CN108125815A

CN108125815A - A kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function and preparation method thereof

Info

Publication number: CN108125815A
Application number: CN201810107292.7A
Authority: CN
Inventors: 高勇; 高翔
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-02-02
Filing date: 2018-02-02
Publication date: 2018-06-08

Abstract

The present invention provides a kind of oral cavity helicobacter pylori resistant and the toothpaste of anti-caries stomach strengthening function, including toothpaste base-material, bismuth glycyrrhetate and functional form powder preparation；The bismuth glycyrrhetate and 0.5%~2% functional form powder preparation that mass concentration is 0.01%~5% are included in the toothpaste.Bismuth glycyrrhetate combines the gastric mucosal protection function of the anti-inflammatory of glycyrrhizic acid, analgesic, antiulcer, antioxidation and bismuth agent, has multiple antiulcer pharmacology, by improving Ulcer cicatrization quality comprehensively, realizes and cures ulcer, inhibits the effect of recurrence.The bismuth glycyrrhetate toothpaste of the present invention can effectively kill HP and cariogenic bacteria, while bismuth glycyrrhetate is plaque inhibition and detergent, so as to be conducive to inhibit and remove plaque, reduce the chance of bacterial adhesion and aggregation, reach treating both manifestation and root cause of disease；Toothpaste, which is made, can easily and effectively kill helicobacter pylori in oral cavity, so as to achieve the purpose that effectively to prevent alimentary infection and prevent the recurrence of gastritis, gastric and duodenal ulcer.

Description

Toothpaste and its preparation of a kind of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function Method

Technical field

The present invention relates to oral health care product field, in particular to a kind of oral cavity helicobacter pylori resistant and anti-caries Toothpaste of stomach strengthening function and preparation method thereof.

Background technology

The antrum rete malpighii and epithelium of nineteen eighty-three Australia scholar Warren and Marshall from Patients with Chronic Gastritis are thin Isolate helicobacter pylori (HP) in born of the same parents for the first time, Australia scholar Krajden in 1989 is from the tooth of Gastritis Buccodental HP is detected in bacterial plaque, and confirms that it is identical with HP in stomach from molecular level.WHO in 1994 is classified as HP infection the infection newly regarded Disease, domestic and foreign literature report HP is a kind of infectious disease orally propagated.Oral cavity HP is the important letter person warehousing of stomach HP infection.Through stream Row disease investigates our less than 12 years old teenager's HP infection rate and is up to 40%, and adult's HP infection rates are up to more than 60%, and saprodontia is by WHO The disease for endangering mankind's most serious greatly with tumour, angiocardiopathy arranged side by side three is classified as, teenager's caries incidence is high below China 12 years old Up to 80%.

Helicobacter pylori is Gram-negative, microaerophilic bacterium, survives in oral cavity, stomach and duodenal each region It is interior.Helicobacter pylori can cause children and adults' gastric cancer, peptic ulcer, gastritis, also with recurrent oral ulceration, periodontitis, Hypoferric anemia, Idiopathic Thrombocytopenic Purpura, growth retardation etc. are closely related.HP and cariogenic bacteria belong to micro- aerobic Bacterium, the two complement each other bacterium collection adherency on the plaque, the two have infection generality and concealment, the family of morbidity and Aggregation has high infection rate in the whole world and China.As gastral entrance, the presence influence of helicobacter pylori is deep and remote in oral cavity The effect of Helicobacter pylori eradication therapy, particularly late result.Helicobacter pylori in oral cavity is stored in plaque, oral cavity sticks Film, calculus dentalis, gingival pocket, saliva, lesion dental pulp in.Plaque has unique " biomembrane " structure, and dental pulp is in opposite envelope In the lacuna closed, helicobacter pylori can escape the killing of antibiotic, thus systemic administration it is acted on it is little.With the time Passage, helicobacter pylori is also higher and higher to the resistant rate of common antibiotics, and eradication rate is with regard to lower and lower.Therefore control its mouth- Oral instructions are broadcast to be even more important with mouth-stomach propagation.Pay attention to oral hygiene, prevent that illness finds its way in by the mouth, increasingly become prevention helicobacter pylori The important measures of infection, prevention stomach trouble and gastric cancer.Periodontal scaling is periodically done, removes bacterial plaque and dental calculus, eliminates oral pocket；Prevention and Saprodontia, dental pulp and periodontal disease are treated, pays attention to artificial tooth sanitation and hygiene, it is very necessary to remove helicobacter pylori and hide with staying.It is existing There is technology to be taken simultaneously using large dosage of Multiple Classes of Antibiotics and kill helicobacter pylori, increase the drug resistance of helicobacter pylori, easily Lead to disease recurrent exerbation, increase treatment difficulty.The shortcomings that prior art is：Taking large dosage of antibiotic makes helicobacter pylori It develops immunity to drugs.Antibiotic is effective means of the mankind to bacterial-infection resisting, and bacterium, which generates drug resistance, makes effective antibiosis originally The therapeutic effect of element is reduced or is lost, and increases the treatment difficulty and medical treatment cost of patient disease.

