CN1088086A - A kind of novel skin-protection health products - Google Patents
A kind of novel skin-protection health products Download PDFInfo
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- CN1088086A CN1088086A CN 92114587 CN92114587A CN1088086A CN 1088086 A CN1088086 A CN 1088086A CN 92114587 CN92114587 CN 92114587 CN 92114587 A CN92114587 A CN 92114587A CN 1088086 A CN1088086 A CN 1088086A
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- CN
- China
- Prior art keywords
- sod
- skin
- health products
- health care
- superoxide dismutase
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000036541 health Effects 0.000 title claims abstract description 14
- 102000019197 Superoxide Dismutase Human genes 0.000 claims abstract description 40
- 108010012715 Superoxide dismutase Proteins 0.000 claims abstract description 40
- -1 superoxide ions Chemical class 0.000 claims abstract description 13
- 239000000126 substance Substances 0.000 claims abstract description 12
- 208000002193 Pain Diseases 0.000 claims abstract description 6
- 150000001875 compounds Chemical class 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- SBDNJUWAMKYJOX-UHFFFAOYSA-N Meclofenamic Acid Chemical compound CC1=CC=C(Cl)C(NC=2C(=CC=CC=2)C(O)=O)=C1Cl SBDNJUWAMKYJOX-UHFFFAOYSA-N 0.000 claims description 7
- 229960003803 meclofenamic acid Drugs 0.000 claims description 7
- 229960003464 mefenamic acid Drugs 0.000 claims description 7
- 239000000758 substrate Substances 0.000 claims description 5
- DMBHHRLKUKUOEG-UHFFFAOYSA-N diphenylamine Chemical compound C=1C=CC=CC=1NC1=CC=CC=C1 DMBHHRLKUKUOEG-UHFFFAOYSA-N 0.000 claims description 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 150000003431 steroids Chemical class 0.000 claims description 2
- 241001597008 Nomeidae Species 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000003863 ammonium salts Chemical class 0.000 claims 1
- 239000000039 congener Substances 0.000 claims 1
- HYYBABOKPJLUIN-UHFFFAOYSA-N mefenamic acid Chemical compound CC1=CC=CC(NC=2C(=CC=CC=2)C(O)=O)=C1C HYYBABOKPJLUIN-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 7
- 230000003851 biochemical process Effects 0.000 abstract description 5
- 230000002779 inactivation Effects 0.000 abstract description 5
- 230000004071 biological effect Effects 0.000 abstract description 4
- 201000004624 Dermatitis Diseases 0.000 abstract description 3
- 206010013082 Discomfort Diseases 0.000 abstract description 2
- 230000007815 allergy Effects 0.000 abstract description 2
- 231100000957 no side effect Toxicity 0.000 abstract description 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 238000004925 denaturation Methods 0.000 abstract 1
- 230000036425 denaturation Effects 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000002894 organic compounds Chemical class 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 230000037384 skin absorption Effects 0.000 abstract 1
- 231100000274 skin absorption Toxicity 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 9
- 239000000047 product Substances 0.000 description 8
- PJJGZPJJTHBVMX-UHFFFAOYSA-N 5,7-Dihydroxyisoflavone Chemical compound C=1C(O)=CC(O)=C(C2=O)C=1OC=C2C1=CC=CC=C1 PJJGZPJJTHBVMX-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 229940070818 glycyrrhizate Drugs 0.000 description 5
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- PYSICVOJSJMFKP-UHFFFAOYSA-N 3,5-dibromo-2-chloropyridine Chemical compound ClC1=NC=C(Br)C=C1Br PYSICVOJSJMFKP-UHFFFAOYSA-N 0.000 description 3
- 230000007850 degeneration Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- IMCFRCUCBHZBTN-UHFFFAOYSA-M sodium;2-(2,3-dimethylanilino)benzoate Chemical compound [Na+].CC1=CC=CC(NC=2C(=CC=CC=2)C([O-])=O)=C1C IMCFRCUCBHZBTN-UHFFFAOYSA-M 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 238000006555 catalytic reaction Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000007323 disproportionation reaction Methods 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 230000004962 physiological condition Effects 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000000284 resting effect Effects 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical class [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 238000003483 aging Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003260 anti-sepsis Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 208000013527 cardiovascular neoplasm Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 229910052752 metalloid Inorganic materials 0.000 description 1
- 150000002738 metalloids Chemical class 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000002884 skin cream Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明公开了一种含有与天然超氧化物歧化酶 (SOD)功能相似的类SOD有机化合物的护肤保健 品，这些类SOD化合物对人无毒无副作用，可被皮 肤吸收，直接参与人机体的生物化学过程，能够有效 地清除超氧离子，对由超氧离子自由基引起的皮肤炎 症、过敏、疼痛等不适起预防保健作用。这些类SOD 物质化学性质稳定，其生物活性不受使用环境如酸碱 性、温度、保存时间等因素的影响，无变性失活、腐败 变质之虞。本发明公开的这种护肤保健品制作简单， 性能稳定，有效期长。The invention discloses a method containing natural superoxide dismutase (SOD) Skin care and health care of SOD-like organic compounds with similar functions products, these SOD-like compounds are non-toxic and have no side effects on humans, and can be applied to the skin Skin absorption, directly participate in the biochemical process of the human body, can effectively effectively remove superoxide ions, and treat dermatitis caused by superoxide ion free radicals Diseases, allergies, pain and other discomforts play a role in preventive health care. These class SOD The chemical properties of the substance are stable, and its biological activity is not affected by the use environment such as acid and alkali Influenced by factors such as sex, temperature, and storage time, there is no denaturation, inactivation, or corruption Risk of deterioration. The skin care and health care product disclosed by the invention is simple to make, Stable performance and long validity period.
