CN108402075A - A kind of compound Chinese medicinal material curing agent and preparation method and application of long-acting controllable sustained-release chlorine dioxide - Google Patents
A kind of compound Chinese medicinal material curing agent and preparation method and application of long-acting controllable sustained-release chlorine dioxide Download PDFInfo
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- CN108402075A CN108402075A CN201810399465.7A CN201810399465A CN108402075A CN 108402075 A CN108402075 A CN 108402075A CN 201810399465 A CN201810399465 A CN 201810399465A CN 108402075 A CN108402075 A CN 108402075A
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- Prior art keywords
- starch
- curing agent
- chlorine dioxide
- sodium chlorite
- powder
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- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 title claims abstract description 161
- 239000003795 chemical substances by application Substances 0.000 title claims abstract description 84
- 239000004155 Chlorine dioxide Substances 0.000 title claims abstract description 79
- 235000019398 chlorine dioxide Nutrition 0.000 title claims abstract description 77
- 239000000463 material Substances 0.000 title claims abstract description 57
- 238000013268 sustained release Methods 0.000 title claims abstract description 30
- 239000012730 sustained-release form Substances 0.000 title claims abstract description 30
- 150000001875 compounds Chemical class 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims description 19
- 229920002472 Starch Polymers 0.000 claims abstract description 91
- 239000008107 starch Substances 0.000 claims abstract description 91
- 235000019698 starch Nutrition 0.000 claims abstract description 91
- 239000003814 drug Substances 0.000 claims abstract description 85
- 239000000843 powder Substances 0.000 claims abstract description 68
- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 claims abstract description 64
- 229960002218 sodium chlorite Drugs 0.000 claims abstract description 64
- 238000005253 cladding Methods 0.000 claims abstract description 37
- 239000002253 acid Substances 0.000 claims abstract description 35
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 34
- 239000011707 mineral Substances 0.000 claims abstract description 34
- 150000003839 salts Chemical class 0.000 claims abstract description 26
- 238000000034 method Methods 0.000 claims abstract description 11
- -1 small molecule organic compounds Chemical class 0.000 claims abstract description 10
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 claims abstract description 8
- 230000008569 process Effects 0.000 claims abstract description 7
- BNGXYYYYKUGPPF-UHFFFAOYSA-M (3-methylphenyl)methyl-triphenylphosphanium;chloride Chemical compound [Cl-].CC1=CC=CC(C[P+](C=2C=CC=CC=2)(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 BNGXYYYYKUGPPF-UHFFFAOYSA-M 0.000 claims abstract description 6
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 6
- 238000012423 maintenance Methods 0.000 claims description 44
- 235000010755 mineral Nutrition 0.000 claims description 31
- 239000007787 solid Substances 0.000 claims description 14
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 13
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 6
- 229920001592 potato starch Polymers 0.000 claims description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- 229910021536 Zeolite Inorganic materials 0.000 claims description 5
- XTVVROIMIGLXTD-UHFFFAOYSA-N copper(II) nitrate Chemical compound [Cu+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O XTVVROIMIGLXTD-UHFFFAOYSA-N 0.000 claims description 5
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 5
- 239000011148 porous material Substances 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- 239000010457 zeolite Substances 0.000 claims description 5
- 229920002261 Corn starch Polymers 0.000 claims description 4
- 244000017020 Ipomoea batatas Species 0.000 claims description 4
- 235000002678 Ipomoea batatas Nutrition 0.000 claims description 4
- 239000000440 bentonite Substances 0.000 claims description 4
- 229910000278 bentonite Inorganic materials 0.000 claims description 4
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 4
- 239000008120 corn starch Substances 0.000 claims description 4
- 229940099112 cornstarch Drugs 0.000 claims description 4
- 238000007789 sealing Methods 0.000 claims description 4
- 239000004113 Sepiolite Substances 0.000 claims description 3
- 229960000892 attapulgite Drugs 0.000 claims description 3
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 claims description 3
- 229940077239 chlorous acid Drugs 0.000 claims description 3
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 claims description 3
- 239000010439 graphite Substances 0.000 claims description 3
- 229910002804 graphite Inorganic materials 0.000 claims description 3
- 235000011147 magnesium chloride Nutrition 0.000 claims description 3
- 229910052625 palygorskite Inorganic materials 0.000 claims description 3
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 3
- 229910052624 sepiolite Inorganic materials 0.000 claims description 3
- 235000019355 sepiolite Nutrition 0.000 claims description 3
- 239000010455 vermiculite Substances 0.000 claims description 3
- 229910052902 vermiculite Inorganic materials 0.000 claims description 3
- 235000019354 vermiculite Nutrition 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims 2
- 239000010425 asbestos Substances 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 229910052895 riebeckite Inorganic materials 0.000 claims 1
- 238000003860 storage Methods 0.000 abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 15
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract description 12
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract description 11
- 239000007789 gas Substances 0.000 abstract description 8
- 239000011593 sulfur Substances 0.000 abstract description 8
- 229910052717 sulfur Inorganic materials 0.000 abstract description 8
