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CN108272900B - 一种治疗类风湿性关节炎的中药组合物 - Google Patents

一种治疗类风湿性关节炎的中药组合物 Download PDF

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CN108272900B
CN108272900B CN201810281694.9A CN201810281694A CN108272900B CN 108272900 B CN108272900 B CN 108272900B CN 201810281694 A CN201810281694 A CN 201810281694A CN 108272900 B CN108272900 B CN 108272900B
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邹方昕
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Abstract

本发明涉及一种治疗类风湿性关节炎的中药组合物，属于中药的技术领域。本制剂由生地、熟地、当归等药材组方，分别制成药剂学上常用的剂型。本发明制剂稳定性好，生物利用度高，服用方便，外观美洁，易于患者接受；所提供的制备方法能够有效制备需要的制剂、保证得到的制剂生产工艺科学合理。

Description

一种治疗类风湿性关节炎的中药组合物
技术领域
本发明是一种治疗类风湿性关节炎的中药组合物，属于中药的技术领域。
技术背景
类风湿性关节炎，是一种全身性慢性疾病，以关节和关节周围组织的炎症为主，其发病与自身免疫、遗传因素、感染及内分泌因素有关。在国内，和肿瘤、心脑血管疾病相比，人们对类风湿性关节炎的关注度相对不高，但是，类风湿性关节炎不仅发病率较高，而且，对人体伤害很大，会造成劳动力下降，若不能早期进行及时有效的治疗，可能会致残。治疗类风湿性关节炎，西医主要是选用非甾体类抗炎药、免疫抑制剂，以及糖皮质激素类药，这些药物的使用，虽然在一定程度上能够缓解症状，但是难以治愈。从中医角度来讲，类风湿性关节炎归属于“痹症”范畴，多年来积累了较多的临床经验，鉴于这些情况，基于中医传统理论和大量的临床实践，提供一种疗效确切、毒副作用小、服用方便的中药组合物，用于治疗类风湿性关节炎，是急需解决的事情。
发明内容
本发明所要解决的技术问题是提供一种治疗类风湿性关节炎的中药组合物；本发明针对现有技术，提供的产品疗效确切、毒副作用小、服用方便。
本发明的技术方案是这样构成的：它包含以下重量份的组分：生地80-120份、熟地80-120份、当归80-120份、鸡血藤80-120份、淫羊霍80-120份、仙鹤草80-120份、肉苁蓉80-120份、乌梢蛇80-120份、全蝎10-30份、蜈蚣5-15份、蜂房80-120份、僵蚕80-120份、地龙80-120份、土鳖虫80-120份、透骨草50-70份、玄参50-70份、骨碎补80-120份、狗脊80-120份、甘草20-40份、白术50-70份、威灵仙50-70份、白芍50-70份、忍冬藤120-160份。进一步优选为：生地100份、熟地100份、当归100份、鸡血藤100份、淫羊霍100份、仙鹤草100份、肉苁蓉100份、乌梢蛇100份、全蝎20份、蜈蚣10份、蜂房100份、僵蚕100份、地龙100份、土鳖虫100份、透骨草60份、玄参60份、骨碎补100份、狗脊100份、甘草30份、白术60份、威灵仙60份、白芍60份、忍冬藤140份。所述的治疗类风湿性关节炎的中药组合物，可制成多种口服剂型，包括：片剂、胶囊剂、颗粒剂、丸剂、口服液体制剂。
类风湿病患者，常见关节疼痛、肿大、红肿热痛、屈伸不利、肌肉疼痛、瘦削或僵硬，由于寒热错杂，痹症日久伤阳，损伤气血，痹疴经络之症。本发明以生地、忍冬藤、透骨草、玄参清热解毒，以仙灵脾、肉苁蓉、狗脊、骨碎补散寒温阳除湿，寒热并用，以鸡血藤、蜂房、土鳖虫、乌梢蛇、威灵仙活血化瘀通络，以白术、当归、白芍、熟地、仙鹤草补虚扶正，以全蝎、蜈蚣、僵蚕、地龙搜风止痛，甘草调和诸药，共起清热解毒、散寒温阳除湿活血化瘀补虚扶正搜风通络于一炉。
实验例1 对大鼠角叉菜胶所致足肿胀的影响
1组：生地100份、熟地100份、当归100份、鸡血藤100份、淫羊霍100份、仙鹤草100份、肉苁蓉100份、乌梢蛇100份、全蝎20份、蜈蚣10份、蜂房100份、僵蚕100份、地龙100份、土鳖虫100份、透骨草60份、玄参60份、骨碎补100份、狗脊100份、甘草30份、白术60份、威灵仙60份、白芍60份、忍冬藤140份
2组：生地80份、熟地80份、当归120份、鸡血藤120份、淫羊霍80份、仙鹤草80份、肉苁蓉120份、乌梢蛇120份、全蝎10份、蜈蚣5份、蜂房80份、僵蚕80份、地龙120份、土鳖虫120份、透骨草50份、玄参50份、骨碎补120份、狗脊120份、甘草20份、白术50份、威灵仙70份、白芍70份、忍冬藤120份。
3组：生地120份、熟地120份、当归80份、鸡血藤80份、淫羊霍120份、仙鹤草120份、肉苁蓉80份、乌梢蛇80份、全蝎30份、蜈蚣15份、蜂房120份、僵蚕120份、地龙80份、土鳖虫80份、透骨草70份、玄参70份、骨碎补80份、狗脊80份、甘草40份、白术70份、威灵仙50份、白芍50份、忍冬藤160份。
SD大鼠50只，雄性，随机分为对照组、阿司匹林组、本发明1组、本发明2组、本发明3组，试验前每鼠右后足踝关节处用记号笔作一横线，排水法测鼠足跖正常体积。灌胃给药，连续3天，末次给药后30min，每鼠右后足跖皮下注射1％角叉菜胶混悬液0.1ml/只，每隔1小时按上法测一次足跖容积，连续3次，计算足肿胀度，见下表：
Figure BSA0000161660530000021
结果表明：本发明组合对大鼠角叉菜胶所致足肿胀的具有明显的抑制作用，尤其是本发明1组。
具体的实施方式
实施例1：生地100份、熟地100份、当归100份、鸡血藤100份、淫羊霍100份、仙鹤草100份、肉苁蓉100份、乌梢蛇100份、全蝎20份、蜈蚣10份、蜂房100份、僵蚕100份、地龙100份、土鳖虫100份、透骨草60份、玄参60份、骨碎补100份、狗脊100份、甘草30份、白术60份、威灵仙60份、白芍60份、忍冬藤140份。
以上药味，加水煎煮三次，第一次加8倍量水煎煮1.5小时，第二次、第三次都加6倍量水，分别煎煮1.5小时、1小时，合并煎液，滤过，滤液减压浓缩，干燥，粉碎，按照1∶1∶1的比例，加入淀粉和蔗糖，混匀，制粒，干燥后，即得颗粒剂，口服，一日2次，10g/次
实施例2：生地80份、熟地80份、当归120份、鸡血藤120份、淫羊霍80份、仙鹤草80份、肉苁蓉120份、乌梢蛇120份、全蝎10份、蜈蚣5份、蜂房80份、僵蚕80份、地龙120份、土鳖虫120份、透骨草50份、玄参50份、骨碎补120份、狗脊120份、甘草20份、白术50份、威灵仙70份、白芍70份、忍冬藤120份。
以上药味，加水煎煮两次，第一次加10倍量水煎煮1小时，第二次加8倍量水，煎煮1小时，合并煎液，过滤，浓缩，真空干燥，粉碎；加入等量的淀粉，混匀，制粒，干燥，装胶囊，即得胶囊剂。
实施例3：生地120份、熟地120份、当归80份、鸡血藤80份、淫羊霍120份、仙鹤草120份、肉苁蓉80份、乌梢蛇80份、全蝎30份、蜈蚣15份、蜂房120份、僵蚕120份、地龙80份、土鳖虫80份、透骨草70份、玄参70份、骨碎补80份、狗脊80份、甘草40份、白术70份、威灵仙50份、白芍50份、忍冬藤160份。
以上药味，加水煎煮2次，第一次加5倍量水煎煮2小时，第二次4倍量水，煎煮1小时，合并煎液，滤过，滤液减压浓缩，真空干燥，粉碎，加入等量的淀粉，压片，即得片剂。
实施例4：生地100份、熟地100份、当归100份、鸡血藤100份、淫羊霍100份、仙鹤草100份、肉苁蓉100份、乌梢蛇100份、全蝎20份、蜈蚣10份、蜂房100份、僵蚕100份、地龙100份、土鳖虫100份、透骨草60份、玄参60份、骨碎补100份、狗脊100份、甘草30份、白术60份、威灵仙60份、白芍60份、忍冬藤140份。
以上药味，加水煎煮2次，每次加8倍量水煎煮2小时，合并煎液，过滤，浓缩，干燥，粉碎，泛丸即得丸剂。
实施例5：生地110份、熟地110份、当归90份、鸡血藤90份、淫羊霍100份、仙鹤草100份、肉苁蓉90份、乌梢蛇100份、全蝎25份、蜈蚣15份、蜂房110份、僵蚕100份、地龙90份、土鳖虫90份、透骨草65份、玄参65份、骨碎补90份、狗脊95份、甘草30份、白术60份、威灵仙60份、白芍50份、忍冬藤140份。
以上药味，加水煎煮2次，每次加8倍量水煎煮2小时，合并煎液，过滤，浓缩，即得口服溶液剂。