Toothpaste is the oral health care articles for use that must all use for each person every day, and the existing toothpaste with sterilizing function has Addition antibiotic, disinfectant, harmful bacteria, beneficial bacterium are all killed, destroy the micro- life in oral cavity by such as triclosan, chlorohexidene State environment increases the drug resistance of bacterium.Effectively inhibit harmful bacteria growth because the invention is a kind of, improve Oral health behaviours, promote The reparation and defence of oral mucosa have and kill helicobacter pylori and prevention, treatment dental caries function, easy to use, treatment cost Low, universal extensive anti-oral helicobacter pylori Chinese medicinal toothpaste, is very significant.

Invention content

The object of the present invention is to provide a kind of helicobacter pylori that can be killed in oral cavity and kill cariogenic in oral cavity Bacterium, with the anti-oral helicobacter pylori for preventing gastric cancer, gastric ulcer, enterelcosis and the preventing decayed tooth that cleans the teeth, oral cavity antiallergic deodouring effect Toothpaste and preparation method thereof.

To achieve the above object, the present invention provides following technical solution：

The toothpaste of a kind of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function, the toothpaste include toothpaste base-material, sweet Bismuth oxalate and functional form powder preparation；The bismuth glycyrrhetate for including a concentration of 0.01% weight to 5% weight in the toothpaste；It is preferred that , the bismuth glycyrrhetate for including a concentration of 0.5% weight to 3% weight in the toothpaste；Comprising a concentration of in the toothpaste The functional form powder preparation of 0.5% weight to 2% weight.

Preferably, the bismuth glycyrrhetate is contained bismuth glycyrrhetate, is pressed by licorice root ointment solution and bismuth nitrate solution precipitation gained, this product Dry product is calculated with bismuth (Bi), should be 11.0%~15.0%.

Further, the functional form powder preparation is made of the raw material of following weight parts：Edible rosin glycerides 2-4 parts, 10-15 parts of starch, 0.5-1 parts of carboxymethyl oligosaccharide malt sugar calcium；The preparation method of the functional form powder preparation is：It takes Edible rosin glycerides, are added in the absolute ethyl alcohol of 3-5 times of its weight, stir evenly；Starch is added to its weight 20-30 In deionized water again, stir evenly, mixed with the ethanol solution of above-mentioned edible rosin glycerides, keep the temperature and stir at 60-70 DEG C It mixes 3-4 hours, adds in carboxymethyl oligosaccharide malt sugar calcium, continue insulated and stirred 20-30 minutes, ethyl alcohol is distilled off, be sent into baking oven In, at 50-60 DEG C dry to water content within 2% to get.Following (its of the carboxymethyl oligosaccharide malt sugar calcium structural formula Middle n is 1-3)：

The preparation method of the carboxymethyl oligosaccharide malt sugar calcium is as follows：

(1) 10-15 parts of commercially available food grade maltodextrins are added in into 30-50 parts of calcium hydroxide saturated solutions, heated To 40-70 DEG C, then insulation reaction 2-4 hours filters to obtain the pure type oligomeric maltose of alkali carries；

(2) 10-20 parts of chloroacetic acid is added in the pure type oligomeric maltose of above-mentioned alkali carries, and maintains slurry temperature 40-70 DEG C, insulation reaction 6-12 hours obtains oligomeric maltose crude product after being cooled to room temperature；

(3) the complete chloroacetic acid of unreacted in step (2) is removed using vacuum distillation, then vacuum is done at 50-60 DEG C Dry 20-25 hours to get the carboxymethyl oligosaccharide malt sugar calcium.

Preferably, the toothpaste base-material include moisturizer, thickener, rubbing agent, foaming agent, essence, preservative and its Its additive；The thickener for sodium carboxymethylcellulose, hydroxyethyl cellulose, carbomer, xanthans, hydroxypropyl melon glue, One or more of mixing of carragheen；The moisturizer is one or more of sorbierite, glycerine, propylene glycol or polyethylene glycol Mixing；The rubbing agent is titanium dioxide, calcium carbonate, calcium phosphate dibasic dihydrate, calcium phosphate dibasic anhydrous, calcium pyrophosphate, titanium dioxide The mixing of one or more of silicon, aluminium hydroxide, hibbsite, calcite in powder, leuchtenbergite；The foaming agent is ten Sodium dialkyl sulfate, Cocoamidopropyl betaine or dodecanoyl sodium sarcosinate；The preservative is triclosan, Metagin The mixing of one or more of ester, ethylparaben, sodium benzoate；The essence for peppermint oil, lemon sesame oil, spearmint oil, Orange oil, mandarin oil, wintergreen, caryophyllus oil, cinnamon oil, fennel oil, menthol, borneol, citral, lauryl aldehyde, vanillic aldehyde, acetic acid The mixing of one or more of pentyl ester；Other additives are colorant, antioxidant, pH adjusting agent, taste-modifier, work( Imitate one or more of mixing of additive.

Further, the taste-modifier for xylitol, saccharin sodium, Aspartame, Sucralose, sodium chloride one Kind or several mixing；The colorant is chlorophyll, titanium dioxide, allured red pigment, bright blue pigment, lemon yellow pigment, pearl powder At least one of；The pH adjusting agent is sodium pyrophosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium carbonate, sodium bicarbonate, silicon One or more of mixing of sour sodium；The antioxidant is butylated hydroxy anisole (BHA), dibutyl hydroxy toluene (BHT), chlorine Change one or more of mixing of stannous, phytic acid, vitamin C, vitamin E；The functional additive is caries preventive agent, desensitizer, is resisted The agent of bacterium anti-inflammation hemostasia, one or more of mixing except stain brightening agent, calculus dentalis inhibitor, flavorants.

Preferably, in toothpaste prescription each component weight percent be 0.001%~10% bismuth glycyrrhetate, 0.5%~ 2% is functional form powder preparation, 10%~30% moisturizer, 1%~3% thickener, 40%~50% rubbing agent, 1% ~3% foaming agent, 0.5%~1.5% fragrance, 0.1%~0.5% preservative, other additives 0%~5%, surplus are Water.Alternatively, the bismuth glycyrrhetate that the weight percent of each component is 0.001%~10% in the toothpaste prescription, 35%~65% Moisturizer, 0.2%~1% thickener, 10%~25% rubbing agent, 1%~2% foaming agent, 0.5%~2% essence, 0.1%~0.5% preservative, other additives 0%~5%, surplus are water.Further, the preparation of the toothpaste Method, it is characterised in that include the following steps：

1) bismuth glycyrrhetate is crushed, crosses 150-200 mesh sieve；

2) above-mentioned bismuth glycyrrhetate powder, moisturizer and preservative are mixed and be put into deionized water made of stirring go from Sub- aqueous solution then adds in functional form powder preparation, thickener, rubbing agent, foaming agent, the mixing of other additives, is sent into three-in-one Vacuum Manufacturing medicine extract machine, high-speed stirred are milled 25~40 minutes, vacuum outgas, and then addition essence is stirred for milling 10~25 minutes and mix It is even, lotion of toothpaste is obtained, passes through sterile filling, packaging.

Preferably, in the toothpaste prescription each component weight percent be 0.001%~10% bismuth glycyrrhetate, 0.5%~2% is functional form powder preparation, 50%~80% moisturizer, 0.5%~1% thickener, 10%~30% is rubbed Liniment, 1%~2% foaming agent, 0.5%~1.5% essence, 0.1%~0.5% preservative, other additives 0%~5%, Water is 0%；The thickener is carbomer；The moisturizer is polyethylene glycol, the mixed liquor of glycerine, propylene glycol.Further , the preparation method of the toothpaste, it is characterised in that include the following steps：

1) bismuth glycyrrhetate is crushed, crosses 150-200 mesh sieve；

2) carbomer Carbopol is distributed in polyethylene glycol；Glycerine, propylene glycol moisturizer are added in into carbomer In Carbopol- polyethylene glycol 400 solution, liquid material is made in moderate-speed mixer 5-10 minutes；Then by above-mentioned bismuth glycyrrhetate powder, Functional form powder preparation, thickener, rubbing agent, foaming agent, the mixing of other additives, are sent into three-in-one vacuum Manufacturing medicine extract machine, high-speed stirring It mixes and mills 25~40 minutes, vacuum outgas then adds in essence and is stirred for 10~25 minutes mixings of milling, obtains lotion of toothpaste, Pass through sterile filling, packaging.

Compared with prior art, the beneficial effects of the invention are as follows：

1) glycyrrhizic acid has anti-inflammatory, antiulcer, antiviral, enhancing immune function, antiallergy, antibiooxidation, resistance state Reaction lamp pharmacological activity.Bismuth agent is clinically used gastric mucosa protective agent and medicine for anti Helicobacter pylori, can stimulate mucus Secretion increases gastric mucosal barrier effect.Bismuth glycyrrhetate combines the anti-inflammatory of glycyrrhizic acid, analgesic, antiulcer, antioxidation and bismuth The gastric mucosal protection function of agent has multiple antiulcer pharmacology, by improving Ulcer cicatrization quality comprehensively, realize cure ulcer, The effect of inhibiting recurrence.Bismuth glycyrrhetate was worn into the superfine powder of 200 mesh sieve by the present invention using colloid mill, increased drug Specific surface area makes it have larger contact surface with helicobacter pylori in the oral cavity, increases the sterilizing ability of drug, so as to Reduce the dosage of drug.Formulation of tooth-paste of the present invention is reasonable, simple for process, and lotion is uniform and stable, is easy to industrialization；It is made into External application toothpaste, allow one to it is effective, conveniently, enduringly kill oral cavity in helicobacter pylori, so as to reach effective prevention Alimentary infection and the purpose of recurrence for preventing gastritis, gastric and duodenal ulcer.

2) bismuth glycyrrhetate toothpaste of the invention is a kind of common oral amenities, and practical and convenient, a product multiple-effect can be effective Killing HP and cariogenic bacteria, while bismuth glycyrrhetate be plaque inhibit and detergent, so as to be conducive to inhibit and remove plaque, The chance of bacterial adhesion and aggregation is reduced, reaches treating both manifestation and root cause of disease, improves control effect.Clinical test shows that 500 are burst with stomach For the patient of ulcer with this product after continuous one month brush teeth, 1 year Follow-up observation, the negative conversion rate of oral cavity HP reaches more than 92%.

3) oligomeric maltose has aerogenesis pod of the suppression to toxin a variety of in body secretion as the nutriment in the toothpaste Film clostruidium has obvious inhibiting effect, and strengthen immunity reduces cholesterol and blood fat, promotes the elderly to calcareous suction It receives, is the effective nutritional supplement for being on garrison duty senile osteoporosis, can also sucrose be blocked to be decomposed by Streptococcus mutans, inhibit decayed tooth. The modified oligosaccharide malt sugar calcium that the present invention adds in is easier to absorb, and rich in free organic calcium ion, is conducive to the bone of human body Bone is developed；The present invention handles modified oligosaccharide malt sugar calcium using the starch cladding of esterification, effectively reduces nutrients The loss of matter, improves heat resisting temperature, extends the service life of finished toothpaste；Being carried out cladding processing simultaneously can rise To certain slow release effect, dissolved out when brushing teeth by the active principle therein that rubs, ensure that is brushed teeth every time Quality, the carboxymethyl oligosaccharide malt sugar calcium that adds in of the present invention, oligomeric maltose and calcium are effectively combined, relative to being individually added into Oligomeric maltose and calcium ion, being capable of the significantly more efficient supplementary result for promoting absorption of the human body to calcium ion, enhancing calcium ion.

Each component in toothpaste can be used but be not limited to following component：

1st, rubbing agent

Abrasive is can to wipe the soft dirt of dental surface with toothbrush collective effect in toothpaste, mitigates tooth stain, plaque, tooth The solid material ingredient of the foreign substances such as calculus.Abrasive is one of main component of toothpaste, powdery generally not soluble in water Solid, particle and quality are moderate, do not damage enamel and dentine.There can be natural magnesium as the common raw material of toothpaste abrasive Calcium, dicalcium phosphate dihydrate (dicalcium phosphate dihydrate), hydrated silica (silica), precipitated calcium carbonate, aluminium hydroxide, phosphoric acid Hydrogen calcium (calcium phosphate dibasic anhydrous) etc..There is common rubbing agent in toothpaste：

1) calcium carbonate (CaCO₃)：Calcium carbonate has two kinds of a heavy and lightweight, powdered whiting be by the limestone in rock and Calcite crushes, grinding, refined forms.Precipitated calcium carbonate is that calcium salt is dissolved in hydrochloric acid, then is passed through carbon dioxide, obtains carbonic acid Calcium precipitate.Precipitated calcium carbonate particle is thin, light specific gravity, available for toothpaste.

2) calcium monohydrogen phosphate (two water salt CaHPO of calcium monohydrogen phosphate₄·2H₂O and calcium monohydrogen phosphate anhydrous salt CaHPO₄)：Calcium monohydrogen phosphate It is divided into two kinds of two water salt of two molecular waters and anhydrous salt.Two water salt and other compositions have good Combination, but due to anhydrous salt Hardness is high, and frictional force is strong, therefore special except in the toothpaste of smoke puff, being mixed into 5%~10% anhydrous salt in two water salt.

3) calcium pyrophosphate (Ca₂P₂O₇)：Calcium pyrophosphate is will be obtained from calcium monohydrogen phosphate high-temperature process.It is got along well and contained due to it Fluorine compounds react, therefore can be used as the base-material of toothpaste with fluoride.

4) silicic acid hydrate (SiO₂·nH₂O)：Silicic acid hydrate is very thin white particles, available in transparent toothpaste.Separately Outside, since its specific volume is big, the incremental agent and tackifier that can make toothpaste use.

5) aluminium hydroxide (A1 (OH)₃)：The particle of aluminium hydroxide is thicker, but not damages enamel, and can increase toothpaste Brightness, and with the excellent power that cleans the teeth.

2nd, moisturizer

Moisturizer is that have keep lotion moisture, safeguard lotion mobility, reduce lotion freezing point in order to life in toothpaste The liquid charging stock ingredient that production processing and consumer use.Moisturizer is one of main component of toothpaste, generally polyalcohols object Matter can make lotion keep flexibility and mobility, be easy to pipeline and filling processing.Within the toothpaste shelf-life, it can keep Lotion is not dry, is not hardened, and does not influence to squeeze out from hose；The congealing point of lotion is reduced, prevents from losing conjunction when after frost melting There is separation of solid and liquid phenomenon in suitable consistency.Toothpaste moisturizer can be used as.There are glycerine, D-sorbite for the wetting agent in toothpaste Liquid (sorbierite), propylene glycol, polyethylene glycol etc..