- 150000001299 aldehydes Chemical class 0.000 abstract description 7
- 150000001336 alkenes Chemical class 0.000 abstract description 6
- VCJMYUPGQJHHFU-UHFFFAOYSA-N iron(3+);trinitrate Chemical compound [Fe+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O VCJMYUPGQJHHFU-UHFFFAOYSA-N 0.000 abstract description 6
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract description 5
- 229910021529 ammonia Inorganic materials 0.000 abstract description 5
- 230000006378 damage Effects 0.000 abstract description 5
- 150000002148 esters Chemical class 0.000 abstract description 5
- 150000002576 ketones Chemical class 0.000 abstract description 5
- 102000002322 Egg Proteins Human genes 0.000 abstract description 4
- 108010000912 Egg Proteins Proteins 0.000 abstract description 4
- 210000004681 ovum Anatomy 0.000 abstract description 4
- 239000005864 Sulphur Substances 0.000 abstract description 3
- 230000007423 decrease Effects 0.000 abstract description 3
- 230000001590 oxidative effect Effects 0.000 abstract description 3
- 230000000505 pernicious effect Effects 0.000 abstract description 3
- 238000004806 packaging method and process Methods 0.000 description 13
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 10
- 238000013461 design Methods 0.000 description 10
- 241000238631 Hexapoda Species 0.000 description 7
- 230000008859 change Effects 0.000 description 7
- 238000012856 packing Methods 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 241000607479 Yersinia pestis Species 0.000 description 6
- 238000007599 discharging Methods 0.000 description 6
- 231100001261 hazardous Toxicity 0.000 description 6
- 239000002985 plastic film Substances 0.000 description 6
- 229920006255 plastic film Polymers 0.000 description 6
- 239000002699 waste material Substances 0.000 description 6
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000011888 foil Substances 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- 238000009461 vacuum packaging Methods 0.000 description 5
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- BZSXEZOLBIJVQK-UHFFFAOYSA-N 2-methylsulfonylbenzoic acid Chemical compound CS(=O)(=O)C1=CC=CC=C1C(O)=O BZSXEZOLBIJVQK-UHFFFAOYSA-N 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 239000000645 desinfectant Substances 0.000 description 3
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 229910052901 montmorillonite Inorganic materials 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 239000004927 clay Substances 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000003912 environmental pollution Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 235000012055 fruits and vegetables Nutrition 0.000 description 2
- 238000003958 fumigation Methods 0.000 description 2
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 2
- 239000000575 pesticide Substances 0.000 description 2
- 239000004575 stone Substances 0.000 description 2
- 239000007939 sustained release tablet Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- IHGSAQHSAGRWNI-UHFFFAOYSA-N 1-(4-bromophenyl)-2,2,2-trifluoroethanone Chemical compound FC(F)(F)C(=O)C1=CC=C(Br)C=C1 IHGSAQHSAGRWNI-UHFFFAOYSA-N 0.000 description 1
- 206010008428 Chemical poisoning Diseases 0.000 description 1
- 244000241838 Lycium barbarum Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 241000361919 Metaphire sieboldi Species 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001857 anti-mycotic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000002543 antimycotic Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- MAHNFPMIPQKPPI-UHFFFAOYSA-N disulfur Chemical class S=S MAHNFPMIPQKPPI-UHFFFAOYSA-N 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000013265 extended release Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910000069 nitrogen hydride Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004076 pulp bleaching Methods 0.000 description 1
- 210000004767 rumen Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012956 testing procedure Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A kind of compound Chinese medicinal material curing agent of long-acting controllable sustained-release chlorine dioxide is to react to form faintly acid with the residual water in strong acid weak base inorganic salts and Chinese medicine, then react with the sodium chlorite of starch cladding, slow release chlorine dioxide；The sodium chlorite that starch coats is supported on porous mineral powder and further decreases rate of release；Release chlorine dioxide total amount is controlled by controlling sodium chlorite total amount；Rate of release is controlled by controlling porous mineral powder and content of starch；Strong acid weak base salt used includes：U-Ramin MC or ferric trichloride or aluminum nitrate or ferric nitrate etc.；By the strong oxidizing property of the chlorine dioxide of sustained release, mould and worm's ovum are killed, and aoxidizes other small molecule organic compounds such as alkene, aldehyde, acid, ester, phenol, ketone etc. that the sulphur in Chinese medicine, ammonia and storage release in the process；Porous mineral in curing agent can also adsorb these pernicious gases.Curing agent can effectively prevent that Chinese medicine is mouldy during storage, damages by worms, and reduce sulfur content and color protection.
Description
Technical field
The invention belongs to Chinese medicine storage and conservation technology fields, particularly relate to a kind of long-acting controllable sustained-release chlorine dioxide
Compound Chinese medicinal material curing agent and preparation method thereof.
Background technology
The general water content of Chinese medicine in 6-13%, during storage mould, worm's ovum its surface or it is internal grow, it is numerous
Grow, so as to cause medicinal material go bad it is mouldy, damage by worms.Chinese medicine moldy metamorphism and is damaged by worms during storage in order to prevent, needs to pacify
Complete effective method antimycotic antiseptic desinsection.