Description
The present invention relates to a kind of skin-protection health products that contains natural superoxide dismutase (SOD) similar substance, it is specially adapted to remove the superoxide ion free radical that is produced by Biochemical processes in the human body, can prevent the local skin inflammation, allergy and the pain that cause by superoxide ion, play the skin-protection and health-care effect.
Existing traditional skin-protection health products mainly contains easily by the chemical substance of skin absorbs, makes Skin Cell keep enough moisture, with skin care.These quasi-tradition skin care item are not considered the Biochemical processes of human body.Medical research shows that superoxide ion can react with various biomolecule and have toxicity, with physiological phenomenons such as inflammation, cardiovascular diseases, tumor and agings tangible dependency is arranged.Therefore, there are the skin care item that contain natural superoxide dismutase (SOD) to come out in recent years.Natural superoxide dismutase (SOD) is a metalloid enzyme; it protects body to avoid its murder by poisoning by catalysis superoxide ion disproportionation; but natural superoxide dismutase (SOD) its biological activity under non-physiological condition is subjected to the influence of factors such as environment for use, resting period very big; easy degeneration inactivation; putrid and deteriorated, use with preservation condition comparatively harsh.In addition, natural superoxide dismutase (SOD) and molecular weight big, the transdermal ability is difficult to enter subcutaneous, thereby its effect of removing superoxides is limited.
Compare with technology in the past; outstanding progress of the present invention is: one; contain in the skin-protection health products of the present invention and the functionally similar material of natural superoxide dismutase (SOD); these materials are abiotic organic micromolecule compounds; their easy transdermals; participate in the intravital Biochemical processes of people directly; the dismutation reaction of catalysis superoxide ion (Chinese Chemical Letters; 1992; 3(1); 67) remove superoxide ion effectively; the protection body is avoided its evil, to the inflammation that is caused by superoxide ion; irritated; discomforts such as pain have prevention and medical function.Two, the natural superoxide dismutase (SOD) that uses of the present invention though similar substance do not have life but the biological activity height, no degeneration inactivation, putrid and deteriorated shortcoming.Their chemical stability is good, and it removes the influence that superoxide ion effect is not subjected to service condition such as acid-base value, ambient temperature, holding time, occurrence patterns, and service condition is very tolerant, and effect is lasting, effect stability.Three, the similar substance of the natural superoxide dismutase (SOD) of the present invention's use is non-steroid antiinflammation pain-stopping pharmaceutical mefenamic acid, meclofenamic acid an ex hoc genus anne thing, and nonhazardous has no side effect to human body for they.Four, the similar substance mefenamic acid of the natural superoxide dismutase (SOD) of the present invention's use, meclofenamic acid ex hoc genus anne thing itself also has the fungus-proof antisepsis effect, these materials are added among traditional skin care item substrate, can no longer add antiseptic such as benzoic acid etc.
The objective of the invention is to from the Biochemical processes of human body actual, keeping on traditional skin-protection health products basic feature basis, with replacing natural superoxide dismutase (SOD) with the intimate organic molecule medicine of natural superoxide dismutase (SOD), so both guaranteed that skin care item had the removing superoxide ion function of lasting stability, overcome again and used natural superoxide dismutase (SOD) service condition harsh, the changeableness inactivation, shortcoming such as putrid and deteriorated, give full play to these organic molecule pharmaceutical chemistry stable in properties simultaneously, not influenced by service condition, have characteristics such as anticorrosion mildew-proof function.
What the present invention used belongs to diphenylamine compound with the functionally similar organic substance of natural superoxide dismutase (SOD), and its general structure is:
In the formula, R
1, R
2, R
3And R
4Can-CH
3,-CI, substituted radicals such as-COOH.Work as R
1=R
2=CH
3, R
3=H, R
4During=COOH, be the antiinflammation pain-stopping pharmaceutical mefenamic acid; Work as R
1=CH
3, R
2=R
3=CI, R
4It during=COOH meclofenamic acid; Work as R
1=R
2=R
3=H, R
4During=COOH, be vanadium reagents.