Claims (3)

1.一种用于治疗类风湿性关节炎的中药组合物，其特征在于：该中药组合物由以下重量份的原料制成：生地80-120份、熟地80-120份、当归80-120份、鸡血藤80-120份、淫羊霍80-120份、仙鹤草80-120份、肉苁蓉80-120份、乌梢蛇80-120份、全蝎10-30份、蜈蚣5-15份、蜂房80-120份、僵蚕80-120份、地龙80-120份、土鳖虫80-120份、透骨草50-70份、玄参50-70份、骨碎补80-120份、狗脊80-120份、甘草20-40份、白术50-70份、威灵仙50-70份、白芍50-70份和忍冬藤120-160份。
2.根据权利要求1所述的用于治疗类风湿性关节炎的中药组合物，其特征在于：该中药组合物由以下重量份的原料制成：生地100份、熟地100份、当归100份、鸡血藤100份、淫羊霍100份、仙鹤草100份、肉苁蓉100份、乌梢蛇100份、全蝎20份、蜈蚣10份、蜂房100份、僵蚕100份、地龙100份、土鳖虫100份、透骨草60份、玄参60份、骨碎补100份、狗脊100份、甘草30份、白术60份、威灵仙60份、白芍60份和忍冬藤140份。
3.根据权利要求1所述的用于治疗类风湿性关节炎的中药组合物，其特征在于：该中药组合物制剂的剂型为胶囊剂、片剂、颗粒剂、丸剂或口服液。
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