The method of the mould proof desinsection storage of Chinese medicine tradition is that sulfur fumigation or highly toxic pesticide aluminum phosphide fumigation, two methods exist
Huge environmental pollution is generated during use.And it is more than standards of pharmacopoeia that former approach, which often results in sulfur content in Chinese medicine,
And actual bodily harm is brought to patient after so that the Chinese medicine that medicinal material is scrapped or sulfur-bearing is excessive is eaten；Later approach kind uses
Aluminum phosphate is highly toxic pesticide, it has not been convenient to which management and control increases management and control cost, and remaining aluminum phosphate if usage is improper, in Chinese medicine will lead
Cause eater's pesticide poisoning.
Chlorine dioxide (ClO2) as a kind of excellent disinfectant and strong oxidizer, it is praised highly as forth generation disinfectant, is
A1 grades wide spectrum, safety and the high effect disinfectants that the World Health Organization (WHO) is recommended to the whole world, have been widely used in drinking water
The fields such as purification system, association with pulp bleaching industry, the disinfection of medical instrument, fruit and vegetable storage and transportation be fresh-keeping.ClO2Guarantor as fruits and vegetables, food
Fresh dose, mainly using its oxidisability make bacterium and it is mould persistently aoxidized, to kill bacterium and remove influence food protect
The unfavorable ingredient of some fresh (such as ethylene) achieves the goal.From the eighties in 19th century, people recognize ClO2Since, both at home and abroad
Work out a variety of ClO2The preparation method of gas.Crowd sees solid ClO2The preparation method of sustained release tablets is primarily present following defect：(1)
Effective concentration is low, and effective storage life is very short；(2) solid ClO is increased2The dosage of sustained release tablets can be concentrated in short-term 5-15 days
Discharge ClO2, rate of release is too fast, is easy the Chinese medicine that injury is conserved, Chinese medicine selective oxidation is caused excessively to lose medicine
Effect.(3) since chlorine dioxide release time is generally less than 30 days, and easily infested easily mouldy Chinese medicine stores some needs
It preserves 1 year to two years.A kind of compound Chinese medicinal material curing agent for long-acting sustained-release chlorine dioxide that the application proposes can be two
Certain density chlorine dioxide sustained release is kept in year.
Invention content
The technical problem to be solved in the present invention is to provide a kind of maintenances of the compound Chinese medicinal material of long-acting controllable sustained-release chlorine dioxide
Agent and preparation method thereof, the curing agent are to form weak acid with the residual water reaction (hydrolysis) in strong acid weak base inorganic salts and Chinese medicine
Property, then reacted with the sodium chlorite of starch cladding, slow release chlorine dioxide.It is compared with acid is directly added into,
Rate of release is more slow.
In order to solve the above technical problems, the embodiment of the present invention provide a kind of long-acting controllable sustained-release chlorine dioxide it is compound in
Medicinal material curing agent, wherein the mass ratio of starch and sodium chlorite is 1:3~10, the strong acid weak base inorganic salts and starch coat
Sodium chlorite mass ratio be 1:1.1~1.5.
Preferably, the strong acid weak base inorganic salts are U-Ramin MC or magnesium dichloride or dichloride copper or ferric trichloride or nitre
Sour calcium or aluminum nitrate or ferric nitrate or copper nitrate.
Preferably, the starch is solid starch, specially cornstarch or starch from sweet potato or potato starch.
Preferably, in order to further decrease the rate of release chlorine dioxide, the sodium chlorite of the starch cladding is negative
It is loaded on porous mineral powder, the sodium chlorite of starch cladding and the mass ratio for the porous powder being added are 1:4~15.Pass through
Control curing agent in sodium chlorite total amount come control release chlorine dioxide total amount, according to by maintenance Chinese medicine water content, pass through control
The content of porous mineral powder content and starch processed controls rate of release.
Preferably, the porous mineral powder is zeolite, diatomite, the activated carbon of three-dimensional fine pore passage structure, or two dimension
The bentonite (montmorillonite) of pore passage structure, attapulgite, sepiolite, the stone of vermiculite, galapectite, graphite or one-dimensional tunnel structure
Cotton.
By the curing agent of preparation with the paper bag of gas can be penetrated or packaged by plastic film with small hole is at pouch, put
In the airtight space for entering Chinese medicine storage.Chinese medicine typically contains the water of 6-13%, and vapor is through small paper or plastic foil
Aperture makes strong acid weak base salt hydrolysis release hydrogen ion, and sodium chlorite decomposes to give off chlorine dioxide under hydrogen ion effect,
By the strong oxidizing property of chlorine dioxide, mould and worm's ovum are killed, and aoxidizes the sulphur in Chinese medicine, ammonia and Chinese medicine storage
Other small molecule organic compounds such as alkene, aldehyde, acid, ester, phenol, ketone released in the process etc.；In addition, being released during Chinese medicine storage
If these small molecule organic compounds such as alkene, aldehyde, acid, ester, phenol, ketone etc. released do not remove, the mouldy change of Chinese medicine will be promoted
Matter.Porous mineral materials in the application curing agent can also adsorb these pernicious gas substances.In maintenance processes, Chinese medicine is not
It is in direct contact curing agent.After Chinese medicine storage maintenance, the curing agent for being adsorbed with harmful substance falls according to domestic rubbish disposal,
It is equivalent to and primary purification has been carried out to Chinese medicine.
A kind of preparation method of the compound Chinese medicinal material curing agent of long-acting controllable sustained-release chlorine dioxide, includes the following steps：
The sodium chlorite preparation of S1, starch cladding
By solid starch and sodium chlorite according to 1:3~10 weigh, and in the ball mill, sodium chlorite solid abrasive are first added
After 1 hour, starch is divided into 3-5 equal portions, adds a starch every a hour, after to the last a starch adds, grinding 2
Hour, obtain the sodium chlorite powder of starch cladding；
S2, the sodium chlorite powder that starch cladding is loaded on porous mineral materials
Porous mineral materials powder is crossed into 40 mesh sieve, with the porous mineral powder sieved less than 40 mesh, the Asia that starch is coated
Sodium chlorate powder and porous mineral materials mixing, continue ground and mixed 4-6 hours in the ball mill；Starch and sodium chlorite it is total
The mass ratio of quality and the porous powder being added is 1:4~15；
S3, strong acid weak base salt is added
Strong acid weak base salt is added in continuation in the ball mill, grinds 4-6 hours, obtains compound Chinese medicinal material curing agent powder.
S4, the drying of compound Chinese medicinal material curing agent
The compound Chinese medicinal material curing agent powder of acquisition is dried into 1 hour postcooling at 120 DEG C to obtain the final product.
Preferably, the strong acid weak base inorganic salts are U-Ramin MC or magnesium dichloride or dichloride copper or ferric trichloride or nitre
Sour calcium or aluminum nitrate or ferric nitrate or copper nitrate.
Preferably, the starch is solid starch, specially cornstarch or starch from sweet potato or potato starch.
Preferably, the porous mineral powder is zeolite, diatomite, the activated carbon of three-dimensional fine pore passage structure, or two dimension
The bentonite (montmorillonite) of pore passage structure, attapulgite, sepiolite, the stone of vermiculite, galapectite, graphite or one-dimensional tunnel structure
Cotton.
The present invention regulates and controls releasing for chlorine dioxide according to the content of starch and porous powder in prepared curing agent
Rate is put, achievees the purpose that long-acting slow-release.Sodium chlorite is released during storage with Chinese medicine in prepared curing agent
Water reacts under acidic environment, releases chlorine dioxide.
The release profiles of the prepared Chinese medicine curing agent release chlorine dioxide of test, specific test method is, with 7 layers
The heat-sealing of co-extrusion high diaphragm is put into the curing agent prepared by 20 grams, is sealed with heat sealing machine at the airtight space that volume is 0.5m3,
The pressure of air is about an atmospheric pressure in airtight space.It places after a certain period of time, opens packaging, directly use brand entitled
The chlorine dioxide tester of Skyeaglee, model SK-600-ClO directly test the content of chlorine dioxide in airtight space.Weight
Multiple above-mentioned testing procedure, places the different time, obtains the release profiles of chlorine dioxide.
The total amount for discharging the speed and release chlorine dioxide of chlorine dioxide according to obtained curing agent is tested.For specific
By the attribute of maintenance Chinese medicine, water content and storage time, the sustained release rate of chlorine dioxide and required chlorine dioxide are determined
Total amount, obtain curing agent and be specifically formulated.
The packing of compound Chinese medicinal material curing agent, packaging
The curing agent of preparation is first divided in the paper bag that can be breathed freely or cellular plastic film pouch, such as each pouch
10-100 grams, then again by the small packed such as packaging of multiple curing agents, if 50-100 pouches one wrap, vacuum packaging, record is given birth to
It produces the date and applicable Chinese medicine conserves kind, used when for Chinese medicine maintenance.
Application of the compound Chinese medicinal material curing agent in Chinese medicine maintenance：
The curing agent of preparation is packed with the paper bag that can be breathed freely or the plastic film bag with small air hole, after sealing directly
It is put into the airtight space of Chinese medicine maintenance, the chlorine dioxide of sustained release enters Chinese medicine by the air hole of paper or plastic foil
Material hermetically sealed packaging.
It, can be directly when house refuse waste treatment since curing agent is free of any hazardous component after maintenance.
Chinese medicine appearance after maintenance, which is substantially better than, does not conserve medicinal material, free from insect pests, without go mouldy, change colour, bellding phenomena such as.
The advantageous effect of present patent application is：
(1) since chlorine dioxide release time is generally less than 30 days, and easily infested easily mouldy Chinese medicine stores
It needs to preserve 1 year to two years.A kind of compound Chinese medicinal material curing agent for long-acting sustained-release chlorine dioxide that the application proposes can
To keep certain density chlorine dioxide sustained release within two years.The strong oxidizing property of chlorine dioxide will lead to mould and worm
Ovum is dead, achievees the purpose that long-term mildew and insect proof moth.
