CN108196081A - A kind of POCT specific proteins analysis system - Google Patents
A kind of POCT specific proteins analysis system Download PDFInfo
- Publication number
- CN108196081A CN108196081A CN201810066635.XA CN201810066635A CN108196081A CN 108196081 A CN108196081 A CN 108196081A CN 201810066635 A CN201810066635 A CN 201810066635A CN 108196081 A CN108196081 A CN 108196081A
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- pipette tips
- centrum
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- cup
- sample
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- 238000012123 point-of-care testing Methods 0.000 title claims abstract description 31
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 29
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 29
- 238000012360 testing method Methods 0.000 claims abstract description 128
- 238000006243 chemical reaction Methods 0.000 claims abstract description 66
- 230000007246 mechanism Effects 0.000 claims abstract description 55
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 46
- 230000003287 optical effect Effects 0.000 claims abstract description 32
- 238000009434 installation Methods 0.000 claims description 19
- 230000005540 biological transmission Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 abstract description 14
- 239000000523 sample Substances 0.000 description 94
- 239000008280 blood Substances 0.000 description 16
- 210000004369 blood Anatomy 0.000 description 16
- 239000000243 solution Substances 0.000 description 10
- 239000003219 hemolytic agent Substances 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 8
- 238000010586 diagram Methods 0.000 description 7
- 239000012488 sample solution Substances 0.000 description 7
- 239000002904 solvent Substances 0.000 description 5
- 238000002835 absorbance Methods 0.000 description 4
- 238000007639 printing Methods 0.000 description 4
- 239000007853 buffer solution Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 101100327917 Caenorhabditis elegans chup-1 gene Proteins 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The present invention discloses a kind of POCT specific proteins analysis system, which includes test card and detection part.Wherein, detection part includes the operating mechanism being installed in mounting base, optical facilities and loader mechanism.Operating mechanism includes sample adding device and power plant, and sample adding device is equipped with pipette tips centrum, and power plant connects pipette tips centrum so that it is moved up and down.Loader mechanism is equipped with card slot, and card slot corresponds to the setting of pipette tips centrum.Test card is set on card slot, and test card is equipped with groove body, reaction cup and the test pipette tips of multiple pre-packaged reagents.Loader mechanism driving test card movement, to switch the position of groove body, reaction cup or test pipette tips with respect to pipette tips centrum, pipette tips centrum can be with testing pipette tips assembling or separating, and reaction cup is set in the light path of optical facilities.Technical solution of the present invention is easy to operate, improves detection efficiency.
Description
Technical field
The present invention relates to medical equipment technological field, more particularly to a kind of POCT specific proteins analysis system.
Background technology
POCT (Point of Care Testing), is to detect immediately, refers to sample and analyzed at once at the scene,
Complex process program of the sample in laboratory is saved, quickly obtains a kind of new method of inspection result.
At present, in the detection method of POCT specific protein analysis systems, by using reaction cup, haemolysis is first quantitatively drawn
Agent is put into reaction cup, then after directly being taken a blood sample by quantitative sampler, and blood sample is quantitatively adding in reaction cup and hemolytic agent carries out
It is measured after reaction.Either using the reaction cup with pre-packaged hemolytic agent (or reagent), directly taken a blood sample using quantitative sampler
Afterwards, it is measured after blood sample being quantitatively adding into reaction cup reaction.Further more, be the sample injector using integral type, sample injector band
There are sample adding device and quantitative sampler, since this quantitative sampler cannot directly be taken a blood sample, such as adopt finger blood with human contact, because
This is needed after being taken a blood sample using other medical supplies, then is sampled using quantitative sampler, then by being packed on quantitative sampler
Sample adding device adds in blood sample into reaction cup.
It uses with upper type, manual multi-pass operation absorption reagent or hemolytic agent is needed to be mixed with blood sample, to prepare sample
This solution, operation sequence is more, and because the different of reagent are placed also so that inconvenient, causes detection efficiency relatively low.
Invention content
The main object of the present invention is to provide a kind of POCT specific proteins analysis system, it is intended to simplify operation, improve detection
Efficiency.
To achieve the above object, POCT specific proteins analysis system proposed by the present invention, including mounting base, including erecting bed
And the support base upwardly extended from the erecting bed；Operating mechanism, set on the support base, the operating mechanism includes sample-adding and fills
It puts and power plant, the sample adding device is equipped with pipette tips centrum, it is described to drive that the power plant connects the pipette tips centrum
Pipette tips centrum moves up and down relative to the support base；Optical facilities, set on the erecting bed；Loader mechanism, set on the peace
Platform is filled, the loader mechanism is equipped with card slot, and the card slot corresponds to the pipette tips centrum setting；Test card, the test card include
Test card ontology, diaphragm seal, test pipette tips and reaction cup, the test card ontology are equipped with installation opening and multiple slots with opening
Body, the groove body include mounting groove, sample cup, reagent cup, and the diaphragm seal corresponds to opening for the sample cup and the reagent cup
Mouth setting；The test pipette tips are set on the mounting groove；The reaction cup is set on the installation opening；Wherein, the test card is set
In the card slot, the loader mechanism drives the test card movement, to switch the sample cup, the reaction cup, the examination
Agent cup or the position of the test relatively described pipette tips centrum of pipette tips, the pipette tips centrum can be assembled or divide with the test pipette tips
It opens, the reaction cup is set in the light path of the optical facilities.
Optionally, the opening of the sample cup is special-shaped mouth, and the abnormity mouth includes a square orifice and an arc-shaped mouth.
Optionally, the diaphragm seal, which corresponds to, is equipped with tear line at the arc-shaped mouth.
Optionally, the installation opening extends outward to form limited wall from the bottom surface of the test card ontology.
Optionally, the test card ontology is equipped with loophole, and the loophole is used to test system with POCT specific proteins
In sensor cooperation.
Optionally, the outer surface of the diaphragm seal is equipped with identification code.
Optionally, control module is further included, the control module connects the sample adding device, power plant, described
Optical facilities and the loader mechanism.
Optionally, the loader mechanism is additionally provided with thermostat, and the thermostat is set on the card slot, and described in correspondence
Reaction cup is set, and the thermostat connects the control module.
Optionally, the loader mechanism includes first straight line motor, movable block and sliding slot, the first straight line motor connection
The control module, the first straight line motor are set on the one end of the sliding slot far from the support base, the first straight line electricity
Machine is equipped with pull rod, and the movable block is equipped with pilot hole, and the pull rod is arranged in the pilot hole, and the lower end of the movable block is equipped with
Convex block, the both ends of the convex block are caught in the sliding slot, and the card slot is set on the top of the movable block；The optical facilities are set on
The other end of the sliding slot, and the corresponding reaction cup setting.
Optionally, the power plant includes second straight line motor, sliding rail and fixed plate, and the pipette tips centrum is set on described
Fixed plate, the fixed plate are equipped with mounting hole, and the second straight line motor is equipped with push rod, and the push rod is arranged in the installation
Hole, the both ends of the fixed plate are equipped with sliding block, and the sliding block is embedded in the sliding rail, and the second straight line motor connects the control
Module；
The sample adding device further includes injector motor, syringe and connecting tube, and the injector motor connects the control
Molding block, the injector motor are equipped with telescopic rod, and the telescopic rod connects the piston handle of the syringe, the connecting tube
Both ends connect the connector of the syringe and the pipette tips centrum respectively.
Technical solution of the present invention is by using operating mechanism, loader mechanism, optical facilities and test card, on the one hand, passes through
Required hemolytic agent or reagent is pre-packaged in multiple groove bodies of test card ontology respectively, and test pipette tips and reaction cup are set
In on test card ontology so that prepare solvent and being integrated in one of operation utensil needed for sample and be set on test card, to grasp
Sample preparation can be completed by test card when making to operate, facilitate sample preparation.On the other hand, test card is made by loader mechanism to move back
Dynamic, to test after pipette tips and pipette tips centrum assemble, operating mechanism control test pipette tips quantitatively draw solvent or addition extremely
Reaction cup is mixed with sample solution, and passes through optical facilities and sample to be tested in reaction cup is detected, and realizes automatic sample
And detection, it is easy to operate, quick, significantly improve detection efficiency.
Description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, to embodiment or will show below
There is attached drawing needed in technology description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention, for those of ordinary skill in the art, without creative efforts, can be with
Structure according to these attached drawings obtains other attached drawings.
Fig. 1 is a kind of structure diagram of one embodiment of POCT specific proteins analysis system of the present invention；
Fig. 2 is the structure diagram of one embodiment of test card in Fig. 1；
Fig. 3 is the structure diagram that test card combines latter embodiment with quantitative sampler in Fig. 2；
Fig. 4 is the decomposition texture schematic diagram that test card is combined with quantitative sampler in Fig. 3；
Fig. 5 is the structure diagram of an embodiment individually stored of quantitative sampler in Fig. 2；
Fig. 6 is a kind of structure diagram of one embodiment of control module in POCT specific proteins analysis system in Fig. 1；
Fig. 7 is a kind of structural representation of an embodiment of the unassembled test card of POCT specific proteins analysis system of the present invention
Figure；
Fig. 8 is a kind of structure diagram at another visual angle of POCT specific proteins analysis system in Fig. 7.
Drawing reference numeral explanation：
| Label | Title | Label | Title |
| 10 | Mounting base | 11 | Erecting bed |
| 12 | Support base | 20 | Loader mechanism |
| 21 | Card slot | 22 | First straight line motor |
| 23 | Pull rod | 24 | Movable block |
| 25 | Sliding slot | 31 | Sample adding device |
| 311 | Pipette tips centrum | 312 | Injector motor |
| 313 | Telescopic rod | 314 | Syringe |
| 315 | Connecting tube | 32 | Power plant |
| 321 | Second straight line motor | 322 | Push rod |
| 323 | Sliding rail | 33 | Fixed plate |
| 34 | Eccentric wheel | 40 | Optical rack |
| 50 | Thermostat | 60 | Sensor |
| 70 | Test card | 71 | Sample cup |
| 711 | Sample cup is open | 712 | Quantitative sampler |
| 7121 | Sampler head | 7121 | Micropipet |
| 72 | Reagent cup | 721 | Reagent cup one |
| 722 | Reagent cup two | 723 | Reagent cup three |
| 73 | Reaction cup | 731 | Installation opening |
| 74 | Test pipette tips | 741 | Mounting groove |
| 75 | Diaphragm seal | 751 | Tear line |
| 752 | Identification code | 76 | Loophole |
| 80 | Identification code scanning means | 91 | Processor unit |
| 911 | First processor | 912 | Second processor |
| 92 | Printing device | 93 | LIS systems |
| 94 | User terminal | 95 | RAM card |
The embodiments will be further described with reference to the accompanying drawings for the realization, the function and the advantages of the object of the present invention.
Specific embodiment
Below in conjunction with the attached drawing in the embodiment of the present invention, the technical solution in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only the part of the embodiment of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art obtained without creative efforts it is all its
His embodiment, shall fall within the protection scope of the present invention.
It is to be appreciated that the directional instruction (such as up, down, left, right, before and after ...) of institute is only used in the embodiment of the present invention
In explaining relative position relation, motion conditions under a certain particular pose (as shown in drawings) between each component etc., if should
When particular pose changes, then directionality instruction also correspondingly changes correspondingly.
In addition, the description for being related to " first ", " second " etc. in the present invention is only used for description purpose, and it is not intended that referring to
Show or imply its relative importance or imply the quantity of the technical characteristic indicated by indicating." first ", " are defined as a result,
At least one this feature can be expressed or be implicitly included to two " feature.In addition, the technical solution between each embodiment can
To be combined with each other, but must can be implemented as basis with those of ordinary skill in the art, when the combination of technical solution occurs
Conflicting or can not realize when, will be understood that the combination of this technical solution is not present, also not the present invention claims protection model
Within enclosing.
The present invention proposes a kind of POCT specific proteins analysis system.
Referring to figs. 1 to 7.
In embodiments of the present invention, which includes mounting base 10, operating mechanism, optics machine
Structure 40, loader mechanism 20 and test card 70.Wherein, mounting base 10 includes the support that erecting bed 11 and self installation platform 11 upwardly extend
Seat 12；Operating mechanism is set on support base 12, and operating mechanism includes sample adding device 31 and power plant 32, and sample adding device 31 is equipped with rifle
Head centrum 311, power plant 32 connect pipette tips centrum 311 so that pipette tips centrum 311 to be driven to be moved up and down relative to support base 12；Light
It learns mechanism 40 and is set on erecting bed 11；Loader mechanism 20 is set on erecting bed 11, and loader mechanism 20 is equipped with card slot 21, and card slot 21 corresponds to rifle
Head centrum 311 is set；Test card 70 includes test card ontology, diaphragm seal 75, test pipette tips 74 and reaction cup 73, test card ontology
Include mounting groove 741, sample cup 71, reagent cup 72, diaphragm seal equipped with installation opening 731 and multiple groove bodies with opening, groove body
75 correspond to the opening setting of sample cup 71 and reagent cup 72；It tests pipette tips 74 and is set on mounting groove 741；Reaction cup 73 is set on installation opening
731；Wherein, test card 70 is set on card slot 21, and loader mechanism 20 drives test card 70 to move, to switch sample cup 71, reaction cup
73rd, reagent cup 72 or test pipette tips 74 with respect to pipette tips centrum 311 position, pipette tips centrum 311 can be assembled with test pipette tips 74 or
It separates, reaction cup 73 is set in the light path of optical facilities 40.
Specifically, mounting base 10 is used for the assembling of other assemblies in the POCT specific proteins analysis system 1, and mounting base 10 is wrapped
The support base 12 that erecting bed 11 and self installation platform 11 upwardly extend is included, will pass through erecting bed 11 convenient for assembling, passes through support base
12 utilize relative space position, realize the mutual cooperation of inter-module.
Test card 70 includes test card ontology, diaphragm seal 75, test pipette tips 74 and reaction cup 73, and test card ontology is equipped with more
A groove body with opening, groove body include mounting groove 741, sample cup 71 and reagent cup 72.Mounting groove 741 is tested for assembling
Pipette tips 74, test pipette tips 74 for quantitatively draw reagent carry out sample preparation, make test pipette tips 74 need can be taken out out of mounting groove 741 into
It exercises and uses, and be positioned in mounting groove 741 not used when.It is pre-loaded into what is directly mixed with acquisition blood sample in sample cup 71
Hemolytic agent or buffer solution are preinstalled with the reagent for preparing test sample in reagent cup 72, can be according to the need of specific test event
Will, the type of determining required reagent, to determine the number of reagent cup 72.Therefore, the number of reagent cup 72 can be one, two or
It is multiple, to meet the detection needs of the specific protein intermediate item of single reagent and entry.In the present embodiment, to set, there are three reagents
It is illustrated for cup 72.As shown in figure 3, with reagent cup 1, reagent cup 2 722, reagent cup 3 723.Make diaphragm seal 75
The opening setting of corresponding sample cup 71 and reagent cup 72, the reagent of prepackage is sealed with to be used.Test card ontology is also set
There is installation opening 731, reaction cup 73 is made to be assemblied in test card ontology by installation opening 731, reaction cup 73 is used to be placed through sample
The sample to be tested that solution and reagent are mixed with, by measuring the absorbance change value of sample to be tested in reaction cup 73, to measure
Item argument in sample.Reaction cup 73 can be and detachably be assemblied in test card 70, also can be with 70 integrated setting of test card.This
In embodiment, for ease of use, meet POCT test needs, reaction cup 73 and 70 integrated setting of test card, be disposable
Articles for use, and be made of the polystyrene material with preferable light transmittance.By test card 70, make the reagent needed for test event
It is integrated in one with device, is conveniently operated use.
In order to coordinate the use of test card 70, realize automatic sample, operating mechanism is set.Operating mechanism is set on support base
12, and including sample adding device 31 and power plant 32, sample adding device 31 is equipped with pipette tips centrum 311, power plant 32 connects pipette tips
Centrum 311 is to drive pipette tips centrum 311 to be moved up and down relative to support base 12.By sample adding device 31, to pass through pipette tips centrum
311, to test 74 Repeated Compression air of pipette tips, make to generate positive pressure or negative pressure in the inner cavity of test pipette tips 74, so as to release reagent
When, compressing action repeatedly occurs, is sufficiently mixed so as to prepare sample, realizes accurate sample-adding.Rifle is driven by power plant 32
Head centrum 311 move down, make pipette tips centrum 311 with test pipette tips 74 assemble, after pass through power plant 32 driving pipette tips centrum
311 move up, and test pipette tips 74 is made to be detached from test card 70, realize the use of test pipette tips 74.
After pipette tips centrum 311 is assembled with test pipette tips 74, reagent progress sample preparation need to be drawn by testing pipette tips 74.Setting
Loader mechanism 20 makes loader mechanism 20 be assemblied in erecting bed 11, and is fixed.Loader mechanism 20 is equipped with card slot 21, card slot 21
Corresponding pipette tips centrum 311 is set.Due to card slot 21 for placing test card 70, so that test card 70 corresponds to test pipette tips 74, and
In the lower section of test pipette tips 74.Meanwhile loader mechanism 20 moves test card 70, to switch sample cup 71, reagent cup 72, survey
The position of pipette tips 74 or reaction cup 73 with respect to pipette tips centrum 311 is tried, by the movement of test card 70, be directed at test pipette tips 74
Pipette tips centrum 311 realizes the assembling of the two.After reagent cup 72 is made to be directed at pipette tips centrum 311, so that pipette tips centrum 311 is to moving down
After dynamic, test pipette tips 74 are inserted into reagent cup 72 after absorption reagent, and pipette tips cone is lifted together with test pipette tips 74.Make again anti-
Cup 73 is answered to be directed at pipette tips centrum 311, is moved down by pipette tips centrum 311, test pipette tips 74 is made to be inserted into reaction cup 73, and will
Reagent is released, and realizes sample preparation.
The POCT specific proteins analysis system 1 is by measuring in reaction cup 73 the absorbance change value with test sample sheet to project
Parameter is measured, therefore further includes optical facilities 40, and optical facilities 40 are set on erecting bed 11, and is set on reaction cup 73
In the light path of optical facilities 40, so that projection light is irradiated in the sample to be tested in reaction cup 73.
