CN108338166A - A kind of microbicide compositions including emodin derivates and amides - Google Patents
A kind of microbicide compositions including emodin derivates and amides Download PDFInfo
- Publication number
- CN108338166A CN108338166A CN201710204459.7A CN201710204459A CN108338166A CN 108338166 A CN108338166 A CN 108338166A CN 201710204459 A CN201710204459 A CN 201710204459A CN 108338166 A CN108338166 A CN 108338166A
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- CN
- China
- Prior art keywords
- emodin
- aloe
- physcion
- dimethomorph
- active component
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 77
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- 239000010282 Emodin Substances 0.000 title description 3
- RHMXXJGYXNZAPX-UHFFFAOYSA-N emodin Chemical compound C1=C(O)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O RHMXXJGYXNZAPX-UHFFFAOYSA-N 0.000 title description 3
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- 230000006378 damage Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000010459 dolomite Substances 0.000 description 1
- 229910000514 dolomite Inorganic materials 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 229910052622 kaolinite Inorganic materials 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- ZQEIXNIJLIKNTD-UHFFFAOYSA-N methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate Chemical class COCC(=O)N(C(C)C(=O)OC)C1=C(C)C=CC=C1C ZQEIXNIJLIKNTD-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000012764 mineral filler Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052901 montmorillonite Inorganic materials 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229940044654 phenolsulfonic acid Drugs 0.000 description 1
- LGRFSURHDFAFJT-UHFFFAOYSA-N phthalic anhydride Chemical compound C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 239000011265 semifinished product Substances 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 1
- KKDONKAYVYTWGY-UHFFFAOYSA-M sodium;2-(methylamino)ethanesulfonate Chemical compound [Na+].CNCCS([O-])(=O)=O KKDONKAYVYTWGY-UHFFFAOYSA-M 0.000 description 1
- 238000009331 sowing Methods 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000012622 synthetic inhibitor Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
- A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/06—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention provides a kind of microbicide compositions, the composition includes two kinds of effective constituents As and B, active component A is one kind in Physcion or aloe-emodin, and active component B is one kind in dimethomorph, mandipropamid or Metalaxyl-M, and the weight ratio between two components is 20~1:1~100.The present invention also provides the Preparation method and uses of the composition.Test result shows that above-mentioned bactericidal composition synergy provided by the invention is apparent, it is often more important that amount of application is reduced, and use cost reduces.The bactericidal composition can effectively prevent certain specific bacteriums or the fungal disease of crop.By compounding the fungicide of different role mechanism and the mode of action, there is good effect for expand fungicidal spectrum and delay germ resistance and improve control effect etc..
Description
Technical field
The invention belongs to agriculture plant protection fields, more particularly to a kind of bactericidal composition for having and improving performance, tool
Say to body it is to be related to a kind of including a kind of and dimethomorph in Physcion or aloe-emodin, mandipropamid or smart first frost
A kind of bactericidal composition in spirit.
Background technology
Physcion (Physcion) and aloe-emodin (Aloeemodin) belong to anthraquinone analog compound.In medicine
These compounds of field are widely used, if immunoregulation acts on, scavenging activated oxygen effect, and antibacterial, anti-inflammatory, antiviral work
With, diuresis, the protective effect to cerebrum ischemia damage, cardiovascu- lar effects, antitumor action.In recent years, these anthracenes
Quinones is just gradually applied to agriculture field, for preventing fungi or bacterial disease.Such compound is from medium-height grass
A kind of highly active vegetable source bactericide extracted in the root of medicine plant rheum officinale, stem belongs to anthraquinone analog compound, to veterinary antibiotics, paddy
The multiple diseases such as powdery mildew, downy mildew, gray mold, the anthracnose of object etc. have good control effect, while less toxic to people and animals,
It is environmentally friendly, with other chemical agent no interactions resistances, have preferable uptake and translocation effect, lasting effect strong.It, which is sterilized, makees
It is the biosynthesis by interfering disease fungus cell wall chitin with mechanism, inhibits the sprouting of pathogen spore, the life of mycelia
Long, haustorium formation also can induce crop and generate degeneration-resistant defense reaction, achieve the effect that diseases prevention to block the sprawling of disease.
Dimethomorph (Dimethomorph) is a kind of therapeutic special less toxic acid amide fungicides of novel interior suction, effect
Mechanism is to destroy the formation of germ cell wall film, causes the decomposition of spore cyst wall, and keeps germ dead.Except zoospore formed and
Outside spore swarm stage, there are effect, the especially formation stages to sporangiophore and egg spore to each stage of oomycetes history of life
It is more sensitive, if the medication before sporangium and egg spore are formed, can completely inhibit the generation of spore.The medicine absorbability is strong, root
Dispenser can enter each position of plant by root；Blade sprays, and can enter blade interior.The benzamides such as itself and metalaxyl
Series bactericidal agent does not have cross resistance.To downy mildew, peronospora tabacina, late blight, epidemic disease (mould) disease, phytophthora rot, rotten mildew, balck shank etc.
Lower fungus venereal disease evil all has good control effect.It can be applied to grape, lichee, cucumber, muskmelon, balsam pear, tomato, peppery
Green pepper, potato, brassicaceous vegetable.
Mandipropamid (Mandipropamid) is acid amide fungicides.Its mechanism of action is that the biology of phosphatide is inhibited to close
At, to absolutely greatly count leaf and fruit diseases caused by egg bacteria have good preventive effect.Have to spore in the stage of sprouting
Higher activity, and can inhibit mycelia growth and sporogenesis.It can be rapidly absorbed by blade, and rest on leaf table wax
In layer, shield to blade.Suitable for causing the rhizoctonia of root rot, droop on the crops such as tomato, eggplant, cucumber
Belong to etc. soil fungis be it is effective, it is especially effective to Basidiomycetes.