(2) oxidation and adsorption-decomposition function pernicious gas, especially hydrogen sulfide, sulfur dioxide, ammonia and organic molecule object
Matter, such as alkene, aldehyde, acid harmful substance reduce Chinese medicine sulfur content, it is ensured that Chinese medicine quality.
In addition to will produce stink damp external for Chinese medicine kind Rumen protein fermentation decomposable process.Hydrogen sulfide is frequently present in a variety of
In production process and in nature.Especially current environmental pollution getting worse also contains hydrogen sulfide, titanium dioxide in water, air
Sulphur sulfides.Chinese medicine in process, will inevitably contact water body and air, Chinese medicine pharmacopoeial requirements sulfur content
More lower, better.The curing agent that the application proposes, other than can be with slowly-releasing chlorine dioxide, due also to chlorine dioxide has Strong oxdiative
Property, the function with adsorption-decomposition function hydrogen sulfide and sulfur dioxide can be aoxidized.In addition, due to having in porous mineral powder body material
The hole in many micro-nano size apertures, surface area is huge, can effectively adsorb NH3, alkene that Chinese medicine releases during storage,
Harmful small molecule organic compound such as aldehyde, acid, ester, phenol, ketone.
These small molecule organic compound oxidation products are nontoxic, will not generate harm by Chinese medicine.What is more important, Chinese medicine
Sulfur dioxide gas is formed after sulphur oxidation in material, after maintenance, the sulfur dioxide gas of generation is dispersed into air；Or
It is adsorbed in the porous hole of curing agent, the sulfur content in the Chinese medicine after curing agent maintenance by present patent application will drop
It is low.
(4) curing agent of the application is using ventilative paper or the packaged by plastic film with micro hole, and curing agent itself is no
Containing harmful constituent, be not directly contacted with Chinese medicine, be adsorbed with after maintenance, in curing agent a small amount of sulfur dioxide, ammonia, alkene, aldehyde,
Harmful small molecule organic compound such as acid, ester, ketone, phenol, curing agent are equivalent to and are carried out to Chinese medicine after general domestic rubbish disposal
Primary purification, does not have any component and remains on Chinese medicine, centering medical material quanlity does not generate any negative effect.
Therefore, it can ensure to have in effective slow release in two years using present patent application curing agent and kill mould sterilizing function
Chlorine dioxide, mould proof desinsection.Simultaneously also there is oxygenolysis and absorption ammonia, ethylene, aldehyde, acid etc. to have Chinese medicine storing up
It deposits the function for the harmful organic molecule gas released in the process and reduces the sulfur content function of Chinese medicine, improve Chinese medicine material
Amount.
Specific implementation mode
To keep the technical problem to be solved in the present invention, technical solution and advantage clearer, below in conjunction with specific implementation
Example is described in detail.
Embodiment 1
The total amount for discharging the speed and release chlorine dioxide of chlorine dioxide according to obtained curing agent is tested.For specific
By the attribute of maintenance Chinese medicine, water content and storage time, the sustained release rate of chlorine dioxide and required chlorine dioxide are determined
Total amount, obtain curing agent and be specifically formulated.
The first step, the starch cladding of sodium chlorite
By cornstarch and sodium chlorite according to mass ratio 1:3 ratios weigh.In the ball mill, it is solid that sodium chlorite is first added
After body is ground 1 hour, starch is divided into 3-5 equal portions, adds a starch every a hour, to the last a starch adds
Afterwards, it grinds 2 hours, obtains the sodium chlorite powder of starch cladding.
Second step loads the sodium chlorite powder of starch cladding on porous mineral materials
By porous mineral materials, zeolite powder crosses 40 mesh sieve, with the powder sieved less than 40 mesh, the chlorous acid that starch is coated
Sodium powder body and porous mineral materials are mixed according to the metering of design, continue ground and mixed in the ball mill 4-6 hours, starch and Asia
The mass ratio of the gross mass of sodium chlorate and the zeolite powder being added is 1:10.
Third walks, and strong acid weak base salt is added
Continue that the strong acid weak base salt U-Ramin MC according to design metering is added in the ball mill, grinds 4-6 hours, obtain powder
The mass ratio of body, quality and the sodium chlorite of starch cladding that U-Ramin MC is added is 1:1.1.
4th step, it is dry
The dry cooling in 1 hour at 120 DEG C by the powder of acquisition.
5th step tests the release profiles of prepared Chinese medicine curing agent release chlorine dioxide.
6th step, packing, packaging
The curing agent of preparation is first divided in the paper bag that can be breathed freely, 50 grams of each pouch, then every 50 it is packed enter one
In a big polybag, vacuum packaging, standby Chinese medicine uses when maintenance.
7th step, Chinese medicine maintenance
The curing agent of paper bag packing is directly placed into the airtight space of Chinese medicine matrimony vine maintenance, the chlorine dioxide of sustained release
Body enters Chinese medicine hermetically sealed packaging by paper air hole.
It, can be directly when house refuse waste treatment since curing agent is free of any hazardous component after maintenance.