The present invention realizes like this, with the similar substance of superoxide dismutase (SOD) such as mefenamic acid, meclofenamic acid ex hoc genus anne thing with the form of former compound or its salt by a certain percentage [as 0.001～1%(W/W)] be added to mixing in the suitable substrate (the various cream emulsions of using as ethanol, water, carboxymethyl cellulose and other traditional skin protection), can make skin-protection health products according to a conventional method with dosage forms such as alcohol, water, powder, book film and various cream emulsions.The whole pH of scalable skin care item is within 7.2～7.4 scopes in case of necessity.In traditional skin-protection health products substrate, add the analog of the superoxide dismutase (SOD) of indication of the present invention, need not special technique measure such as temperature, pressure etc., also need not to change original technology and equipment, can they be added in the later stage of former skin-protection health products manufacture process, as long as guarantee that these analog have good dispersion, dissolubility, and guarantee can not run off to get final product.
Advantage of the present invention is: one, the present invention use with the functionally similar material of natural superoxide dismutase (SOD), the biological activity height, cheap and easy to get.Two, these similar SOD materials of the present invention's use are chemically stable, its function of removing superoxide ion is not subjected to the influence of ambient temperature, Acidity of Aikalinity, resting period, occurrence patterns, natural superoxide dismutase (SOD) easily inactivation degeneration under non-physiological condition, putrid and deteriorated shortcoming have been overcome, can be attached to according to actual needs in the existing skin care item substrate, be extensive use of.Three, enforcement method of the present invention is very simple, need not to increase equipment investment, also need not to change former technological process.
It is as follows to implement preferred example of the present invention:
1, antiinflammatory antiallergic floral water is made up of mefenamic acid or meclofenamic acid (0.1～0.5 gram), dipotaccium glycyrrhizate or ammonium (0.5～1.0 gram), essence (in right amount), pigment (in right amount), 70% ethanol (1000 milliliters).
Its compound method is: restrain mefenamic acid or meclofenamic acid powder 0.5～1.0 gram dipotaccium glycyrrhizate or ammonium with 0.1～0.5 and be dissolved in 300 ml waters, regulating pH with weak ammonia is 7.2～7.4, adds an amount of essence and pigment again, shakes up, add 700 milliliters of anhydrous alcohols at last, shake up.
2, quasi-SOD protective skin cream (breast), deionized water 35.0% an amount of by stearic acid 2.5%, glyceryl monostearate 11.0%, vaseline 10.0%, lanoline 22.0%, hexadecanol 1.5%, liquid paraffin wax 9.0%, Polyethylene Glycol (1500) 3%, triethanolamine 1%, mefenamic acid sodium or meclofenamate sodium 0.02%, dipotaccium glycyrrhizate 0.05%, essence formed.
Its method for production is: except that mefenamic acid sodium or meclofenamate sodium, dipotaccium glycyrrhizate, essence, with the manufacture method dissolving routinely of other material, mixed, emulsifying and then add mefenamic acid sodium or meclofenamate sodium, dipotaccium glycyrrhizate, essence, continuation emulsifying to even cooling gets final product.
Claims (3)
1, is the skin-protection health products that contains the quasi-SOD material of substrate by traditional skin protection with cream emulsion and ethanol, it is characterized in that containing the organic micromolecule compound with natural superoxide dismutase (SOD) identity function, in that chemically it belongs to the diphenylamine derivant.
2, the strong product of skin protection that contain the quasi-SOD material according to claim 1 is characterized in that diphenylamine derivatives chemical general structure is
In the general formula, R
1, R
2, R
3And R
4Mainly be H, CH
3, CI, substituted radical and combinations thereof such as COOH.
3, the skin-protection health products that contains the quasi-SOD material according to claim 1 is characterized in that employed organic micromolecule compound is a non-steroid antiinflammation pain-stopping pharmaceutical mefenamic acid, meclofenamic acid and its congener with and alkali metal salt and ammonium salt.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92114587 CN1088086A (en) | 1992-12-14 | 1992-12-14 | A kind of novel skin-protection health products |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92114587 CN1088086A (en) | 1992-12-14 | 1992-12-14 | A kind of novel skin-protection health products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1088086A true CN1088086A (en) | 1994-06-22 |
Family
ID=4947017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 92114587 Pending CN1088086A (en) | 1992-12-14 | 1992-12-14 | A kind of novel skin-protection health products |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1088086A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998058636A1 (en) * | 1997-06-20 | 1998-12-30 | G.D. Searle & Co. | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
-
1992
- 1992-12-14 CN CN 92114587 patent/CN1088086A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998058636A1 (en) * | 1997-06-20 | 1998-12-30 | G.D. Searle & Co. | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
| US6395725B1 (en) | 1997-06-20 | 2002-05-28 | G.D. Searle & Co. | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |