CN108542801A - A kind of skin care patch Essence of preservative free - Google Patents
A kind of skin care patch Essence of preservative free Download PDFInfo
- Publication number
- CN108542801A CN108542801A CN201810247348.9A CN201810247348A CN108542801A CN 108542801 A CN108542801 A CN 108542801A CN 201810247348 A CN201810247348 A CN 201810247348A CN 108542801 A CN108542801 A CN 108542801A
- Authority
- CN
- China
- Prior art keywords
- skin care
- essence
- moisturizer
- pasted
- preservative free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003755 preservative agent Substances 0.000 title claims abstract description 65
- 230000002335 preservative effect Effects 0.000 title claims abstract description 64
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 37
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 36
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 36
- 230000001815 facial effect Effects 0.000 claims abstract description 35
- 230000003020 moisturizing effect Effects 0.000 claims abstract description 25
- VJVOFLWZDWLHNR-MRCUWXFGSA-N icosan-9-yl (z)-docos-13-enoate Chemical compound CCCCCCCCCCCC(CCCCCCCC)OC(=O)CCCCCCCCCCC\C=C/CCCCCCCC VJVOFLWZDWLHNR-MRCUWXFGSA-N 0.000 claims abstract description 22
- 230000003110 anti-inflammatory effect Effects 0.000 claims abstract description 19
- 239000007788 liquid Substances 0.000 claims abstract description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 92
- 235000011187 glycerol Nutrition 0.000 claims description 46
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 36
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 30
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 29
- 229920000570 polyether Polymers 0.000 claims description 29
- 239000004909 Moisturizer Substances 0.000 claims description 27
- 230000001333 moisturizer Effects 0.000 claims description 27
- 239000003002 pH adjusting agent Substances 0.000 claims description 26
- 229960003237 betaine Drugs 0.000 claims description 24
- 239000002738 chelating agent Substances 0.000 claims description 24
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 24
- 239000002562 thickening agent Substances 0.000 claims description 24
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 22
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 22
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 22
- 150000003384 small molecules Chemical class 0.000 claims description 20
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 18
- 229920002125 Sokalan® Polymers 0.000 claims description 18
- 229960001631 carbomer Drugs 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 15
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 15
- 229960000458 allantoin Drugs 0.000 claims description 15
- 239000002994 raw material Substances 0.000 claims description 15
- 239000004475 Arginine Substances 0.000 claims description 14
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 14
- 229940074410 trehalose Drugs 0.000 claims description 12
- -1 D-pantothenyl Chemical group 0.000 claims description 11
- 239000003906 humectant Substances 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 8
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 239000000043 antiallergic agent Substances 0.000 claims 2
- 241001474374 Blennius Species 0.000 claims 1
- 241000195493 Cryptophyta Species 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 230000003266 anti-allergic effect Effects 0.000 claims 1
- 229960003121 arginine Drugs 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 16
- 230000008859 change Effects 0.000 abstract description 3
- 230000007794 irritation Effects 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 description 20
- 238000004659 sterilization and disinfection Methods 0.000 description 18
- 238000012360 testing method Methods 0.000 description 12
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 239000011701 zinc Substances 0.000 description 6
- 229910052725 zinc Inorganic materials 0.000 description 6
- 230000004888 barrier function Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 229960005150 glycerol Drugs 0.000 description 5
- 229920002674 hyaluronan Polymers 0.000 description 5
- 229960003160 hyaluronic acid Drugs 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 238000004806 packaging method and process Methods 0.000 description 4
- 230000001953 sensory effect Effects 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 208000026935 allergic disease Diseases 0.000 description 3
- 230000007815 allergy Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 229960004063 propylene glycol Drugs 0.000 description 3
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 230000001741 anti-phlogistic effect Effects 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000002932 luster Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- 238000011169 microbiological contamination Methods 0.000 description 2
- 229940101267 panthenol Drugs 0.000 description 2
- 235000020957 pantothenol Nutrition 0.000 description 2
- 239000011619 pantothenol Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000037394 skin elasticity Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000700647 Variola virus Species 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- HYBIBLNGGIWWAY-UHFFFAOYSA-N [K].[K].OC(=O)C(O)=O Chemical compound [K].[K].OC(=O)C(O)=O HYBIBLNGGIWWAY-UHFFFAOYSA-N 0.000 description 1
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000011506 response to oxidative stress Effects 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 210000001626 skin fibroblast Anatomy 0.000 description 1
- 229940083982 sodium phytate Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 230000001228 trophic effect Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of skin cares of preservative free to paste Essence, and the essence formula of liquid of the facial mask reduces irritation of the facial mask to skin, sensitive flesh is applicable in without sensitizers such as preservatives；The all the components of the formula can at 115 DEG C 15 to 30 minutes invariance, and physical state does not change, adding zinc hyaluronate simultaneously has effects that anti-inflammatory, moisturizing, and the molecular weight of Sodium Hyaluronate has large, medium and small three kinds, and between ratio control after can reach best moisturizing effect.
Description
Technical field
The present invention relates to medical treatment, beauty treatment fields, Essence is pasted in the skin care of specially a kind of preservative free.
Background technology
Skin care patch includes facial mask, eye mask and cold compress patch etc., generally includes membrane material and Essence, and the membrane material after folding is impregnated
In Essence, because there is higher trophic function with moisturizing, reparation, Essence ingredient that is anti-ageing, correcting function, very
Be easy for Institute of Micro-biology pollution to solve this problem, at present it is almost all of emerge skin care patch in contain preservative at
Point, to solve microorganism problem；Even if declaring that the skin care patch of preservative free is also pseudo- proposition, only it is added to and novel does not exist
Ingredient in preservative catalogue is to reach corrosion-resistant purpose.The addition of preservative, solves the problems, such as the shelf-life, but also band simultaneously
The other problems such as stimulation, allergy are carried out, have made people seeking beauty through platitude " corruption " discoloration.Some researches show that in skin care patch and cosmetics
Cause in the factor of stimulation and allergy 30% to 45% to be preservative.And be added to and have anti-corrosion function novel components, due to it
The imperfection of research, it is bigger that potential risks, which are compared with allergy influence,.After completing just package encapsulation, that is, complete barrier
After packaging, the gnotobasis in barrier packaging is realized using sterilization technology.Although all kinds of sterilization technologies have been widely to use
Mature technology, but barrier packaging in, used sterilization method and method, can complete barrier packaging in sterile shape
State, and can guarantee the architectural characteristic and activity of all components.Simultaneously using the variation of sterilization process, the finger of needs is reached in control
The characteristics of mark, this is this technology.
But new technical problem can be brought using high-temperature sterilization again：Most important in facial mask is exactly various in Essence
Active material, the Essence of most of facial mask is after high-temperature heating on the market, it may occur that irreversible denaturation so that essence
Liquid does not have the change of specific effect or the state generation essence of facial mask.
Invention content
The goal of the invention of the present invention is to provide a kind of skin care patch Essence of preservative free, which pastes Essence can be resistance to
By high-temperature heat sterilization condition without being denaturalized, while there are preferable moisturizing and antiphlogistic effects.In order to realize foregoing invention
Purpose, the present invention provides following technical solutions：
Essence is pasted in the skin care of scheme 1, a kind of preservative free, and the skin care patch is one in facial mask, eye mask or cold compress patch
Kind, skin care patch Essence is made of the raw material of following weight percent：Moisturizer 10%~20%, pH adjusting agent 0.05~
0.3%, thickener 0.05~0.2%, anti-inflammatory anti-sensitizer 0.05~0.2%, chelating agent 0.02~0.05%, remaining is water；Institute
State moisturizer, pH adjusting agent, thickener, anti-inflammatory anti-sensitizer and chelating agent be satisfied by 115 DEG C keep 30min do not become
Property；The one kind or combinations thereof of the anti-inflammatory anti-sensitizer in dipotassium glycyrrhizinate, zinc hyaluronate, allantoin.
Essence is pasted in the skin care of scheme 2, preservative free according to scheme 1, the moisturizer include moisturizing factor and
Humectant solvent；Moisturizing factor selects one in D-pantothenyl aleohol, allantoin, glycerin polyether -26, Sodium Hyaluronate, trehalose, glycine betaine
Kind or combinations thereof, humectant solvent selects one kind or combinations thereof in propylene glycol, glycerine.
Essence is pasted in the skin care of scheme 3, preservative free according to scheme 1 or 2, and the anti-inflammatory anti-sensitizer is selected transparent
After matter acid zinc, moisturizer contains glycerin polyether -26, is in terms of 100% benchmark by skin care patch Essence weight percent, the glycerine is poly-
- 26 content of ether is 0.1-1%, and the content ratio of zinc hyaluronate and glycerin polyether -26 is 1:15~1:5.
Essence is pasted in the skin care of scheme 4, preservative free according to scheme 3, and the anti-inflammatory anti-sensitizer selects hyalomitome
After sour zinc, moisturizer contains glycerin polyether -26, is in terms of 100% benchmark by skin care patch Essence weight percent, the glycerine is poly-
- 26 content of ether is 0.50%, and the content ratio of zinc hyaluronate and glycerin polyether -26 is 1:10.
Zinc hyaluronate not only with performance of keeping humidity also as introduce zinc ion and with not available for Sodium Hyaluronate
Performance, zinc hyaluronate can promote wound healing, and being cured conducive to the subtle wound of face, small pox etc. is posted for facial skin care
It closes；Skin elasticity can also be improved, wrinkle is reduced；The cell and gene damage of ultraviolet induction can be reduced；There is the anti-inflammatory quick work that disappears
With；Tolerance of the skin fibroblasts to response to oxidative stress can be increased.But it meanwhile being used in facial skin care patch
Can more strong convergence sense, skin sense is bad when use, it is therefore desirable to glycerin polyether -26 is added in moisturizer, it is saturating to adjust
The convergence sense that bright matter acid zinc is brought improves skin sense when using.Verified by test of many times, when skin care patch in zinc hyaluronate and
The content ratio of glycerin polyether -26 is 1:When 10, skin sense is best.
Normally transparent matter acid zinc is relatively stable between pH 6-6.5, and the pH average values of application on human skin are about 5.8, thus is
The function factor in facial mask is set preferably to absorb, facial mask needs similar to application on human skin acid-base property, therefore the pH value of facial mask should
Between 5.5-7.0, therefore, in the present invention, pH adjusting agent need by the pH of essence liquid system be finally adjusted to 6-6.5 it
Between.