Chinese medicine appearance after maintenance 2 years is substantially better than and does not conserve medicinal material, free from insect pests, without go mouldy, change colour, bellding etc. it is existing
As.
Embodiment 2
The total amount for discharging the speed and release chlorine dioxide of chlorine dioxide according to obtained curing agent is tested.For specific
By the attribute of maintenance Chinese medicine, water content and storage time, the sustained release rate of chlorine dioxide and required chlorine dioxide are determined
Total amount, obtain curing agent and be specifically formulated.
The first step, the starch cladding of sodium chlorite
By starch from sweet potato and sodium chlorite according to mass ratio 1:10 ratios weigh.In the ball mill, sodium chlorite is first added
After solid abrasive 1 hour, starch is divided into 3-5 equal portions, adds a starch every a hour, to the last a starch adds
Afterwards, it grinds 2 hours, obtains the sodium chlorite powder of starch cladding.
Second step loads the sodium chlorite powder of starch cladding on porous mineral materials
By porous mineral, natural montmorillonite powder crosses 40 mesh sieve, with the powder sieved less than 40 mesh, the sub- chlorine that starch is coated
Sour sodium powder body and porous mineral materials are mixed according to the metering of design, continue ground and mixed in the ball mill 4-6 hour, starch with
The mass ratio of the gross mass of sodium chlorite and the bentonite powder being added is 1:15.
Third walks, and strong acid weak base salt is added
Continue that the strong acid weak base salt according to design metering is added in the ball mill, ferric trichloride grinds 4-6 hours, obtains
Powder.The mass ratio of quality and the sodium chlorite of starch cladding that ferric trichloride is added is 1:1.5.
4th step, it is dry
The dry cooling in 1 hour at 120 DEG C by the powder of acquisition.
5th step tests the release profiles of prepared Chinese medicine curing agent release chlorine dioxide, corrects formula.
6th step, packing, packaging
The curing agent of preparation is first divided in small hole plastic foil pouch, 100 grams of each pouch, then again by 20
Pouch curing agent is put into one big polybag, vacuum packaging, and standby Chinese medicine uses when maintenance.
7th step, Chinese medicine maintenance
Curing agent is directly placed into the airtight space of Chinese medicine maintenance, such as in Herb paeony root hermetically sealed packaging bag, sustained release
Chlorine dioxide enters Chinese medicine hermetically sealed packaging by the air hole of plastic foil.
It, can be directly when house refuse waste treatment since curing agent is free of any hazardous component after maintenance.
Chinese medicine appearance after maintenance, which is substantially better than, does not conserve medicinal material, free from insect pests, without go mouldy, change colour, bellding phenomena such as.
Embodiment 3
The total amount for discharging the speed and release chlorine dioxide of chlorine dioxide according to obtained curing agent is tested.For specific
By the attribute of maintenance Chinese medicine, water content and storage time, the sustained release rate of chlorine dioxide and required chlorine dioxide are determined
Total amount, obtain curing agent and be specifically formulated.
The first step, the starch cladding of sodium chlorite
By potato starch and sodium chlorite according to mass ratio 1:6 ratios weigh.In the ball mill, sodium chlorite is first added
After solid abrasive 1 hour, starch is divided into 3-5 equal portions, adds a starch every a hour, to the last a starch adds
Afterwards, it grinds 2 hours, obtains the sodium chlorite powder of starch cladding.
Second step loads the sodium chlorite powder of starch cladding on porous mineral materials
Porous mineral powder is chosen to be the activated carbon purchased in the present embodiment, by the sodium chlorite powder of starch cladding and work
Property carbon mixed according to the metering of design, continue ground and mixed 4-6 hour in the ball mill, the gross mass of starch and sodium chlorite and
The mass ratio for the activated carbon powder being added is 1:4.
Third walks, and strong acid weak base salt is added
Continue that the strong acid weak base salt according to design metering is added in the ball mill, copper nitrate grinds 4-6 hours, obtains powder
The mass ratio of body, quality and the sodium chlorite of starch cladding that copper nitrate is added is 1:1.3.
4th step, it is dry
The dry cooling in 1 hour at 120 DEG C by the powder of acquisition.
5th step tests the release profiles of prepared Chinese medicine curing agent release chlorine dioxide, corrects formula.
6th step, packing, packaging
The curing agent of preparation is first divided in the paper bag that can be breathed freely, such as 10 grams of each pouch, it is then small by 100 again
The curing agent of bag is encapsulated as a packet, is vacuum-packed, and standby Chinese medicine uses when maintenance.
7th step, Chinese medicine maintenance
The curing agent paper bag of preparation is directly placed into Chinese medicine, in the airtight space of earthworm or ground bettle maintenance, sustained release
Chlorine dioxide enters Chinese medicine hermetically sealed packaging by the air hole of paper or plastic foil.
It, can be directly when house refuse waste treatment since curing agent is free of any hazardous component after maintenance.
Chinese medicine appearance after maintenance 2 years is substantially better than and does not conserve medicinal material, free from insect pests, without go mouldy, change colour, bellding etc. it is existing
As.
