally improves degree evaluation
Test method：Volunteer 220 (25-40 years old age) is randomly divided into 11 groups by the principle of parallel control, respectively
For：The invention patent embodiment 1-5, comparative example 1-6.Respectively 0.5g or so is taken to be applied to face after test volunteer's morning and evening face cleaning,
After 30d, carrying out skin integrally improves the assessment of degree.
Evaluation criteria：To the uniformity of volunteer's recipient site colour of skin, slickness, greasy degree, pigmentation, skin bullet
Property, anti-wrinkle effect, freckle effect, whitening effect, moistening effect etc. improvement make assessment, improve effective percentage and be shown in Table 1.
Table 1
As seen from Table 1, the cosmetics disclosed by the embodiments of the present invention containing Rosa Damascana, with the existing makeup condition in market
Than having preferable whitening, moisturizing, anti-aging effects.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and what is described in the above embodiment and the description is only the present invention
Principle, various changes and improvements may be made to the invention without departing from the spirit and scope of the present invention, these variation and
Improvement is both fallen in the range of claimed invention.The present invention claims protection scope by appended claims and its
Equivalent defines.
Claims (10)
1. a kind of cosmetics containing Rosa Damascana, which is characterized in that be made of the ingredient of following parts by weight：Galactoside nerve
10-15 parts of amide derivatives, 1-5 parts of glycyrrhizic acid surface-modified fullerenes, modified Polyquaternium-10 10-15 parts, Rosa Damascana
0.1-0.3 parts, 0.01-0.03 parts of Ruscus extract, 0.01-0.03 parts of carnation essential oil, 0.01-0.03 parts of osmanthus essential oil,
1-5 parts of hamameli tannin, 0.5-2 parts of resveratrol, 0.5-1 parts of thickener, 2-4 parts of emulsifier, 15-20 parts of water.
2. the cosmetics according to claim 1 containing Rosa Damascana, which is characterized in that the thickener is selected from card wave
980, at least one of xanthan gum；The emulsifier be selected from lauryl sodium sulfate, fatty alcohol polyoxyethylene ether,
One or more of oliver1000 combination.
3. the cosmetics according to claim 1 containing Rosa Damascana, which is characterized in that the galactosyl ceramide
The preparation method of derivative, includes the following steps：Under nitrogen or atmosphere of inert gases, galactosyl ceramide and dimension are given birth to
Plain A be added to equipped with reflux condensing tube, electric mixer there-necked flask in, then high boiling solvent is added into bottle, in 110-120
Reflux is stirred to react 4-6 hours at DEG C, and solvent is evaporated off in back spin, obtains galactosyl ceramide derivative.
4. the cosmetics according to claim 3 containing Rosa Damascana, which is characterized in that the galactoside nerve acyl
Amine, vitamin A, high boiling solvent mass ratio be 1.75:1:(10-15).
5. the cosmetics according to claim 3 containing Rosa Damascana, which is characterized in that the inert gas is selected from helium
One or more of gas, neon, argon gas；The high boiling solvent is selected from dimethyl sulfoxide, N-Methyl pyrrolidone, N, N- diformazan
One or more of base formamide.
6. the cosmetics according to claim 1 containing Rosa Damascana, which is characterized in that the Radix Glycyrrhizae acid surfaces are modified rich
The preparation method for strangling alkene, includes the following steps：Disperse amino modified fullerene in organic solvent and form dispersion liquid, then to its
Middle addition glycyrrhizic acid, 1- ethyl-(3- dimethylaminopropyl) carbodiimide hydrochloride, 4-dimethylaminopyridine, at 70-80 DEG C
Under be stirred to react 4-6 hours, it is rear to filter, product is washed with water 3-5 time, then with ethanol washing product 4-6 times, is placed on vacuum and does
It is 10-15 hours dry at 80-90 DEG C of dry case, obtain glycyrrhizic acid surface-modified fullerenes.