Essence is pasted in the skin care of scheme 5, preservative free according to scheme 2, and the moisturizing factor is selected from glycerin polyether-
26, one kind or combinations thereof in Sodium Hyaluronate, trehalose and glycine betaine；The Sodium Hyaluronate, the Sodium Hyaluronate packet
Macromolecular, middle molecule and small molecule are included, the ratio of macromolecular, middle molecule and small molecule is 3:4:8.
Essence is pasted in the skin care of scheme 6, preservative free according to scheme 1 or 2, and the thickener is carbomer.
Essence is pasted in the skin care of scheme 7, preservative free according to scheme 6, and the pH adjusting agent selects alkaline pH tune
Save agent.
Essence is pasted in the skin care of scheme 8, preservative free according to scheme 7, and the pH adjusting agent selects arginine.
Essence is pasted in the skin care of scheme 9, preservative free according to scheme 1 or 2, and the chelating agent is EDTA-2Na.
Essence is pasted in the skin care of scheme 10, preservative free according to scheme 1, and skin care pastes Essence by the following raw material system
At：It is EDTA-2Na, D-pantothenyl aleohol, allantoin, glycerin polyether -26, Sodium Hyaluronate, propylene glycol, glycerine, trehalose, glycine betaine, sweet
Oxalic acid dipotassium, arginine, zinc hyaluronate, carbomer, water.
Essence is pasted in the skin care of scheme 11, preservative free according to scheme 10, and skin care pastes Essence by following weight
The raw material of percentage is made：EDTA-2Na 0.05%, D-pantothenyl aleohol 0.50%, allantoin 0.15%, glycerin polyether -26
0.50%, Sodium Hyaluronate 0.15%, propylene glycol 4%, glycerine 3%, trehalose 1%, glycine betaine 3%, dipotassium glycyrrhizinate
0.10%, arginine 0.15%, zinc hyaluronate 0.05%, carbomer 0.10%, remaining is water.
Essence is pasted in the skin care of scheme 12, a kind of preservative free, and the skin care patch is one in facial mask, eye mask or cold compress patch
Kind, skin care patch Essence is made of the raw material of following weight percent：Moisturizer 10%~20%, pH adjusting agent 0.05~
0.3%, thickener 0.05~0.2%, chelating agent 0.02~0.05%, remaining is water；The moisturizer, pH adjusting agent, thickening
Agent, anti-inflammatory anti-sensitizer and chelating agent are satisfied by keeps 30min not to be denaturalized at 115 DEG C；The moisturizer include moisturizing because
Son and humectant solvent；Moisturizing factor is selected in D-pantothenyl aleohol, allantoin, glycerin polyether -26, Sodium Hyaluronate, trehalose, glycine betaine
One kind or combinations thereof.
Essence is pasted in the skin care of scheme 13, preservative free according to scheme 12, and the moisturizing factor selects trehalose
When with glycine betaine, the ratio of trehalose and glycine betaine is 1:3.
Trehalose has the function of that water lock, glycine betaine have the function of moisturizing, and the facial mask later stage is coordinated to need high-temperature sterilization,
Show that when the ratio of trehalose and glycine betaine be 1 through numerous studies:When 3, applies sense and moistening effect reaches Best Point.In formula
When trehalose ratio is excessive, applies and feel bad, it is excessively glutinous；When glycine betaine ratio is too small, moistening effect cannot reach optimum efficiency again.
Essence is pasted in the skin care of scheme 14, preservative free according to scheme 12, it is characterised in that：The hyaluronic acid
Sodium, the Sodium Hyaluronate include macromolecular, middle molecule and small molecule, and the ratio of macromolecular, middle molecule and small molecule is 1~5：
2~6：8~15.
Essence is pasted in the skin care of scheme 15, preservative free according to scheme 14, and the Sodium Hyaluronate includes big point
The ratio of sub, middle molecule and small molecule, macromolecular, middle molecule and small molecule is 3:4:8.
Sodium Hyaluronate is divided into macromolecular, middle molecule and small molecule with molecular size range difference：Wherein macromolecular (molecular weight
1,800,000~2,200,000 dalton of range), one layer of ventilative thin-film barrier alien bacteria, ash can be formed in skin surface
The intrusion of dirt, ultraviolet light；Middle molecule (100,0000~1,800,000 dalton of molecular weight ranges) can form water lock wall, subtract
Few moisture loss；The hyaluronic acid of small molecule (400,000~1,000,000 dalton of molecular weight ranges) this rank can be directly
It penetrates into corium and directly acts on basal layer, have and increase blood circulation, the effect for promoting skin-nourishing to absorb has stronger disappear
Wrinkle function, can increase skin elasticity.Therefore, the effect of the hyaluronic acid of different molecular weight in skin care is different, and three kinds not
Hyaluronic acid function with molecular weight cooperates, and the skin care item effect for containing only unimodal molecular weight hyaluronic acid is very limited, and
The best skin-care effect of sodium hyaluronate cannot be played.By largely testing to obtain, when the ratio of macromolecular, middle molecule and small molecule is
3:4:When 8, applies sense and moistening effect reaches optimal balance point.
Essence is pasted in the skin care of scheme 16, preservative free according to scheme 12, the humectant solvent select propylene glycol,
One kind in glycerine or combinations thereof.
Essence is pasted in the skin care of scheme 17, preservative free according to scheme 12, and the thickener is carbomer；It is described
PH adjusting agent selects alkaline matter.
Essence is pasted in the skin care of scheme 18, preservative free according to scheme 15, and the pH adjusting agent selects arginine.
Essence is pasted in the skin care of scheme 19, preservative free according to scheme 12, and the chelating agent is EDTA-2Na.
Essence is pasted in the skin care of scheme 20, a kind of preservative free, and the skin care patch includes in facial mask, eye mask or cold compress patch
One kind, skin care patch Essence are made of the raw material of following weight percent：Moisturizer 10%~20%, pH adjusting agent 0.05~
0.3%, thickener 0.05~0.2%, chelating agent 0.02~0.05%, remaining is water；The moisturizer, pH adjusting agent, thickening
Agent, anti-inflammatory anti-sensitizer and chelating agent are satisfied by keeps 30min not to be denaturalized at 115 DEG C, and the thickener is carbomer.
The thickener that can be used for facial mask further includes xanthans, but xanthans non-refractory, viscosity rapid drawdown after high temperature, is risen not
To the thickening effect for wanting to have, and this problem is not present in carbomer, is suitble to process requirements in the present invention.
The facial treatment essence liquid of scheme 21, preservative free according to scheme 20, the pH adjusting agent select alkaline matter.
The facial treatment essence liquid of scheme 22, preservative free according to scheme 21, the pH adjusting agent select arginine.
The facial treatment essence liquid of scheme 23, preservative free according to scheme 20, the moisturizer include moisturizing factor and
Humectant solvent；Moisturizing factor selects one in D-pantothenyl aleohol, allantoin, glycerin polyether -26, Sodium Hyaluronate, trehalose, glycine betaine
Kind or combinations thereof, humectant solvent selects one kind or combinations thereof in propylene glycol, glycerine.
The facial treatment essence liquid of scheme 24, preservative free according to scheme 21, the moisturizing factor are selected from glycerin polyether-
26, one kind or combinations thereof in Sodium Hyaluronate, trehalose and glycine betaine；The Sodium Hyaluronate includes macromolecular, middle molecule
And small molecule, the ratio of macromolecular, middle molecule and small molecule is 3:4:8.
The facial treatment essence liquid of scheme 25, preservative free according to scheme 20, the chelating agent are EDTA-2Na.
Essence is pasted in the skin care of scheme 26, a kind of preservative free, and the skin care patch includes in facial mask, eye mask or cold compress patch
One kind, skin care patch Essence include that the raw material of following number ratio is made：10~20 parts of moisturizer, pH adjusting agent 0.05~0.3
Part, 0.05~0.2 part of thickener, 0.01~0.1 part of chelating agent；It is characterized in that：The moisturizer, pH adjusting agent, thickener,
Anti-inflammatory anti-sensitizer and chelating agent are satisfied by keeps 30min not to be denaturalized at 115 DEG C, and the chelating agent is EDTA-2Na.
The chelating agent that can be used for facial mask further includes EDTA-4Na, sodium phytate etc., it is contemplated that cost and effect, preferably
EDTA-2Na.EDTA-2Na has the function of exclusion heavy metal ion strongly, can be effectively protected human body not by weight
The harm of metal ion.
The facial treatment essence liquid of scheme 27, preservative free according to scheme 26, the moisturizer include moisturizing factor and
Humectant solvent；Moisturizing factor selects one in D-pantothenyl aleohol, allantoin, glycerin polyether -26, Sodium Hyaluronate, trehalose, glycine betaine
Kind or combinations thereof, humectant solvent selects one kind or combinations thereof in propylene glycol, glycerine.
The facial treatment essence liquid of scheme 28, preservative free according to scheme 26, the moisturizing factor are selected from glycerin polyether-
26, one kind or combinations thereof in Sodium Hyaluronate, trehalose and glycine betaine；The Sodium Hyaluronate, the Sodium Hyaluronate packet
Macromolecular, middle molecule and small molecule are included, the ratio of macromolecular, middle molecule and small molecule is 3:4:8.
The facial treatment essence liquid of scheme 29, preservative free according to scheme 26, the thickener are carbomer.
The facial treatment essence liquid of scheme 30, preservative free according to scheme 26, the pH adjusting agent select alkaline matter.
The facial treatment essence liquid of scheme 31, preservative free according to scheme 30, the conditioning agent select arginine.
Compared with prior art, the skin care patch Essence for using a kind of preservative free of above-mentioned technical proposal, has such as
Lower advantageous effect：
One, Essence is pasted in a kind of skin care of preservative free using the present invention, and the causes such as preservative are free of in the face pack prescription
Quick substance, reduces irritation of the facial mask to skin, and sensitive flesh is applicable in；
Two, Essence is pasted in a kind of skin care of preservative free using the present invention, the equal high temperature resistant of ingredient in the face pack prescription,
Can under the conditions of 115 DEG C 30min invariance, therefore can apply high-temperature heat sterilization method sterilize, control content of microorganisms；
Three, disappear quick dose containing anti-inflammatory in the skin care patch essence formula of liquid of preservative free of the invention, the hyaluronic acid of selection
Not only performance of keeping humidity is good for zinc, and has antiphlogistic effects, is conducive to formula and simplifies；
Four, the Sodium Hyaluronate in the skin care patch essence formula of liquid of preservative free of the invention is divided into macromolecular, middle molecule
And small molecule, the Sodium Hyaluronate of different molecular weight cooperate, moisturizing is better.
Specific implementation mode
The present invention is described further with reference to embodiment.
Embodiment 1 is to embodiment 7
As seen from the above table, between embodiment 1- embodiments 4 difference lies in chelating agent EDTA-2Na in system ratio, it is real
Apply the ratio difference lies in thickener carbomer in system between example 1 and embodiment 5-7.Wherein arginine is in the system
Effect be to adjust PH, be carbomer because influencing maximum ingredient to pH in the system, thus arginic additive amount mainly by
The amount of carbomer determines that therefore, the arginine amount of embodiment 1 and embodiment 5-7 also accordingly adjust.
It is first that carbomer, Sodium Hyaluronate, zinc hyaluronate is molten in advance by each raw material of upper table formula rate precise
It is swollen, by 1% swelling.Add suitable quantity of water under room temperature in Agitation Tank, in the case where spiral agitator persistently stirs, EDTA-2Na, D- is added
Panthenol, allantoin, glycerin polyether -26, propylene glycol, glycerine, trehalose, glycine betaine, dipotassium glycyrrhizinate are added molten after dissolving completely
Swollen good Sodium Hyaluronate, zinc hyaluronate, carbomer, stirring add arginine to adjust in ph to range, are supplied with water, stir
Uniformly, the skin care patch Essence of preservative free is obtained.
The Essence obtained in upper step is distributed into 25 grams every bag, which is sealed in high temperature resistant PE soft bags,
High-temperature heat sterilization 30min at 115 DEG C obtains pre-packaged skin care patch.Obtained pre-packaged skin care exchange premium row specificity analysis is tried
It tests.
1, appearance
10 samples are randomly selected from the pre-packaged skin care patch obtained in each embodiment, are labeled as experimental group embodiment
1-7；Each embodiment is respectively randomly selected 10 completions and is packed, and does not carry out the sample of high-temperature heat sterilization, labeled as control
Group.After experimental group in above-mentioned each embodiment and control group are amounted to 140 sample random numbers, by 5 sensory testing personnel
Sensory testing is carried out, comparing the color and luster of this 140 skin cares patch Essence, viscosity, mobility has no significant difference.
Test result：The facial mask essence of embodiment 1-7 difference in appearance after 115 DEG C of high-temperature heat sterilization 30min is unknown
It is aobvious, and the viscosity after sterilizing applies sense more preferably.
2, microbiological indicator
100 are respectively randomly selected from above-mentioned 7 embodiments and completes the pre-packaged skin care patch that sterilizes, and are implemented labeled as experimental group
Example 1-7；It is random again to extract 10 in various embodiments, amount to the 800 pre-packaged skin care not sterilized patches, labeled as pair
According to group.
Conclusion (of pressure testing)：According to upper table it is found that in the present invention a kind of preservative free skin care patch Essence without preservative at
Point, thus equal 100% microbiological contamination under high-temperature cultivation and room temperature culture of unpasteurized control group；Using high-temperature heat sterilization, each reality
It applies an experimental group sample and is satisfied by commercial sterilization effect in experimental period section, meet product requirement.
Embodiment 8- embodiments 14
As seen from the above table, between embodiment 8- embodiments 11 difference lies in the ratio of glycerin polyether -26 and hyaluronic acid,
The ratio that difference lies in zinc hyaluronates in system between embodiment 8 and embodiment 12-14, wherein because of glycerin polyether -26
There is correlation with the ratio of zinc hyaluronate, therefore, -26 percentage of glycerin polyether of embodiment 8 and embodiment 12-14 also phase
It should change.
It is first that carbomer, Sodium Hyaluronate, zinc hyaluronate is molten in advance by each raw material of upper table formula rate precise
It is swollen, by 1% swelling.Add suitable quantity of water under room temperature in Agitation Tank, in the case where spiral agitator persistently stirs, EDTA-2, Na D- is added
Panthenol, allantoin, glycerin polyether -26, propylene glycol, glycerine, trehalose, glycine betaine, dipotassium glycyrrhizinate are added molten after dissolving completely
Swollen good Sodium Hyaluronate, zinc hyaluronate, carbomer, stirring add arginine to adjust in ph to range, finally add water to quarter
Degree, stirs evenly, and obtains the skin care patch Essence of preservative free.
The Essence obtained in upper step is distributed into 25 grams every bag, which is sealed in high temperature resistant PE soft bags,
High-temperature heat sterilization 30min at 115 DEG C obtains pre-packaged skin care patch.Obtained pre-packaged skin care exchange premium row specificity analysis is tried
It tests.
1, appearance
10 samples are randomly selected from the pre-packaged skin care patch obtained in each embodiment, are labeled as experimental group embodiment
8-14；Each embodiment is respectively randomly selected 10 completions and is packed, and does not carry out the sample of high-temperature heat sterilization, labeled as control
Group.After experimental group in above-mentioned each embodiment and control group are amounted to 140 sample random numbers, by 5 sensory testing personnel
Sensory testing is carried out, comparing the color and luster of this 140 skin cares patch Essence, viscosity, mobility has no significant difference.