In the present embodiment, to the operation of the POCT specific proteins analysis system 1, details are as follows：First, using quantitative
Sampler 712 directly takes blood sample (such as finger blood) with human contact, as shown in figure 4, the quantitative sampler 712 includes sampler
First 7121 and micropipet 7122, sampler head 7121 can be assembled with pipette tips centrum 311, micropipet 7122 is made of glass,
For directly blood was collected with human contact.Independent packaging can be used when unused in the quantitative sampler 712, as shown in figure 5,
And make and meet third class medical devices call, meet the requirement of sterilization.After blood sample is taken, will quantitatively it adopt manually
Sample device 712 is put into the sample cup 71 of test card 70, and test card 70 is put into the card slot 21 of loader mechanism 20.Loader mechanism
20 mobile test cards 70 make sample cup 71 be directed at pipette tips centrum 311.Power plant 32 drives pipette tips centrum 311 to move down, and makes
Pipette tips centrum 311 is assembled with sampler head 7121.Sample adding device 31 iterates through pipette tips centrum 311 into micropipet 7122
Chamber compressed air makes to generate positive pressure in the inner cavity of micropipet 7122 and negative pressure, the compressing that micropipet 7122 occurs repeatedly is moved
Make, blood sample is made to be sufficiently mixed with hemolytic agent or buffer solution, avoid loading errors caused by the wall built-up of blood sample, realize accurate add
Sample.Quantitative sampler 712 quantitatively draws sample solution afterwards, and power plant 32 drives pipette tips centrum 311 and quantitative sampler 712 1
With moving up, equipment mechanism mobile test card 70 makes reaction cup 73 be directed at pipette tips centrum 311, and power plant 32 drives pipette tips
Centrum 311 moves down, and quantitative sampler 712 is put into reaction cup 73, and sample adding device 31 is operated using same by sample
Solution is added in reaction cup 73.Then, test card 70 moves, and sample cup 71 is made to be directed at pipette tips centrum 311, pipette tips centrum again
311 move down after detached with quantitative sampler 712, quantitative sampler 712 is put back to.Test card 70 moves, and makes test pipette tips 74 right
Quasi- pipette tips centrum 311, pipette tips centrum 311 are coordinated identical with test pipette tips 74 using pipette tips centrum 311 with quantitative sampler 712
Process by the reagent in reagent cup 1, reagent cup 2 722, reagent cup 3 723, according to needs are measured, is sequentially added to anti-
It answers in cup 73 and is sufficiently mixed with sample solution, to obtain solution to be measured.Reaction cup 73 is made to be moved in the light path of optical facilities 40,
By measuring the variation of absorbance, test is completed.
Technical solution of the present invention is by using operating mechanism, loader mechanism 20, optical facilities 40 and test card 70, a side
Face by the way that required hemolytic agent or reagent is pre-packaged in multiple groove bodies of 70 ontology of test card respectively, and will test pipette tips
74 and reaction cup 73 be set on 70 ontology of test card on so that prepare being integrated in one of solvent and operation utensil needed for sample and set
In test card 70, operated so that sample preparation can be completed by test card 70 during convenient to operate, facilitate sample preparation.On the other hand, pass through loading
Mechanism 20 moves back and forth test card 70, to test after pipette tips 74 and pipette tips centrum 311 assemble, operating mechanism control survey
Examination pipette tips 74 are quantitatively drawn solvent or are added in reaction cup 73 and mixed with sample solution, and pass through optical facilities 40 to reaction cup 73
Interior sample to be tested is detected, and realizes automatic sample and detection, easy to operate, quick, significantly improves detection efficiency.
As shown in figure 4, the opening 711 of sample cup is special-shaped mouth, special-shaped mouth includes a square orifice and an arc-shaped mouth.So that
Sample cup 71 includes a square body space and arc-shaped space, increases the volume of sample cup 71.On the one hand, make quantitative sampling
Device 712 is positioned in arc-shaped space, convenient for placing and taking；On the other hand, quantitative sampler 712 is positioned over sample cup 71
It is interior, the space in sample cup 71 is occupied, by the hemolytic agent in sample cup 71 or buffer solution outwardly against making hemolytic agent or slow
It rushes solution to flow in square body space, effectively prevents the solvent in sample cup 71 because the occupancy in space is extruded sample cup 71
Outside, sample solution is caused to lose, leads to happening for sample failure.It of courses, in order to reach increase 71 volume of sample cup
Effect in practical applications, can also be used other shapes and be combined instead of square orifice with arc-shaped mouth, such as arc-shaped, diamond shape.
As shown in Fig. 2, diaphragm seal 75, which corresponds to, is equipped with tear line 751 at arc-shaped mouth.Since arc-shaped space is to quantitatively adopting
The adaptation and support effect that sample device 712 has had, quantitative sampler 712, which needs to be properly inserted arc-shaped mouth, to be put into sample cup 71
It is interior.Tear line 751 is set, the insertion position of quantitative sampler 712 is marked on the outer surface of diaphragm seal 75, to adopt
Quantitative sampler 712 is properly inserted by tear line 751 manually after sample.It avoids slipping up when being inserted into, causes sample
Loss, significantly improves effective sample rate.
As shown in Figures 2 to 4, the bottom surface of 731 self-test card of installation opening, 70 ontology extends outward to form limited wall.Reaction cup
73, which are arranged in installation opening 731, is assemblied in test card 70.Reaction cup 73 and the contact area of test card 70 are only limitted to installation opening 731
Inner surface, area is smaller.The bottom surface of 731 self-test card of installation opening, 70 ontology extends outward to form limited wall, considerably increases
Reaction cup 73 and the contact area of 70 ontology of test card assembling, are conducive to fix the limiting of reaction cup 73, prevent reaction cup 73
Occur unstable or shake, be easy to use.