7. the cosmetics according to claim 6 containing Rosa Damascana, which is characterized in that the amino modified fullerene,
Organic solvent, glycyrrhizic acid, 1- ethyl-(3- dimethylaminopropyl) carbodiimide hydrochloride, 4-dimethylaminopyridine quality
Than for (3-5):(10-15):1:0.4:0.2；The organic solvent be selected from one of ethyl acetate, ethyl alcohol, methylene chloride or
It is several.
8. the cosmetics according to claim 1 containing Rosa Damascana, which is characterized in that the modified Polyquaternium-10
Preparation method, include the following steps：Polyquaternium-10,6'- saliva lactose sodium salt are added in tetrahydrofuran, in 50-70
It is stirred to react at DEG C 8-10 hours, tetrahydrofuran is evaporated off in back spin, adds acetone, and by filtering, revolving removes acetone, obtains
Modified Polyquaternium-10.
9. the cosmetics according to claim 8 containing Rosa Damascana, which is characterized in that the Polyquaternium-10,6'-
Saliva lactose sodium salt, tetrahydrofuran mass ratio be (3-5):2:(15-20).
10. a kind of preparation method of the cosmetics containing Rosa Damascana described in -9 any one according to claim 1, feature exist
In including the following steps：Each components in certain proportion is mixed, magnetic agitation 3-4 hours at 30-40 DEG C, after be cooled to room temperature, add
Enter triethanolamine and be neutralized to PH=7, stops stirring, discharging packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810950382.2A CN108836897A (en) | 2018-08-21 | 2018-08-21 | A kind of cosmetics and preparation method thereof containing Rosa Damascana |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810950382.2A CN108836897A (en) | 2018-08-21 | 2018-08-21 | A kind of cosmetics and preparation method thereof containing Rosa Damascana |
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| Publication Number | Publication Date |
|---|---|
| CN108836897A true CN108836897A (en) | 2018-11-20 |
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| CN201810950382.2A Withdrawn CN108836897A (en) | 2018-08-21 | 2018-08-21 | A kind of cosmetics and preparation method thereof containing Rosa Damascana |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109749521A (en) * | 2019-01-28 | 2019-05-14 | 潍坊护理职业学院 | A kind of environmental and durable chalk material |
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| US20040132688A1 (en) * | 2001-02-28 | 2004-07-08 | Griffin John H. | Plasma glucosylceramide deficiency as risk factor for thrombosis and modulator of anticoagulant protein C |
| CN103230604A (en) * | 2013-04-19 | 2013-08-07 | 郑州大学 | Magnetic water-soluble fullerene, and preparation method and application thereof |
| CN105503631A (en) * | 2015-12-25 | 2016-04-20 | 四川大学 | Degradable gemini quaternary ammonium salt bactericide and preparation method thereof |
| CN108096116A (en) * | 2018-01-22 | 2018-06-01 | 青海大学 | A kind of preparation method of the antibacterial lip gloss containing natural pigment |
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2018
- 2018-08-21 CN CN201810950382.2A patent/CN108836897A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040132688A1 (en) * | 2001-02-28 | 2004-07-08 | Griffin John H. | Plasma glucosylceramide deficiency as risk factor for thrombosis and modulator of anticoagulant protein C |
| CN103230604A (en) * | 2013-04-19 | 2013-08-07 | 郑州大学 | Magnetic water-soluble fullerene, and preparation method and application thereof |
| CN105503631A (en) * | 2015-12-25 | 2016-04-20 | 四川大学 | Degradable gemini quaternary ammonium salt bactericide and preparation method thereof |
| CN108096116A (en) * | 2018-01-22 | 2018-06-01 | 青海大学 | A kind of preparation method of the antibacterial lip gloss containing natural pigment |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109749521A (en) * | 2019-01-28 | 2019-05-14 | 潍坊护理职业学院 | A kind of environmental and durable chalk material |
| CN109749521B (en) * | 2019-01-28 | 2021-09-07 | 潍坊护理职业学院 | Environment-friendly durable chalk material |
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