3rd, thickener

Thickener is also known as adhesive, adhesive, is dispersion, swells in toothpaste liquid phase, forms stable colloid with the toothpaste that suspends Solid phase prevents the material composition that solid phase components are detached with liquid phase component in toothpaste.Thickener is one of main component of toothpaste, often There are 3 classes：Organic synthesis glue, such as cellulose gum (sodium carboxymethylcellulose), hydroxyethyl cellulose, carbomer (carbomer) Deng；Natural plant, such as xanthans (xanthan gum), hydroxypropyl melon glue, Chondrus crispus (carragheen)；Inorganic glue such as increases Thick type hydrated silica (silica), colloidality aluminum magnesium silicate etc..

4th, foaming agent

Foaming agent (surfactant) is that surface tension of liquid can be reduced in toothpaste, has good wetting, foaming, breast Change, the material composition of detergent action.Foaming agent is one of main component of toothpaste, is that a kind of safety is good, irritation is small, foam Abundant surfactant can make tartar, plaque etc. be emulsified and suspend, and oral cavity is removed by gargling, clear so as to reach The purpose of clean mouth chamber.It can having as toothpaste foaming agent：Laruyl alcohol sodium sulfovinate (lauryl sodium sulfate), Hamposyl L Sodium (dodecanoyl sodium sarcosinate) etc..Widely used at present is neutral detergent-sodium lauryl sulfonate.Energy fast foaming, both Can foam foam, and the dirt in rinsing the mouth.The surfactant purity requirement of toothpaste is very high, it is impossible to have peculiar smell, generally Dosage is 2%.

5th, preservative

Preservative refers to prevent toothpaste corruption, rotten material composition within the shelf-life.Toothpaste has a variety of organic principles, Production process is complicated, and the microorganism of may be infected is also diversified, therefore the selection of toothpaste preservative is needed by micro- Biological challenge experiment could be determined finally.Common toothpaste preservative mainly includes：Sodium benzoate, methyl hydroxybenzoate (Metagin Ester) etc..Toothpaste efficiency ingredient such as Chlorhexidine, Cetylpyridinium Chloride, triclosan, sodium fluoride, sodium monofluorophosphate etc. also have anti-corrosion effect.

6th, essence

Toothpaste essence is the fragrance with reference to natural plants, is formed using natural perfume material and synthetic perfume are formulated, is to have The mixture of natural flavour mountaineous and various odor types.Essence is one of main component of toothpaste, generally by meeting food hygiene requirement Tens of kinds of perfume materials are made, and assign toothpaste refrigerant, tasty and refreshing and pure and fresh feeling, can cover bad possessed by toothpaste various composition Smell and taste do not influence the stability of toothpaste.Can have as the raw material of toothpaste essence it is hundreds of, after rational allocation become tool There is the essence of certain feature odor type, as Mint Essence, spearmint essence, Chinese ilex essence, fruit essence, tea are felt well essence, medicine essence Deng.Toothpaste is mainly peppermint with fragrance, it is to confer to a kind of indispensable ingredient of toothpaste cooling feeling.It is thin that pennyroyal, which is divided into, The many kinds of substance such as lotus alcohol (menthol), peppermint oil, peppermint and the fragrance derived from by it.In addition, fruits also can be used Essence, such as citrus flavors.

7th, taste-modifier

Taste-modifier refers to cover the poor taste of the certain ingredients of toothpaste, assign the original of the pleasant taste of toothpaste Expect ingredient.Taste-modifier is presently mainly sweetener and savory agent.Taste-modifier is one of main component of toothpaste, is commonly used Have xylitol, saccharin sodium, aspartame (Aspartame), tri-chloro galactose type sugared (Sucralose) etc., common toothpaste savory agent There is food grade sodium chloride etc..To improve the mouthfeel of toothpaste, a small amount of saccharin is added in toothpaste.Glycerine due to being used as wetting agent etc. With sweet taste, therefore saccharin is generally 0.01%~0.1% with dosage.

8th, antioxidant

Antioxidant is that one kind leads to discoloration, spoiled phenomenon for preventing, inhibiting or postponing toothpaste due to oxidation, from And improve the material composition that toothpaste stablizes the flight of steps leading to a palace hall.Antioxidant needs to add according to special formulation, is applied in toothpaste Antioxidant have butylated hydroxy anisole (BHA), dibutyl hydroxy toluene (BHT), stannous chloride, phytic acid, ascorbic acid (dimension Raw element C), tocopherol (vitamin E) etc..

9th, colorant

Colorant refers to, for changing toothpaste appearance, create the material composition of specific visual experience and effect association, It uses when necessary.The kind of current existing application includes pigment, the color lake of pigment, colour particles etc..There are many toothpaste pigment, greatly Cause is divided into natural pigment (such as chlorophyll) and chemical synthesis pigment (such as titanium dioxide CI 77891, amaranth cI 16185, lemon yellow CI 19140, brilliant blue CI 42090 etc.), when use can be a kind of or a variety of blendings.The color lake of pigment is mainly used for Among striped toothpaste, make toothpaste that there is vivid color, it is desirable that meet relative national standards, do not influence the stability and tool of toothpaste There is excellent anti-diffusion.Colour particles, which are applied to toothpaste, can generate novel appearance and unique mouthfeel, it is desirable that meet state The related standard requirement of family, hardness must not generate abrasion to dentine.