As shown in Figures 2 to 4,70 ontology of test card is equipped with loophole 76, and loophole 76 is used to survey with POCT specific proteins
Sensor 60 in test system coordinates.By loophole 76, make sensor 60 by sensing the variation of light, so as to judge in standard
During standby measure, whether the reaction cup 73 in test card 70 is located in the light path of optical facilities 40, to determine whether to be detected, carries
High system it is intelligent.In the present embodiment, to coordinate with loophole 76, be equipped on loader mechanism 20 sensor 60 and with sensing
The anti-dazzling screen that device 60 connects makes anti-dazzling screen be set set on card slot 21 and corresponding loophole 76.When reaction cup 73 is not in optics machine
When in the light path of structure 40, loophole 76 does not correspond to anti-dazzling screen, and anti-dazzling screen is sensed less than light；When reaction cup 73 is located at correctly inspection
When on location, loophole 76 corresponds to anti-dazzling screen, and anti-dazzling screen receives the light transmitted by loophole 76, can start optical facilities
40 are detected.In other embodiments, other modes, such as microswitch can also be used in the sensor 60 in the system,
This is not specifically limited.
As shown in Fig. 2, the outer surface of diaphragm seal 75 is equipped with identification code 752.Specific sample letter is loaded in the identification code 752
Breath by scanning the identification code 752, can obtain the name of such as sampler, age, gender, item detection result, make automatically
It obtains data record and preservation is more convenient, the use of system is more intelligent.It is automatic in order to which system is enable to pass through identification code 752
It reads or stores data information, identification code scanning means 80 is equipped on support base 12, identification code scanning means 80 is made to correspond to card
Slot 21 is set, to be scanned to identification code 752.In addition, bar code, Quick Response Code etc. can be used in identification code 752.
As shown in fig. 6, control module is further included, control module connection sample adding device 31, power plant 32, optical facilities 40
With loader mechanism 20.By control module, the operation of system is set, to accurately control sample adding device 31, power plant
32nd, loader mechanism 20 and the operation of optical facilities 40 significantly improve the intelligence of system, realize full-automatic operation.Tool
Body, the control module include processor unit 91, user terminal 94, printing device 92, hospital laboratory information system
(Laboratory Information System, abbreviation LIS system 93) makes processor connection user terminal 94, printing device
92nd, LIS systems 93, sample adding device 31, power plant 32, loader mechanism 20 and optical facilities 40.Due to the number of single-processor
It is limited according to port, and needed according to different uses using different processors, processor unit 91 is made to include what is be connected with each other
First processor 911 and second processor 912.First processor 911 is mainly used for human-computer interaction, thus with user terminal 94,
Printing device 92, LIS systems 93 connect.Second processor 912 mainly realizes manipulation to system, thus with sample adding device 31,
Power plant 32, loader mechanism 20, optical facilities 40 connect.If in addition, the system is additionally provided with 752 scanning means of identification code, passes
Sensor 60 makes 752 scanning means of identification code and sensor 60 be connect with second processor 912.
The survey to the absorbance change value of sample solution is realized by the specific action of 912 control system of second processor
It is fixed, and first processor 911 will be transferred to after institute's measured value storage.RAM card 95, RAM card 95 are additionally provided in the control module
In be stored with measured value and required detection item argument conversion program and formula, control module is by calling in RAM card 95
Formula corresponding item argument is calculated according to measured value, you can obtain testing result.First processor 911 obtains detection knot
After the feedback of fruit, pass the information on to LIS systems 93 and printer printout.
As shown in fig. 7, loader mechanism 20 is additionally provided with thermostat 50, thermostat 50 is set on card slot 21, and corresponding reaction
Cup 73 is set, 50 link control module of thermostat.Reaction cup 73 into trip temperature is controlled by thermostat 50, reaction can be made
Sample to be tested in cup 73, which is under identical temperature condition, to be detected, and the difference because of external environment is avoided to produce testing result
Raw to influence, stability and accuracy for testing result provide strong guarantee.
As shown in fig. 7, loader mechanism 20 includes first straight line motor 22, movable block 24 and sliding slot 25, first straight line motor
22 link control modules, first straight line motor 22 are set on the one end of sliding slot 25 far from support base 12, and first straight line motor 22 is equipped with
Pull rod 23, movable block 24 are equipped with pilot hole, and pull rod 23 is arranged in pilot hole, and the lower end of movable block 24 is equipped with convex block, and the two of convex block
End is caught in sliding slot 25, and card slot 21 is set on the top of movable block 24；Optical facilities 40 are set on the other end of sliding slot 25, and corresponding reaction
Cup 73 is set.In the present embodiment, first straight line motor 22 drives movable block 24 to move back and forth on sliding slot 25 by pull rod 23, with
Driving test card 70 moves, so as to make sample cup 71, reagent cup 72, test pipette tips 74 or reaction cup 73 with respect to pipette tips centrum 311
Position converts, and realizes sample making course.First straight line motor 22 is set on the one end of sliding slot 25 far from support base 12, so that test
Card 70 and operating mechanism have sufficient operating space.Optical facilities 40 are set on the other end of sliding slot 25, so that reaction cup 73
In in the light path of optical facilities 40, convenient for measuring, and cause compact overall structure.