Embodiment 4
The total amount for discharging the speed and release chlorine dioxide of chlorine dioxide according to obtained curing agent is tested.For specific
By the attribute of maintenance Chinese medicine, water content and storage time, the sustained release rate of chlorine dioxide and required chlorine dioxide are determined
Total amount, obtain curing agent and be specifically formulated.
The first step, the starch cladding of sodium chlorite
By potato starch and sodium chlorite according to mass ratio 1:Any proportion in 9 weighs.In the ball mill, it is first added
After sodium chlorite solid abrasive 1 hour, starch is divided into 3-5 equal portions, adds a starch every a hour, it is to the last a
It after starch adds, grinds 2 hours, obtains the sodium chlorite powder of starch cladding.
Second step loads the sodium chlorite powder of starch cladding on porous mineral materials
By porous mineral materials, diatomite powder crosses 40 mesh sieve, with the powder sieved less than 40 mesh, the sub- chlorine that starch is coated
Sour sodium powder body and porous mineral materials are mixed according to the metering of design, continue ground and mixed in the ball mill 4-6 hour, starch with
The mass ratio of the gross mass of sodium chlorite and the diatomite powder being added is 1:14.
Third walks, and strong acid weak base salt is added
Continue that the strong acid weak base salt according to design metering is added in the ball mill, aluminum nitrate grinds 4-6 hours, obtains powder
The mass ratio of body, quality and the sodium chlorite of starch cladding that aluminum nitrate is added is 1:1.3.
4th step, it is dry
The dry cooling in 1 hour at 120 DEG C by the powder of acquisition.
5th step tests the release profiles of prepared Chinese medicine curing agent release chlorine dioxide, corrects formula.
6th step, packing, packaging
The curing agent of preparation is first divided in the paper bag that can be breathed freely or cellular plastic film pouch, such as each pouch
10-100 grams, curing agent pouch then is housed by multiple again, if 50-100 pouches one wrap, vacuum packaging, standby Chinese medicine maintenance
When use.
7th step, Chinese medicine maintenance
It, can be directly when house refuse waste treatment since curing agent is free of any hazardous component after maintenance.
Chinese medicine appearance after maintenance, which is substantially better than, does not conserve medicinal material, free from insect pests, without go mouldy, change colour, bellding phenomena such as.
Embodiment 5
The total amount for discharging the speed and release chlorine dioxide of chlorine dioxide according to obtained curing agent is tested.For specific
By the attribute of maintenance Chinese medicine, water content and storage time, the sustained release rate of chlorine dioxide and required chlorine dioxide are determined
Total amount, obtain curing agent and be specifically formulated.
The first step, the starch cladding of sodium chlorite
By potato starch and sodium chlorite according to mass ratio 1:Any proportion in 8 weighs.In the ball mill, it is first added
After sodium chlorite solid abrasive 1 hour, starch is divided into 3-5 equal portions, adds a starch every a hour, it is to the last a
It after starch adds, grinds 2 hours, obtains the sodium chlorite powder of starch cladding.
Second step loads the sodium chlorite powder of starch cladding on porous mineral materials
By porous mineral materials, clay powder crosses 40 mesh sieve, with the powder sieved less than 40 mesh, the chlorous acid that starch is coated
Sodium powder body and porous mineral materials are mixed according to the metering of design, continue ground and mixed in the ball mill 4-6 hours, starch and Asia
The mass ratio of the gross mass of sodium chlorate and the clay powder being added is 1:9.
Third walks, and strong acid weak base salt is added
Continue that the strong acid weak base salt according to design metering is added in the ball mill, ferric trichloride grinds 4-6 hours, obtains
The mass ratio of powder, quality and the sodium chlorite of starch cladding that ferric trichloride is added is 1:1.2.4th step, it is dry
The dry cooling in 1 hour at 120 DEG C by the powder of acquisition.
5th step tests the release profiles of prepared Chinese medicine curing agent release chlorine dioxide, corrects formula.
6th step, packing, packaging
The curing agent of preparation is first divided in the cellular plastic film pouch that can be breathed freely, 30 grams of each pouch, then again
60 pouch curing agents are packed into a big polybag, vacuum packaging, standby Chinese medicine uses when maintenance.
7th step, Chinese medicine maintenance
It, can be directly when house refuse waste treatment since curing agent is free of any hazardous component after maintenance.
Chinese medicine appearance after maintenance, which is substantially better than, does not conserve medicinal material, free from insect pests, without go mouldy, change colour, bellding phenomena such as.
In summary embodiment, the application propose a kind of compound Chinese medicinal material maintenance of long-acting controllable sustained-release chlorine dioxide
The function composition of agent, slow release oxygen is sodium chlorite, forms acidic environment after strong acid weak base salt encounters water hydrolysis, delays
On The Drug Release chlorine dioxide；Starch is added to coat and be supported on porous mineral powder, further decreases chlorine dioxide release
Rate, it is the time of extended release chlorine dioxide, fungi-proofing for disinsection mold-proof during Chinese medicine storage, Chinese medicine quality is improved,
It is numerous to list herein.