Metalaxyl-M (Metalaxyl-M) nickname mefenoxam category acid amide fungicides, to Pseudoperonospora cubensis, phytophthora root rot
Bacterium, the vegetables caused by rotten mildew fungus, fruit tree, tobacco, oil plant, cotton, the crop diseases such as grain have efficient.Its bactericidal effect is special
The synthetic inhibitor of point rRNA I, has the systemic fungicide of protection, therapeutic effect, can be by the root, stem, leaf of plant
It absorbs, and is transferred to each organ of plant with Dynamic water transport in plant.
Actual pesticide experience have shown that, repeat and a kind of reactive compound of single-minded application prevent harmful fungoid very
The fast selective that will lead to fungal bacterial strain in the case of more, to reduce the danger of refractory fungal bacterial strain selectivity, at present usually
Harmful fungoid is prevented using the mixture of different activities compound.By will have the reactive compound of different role mechanism into
Row combination, can delaying drug resistance generate, reduce amount of application, reduce cost accounting.
Invention content
The purpose of the present invention is being directed to fungicide resistance and pedo relict problem in practical applications, filters out difference and kill
The fungicide of bacterium principle is compounded, and a kind of new microbicide compositions are obtained, to improve bactericidal agent for preventing and treating effect, delaying drug resistance
It generates, reduces amount of application, reduce cost accounting.
It is a further object to provide the preparation method comprising two kinds of effective constituents As and B bactericidal compositions and
Agriculture field prevents the application in corps diseases.
The purpose of the present invention can be achieved by the following measures：
A kind of microbicide compositions with synergistic effect, the composition include two kinds of active components of A and B, active component A
For in anthraquinone series bactericidal agent, any one fungicide in Physcion and aloe-emodin, active component B is amide
In series bactericidal agent, any one in dimethomorph, mandipropamid and Metalaxyl-M, the weight ratio between two components is
20~1:1~100.
Inventor is found by experiment that composition of the invention is for preventing crops bacterium or fungal disease prevention
Synergy is apparent, it is often more important that amount of application is reduced, and reduces use cost.Compound structure type containing component A and component B is not
Together, mechanism of action is different, and the two compounding can expand fungicidal spectrum, and can delay the production of pathogen resistance to a certain extent
Raw and development speed, and no interactions resistance between component A and component B.
In a kind of preferred embodiment, the weight ratio of active component A and active component B are 1:1~100, to make function and effect
It can be more preferably 1 to become apparent from the two weight ratio:1~80.
In a kind of preferred scheme, weight ratio between two component of A and B can arbitrarily in the range of following proportionings into
Row adjustment 20:1、19:1、18:1、17:1、16:1、15:1、14:1、13:1、12:1、11:1、10:1、9:1、8:1、7:1、6:1、
5:1、4:1、3:1、2:1、1:1、1:2、1:3、1:4、1:5、1:6、1:7、1:8、1:9、1:10、1:11、1:12、1:13、1:14、
1:15、1:16、1:17、1:18、1:19、1:20、1:21、1:22、1:23、1:24、1:25、1:26、1:27、1:28、1:29、1:
30、1:31、1:32、1:33、1:34、1:35、1:36、1:37、1:38、1:39、1:40、1:41、1:42、1:43、1:44、1:
45、1:46、1:47、1:48、1:49、1:50、1:51、1:52、1:53、1:54、1:55、1:56、1:57、1:58、1:59、1:
60、1:61、1:62、1:63、1:64、1:65、1:66、1:67、1:68、1:69、1:70、1:71、1:72、1:73、1:74、1:
75、1:76、1:77、1:78、1:79、1:80、1:81、1:82、1:83、1:84、1:85、1:86、1:87、1:88、1:89、1:
90、1:91、1:92、1:93、1:94、1:95、1:96、1:97、1:98、1:99、1:100, can also in any of the above two match
Than being selected in the range of forming, these ratios can be understood as weight ratio, can also include molar ratio.
The dosage form allowed on pesticide can be made by active constituent and insecticides adjuvant or auxiliary material in the composition of the present invention.Into one
Step, the composition forms agriculture by the active component of 5~85% parts by weight and the insecticides adjuvant of 95~15% parts by weight or auxiliary material
The dosage form allowed on medicine.
The present invention provides the bactericidal compositions comprising component A and component B in terms of agriculture field prevents corps diseases
Purposes, the especially purposes in terms of the fungi or bacterial disease for preventing certain crops.
Above-mentioned composition specifically may include insecticides adjuvant or auxiliary material, such as carrier, solvent, dispersant, wetting agent, gluing
Any one or a few in agent, thickener, adhesive, surfactant and fertilizer etc..It can be mixed during application
Common auxiliary agent.
Suitable auxiliary agent or auxiliary material can be solid or liquid, they are typically common substance during formulation,
Such as natural or regenerated minerals, solvent, dispersant, wetting agent, adhesive, thickener, adhesive.
The method of administration of the present composition includes that the composition of the present invention is used for the aerial part of plant growth, especially
It is leaf portion or blade face.It can select to soak seed or be applied to controlling object surface.The frequency and amount of application of application depend on pathogen
Biology and weather life condition.The growth place of plant, such as rice field can be soaked with the liquid preparation of composition, or
Composition is applied in soil by person in solid form, and such as in granular form (soil application), composition can be by soil through planting
Object root enters in plant (systemic action).
The composition of the present invention can be prepared into various dosage forms pesticide-acceptable, including but not limited to missible oil, suspension
Agent, wettable powder, water dispersible granules, pulvis, granula, water dispersible granules, aqueous emulsion, microemulsion, encapsulated form, mother liquor, mother
Powder etc., in a kind of preferred embodiment, dosage form of the invention uses suspending agent, water dispersible granules or wettable powder.According to these
The property of composition and application composition institute purpose to be achieved and ambient conditions can be selected composition to spray, more
Mist dusts, broadcasts sowing or sprinkles the method application poured or the like.
Can by known method can by the present invention composition be prepared into various dosage forms, can by active ingredient with help
Agent can uniformly mix together with surfactant when needing, grind, be prepared into required dose such as solvent, solid carrier
Type.
Above-mentioned solvent can be selected from aromatic hydrocarbon, preferably contain 8-12 carbon atom, such as xylene mixture or substituted benzene, phthalein
Esters of gallic acid, if Dibutyl phthalate or phthalandione two are sad, fat hydrocarbon, such as thiacyclohexane or paraffin, the ether of alcohol and ethylene glycol and they
And ester, such as ethyl alcohol, ethylene glycol, ethylene glycol monomethyl；Ketone, such as cyclohexanone, highly polar solvent, such as N- methyl -2- pyrrolidines
Ketone, dimethyl sulfoxide (DMSO) or dimethylformamide and vegetable oil or vegetable oil, such as soybean oil.
Above-mentioned solid carrier, such as pulvis and dispersible dose of typically natural mineral fillers, such as talcum, kaolinite
Soil, montmorillonite or atlapulgite.In order to manage the physical property of composition, polymolecularity silicic acid or polymolecularity can also be added
Adsorpting polymerization object carrier, such as granulated adsorptive carriers or non-adsorbed carrier, suitable granulated adsorptive carriers are porous types, it is such as floating
Stone, bentonite or bentonite；Suitable non-adsorbed carrier such as calcite or sand.Further, it is possible to use a large amount of inorganic in nature or having
The prefabricated material to granulate of machine property is as carrier, especially dolomite.
The chemical property of active ingredient in composition according to the present invention, suitable surfactant are sulfomethylated lignin
Acid, naphthalene sulfonic acids, phenolsulfonic acid, alkali salt or amine salt, alkylaryl sulfonates, alkyl sulfate, alkylsulfonate, fat
Alcohol sulfate, aliphatic acid and sulphated fatty alcohol glycol ether, the also condensation product of sulfonated naphthalene and naphthalene derivatives and formaldehyde, naphthalene or
The condensation product of naphthalene sulfonic acids and phenol and formaldehyde, NONIN HS 240, ethoxylated isooctyl-phenol, octyl phenol, nonyl phenol,
Alkylaryl polyglycol ether, tributyl benzene polyglycol ether, three stearyl phenyl polyglycol ethers, alkyl aryl polyether alcohol,
Ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensation product, ethoxylation polyoxypropylene, bay acid polyethylene glycol
Ether acetal, sorbitol ester, lignin sulfite waste liquor and methylcellulose.
Two kinds of active ingredients show as synergistic effect in the composition of the present invention, and the activity of the composition is than using individualized
The independent activity of the expected summation of activity and single compound of closing object is more notable.Synergistic effect shows as allowing amount of application
Reduction, broader antifungal control spectrum, quick, more longlasting control effect, by a small number of applying only once or several times more
Good control plant pest fungi and broaden the possible administration interval time.These characteristics are plant epiphyte control practices
It especially needs in the process.
In terms of the microbicide compositions of the present invention can be applied to agriculture field prevention corps diseases, farming referred herein
Object disease especially uncinula necator, powdery mildew of cucumber, cucumber downy mildew, balsam pear powdery mildew, graw mold of tomato, wheat white powder
Disease, rice blast.But the present invention composition other than it can prevent aforementioned disease, moreover it is possible to the specific illness of prevention include but
It is not limited to wheat diseases (such as：Wheat scab, wheat powdery mildew, wheat rust etc.), rice disease (such as：Rice sheath blight disease, water
Rice false smut, paddy bacterial streak etc.), maize diseases (such as：Smut of maize, the leaf blight of corn, corn southern leaf blight), cucumber
Disease is (such as：Powdery mildew of cucumber, cucumber anthracnose, gray mold of cucumber, cucumber bacterial angular leaf spot etc.), tomato disease (such as：Tomato
Powdery mildew, anthracnose of tomato, tomato virus disease, tomato bacterial angular leaf spot etc.), grape disease (such as：Downy mildew of garpe, grape
Gray mold), apple disease (such as：Ring rot of apple, apple anthracnose etc.), citrus disease (such as：Citrus scab simultaneously, citrus anthrax
Disease), tobacco diseases (such as：Wildfire, Alternaria alternate), rape disease (such as：Sclerotinia sclerotiorum), cotton disease (such as：Cotton
Flower verticillium wilt, cotton wilt) etc..
Other features for showing of bactericidal composition of the present invention are mainly：1, composition mixture of the invention has apparent
Synergistic effect；2, since two single dose chemical constitutions of this composition are widely different, the mechanism of action is entirely different, and there is no hand over
Mutual resistance can delay two single doses that generated resistance problem is used alone；3, composition of the invention is to crop safety, preventive effect
It is good.Tests prove that microbicide compositions chemical property of the present invention is stablized, synergy is notable, is shown significantly to controlling object
Synergy and complementation.
Specific implementation mode
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that described herein, specific examples are only used to explain the present invention, is not used to limit
The fixed present invention, any modifications, equivalent replacements and improvementsmade within the spirit and principles of the invention, etc. should be included in
Within protection scope of the present invention.
Percentage is weight percentage in all formulas of following embodiment.The processing work of the various preparations of the present composition
Skill is the prior art, can be varied from according to different situations.
One, dosage form prepares embodiment
(1) processing of suspending agent and embodiment
By active constituent activity grouping A and active component B, with each components such as dispersant, wetting agent, thickener and water by matching
The ratio of side is uniformly mixed, and after sand milling and/or high speed shear, obtains semi-finished product, is mended after analysis and is mixed with water filtering i.e.
Obtain finished product.
(1) active component A (Physcion) prepares suspending agent with active component B (dimethomorph)
Embodiment 1：2% Physcion dimethomorph suspending agent (1:1)
Physcion 1%, dimethomorph 1%, lignosulfonates 2.5%, lauryl sodium sulfate 3.21%, second two
Alcohol 5%, aluminium-magnesium silicate 0.89%, bentonite 1.2%, silicone oil 0.01%, water complements to 100%.
Embodiment 2：10.3333% Physcion dimethomorph suspending agent (1:30)
Physcion 0.3333%, dimethomorph 10%, alkyl phenol polyoxyethylene ether 3.42%, Nekal BX
5.74%, glycerine 8%, xanthans 1.36%, sodium bicarbonate 2.72%, silicone oil 0.03%, water complements to 100%.
Embodiment 3：50.5% Physcion dimethomorph suspending agent (1:100)
Physcion 0.5%, dimethomorph 50%, fatty alcohol polyoxyethylene ether 6.42%, spaonin powder 8.45%, second two
Alcohol 15%, aluminium-magnesium silicate 2.14%, ammonium sulfate 2.1%, silicone oil 0.07%, water complements to 100%.
(2) active component A (Physcion) prepares suspending agent with active component B (mandipropamid)
Embodiment 4：2% Physcion mandipropamid suspending agent
Physcion 1%, mandipropamid 1%, remaining component are prepared according to the method for embodiment 1.
Embodiment 5：10.3333% Physcion mandipropamid suspending agent
Physcion 0.3333%, mandipropamid 10%, remaining component are prepared according to the method for embodiment 2.
Embodiment 6：50.5% Physcion mandipropamid suspending agent
Physcion 0.5%, mandipropamid 50%, remaining component are prepared according to the method for embodiment 3.
(3) active component A (Physcion) prepares suspending agent with active component B (Metalaxyl-M)
Embodiment 7：2% Physcion Metalaxyl-M suspending agent
Physcion 1%, Metalaxyl-M 1%, remaining component are prepared according to the method for embodiment 1.
Embodiment 8：10.3333% Physcion Metalaxyl-M suspending agent
Physcion 0.3333%, Metalaxyl-M 10%, remaining component are prepared according to the method for embodiment 2.
Embodiment 9：50.5% Physcion Metalaxyl-M suspending agent
Physcion 0.5%, Metalaxyl-M 50%, remaining component are prepared according to the method for embodiment 3.
(4) active component A (aloe-emodin) prepares suspending agent with active component B (dimethomorph)
Embodiment 10：2% aloe-emodin dimethomorph suspending agent
Aloe-emodin 1%, dimethomorph 1%, remaining component are prepared according to the method for embodiment 1.
Embodiment 11：10.3333% aloe-emodin dimethomorph suspending agent
Aloe-emodin 0.3333%, dimethomorph 10%, remaining component are prepared according to the method for embodiment 2.
Embodiment 12：50.5% aloe-emodin dimethomorph suspending agent
Aloe-emodin 0.5%, dimethomorph 50%, remaining component are prepared according to the method for embodiment 3.
(5) active component A (aloe-emodin) prepares suspending agent with active component B (mandipropamid)
Embodiment 13：2% aloe-emodin mandipropamid suspending agent
Aloe-emodin 1%, mandipropamid 1%, remaining component are prepared according to the method for embodiment 1.
Embodiment 14：10.3333% aloe-emodin mandipropamid suspending agent
Aloe-emodin 0.3333%, mandipropamid 10%, remaining component are prepared according to the method for embodiment 2.
Embodiment 15：50.5% aloe-emodin mandipropamid suspending agent
Aloe-emodin 0.5%, mandipropamid 50%, remaining component are prepared according to the method for embodiment 3.
(6) active component A (aloe-emodin) prepares suspending agent with active component B (Metalaxyl-M)
Embodiment 16：2% aloe-emodin Metalaxyl-M suspending agent
Aloe-emodin 1%, Metalaxyl-M 1%, remaining component are prepared according to the method for embodiment 1.
Embodiment 17：10.3333% aloe-emodin Metalaxyl-M suspending agent
Aloe-emodin 0.3333%, Metalaxyl-M 10%, remaining component are prepared according to the method for embodiment 2.
Embodiment 18：50.5% aloe-emodin Metalaxyl-M suspending agent
Aloe-emodin 0.5%, Metalaxyl-M 50%, remaining component are prepared according to the method for embodiment 3.
(2) processing of water dispersible granules and embodiment
By active components A and active constituent B, with auxiliary agent and filler be mixed according to the formula uniformly, through air-flow crushing at
Wettable powder adds a certain amount of water mixing extruder grain, and water dispersible granules product is made after dry sieve.
(1) active component A (Physcion) prepares water dispersible granules with active component B (dimethomorph)
Embodiment 19：1.05% Physcion dimethomorph water dispersion granula (20:1)
Physcion 1%, dimethomorph 0.05%, tributyl benzene polyglycol ether 7.1%, sorbitol ester 5.36%,
Kaolin complements to 100%.
Embodiment 20：20.5% Physcion dimethomorph water dispersion granula (1:40)
Physcion 0.5%, dimethomorph 20%, aliphatic acid and sulphated fatty alcohol glycol ether 15.32%, diatom
Soil complements to 100%.
Embodiment 21：10.1667% Physcion dimethomorph water dispersion granula (1:60)
Physcion 0.1667%, dimethomorph 10%, ethoxylation polyoxypropylene 6.86%, bay acid polyethylene glycol
Ether acetal 9.72%, bentonite complements to 100%.
(2) active component A (Physcion) and active component B (mandipropamid)) prepare water dispersible granules
Embodiment 22：1.05% Physcion mandipropamid water dispersible granules
Physcion 1%, mandipropamid 0.05%, remaining component are prepared according to the method for embodiment 19.
Embodiment 23：20.5% Physcion mandipropamid water dispersible granules
Physcion 0.5%, mandipropamid 20%, remaining component are prepared according to the method for embodiment 20.
Embodiment 24：10.1667% Physcion mandipropamid water dispersible granules
Physcion 0.1667%, mandipropamid 10%, remaining component are prepared according to the method for embodiment 21.
(3) active component A (Physcion) prepares water dispersible granules with active component B (Metalaxyl-M)
Embodiment 25：1.05% Physcion Metalaxyl-M water dispersible granules
Physcion 1%, Metalaxyl-M 0.05%, remaining component are prepared according to the method for embodiment 19.
Embodiment 26：20.5% Physcion Metalaxyl-M water dispersible granules
Physcion 0.5%, Metalaxyl-M 20%, remaining component are prepared according to the method for embodiment 20.
Embodiment 27：10.1667% Physcion Metalaxyl-M water dispersible granules
Physcion 0.1667%, Metalaxyl-M 10%, remaining component are prepared according to the method for embodiment 21.
(4) active component A (aloe-emodin) prepares water dispersible granules with active component B (dimethomorph)
Embodiment 28：1.05% aloe-emodin dimethomorph water dispersion granula
Aloe-emodin 1%, dimethomorph 0.05%, remaining component are prepared according to the method for embodiment 19.
Embodiment 29：20.5% aloe-emodin dimethomorph water dispersion granula
Aloe-emodin 0.5%, dimethomorph 20%, remaining component are prepared according to the method for embodiment 20.
Embodiment 30：10.1667% aloe-emodin dimethomorph water dispersion granula
Aloe-emodin 0.1667%, dimethomorph 10%, remaining component are prepared according to the method for embodiment 21.
(5) active component A (aloe-emodin) and active component B (mandipropamid)) prepare water dispersible granules
Embodiment 31：1.05% aloe-emodin mandipropamid water dispersible granules
Aloe-emodin 1%, mandipropamid 0.05%, remaining component are prepared according to the method for embodiment 19.
Embodiment 32：20.5% aloe-emodin mandipropamid water dispersible granules
Aloe-emodin 0.5%, mandipropamid 20%, remaining component are prepared according to the method for embodiment 20.
Embodiment 33：10.1667% aloe-emodin mandipropamid water dispersible granules
Aloe-emodin 0.1667%, mandipropamid 10%, remaining component are prepared according to the method for embodiment 21.
(6) active component A (aloe-emodin) prepares water dispersible granules with active component B (Metalaxyl-M)
Embodiment 34：1.05% aloe-emodin Metalaxyl-M water dispersible granules
Aloe-emodin 1%, Metalaxyl-M 0.05%, remaining component are prepared according to the method for embodiment 19.
Embodiment 35：20.5% aloe-emodin Metalaxyl-M water dispersible granules
Aloe-emodin 0.5%, Metalaxyl-M 20%, remaining component are prepared according to the method for embodiment 20.
Embodiment 36：10.1667% aloe-emodin Metalaxyl-M water dispersible granules
Aloe-emodin 0.1667%, Metalaxyl-M 10%, remaining component are prepared according to the method for embodiment 21.
(3) processing of wettable powder and embodiment
Active components A and B activity ingredient and various auxiliary agents and filler etc. are sufficiently mixed in proportion, through ultrafine crusher powder
Obtained wettable powder after broken.
(1) active component A (Physcion) prepares wettable powder with active component B (dimethomorph)
Embodiment 37：10.5% Physcion dimethomorph wettable powder (1:20)
Physcion 0.5%, dimethomorph 10%, xanthans 2.46%, lignin naphthalene sulfonate 5.15%, alkylbenzene
Sulfonate 6.07%, precipitated calcium carbonate complements to 100%.
Embodiment 38：76.5% Physcion dimethomorph wettable powder (1:50)
Physcion 1.5%, dimethomorph 75%, aluminium-magnesium silicate 5.81%, lauryl sodium sulfate 7.26%, methyl
Amylalcohol 5.92%, attapulgite complements to 100%.
Embodiment 39：20.25% Physcion dimethomorph wettable powder (1:80)
Physcion 0.25%, dimethomorph 20%, aluminium-magnesium silicate 3.53%, fatty acid amide N methyl taurine sodium salt
8.25%, spaonin powder 9.41%, kaolin complements to 100%.
(2) active component A (Physcion) prepares wettable powder with active component B (mandipropamid)
Embodiment 40：10.5% Physcion mandipropamid wettable powder
Physcion 0.5%, mandipropamid 10%, remaining component are prepared according to the method for embodiment 37.
Embodiment 41：76.5% Physcion mandipropamid wettable powder
Physcion 1.5%, mandipropamid 75%, remaining component are prepared according to the method for embodiment 38.