Optical facilities 40 are equipped with optical rack, and optical rack includes pedestal and upwardly extends the support arm to be formed from the both ends of pedestal,
Light path system is equipped in support arm, and two arm rooms are formed with recessing groove.The recessing groove not only causes test card 70 on the move
Pass through, and reaction cup 73 is made to be located in recessing groove, so that the light path system in support arm is projeced into reaction cup 73, reaction cup 73 is in
In light path.
As shown in Figure 7 and Figure 8, power plant 32 includes second straight line motor 321, sliding rail 323 and fixed plate 33, pipette tips vertebra
Body 311 is set on fixed plate 33, and fixed plate 33 is equipped with mounting hole, and second straight line motor 321 is equipped with push rod 322, and push rod 322 is arranged in
Mounting hole, the both ends of fixed plate 33 are equipped with sliding block, sliding block insertion sliding rail 323,321 link control module of second straight line motor.It is logical
Cross the installation that fixed plate 33 is convenient for pipette tips centrum 311.Second straight line motor 321 drives fixed plate 33 in sliding rail by push rod 322
It is moved in 323, so that pipette tips centrum 311 moves up and down relative to support base 12.It of courses, it is straight instead of second that cylinder can also be used
Line motor 321.Motor is additionally provided in fixed plate 33, the shaft of motor is made to be arranged with eccentric wheel 34, the one of 34 long internal diameter of eccentric wheel
End is equipped with driving lever.Eccentric wheel 34 is driven to rotate by motor, the characteristics of using 34 unbalance stress of eccentric wheel, make 34 band of eccentric wheel
The one end for having driving lever generates acceleration during whereabouts, hurtles down, and driving lever is made to act on quantitative sampler 712 or test
Larger active force is generated during pipette tips 74, so that pipette tips centrum 311 and quantitative sampler 712 or test pipette tips 74 separate.
Sample adding device 31 further includes 314 motor 312 of syringe, syringe 314 and connecting tube 315,314 motor of syringe
312 link control modules, 314 motor 312 of syringe are equipped with telescopic rod 313, and telescopic rod 313 connects the piston handle of syringe 314,
The both ends of connecting tube 315 connect the nipple of syringe 314 and pipette tips centrum 311 respectively.314 motor 312 of syringe passes through flexible
Bar 313 drives the piston handle of syringe 314 to do the reciprocating motion of straight line, with the air of 314 inner cavity of Repeated Compression syringe through even
Take over 315 is delivered to pipette tips centrum 311, to generate positive pressure and negative pressure.
The foregoing is merely the preferred embodiment of the present invention, are not intended to limit the scope of the invention, every at this
The equivalent structure transformation made under the inventive concept of invention using description of the invention and accompanying drawing content or directly/utilization indirectly
It is included in the scope of patent protection of the present invention in other related technical areas.
Claims (10)
1. a kind of POCT specific proteins analysis system, which is characterized in that including：
Mounting base, the support base upwardly extended including erecting bed and from the erecting bed；
Operating mechanism, set on the support base, the operating mechanism includes sample adding device and power plant, and the sample adding device is set
Have a pipette tips centrum, the power plant connect the pipette tips centrum with drive the pipette tips centrum relative to the support base above and below
It is mobile；
Optical facilities, set on the erecting bed；
Loader mechanism, set on the erecting bed, the loader mechanism is equipped with card slot, and the card slot corresponds to the pipette tips centrum and sets
It puts；
Test card, the test card include test card ontology, diaphragm seal, test pipette tips and reaction cup, the test card ontology and set
There are installation opening and multiple groove bodies with opening, the groove body includes mounting groove, sample cup, reagent cup, and the diaphragm seal corresponds to
The opening of the sample cup and the reagent cup is set；The test pipette tips are set on the mounting groove；The reaction cup is set on institute
State installation opening；
Wherein, the test card is set on the card slot, and the loader mechanism drives the test card movement, to switch the sample
The position of cup, the reaction cup, the reagent cup or the test relatively described pipette tips centrum of pipette tips, the pipette tips centrum can be with
The test pipette tips assembling separates, and the reaction cup is set in the light path of the optical facilities.
2. POCT specific proteins analysis system as described in claim 1, which is characterized in that the opening of the sample cup is abnormity
Mouthful, the abnormity mouth includes a square orifice and an arc-shaped mouth.
3. POCT specific proteins analysis system as claimed in claim 2, which is characterized in that the diaphragm seal corresponds to the circular arc
Tear line is equipped at shape mouth.
4. POCT specific proteins analysis system as described in claim 1, which is characterized in that the installation opening is from the test card
The bottom surface of ontology extends outward to form limited wall.