Test result：The facial mask essence of embodiment 8-14 difference in appearance after 115 DEG C of high-temperature heat sterilization 30min is unknown
It is aobvious, and the viscosity after sterilizing applies sense more preferably.
2, microbiological indicator
The pre-packaged skin care patch that sterilizes is completed in random each extraction 100 in above-mentioned 7 embodiments, is labeled as experimental group embodiment
8-14；It is random again to extract 10 in various embodiments, amount to the 800 pre-packaged skin care not sterilized patches, labeled as pair
According to group.
Conclusion (of pressure testing)：According to upper table it is found that in the present invention a kind of preservative free skin care patch Essence without preservative at
Point, thus equal 100% microbiological contamination under high-temperature cultivation and room temperature culture of unpasteurized control group；Using high-temperature heat sterilization, each reality
It applies an experimental group sample and is satisfied by commercial sterilization effect in experimental period section, meet product requirement.
Embodiment 15
Meet a kind of skin care patch Essence of preservative free of goal of the invention of the present embodiment in order to obtain, the present embodiment uses
The following raw material and raw material proportioning：EDTA-2Na 0.05%, D-pantothenyl aleohol 0.50%, allantoin 0.15%, glycerin polyether -26
0.50%, Sodium Hyaluronate 0.15%, propylene glycol 4%, glycerine 3%, trehalose 1%, glycine betaine 3%, dipotassium glycyrrhizinate
0.10%, arginine 0.15%, zinc hyaluronate 0.05%, carbomer 0.10%, pearl powder 0.50%, remaining is water.
It should be appreciated that 1- of embodiment of the present invention embodiments 14 are basic components, on the basic components, resistance to height is added
Other active ingredients of temperature, and the invention thought of the present invention with other formula compatibilities, can be met, it should also in the present invention
Protection domain in.The present embodiment is merely illustrative of, and should not be considered as the restriction to protection scope of the present invention.
The present embodiment is a kind of whitening and skin-protecting patch Essence of preservative free, through above-mentioned experimental verification, the essence formula of liquid
It applies sense and microorganism is up to standard.
The above is the preferred embodiment of the present invention, does not depart from this hair for those of ordinary skill in the art
Under the premise of bright principle, several variations and modifications can also be made, these also should be regarded as protection scope of the present invention.
Claims (9)
1. Essence is pasted in a kind of skin care of preservative free, the skin care patch is one kind in facial mask, eye mask or cold compress patch, skin care patch
Essence is made of the raw material of following weight percent：Moisturizer 10% ~ 20%, pH adjusting agent 0.05 ~ 0.3%, thickener 0.05 ~
0.2%, anti-inflammatory anti-sensitizer 0.05 ~ 0.2%, chelating agent 0.02 ~ 0.05%, remaining is water；It is characterized in that：The moisturizer, pH tune
Section agent, thickener, anti-inflammatory anti-sensitizer and chelating agent are satisfied by keeps 30min not to be denaturalized at 115 DEG C；The anti-inflammatory antiallergic
The one kind or combinations thereof of agent in dipotassium glycyrrhizinate, zinc hyaluronate, allantoin.
2. Essence is pasted in the skin care of preservative free according to claim 1, it is characterised in that：The moisturizer includes moisturizing
The factor and humectant solvent；Moisturizing factor selects D-pantothenyl aleohol, allantoin, glycerin polyether -26, Sodium Hyaluronate, trehalose, glycine betaine
In one kind or combinations thereof, humectant solvent selects one kind or combinations thereof in propylene glycol, glycerine；
After the anti-inflammatory anti-sensitizer selects zinc hyaluronate, moisturizer contains glycerin polyether -26, with skin care patch Essence weight hundred
It is divided into 100% benchmark meter, -26 content of the glycerin polyether is 0.1-1%, and the content ratio of zinc hyaluronate and glycerin polyether -26 is
1:15~1:5；
Preferably, after the anti-inflammatory anti-sensitizer selects zinc hyaluronate, moisturizer contains glycerin polyether -26, and essence is pasted with skin care
Liquid weight percent is 100% benchmark meter, and -26 content of the glycerin polyether is 0.50%, and zinc hyaluronate and glycerin polyether -26 contain
Amount is than being 1:10；
The one kind or combinations thereof of the moisturizing factor in glycerin polyether -26, Sodium Hyaluronate, trehalose and glycine betaine；Institute
State Sodium Hyaluronate, the Sodium Hyaluronate includes macromolecular, middle molecule and small molecule, macromolecular, middle molecule and small molecule
Ratio is 3:4:8.
3. Essence is pasted in the skin care of preservative free according to claim 1 or 2, it is characterised in that：The thickener is card
Wave nurse；The pH adjusting agent selects alkaline pH adjusting agent；Preferably, the pH adjusting agent selects arginine；The chelating agent is
EDTA-2Na。
4. Essence is pasted in the skin care of preservative free according to claim 1 or 2, it is characterised in that：Skin care paste Essence by
The following raw material is made：EDTA-2Na, D-pantothenyl aleohol, allantoin, glycerin polyether -26, Sodium Hyaluronate, propylene glycol, glycerine, seaweed
Sugar, glycine betaine, dipotassium glycyrrhizinate, arginine, zinc hyaluronate, carbomer, water；
Preferably, EDTA-2Na 0.05%, D-pantothenyl aleohol 0.50%, allantoin 0.15%, glycerin polyether -26 0.50%, hyalomitome
Sour sodium 0.15%, propylene glycol 4%, glycerine 3%, trehalose 1%, glycine betaine 3%, dipotassium glycyrrhizinate 0.10%, arginine 0.15%,
Zinc hyaluronate 0.05%, carbomer 0.10%, remaining is water.