Above example is merely to illustrate and the technical solution of unrestricted present patent application, and those skilled in the art can manage
Solution carries out various variations and equivalence replacement, without departing from present patent application technical solution to the technical solution of present patent application
Principle and range should all cover among present patent application the scope of the claims.
Claims (7)
1. a kind of compound Chinese medicinal material curing agent of long-acting controllable sustained-release chlorine dioxide, which is characterized in that inorganic including strong acid weak base
The mass ratio of the sodium chlorite of salt and starch cladding, the starch and sodium chlorite is 1:3~10, the strong acid weak base is inorganic
The mass ratio of salt and the sodium chlorite of starch cladding is 1:1.1~1.5.
2. the compound Chinese medicinal material curing agent of long-acting controllable sustained-release chlorine dioxide according to claim 1, which is characterized in that institute
It is U-Ramin MC or magnesium dichloride or dichloride copper or ferric trichloride or calcium nitrate or aluminum nitrate or nitre to state strong acid weak base inorganic salts
Sour iron or copper nitrate.
3. the compound Chinese medicinal material curing agent of long-acting controllable sustained-release chlorine dioxide according to claim 1, which is characterized in that institute
It is solid starch, specially cornstarch or starch from sweet potato or potato starch to state starch.
4. special according to the compound Chinese medicinal material curing agent of the long-acting controllable sustained-release chlorine dioxide of claim 1-3 any one of them
Sign is, the sodium chlorite of the starch cladding is supported on porous mineral powder, the sodium chlorite of starch cladding be added
Porous powder mass ratio be 1:4~15.
5. the compound Chinese medicinal material curing agent of long-acting controllable sustained-release chlorine dioxide according to claim 4, which is characterized in that institute
State bentonite that porous mineral powder is the zeolite of three-dimensional fine pore passage structure, diatomite, activated carbon or two-dimensional channel structure,
Attapulgite, sepiolite, the asbestos of vermiculite, galapectite, graphite or one-dimensional tunnel structure.
6. a kind of preparation method of the compound Chinese medicinal material curing agent of long-acting controllable sustained-release chlorine dioxide, includes the following steps：
The sodium chlorite preparation of S1, starch cladding
By solid starch and sodium chlorite according to 1:3~10 mass ratio weighs, and in the ball mill, it is solid that sodium chlorite is first added
After body is ground 1 hour, starch is divided into 3-5 equal portions, adds a starch every a hour, to the last a starch adds
Afterwards, it grinds 2 hours, obtains the sodium chlorite powder of starch cladding；
S2, the sodium chlorite powder that starch cladding is loaded on porous mineral materials
Porous mineral materials powder is crossed into 40 mesh sieve, with the porous mineral powder sieved less than 40 mesh, the chlorous acid that starch is coated
Sodium powder body and porous mineral materials mixing, continue ground and mixed 4-6 hours in the ball mill；Wherein starch cladding sodium chlorite and
Mass ratio between the quality of porous powder is between 1:4~15 ranges are adjusted by starch dosage and porous powder dosage
Chlorine dioxide rate of release；
S3, strong acid weak base salt is added
Strong acid weak base salt is added in continuation in the ball mill, grinds 4-6 hours, obtains compound Chinese medicinal material curing agent powder, wherein strong
The mass ratio of sour weak base inorganic salts and the sodium chlorite of starch cladding is 1:1.1~1.5；
S4, the drying of compound Chinese medicinal material curing agent
The compound Chinese medicinal material curing agent powder of acquisition is dried into 1 hour postcooling at 120 DEG C to obtain the final product.
7. a kind of application of compound Chinese medicinal material curing agent of long-acting controllable sustained-release chlorine dioxide in compound Chinese medicinal material maintenance, special
Sign is that the application process is that curing agent is packaged in ventilative bag, and the airtight sky of Chinese medicine maintenance is directly placed into after sealing
Between in.
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| CN108991007A (en) * | 2018-08-20 | 2018-12-14 | 青岛大学 | A kind of safe slow released ClO 2 disinfectant and preparation method thereof |
| CN109362779A (en) * | 2018-12-06 | 2019-02-22 | 唐山佐仑环保科技有限公司 | A kind of controllable sustained-release type chlorine dioxide material and one one-step preparation method |
| CN110604131A (en) * | 2019-09-30 | 2019-12-24 | 中国有色桂林矿产地质研究院有限公司 | A kind of preparation method of the porous material composition coated with pesticide-loaded slow-release degradable film |
| CN113662004A (en) * | 2021-08-06 | 2021-11-19 | 哈尔滨理工大学 | Slow-release chlorine dioxide disinfection card using zeolite as carrier |
| CN116098154A (en) * | 2023-02-24 | 2023-05-12 | 中国人民解放军火箭军工程大学 | A slow-release natural nanotube-based sterilizing and disinfecting composite material and its preparation method |
| CN119588135A (en) * | 2024-12-29 | 2025-03-11 | 浙江启元环境科技有限公司 | A method for preparing a sustained-release deodorant material |
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Application publication date: 20180817 |
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