Embodiment 42：20.25% Physcion mandipropamid wettable powder
Physcion 0.25%, mandipropamid 20%, remaining component are prepared according to the method for embodiment 39.
(3) active component A (Physcion) prepares wettable powder with active component B (Metalaxyl-M)
Embodiment 43：10.5% Physcion Metalaxyl-M wettable powder
Physcion 0.5%, Metalaxyl-M 10%, remaining component are prepared according to the method for embodiment 37.
Embodiment 44：76.5% Physcion Metalaxyl-M wettable powder
Physcion 1.5%, Metalaxyl-M 75%, remaining component are prepared according to the method for embodiment 38.
Embodiment 45：20.25% Physcion Metalaxyl-M wettable powder
Physcion 0.25%, Metalaxyl-M 20%, remaining component are prepared according to the method for embodiment 39.
(4) active component A (aloe-emodin) prepares wettable powder with active component B (dimethomorph)
Embodiment 46：10.5% aloe-emodin dimethomorph wettable powder
Aloe-emodin 0.5%, dimethomorph 10%, remaining component are prepared according to the method for embodiment 37.
Embodiment 47：76.5% aloe-emodin dimethomorph wettable powder
Aloe-emodin 1.5%, dimethomorph 75%, remaining component are prepared according to the method for embodiment 38.
Embodiment 48：20.25% aloe-emodin dimethomorph wettable powder
Aloe-emodin 0.25%, dimethomorph 20%, remaining component are prepared according to the method for embodiment 39.
(5) active component A (aloe-emodin) prepares wettable powder with active component B (mandipropamid)
Embodiment 49：10.5% aloe-emodin mandipropamid wettable powder
Aloe-emodin 0.5%, mandipropamid 10%, remaining component are prepared according to the method for embodiment 37.
Embodiment 50：76.5% aloe-emodin mandipropamid wettable powder
Aloe-emodin 1.5%, mandipropamid 75%, remaining component are prepared according to the method for embodiment 38.
Embodiment 51：20.25% aloe-emodin mandipropamid wettable powder
Aloe-emodin 0.25%, mandipropamid 20%, remaining component are prepared according to the method for embodiment 39.
(6) active component A (aloe-emodin) prepares wettable powder with active component B (Metalaxyl-M)
Embodiment 52：10.5% aloe-emodin Metalaxyl-M wettable powder
Aloe-emodin 0.5%, Metalaxyl-M 10%, remaining component are prepared according to the method for embodiment 37.
Embodiment 53：76.5% aloe-emodin Metalaxyl-M wettable powder
Aloe-emodin 1.5%, Metalaxyl-M 75%, remaining component are prepared according to the method for embodiment 38.
Embodiment 54：20.25% aloe-emodin Metalaxyl-M wettable powder
Aloe-emodin 0.25%, Metalaxyl-M 20%, remaining component are prepared according to the method for embodiment 39.
Two, drug effect verification test
(1) Assays Example
The incidence that whole strain blade is investigated according to experiment grade scale, calculates disease index and control effect.
Control effect is converted into niqueMin (y), liquor strength (μ g/ml) is converted into logarithm (x), with least square method
Concentration EC50 in calculating virulence equation and inhibiting, the toxicity index and co-toxicity coefficient (CTC) of medicament are calculated according to Sun Yunpei's Method.
Survey toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) * 100
Percentage composition+B medicament toxicity index * the mixtures of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixtures
The percentage composition of middle B
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI)/mixtures theoretical toxicity index (TTI)] * 100
CTC≤80, composition show as antagonism, 80 ＜ CTC ＜ 120, and composition shows as summation action, and CTC >=
120, composition shows as synergistic effect.
1, Physcion and dimethomorph compounding test grey mould of egg plant toxicity test
1. Physcion of table is compounded with dimethomorph to grey mould of egg plant toxicity test interpretation of result
| Medicament title | EC50(ug/mL) | ATI | TTI | CTC |
| Physcion | 3.62 | 100.00 | \ | \ |
| Dimethomorph | 12.46 | 29.05 | \ | \ |
| Physcion：Dimethomorph=1:120 | 11.16 | 32.45 | 29.64 | 109.48 |
| Physcion：Dimethomorph=1:100 | 10.02 | 36.13 | 29.75 | 121.45 |
| Physcion：Dimethomorph=1:90 | 9.52 | 38.02 | 29.83 | 127.45 |
| Physcion：Dimethomorph=1:80 | 8.91 | 40.62 | 29.93 | 135.72 |
| Physcion：Dimethomorph=1:70 | 8.56 | 42.29 | 30.05 | 140.72 |
| Physcion：Dimethomorph=1:60 | 8.33 | 43.46 | 30.21 | 143.85 |
| Physcion：Dimethomorph=1:50 | 7.79 | 46.47 | 30.44 | 152.67 |
| Physcion：Dimethomorph=1:40 | 7.20 | 50.26 | 30.78 | 163.27 |
| Physcion：Dimethomorph=1:30 | 7.41 | 48.83 | 31.34 | 155.81 |
| Physcion：Dimethomorph=1:20 | 7.59 | 47.70 | 32.43 | 147.08 |
| Physcion：Dimethomorph=1:1 | 4.11 | 88.18 | 64.53 | 136.66 |
| Physcion：Dimethomorph=20:1 | 3.02 | 119.86 | 96.62 | 124.05 |
| Physcion：Dimethomorph=40:1 | 3.31 | 109.39 | 98.27 | 111.32 |
As a result (table 1) shows in Physcion：Dimethomorph=20~1:In 1~100 interval range, rheum emodin first
Ether significantly improves the control effect of grey mould of egg plant with dimethomorph compounding, illustrates that the two compounding has grey mould of egg plant prevention
Significant synergistic effect.And except the above protection domain, the two then shows the effect of addition.