5. Essence is pasted in a kind of skin care of preservative free, the skin care patch is one kind in facial mask, eye mask or cold compress patch, skin care patch
Essence is made of the raw material of following weight percent：Moisturizer 10% ~ 20%, pH adjusting agent 0.05 ~ 0.3%, thickener 0.05 ~
0.2%, chelating agent 0.02 ~ 0.05%, remaining is water；It is characterized in that：The moisturizer, pH adjusting agent, thickener, anti-inflammatory antiallergic
Agent and chelating agent are satisfied by keeps 30min not to be denaturalized at 115 DEG C；The moisturizer includes that moisturizing factor and moisturizing are molten
Agent；Moisturizing factor select D-pantothenyl aleohol, allantoin, glycerin polyether -26, Sodium Hyaluronate, trehalose, one kind in glycine betaine or its
Combination.
6. Essence is pasted in the skin care of preservative free according to claim 5, it is characterised in that：The moisturizing factor selects sea
When algae sugar and glycine betaine, the ratio of trehalose and glycine betaine is 1:3.
7. Essence is pasted in the skin care of preservative free according to claim 5, it is characterised in that：The Sodium Hyaluronate, institute
It includes macromolecular, middle molecule and small molecule to state Sodium Hyaluronate, and the ratio of macromolecular, middle molecule and small molecule is 1 ~ 5：2~6：8~
15；
Preferably, the Sodium Hyaluronate includes macromolecular, middle molecule and small molecule, macromolecular, middle molecule and small molecule ratio
Example is 3:4:8.
8. Essence is pasted in a kind of skin care of preservative free, the skin care patch includes one kind in facial mask, eye mask or cold compress patch, skin care
Patch Essence is made of the raw material of following weight percent：Moisturizer 10% ~ 20%, pH adjusting agent 0.05 ~ 0.3%, thickener 0.05
~ 0.2%, chelating agent 0.02 ~ 0.05%%, remaining is water；It is characterized in that：The moisturizer, pH adjusting agent, thickener, anti-inflammatory are anti-
Quick dose is satisfied by the holding 30min at 115 DEG C with chelating agent and is not denaturalized, and the thickener is carbomer.
9. Essence is pasted in a kind of skin care of preservative free, the skin care patch includes one kind in facial mask, eye mask or cold compress patch, skin care
Patch Essence includes that the raw material of following number ratio is made：10% ~ 20 part of moisturizer, 0.05 ~ 0.3 part of pH adjusting agent, thickener
0.05 ~ 0.2 part, 0.02 ~ 0.05% part of chelating agent；It is characterized in that：The moisturizer, pH adjusting agent, thickener, anti-inflammatory antiallergic
Agent and chelating agent are satisfied by keeps 30min not to be denaturalized at 115 DEG C, and the chelating agent is EDTA-2Na.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810247348.9A CN108542801A (en) | 2018-03-23 | 2018-03-23 | A kind of skin care patch Essence of preservative free |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810247348.9A CN108542801A (en) | 2018-03-23 | 2018-03-23 | A kind of skin care patch Essence of preservative free |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108542801A true CN108542801A (en) | 2018-09-18 |
Family
ID=63516971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810247348.9A Pending CN108542801A (en) | 2018-03-23 | 2018-03-23 | A kind of skin care patch Essence of preservative free |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108542801A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109700739A (en) * | 2019-02-25 | 2019-05-03 | 江苏煦音生物科技有限公司 | A kind of taste face cream formula and its configuration method |
| CN110638662A (en) * | 2019-10-11 | 2020-01-03 | 王燕丽 | A kind of preparation method of skin care sticker containing natural animal and plant extracts |
| CN111214423A (en) * | 2020-03-29 | 2020-06-02 | 刘阔 | Essence without preservative and preparation method thereof |
| CN113274310A (en) * | 2021-06-04 | 2021-08-20 | 华熙生物科技股份有限公司 | New application of zinc hyaluronate in repairing skin injury, composition and skin external preparation thereof |
| EP3954359A4 (en) * | 2019-04-11 | 2023-03-01 | Natura Cosméticos S.A. | TOPICAL COSMETIC COMPOSITION AND USES THEREOF |
| EP3954358A4 (en) * | 2019-04-11 | 2023-03-01 | Natura Cosméticos S.A. | COSMETIC COMPLEX AND USES OF IT |
| CN117064794A (en) * | 2023-09-28 | 2023-11-17 | 华熙生物科技股份有限公司 | Oral care composition and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102834417A (en) * | 2010-04-14 | 2012-12-19 | 丘比株式会社 | Process for producing hyaluronic acid metal salt, process for producing cosmetic containing hyaluronic acid metal salt, and zinc hyaluronate and process for producing same |
| CN106109296A (en) * | 2016-06-30 | 2016-11-16 | 彭燕辉 | A kind of moisturizing essence lotion and preparation method thereof |