10th, pH adjusting agent

PH adjusting agent is toothpaste stability contorting pH within the shelf-life, and it is existing to avoid generating when abrasive dissociates water outlet, inflatable The material composition of elephant.PH adjusting agent needs to add according to special formulation.Common toothpaste acid-base buffer agent has tetrasodium pyrophosphate (coke Sodium phosphate), sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium carbonate, sodium bicarbonate, sodium metasilicate etc..Toothpaste abrasive hydrogen phosphate dihydrate Calcium, aluminium hydroxide, silica have buffer effect of fuluic acid simultaneously.

11st, functional additive

Functional additive is to aid in the original for one or more toothpaste efficiencies that effect type toothpaste is realized in addition to basic function Expect ingredient, be the integral component of effect type toothpaste, basic demand is：It is safe to the human body, there is the mechanism of action of science and pass through The effect of authoritative institution, is verified.Currently used category includes：Caries preventive agent, antibacterial anti-inflammatory hemostat, is brightened except stain desensitizer Agent, calculus dentalis inhibitor, flavorants etc..

Caries preventive agent refers to make an addition in the dental products such as toothpaste, can help to prevent and treat the effective component of saprodontia, often Caries preventive agent is xylitol, Yolk immunoglobulin (the IgY factors), hydroxyapatite, calcium glycerophosphate, stannous fluoride, fluorine Change sodium, sodium monofluorophosphate etc..

Desensitizer mainly plays desensitization from the following aspects：1) physical method closing dentinal tubule outer end (is covered Lid acts on)；2) chemical substance reacts with dental tissue and forms precipitation, as salt or proteins precipitate block dentine Tubule (ponding and corrosiveness)；3) Cucumber penetrates into dental pulp through dentinal tubule, blocks or inhibits Intradental nerve quilt Excitation (inhibition and blocking effect)；4) induction secondary dentin forms (inducing action).But the single desensitization mechanism of application is treated The effect limitation of hypersensitive dentin, at present, it is intended to using the desensitizer of mixed type desensitization mechanism, to reach preferably desensitization effect Fruit.Desensitizer is generally divided into：1) inductivity desensitizer can induce secondary dentin and be formed.Such as calcium hydroxide desensitizing paste, Desensitization principle is to promote to form reparative dentin on the corresponding pulp cavity wall of sensitive part, meanwhile, calcium hydroxide is encountered two in air Carbonoxide generates tosca in dentinal tubule, to reduce the reactivity of tooth, plays the role of dual desensitization, and Also there is protective effect to the pulp vitality after standby tooth.2) corrosivity desensitizer can form protein precipitation.It is more representational Effect (Gluma desensitiser), main component are containing the glutaraldehyde and 36% 2- that mass fraction is 5% Hydroxyethyl meth acrylate.3) main component of blocking property desensitizer blocking property desensitizer is various salts, can form salt Precipitation.(1) GreenTM:GreenTM is current domestic most common blocking type desensitizer, wherein A agent phosphoric acid potassium, potassium carbonate, hydroxyl Benzene methyl and deionized water；B agent chloride containings calcium, strontium chloride, deionized water and sodium benzoate.(2) Oxalates desensitizer:Very much Researches show that：The desensitizer of the ingredient containing oxalic acid is applied to dentin surface, can dissolve the calcium ion of release dentin surface, and It is in connection to form insoluble calcium oxalate crystal, so as to achieve the purpose that close dentinal tubule.(3) fluoride:Fluorine The type of compound is more, such as sodium fluoride, ammonium fluoride silver and stannous fluoride.The effect of fluorine be with tissue of tooth formed calcirm-fluoride and Fluor-apatite to block dentinal tubule, reduces its permeability.Pass through fluorine containing the sodium fluoride glycerine paste that mass fraction is 75% Ion is penetrated into dental hard tissue, and the hydroxyl replaced in hydroxyapatite forms fluor-apatite, reduces the straight of dentinal tubule Diameter, to achieve the purpose that desensitization.4) spreadability desensitizer：Spreadability desensitizer is primarily referred to as, using resin as basic material, to send out The desensitizer of raw polymerisation.That clinically applies has：Single Bond、All-Bond、Seal-Protect、One-Step With Prompt L-Pop etc..5) inhibition desensitizer is blocked：Inhibition desensitizer is blocked to can inhibit nerve conduction.Potassium nitrate takes off Quick mechanism is that potassium ion can penetrate into nerve endings at nearly dental pulp in dentine, regulation and control sodium, potassium ion from dentinal tubule It exchanges, makes nerve ending cell membrane depolarization, so as to inhibit the generation of nerve impulse.Potassium nitrate can be made solution, gel and A variety of dosage forms such as paste treat hypersensitive dentin.