2, Physcion and mandipropamid compounding test pimento black spot toxicity test
2. Physcion of table is compounded with mandipropamid to pimento black spot toxicity test interpretation of result
As a result (table 2) shows that Physcion significantly puies forward the control effect of pimento black spot with mandipropamid compounding
Height illustrates that the two compounding has significant synergistic effect to the prevention of pimento black spot.
3, Physcion and Metalaxyl-M compounding test eggplant anthracnose toxicity test
3. Physcion of table is compounded with Metalaxyl-M to eggplant anthracnose toxicity test interpretation of result
As a result (table 3) shows that Physcion significantly improves the control effect of eggplant anthracnose with Metalaxyl-M compounding,
Illustrate that the two compounding has significant synergistic effect to eggplant anthracnose prevention.
4, aloe-emodin and dimethomorph compounding test balsam pear sclerotiniose toxicity test
4. aloe-emodin of table is compounded with dimethomorph to balsam pear sclerotiniose toxicity test interpretation of result
| Medicament title | EC50(ug/mL) | ATI | TTI | CTC |
| Aloe-emodin | 7.26 | 100.00 | \ | \ |
| Dimethomorph | 16.05 | 45.23 | \ | \ |
| Aloe-emodin：Dimethomorph=1:120 | 13.06 | 55.60 | 45.68 | 121.72 |
| Aloe-emodin：Dimethomorph=1:100 | 11.04 | 65.77 | 45.77 | 143.69 |
| Aloe-emodin：Dimethomorph=1:90 | 10.05 | 72.27 | 45.83 | 157.69 |
| Aloe-emodin：Dimethomorph=1:80 | 9.19 | 78.98 | 45.91 | 172.05 |
| Aloe-emodin：Dimethomorph=1:70 | 8.67 | 83.75 | 46.00 | 182.05 |
| Aloe-emodin：Dimethomorph=1:60 | 8.07 | 90.00 | 46.13 | 195.11 |
| Aloe-emodin：Dimethomorph=1:50 | 7.70 | 94.30 | 46.30 | 203.66 |
| Aloe-emodin：Dimethomorph=1:40 | 7.22 | 100.50 | 46.57 | 215.82 |
| Aloe-emodin：Dimethomorph=1:30 | 7.73 | 93.97 | 47.00 | 199.94 |
| Aloe-emodin：Dimethomorph=1:20 | 8.20 | 88.57 | 47.84 | 185.15 |
| Aloe-emodin：Dimethomorph=1:1 | 5.90 | 122.95 | 72.62 | 169.32 |
| Aloe-emodin：Dimethomorph=20:1 | 4.89 | 148.49 | 97.39 | 152.47 |
| Aloe-emodin：Dimethomorph=40:1 | 5.32 | 136.35 | 98.66 | 138.20 |
As a result (table 4) shows in aloe-emodin：Dimethomorph=20~1:In 1~100 interval range, aloe rheum officinale
Acid is compounded to the co-toxicity coefficient of balsam pear sclerotiniose with dimethomorph 152.47 or more, illustrates the two compounding to balsam pear sclerotiniose
Prevention has significant synergistic effect.
5, aloe-emodin and mandipropamid compounding test cucumber rhizoctonia rot toxicity test
5. aloe-emodin of table is compounded with mandipropamid to cucumber rhizoctonia rot toxicity test interpretation of result
As a result (table 5) shows that aloe-emodin significantly puies forward the control effect of cucumber rhizoctonia rot with mandipropamid compounding
Height illustrates that the two compounding has significant synergistic effect to cucumber rhizoctonia rot prevention.
6, aloe-emodin and Metalaxyl-M compounding test celery leaf spot toxicity test
6. aloe-emodin of table is compounded with Metalaxyl-M to celery leaf spot toxicity test interpretation of result
As a result (table 6) shows in aloe-emodin：Metalaxyl-M=20~1:In 1~100 interval range, aloe rheum officinale
Element is compounded to the co-toxicity coefficient of celery leaf spot with Metalaxyl-M 172.95 or more, illustrates the two compounding to celery leaf spot
Prevention has significant synergistic effect.
(2) field efficacy verification test
Test method：At the initial stage of a disease, first time spraying is carried out immediately, and second of dispenser is carried out after 7 days, each handles 4
A cell, 20 square meter of each cell.11 days investigation statistics incidences, 5 points of each cell are random before medicine and after second of medicine
Sampling, 5 plants of crops of every investigation, investigates percentage and classification that the lesion area in whole strain per blade accounts for blade area, calculates
Disease index and control effect.
It is expected that preventive effect (%)=X+Y-XY/100 (wherein, X, Y are single dose preventive effect)
Grade scale：
0 grade：Disease-free spot；
1 grade：Leaf spot lesion is less than 5, and length is less than 1cm；
3 grades：Leaf spot lesion 6-10, part scab length is more than 1cm；
5 grades：Leaf spot lesion 11-25, part scab is linked to be piece, and lesion area accounts for the 10-25% of leaf area；
7 grades：Leaf spot lesion 26 or more, scab are linked to be piece, and lesion area accounts for the 26-50% of leaf area；
9 grades：Scab is linked to be piece, lesion area account for 50% of leaf area or more or full leaf it is withered.