| CN106726743A (en) * | 2016-11-23 | 2017-05-31 | 上海萧雅生物科技股份有限公司 | Facial treatment mask that no added safe pregnant woman can be used and preparation method thereof |
| CN107137263A (en) * | 2017-04-19 | 2017-09-08 | 北京赛尔佳人化妆品有限公司 | A kind of anti-ageing face mask liquid and preparation method thereof |
-
2018
- 2018-03-23 CN CN201810247348.9A patent/CN108542801A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102834417A (en) * | 2010-04-14 | 2012-12-19 | 丘比株式会社 | Process for producing hyaluronic acid metal salt, process for producing cosmetic containing hyaluronic acid metal salt, and zinc hyaluronate and process for producing same |
| CN106109296A (en) * | 2016-06-30 | 2016-11-16 | 彭燕辉 | A kind of moisturizing essence lotion and preparation method thereof |
| CN106726743A (en) * | 2016-11-23 | 2017-05-31 | 上海萧雅生物科技股份有限公司 | Facial treatment mask that no added safe pregnant woman can be used and preparation method thereof |
| CN107137263A (en) * | 2017-04-19 | 2017-09-08 | 北京赛尔佳人化妆品有限公司 | A kind of anti-ageing face mask liquid and preparation method thereof |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109700739A (en) * | 2019-02-25 | 2019-05-03 | 江苏煦音生物科技有限公司 | A kind of taste face cream formula and its configuration method |
| EP3954359A4 (en) * | 2019-04-11 | 2023-03-01 | Natura Cosméticos S.A. | TOPICAL COSMETIC COMPOSITION AND USES THEREOF |
| EP3954358A4 (en) * | 2019-04-11 | 2023-03-01 | Natura Cosméticos S.A. | COSMETIC COMPLEX AND USES OF IT |
| CN110638662A (en) * | 2019-10-11 | 2020-01-03 | 王燕丽 | A kind of preparation method of skin care sticker containing natural animal and plant extracts |
| CN111214423A (en) * | 2020-03-29 | 2020-06-02 | 刘阔 | Essence without preservative and preparation method thereof |
| CN113274310A (en) * | 2021-06-04 | 2021-08-20 | 华熙生物科技股份有限公司 | New application of zinc hyaluronate in repairing skin injury, composition and skin external preparation thereof |
| CN113274310B (en) * | 2021-06-04 | 2023-04-07 | 华熙生物科技股份有限公司 | New application of zinc hyaluronate in repairing skin injury, composition and skin external preparation thereof |
| CN117064794A (en) * | 2023-09-28 | 2023-11-17 | 华熙生物科技股份有限公司 | Oral care composition and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108542801A (en) | A kind of skin care patch Essence of preservative free | |
| JP7600398B2 (en) | Efficacy enhancing compositions and uses thereof | |
| CN107184486A (en) | A kind of facial mask liquid and the facial mask containing the facial mask liquid | |
| TWI753901B (en) | Germinated brown rice saccharomyces veronae fermented liquid | |
| CN106109296A (en) | A kind of moisturizing essence lotion and preparation method thereof | |
| CN1803124B (en) | Gamma-polyglutamic acid, gamma-polyglutamate and application of hydrogel thereof | |
| CN106420398A (en) | Leave-on waterborne spraying type hair conditioner and preparation method thereof | |
| CN116003577A (en) | Recombinant collagen for skin soothing and repairing and application thereof | |
| CN106726743A (en) | Facial treatment mask that no added safe pregnant woman can be used and preparation method thereof | |
| CN107898660A (en) | A kind of tender skin water light stoste and its preparation method and application | |
| CN110464658B (en) | Multi-effect eye freeze-dried film and steam eye-shade | |
| CN110755345A (en) | Prebiotic composition and application thereof | |
| CN108524406A (en) | A kind of Golden flower facial mask and preparation method thereof | |
| CN108261376A (en) | A kind of three-dimensional moisturizing factor | |
| CN105726439B (en) | Golden cicada spends skin whitening, moisturizing medicine cosmetic and preparation method thereof | |
| CN106580829A (en) | Nutritional skin-care aloe gel | |
| CN107569425A (en) | A kind of camellia skin-protection elite formula of liquid and its processing technology | |
| CN109172422B (en) | A kind of hyaluronic acid facial mask liquid and preparation method thereof | |
| CN107375152A (en) | A kind of cation sterilization gel and preparation method thereof and the aloetic bacteriostatic gel product comprising the cation sterilization gel | |
| CN110279626A (en) | With the cosmetic composition and preparation method thereof for cooperateing with long-acting moistening effect | |
| CN107190506A (en) | fibroin finishing agent and its preparation method and application | |
| CN112675071A (en) | Wool keratin freeze-dried mask and preparation method and application thereof | |
| CN112137895A (en) | Eye mask containing tremella polysaccharide and preparation method thereof | |
| CN109966213A (en) | A kind of ferment facial mask and preparation method thereof | |
| CN110840793B (en) | Fibroin mask liquid and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180918 |
|
| RJ01 | Rejection of invention patent application after publication |