5. POCT specific proteins analysis system as described in claim 1, which is characterized in that the test card ontology is equipped with light transmission
Hole, the loophole are used to coordinate with the sensor in POCT specific protein test systems.
6. POCT specific proteins analysis system as described in claim 1, which is characterized in that the outer surface of the diaphragm seal is equipped with
Identification code.
7. such as POCT specific proteins analysis system according to any one of claims 1 to 6, which is characterized in that further include control
Module, the control module connect the sample adding device, the power plant, the optical facilities and the loader mechanism.
8. POCT specific proteins analysis system as claimed in claim 7, which is characterized in that the loader mechanism is additionally provided with constant temperature
Device, the thermostat is set on the card slot, and the corresponding reaction cup setting, the thermostat connect the control mould
Block.
9. POCT specific proteins analysis system as claimed in claim 7, which is characterized in that it is straight that the loader mechanism includes first
Line motor, movable block and sliding slot, the first straight line motor connect the control module, and the first straight line motor is set on described
The one end of sliding slot far from the support base, the first straight line motor are equipped with pull rod, and the movable block is equipped with pilot hole, the drawing
Bar is arranged in the pilot hole, and the lower end of the movable block is equipped with convex block, and the both ends of the convex block are caught in the sliding slot, the card
Slot is set on the top of the movable block；The optical facilities are set on the other end of the sliding slot, and the corresponding reaction cup setting.
10. POCT specific proteins analysis system as claimed in claim 7, which is characterized in that the power plant includes second
Linear motor, sliding rail and fixed plate, the pipette tips centrum are set on the fixed plate, and the fixed plate is equipped with mounting hole, and described the
Two linear motors are equipped with push rod, and the push rod is arranged in the mounting hole, and the both ends of the fixed plate are equipped with sliding block, the sliding block
The embedded sliding rail, the second straight line motor connect the control module；
The sample adding device further includes injector motor, syringe and connecting tube, and the injector motor connects the control mould
Block, the injector motor are equipped with telescopic rod, and the telescopic rod connects the piston handle of the syringe, the both ends of the connecting tube
The connector of the syringe and the pipette tips centrum are connected respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810066635.XA CN108196081A (en) | 2018-01-23 | 2018-01-23 | A kind of POCT specific proteins analysis system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810066635.XA CN108196081A (en) | 2018-01-23 | 2018-01-23 | A kind of POCT specific proteins analysis system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108196081A true CN108196081A (en) | 2018-06-22 |
Family
ID=62590602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810066635.XA Pending CN108196081A (en) | 2018-01-23 | 2018-01-23 | A kind of POCT specific proteins analysis system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108196081A (en) |
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| CN109061212A (en) * | 2018-08-14 | 2018-12-21 | 三诺生物传感股份有限公司 | A kind of Biochemical Analyzer |
| CN109212233A (en) * | 2018-08-31 | 2019-01-15 | 深圳市国赛生物技术有限公司 | Kit components are used in glycosylated hemoglobin detection |
| CN109212235A (en) * | 2018-08-31 | 2019-01-15 | 深圳市国赛生物技术有限公司 | POCT glycolated hemoglobin analysis and POCT glycosylated hemoglobin analysis system |
| CN111257546A (en) * | 2020-04-07 | 2020-06-09 | 北京众驰伟业科技发展有限公司 | POCT detection system |
| CN112881719A (en) * | 2019-11-30 | 2021-06-01 | 深圳市帝迈生物技术有限公司 | Blood analyzer and detection device |
| CN113495085A (en) * | 2020-04-03 | 2021-10-12 | 深圳市帝迈生物技术有限公司 | POCT blood cell analyzer and liquid flow driving device of impedance detection cell |
| CN113495087A (en) * | 2020-04-03 | 2021-10-12 | 深圳市帝迈生物技术有限公司 | POCT blood cell analyzer and detection method thereof |
| CN115248320A (en) * | 2021-04-26 | 2022-10-28 | 深圳市帝迈生物技术有限公司 | POCT blood cell analyzer and method of using the same |
| CN115248325A (en) * | 2021-04-26 | 2022-10-28 | 深圳市帝迈生物技术有限公司 | POCT blood cell analyzer and method of using the same |
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| CN113495085B (en) * | 2020-04-03 | 2023-07-07 | 深圳市帝迈生物技术有限公司 | POCT blood cell analyzer and liquid flow driving device of impedance detection cell |
| CN113495087A (en) * | 2020-04-03 | 2021-10-12 | 深圳市帝迈生物技术有限公司 | POCT blood cell analyzer and detection method thereof |
| CN113495085A (en) * | 2020-04-03 | 2021-10-12 | 深圳市帝迈生物技术有限公司 | POCT blood cell analyzer and liquid flow driving device of impedance detection cell |
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| CN115248320A (en) * | 2021-04-26 | 2022-10-28 | 深圳市帝迈生物技术有限公司 | POCT blood cell analyzer and method of using the same |
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Application publication date: 20180622 |