1, Physcion and dimethomorph compounding field efficacy experiment
7 Physcion of table is with dimethomorph mixture to leek rust control effect
Measurement result (table 7) shows that the compounding of Physcion and dimethomorph significantly improves leek rust preventive effect, says
Both bright compounding has significant synergistic effect to leek rust.
2, Physcion and mandipropamid compounding field efficacy experiment
8 Physcion of table is with mandipropamid mixture to downy mildew of garpe control effect
Measurement result (table 8) shows that Physcion obviously puies forward the preventive effect of downy mildew of garpe with mandipropamid mixture
Height illustrates that the two compounding has significant synergistic effect to downy mildew of garpe.
3, Physcion and Metalaxyl-M compounding field efficacy experiment
9 Physcion of table is with Metalaxyl-M mixture to ring rot of apple control effect
Measurement result (table 9) shows that Physcion significantly improves the preventive effect of ring rot of apple with Metalaxyl-M mixture,
Illustrate that the two compounding has significant synergistic effect to ring rot of apple.
4, aloe-emodin and dimethomorph compounding field efficacy experiment
10 aloe-emodin of table is with dimethomorph mixture to target control effect
Measurement result (table 10) shows that aloe-emodin obviously puies forward the preventive effect of target with dimethomorph mixture
Height illustrates that the two compounding has significant synergistic effect to target.
5, aloe-emodin and mandipropamid compounding field efficacy experiment
11 aloe-emodin of table is with mandipropamid mixture to citrus rubber disease control effect
Measurement result (table 11) shows that aloe-emodin obviously puies forward the preventive effect of citrus rubber disease with mandipropamid mixture
Height illustrates that the two compounding has significant synergistic effect to citrus rubber disease.
6, aloe-emodin and Metalaxyl-M compounding field efficacy experiment
12 aloe-emodin of table is with Metalaxyl-M mixture to anthracnose of tobacco control effect
Measurement result (table 12) shows that aloe-emodin obviously puies forward the preventive effect of anthracnose of tobacco with Metalaxyl-M mixture
Height illustrates that the two compounding has significant synergistic effect to anthracnose of tobacco.
Claims (8)
1. a kind of microbicide compositions, it is characterised in that：The composition includes two kinds of active components of A and B, and active component A is anthracene
Any one fungicide in quinones in Physcion and aloe-emodin, active component B kill for amides
Any one in microbial inoculum in dimethomorph, mandipropamid and Metalaxyl-M, the weight ratio between two components is 20~
1:1~100.
2. microbicide compositions according to claim 1, it is characterised in that：The weight ratio of active component A and active component B
It is 1:1~100.
3. microbicide compositions according to claim 2, it is characterised in that：The weight ratio of active component A and active component B
It is 1:1~80.
4. microbicide compositions according to any one of claims 1 to 3, it is characterised in that：The composition is by activity
The dosage form allowed on pesticide is made in ingredient and insecticides adjuvant or auxiliary material.
5. microbicide compositions according to claim 4, it is characterised in that：The composition by 5~85% parts by weight work
Property component and 95~15% parts by weight insecticides adjuvant or auxiliary material composition pesticide on the dosage form that allows.
6. microbicide compositions according to claim 4, it is characterised in that：The dosage form is suspending agent, water-dispersible grain
Agent or wettable powder.
7. microbicide compositions according to claim 4 or 5, it is characterised in that：The insecticides adjuvant or auxiliary material, which are selected from, to be carried
One or more of body, solvent, dispersant, wetting agent, adhesive, thickener, adhesive, surfactant and fertilizer.
8. purposes of the composition pesticide in terms of agriculture field prevents corps diseases described in claim 1~7 any one.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116982621A (en) * | 2023-08-04 | 2023-11-03 | 四川易宏欣农业科技有限公司 | Crop combined synergistic bactericide and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102548418A (en) * | 2009-07-30 | 2012-07-04 | 玛珑生物创新有限公司 | Plant pathogen inhibitor combinations and methods of use |
| CN106165694A (en) * | 2016-07-26 | 2016-11-30 | 王瑞明 | A kind of bactericidal composition preventing and treating wheat powdery mildew |
| CN106234378A (en) * | 2016-08-01 | 2016-12-21 | 江苏辉丰农化股份有限公司 | A kind of microbicide compositions |
| CN106342832A (en) * | 2016-08-29 | 2017-01-25 | 田文华 | Fluoxastrobin and physcion containing sterilization composition |
-
2017
- 2017-03-31 CN CN201710204459.7A patent/CN108338166A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102548418A (en) * | 2009-07-30 | 2012-07-04 | 玛珑生物创新有限公司 | Plant pathogen inhibitor combinations and methods of use |
| CN104996477A (en) * | 2009-07-30 | 2015-10-28 | 马罗内生物创新公司 | Plant pathogen inhibitor combinations and methods of use |
| CN106165694A (en) * | 2016-07-26 | 2016-11-30 | 王瑞明 | A kind of bactericidal composition preventing and treating wheat powdery mildew |
| CN106234378A (en) * | 2016-08-01 | 2016-12-21 | 江苏辉丰农化股份有限公司 | A kind of microbicide compositions |
| CN106342832A (en) * | 2016-08-29 | 2017-01-25 | 田文华 | Fluoxastrobin and physcion containing sterilization composition |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116982621A (en) * | 2023-08-04 | 2023-11-03 | 四川易宏欣农业科技有限公司 | Crop combined synergistic bactericide and application thereof |
| CN116982621B (en) * | 2023-08-04 | 2024-07-26 | 贵州道元生物技术有限公司 | Crop combined synergistic bactericide and application thereof |
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Application publication date: 20180731 |