Such as：1) dioxygen is often added in toothpaste for the fungicide such as two guanidine radicals hexane of phenyl and cypress alcohol, copper to remove halitosis Chlorophyllin is to preventing halitosis from also having certain effect.2) prevention saprodontia can add in fluorine compounds, and residue in oral cavity can be inhibited to send out Ferment, and strengthen the enamel of dental surface；Consider from safety, Fluoride in Toothpaste content is provided below 1000 micrograms. In the crowd for drinking fluorine-containing natural water, the incidence of saprodontia is relatively low, but drinks the high water of fluorinated volume, and dental surface can be formed Gonorrhoea shape (plaque-like tooth), makes dentine become fragile instead.3) bioactivity glass, active ingredient form hydroxyl after reacting with saliva Base phosphorite crystal is deposited on dental surface, exposed dentinal tubule is closed, available for treating dental hypersensitiveness.Biology is living Property glass forms bottom end is a kind of biology with excellent bio-compatibility and osteogenic activity being made of a variety of inorganic ions Active material.Its Na₂O-CaO-SiO₂-P₂O₅System reacts with water and saliva and generates crystalloid hydroxyapatite layer (ore deposit Change), carbonated hydroxyapatite has high surface area, a large amount of biomolecule can be adsorbed, so as to promote extracellularly to respond.Biology is living Property glass is by generating crystallinity hydroxyapatite layer so that original inert simple glass becomes that specific life can be reached Object activity, therefore it is referred to as bioactivity glass.By development for many years, bio-vitric is applied to be obtained in oral care implement It rapidly develops, the appearance that NovaMin series is good for tooth product is known as the newest revolution of toothpaste industry in the U.S., domestic Camgna (Gai Meila) strontium-reinforced bioactive glass toothpaste also obtains patent property protection.Bio-vitric is good by its Good remineralization effect and antibacterial effect have good answer in terms of the diseases such as treatment dentine hypersensitivity, dental caries and gingivitis It is a kind of safe and effective bioactive materials that can safeguard oral health with prospect.

Specific embodiment

Detailed content and technology about the invention illustrate, are now described further with embodiment, it will be appreciated that , these embodiments are only for illustrating, and are not necessarily to be construed as the limitation of the invention implementation.Bismuth glycyrrhetate： It is the primary raw material of the present invention, selects pharmaceutical grade, purchased from Lanzhou Heshengtang Pharmaceutical Co., Ltd., this product contains bismuth glycyrrhetate, by dry Dry product are calculated with bismuth (Bi), should be 11.0%~15.0%.

Embodiment 1：The preparation of friction-type toothpaste

The prescription of 1 friction-type toothpaste of table

Preparation method：

1) bismuth glycyrrhetate is crushed, crosses 150-200 mesh sieve；

2) above-mentioned bismuth glycyrrhetate powder, functional form powder preparation, moisturizer and preservative are mixed and are put into deionized water Deionized water solution made of stirring then adds in thickener, rubbing agent, foaming agent, the mixing of other additives, is sent into three-in-one Vacuum Manufacturing medicine extract machine, high-speed stirred are milled 25~40 minutes, vacuum outgas, and then addition essence is stirred for milling 10~25 minutes and mix It is even, lotion of toothpaste is obtained, passes through sterile filling, packaging.

Wherein, the preparation method of functional form powder preparation：

Formula：2 parts by weight of edible rosin glycerides, 10 parts by weight of starch, 0.5 parts by weight of carboxymethyl oligosaccharide malt sugar calcium. Feeding rosin glycerides are added in the absolute ethyl alcohol of 3 times of its weight, stir evenly；Starch is added to its weight 20-30 In deionized water again, stir evenly, mixed with the ethanol solution of above-mentioned edible rosin glycerides, the insulated and stirred 3 at 60 DEG C Hour, carboxymethyl oligosaccharide malt sugar calcium is added in, continues insulated and stirred 20 minutes, ethyl alcohol is distilled off, is sent into baking oven, at 50 DEG C It is dry to water content within 2% to get spare.

The preparation method of carboxymethyl oligosaccharide malt sugar calcium：

1) 10 parts of commercially available food grade maltodextrins are added in into 30 parts of calcium hydroxide saturated solutions, are heated to 40 DEG C, Then insulation reaction 2-4 hours filters to obtain the pure type oligomeric maltose of alkali carries；

2) 10 parts of chloroacetic acid is added in the pure type oligomeric maltose of above-mentioned alkali carries, and slurry temperature is made to maintain 40 DEG C, insulation reaction 6 hours obtains oligomeric maltose crude product after being cooled to room temperature；

3) the complete chloroacetic acid of unreacted in step (2) is removed using vacuum distillation, be then dried in vacuo at 50-60 DEG C 20 hours to get the carboxymethyl oligosaccharide malt sugar calcium.

Embodiment 2：The preparation of friction-type toothpaste

The prescription of 2 friction-type toothpaste of table

The preparation method is the same as that of Example 1.

Embodiment 3：The preparation of friction-type toothpaste

The prescription of 3 friction-type toothpaste of table

The preparation method is the same as that of Example 1.

Embodiment 4：The preparation of friction-type toothpaste

The prescription of 4 friction-type toothpaste of table

The preparation method is the same as that of Example 1.

Embodiment 5：The preparation of friction-type toothpaste

The prescription of 5 friction-type toothpaste of table

The preparation method is the same as that of Example 1.

Embodiment 6：The preparation of gel type toothpaste

The prescription of 6 gel type toothpaste of table

Preparation method：

1) bismuth glycyrrhetate is crushed, crosses 150-200 mesh sieve；

Embodiment 7：The preparation of gel type toothpaste

The prescription of 7 gel type toothpaste of table

Preparation method is the same as embodiment 6.

Embodiment 8：The preparation of gel type toothpaste

The prescription of 8 gel type toothpaste of table

Preparation method is the same as embodiment 6.

Embodiment 9：The preparation of anhydrous type toothpaste

The prescription of 9 anhydrous type toothpaste of table

Preparation process：

1) bismuth glycyrrhetate is crushed, crosses 150-200 mesh sieve；

2) Carbopol is distributed in polyethylene glycol；Glycerine, propylene glycol moisturizer are added in into Carbopol- polyethylene glycol In 400 solution, liquid material is made in moderate-speed mixer 5-10 minutes；Then above-mentioned bismuth glycyrrhetate powder, functional form powder preparation are thickened Agent, rubbing agent, foaming agent, the mixing of other additives, are sent into three-in-one vacuum Manufacturing medicine extract machine, and high-speed stirred is milled 25~40 minutes, Vacuum outgas then adds in essence and is stirred for 10~25 minutes mixings of milling, obtain lotion of toothpaste, passes through sterile filling, packaging.

Embodiment 10：The preparation of anhydrous type toothpaste

The prescription of 10 anhydrous type toothpaste of table

Preparation process is the same as embodiment 9.

Embodiment 11：The preparation of anhydrous type toothpaste

The prescription of 11 anhydrous type toothpaste of table

Preparation process is the same as embodiment 9.

Reference examples 1：The preparation of the toothpaste of reference examples is carried out with reference to embodiment 2

The prescription of 12 reference examples toothpaste of table

Preparation method：

1) dipotassium glycyrrhizinate is crushed, crosses 150-200 mesh sieve；

2) above-mentioned dipotassium glycyrrhizinate powder, moisturizer and preservative are mixed and are put into deionized water and gone made of stirring Deionized water solution then adds in thickener, rubbing agent, foaming agent, the mixing of other additives, is sent into three-in-one vacuum Manufacturing medicine extract machine, High-speed stirred is milled 25~40 minutes, vacuum outgas, is then added in essence and is stirred for 10~25 minutes mixings of milling, obtains toothpaste Lotion passes through sterile filling, packaging.

Reference examples 2：The preparation of the toothpaste of reference examples is carried out with reference to number of patent application 200510133661.2

It is formulated (quality %)：Glycyrrhizic acid 1, Phytic acid bismuth 0.2；Dibastic sodium phosphate 40；Sorbierite 7.0；Lauryl sodium sulfate 2.5；Dodecyl diethanol amine 0.5；Carboxymethyl cellulose 1.0；Sodium monofluorophosphate 0.3；Saccharin sodium；Essence 1.0；Distilled water adds To 100.

Test example 1：Fungistatic effect is tested

This effect example has investigated toothpaste made of embodiment 1-8 to saprodontia, the inhibition of plaque, carries out pylorus Pylori turns sugar chain coccus (Streptococcus mutans) and micrococcus scarlatinae (Streptococcus Sobrinus) carry out inhibiting the detection of effect.

The result shows that toothpaste made of embodiment 1-11 is 99.99% to the inhibiting rate of helicobacter pylori, to oral cavity dental caries Turn streptococcic inhibiting rate of sugar of tooth is 99.99% and the inhibiting rate of micrococcus scarlatinae is 99.99%.Above-mentioned two kinds of bacteriums A variety of diseases such as plaque, periodontitis, parulis, sphagitis, tonsillitis can be caused, it is also possible to cause streptococcus pneumonia sense Dye leads to pneumonia and other serious diseases, it is also possible to cause and be infected with malignant tumour (especially alimentary canal) patient bargen's streptococcus Lead to bacteremia, endocarditis and through organ-tissue antigenic similarity, acute rheumatic fever and acute kidney ball ephritis etc. can be caused A variety of diseases.Result of the test confirms that toothpaste made of embodiment has good inhibition saprodontia, plaque, periodontitis and gum purulence The effect of swollen.And toothpaste made of reference examples 2 is 89.51% to the inhibiting rate of helicobacter pylori, turns sugar to dental decayed tooth Streptococcic inhibiting rate is 90.45% and the inhibiting rate of micrococcus scarlatinae is 90.38%.

Test example 2：Calcium-ion absorption performance test

The carboxymethyl oligosaccharide malt sugar calcium of the present invention is directly mixed to get relative to common oligomeric maltose and calcium ion Product is compared, Calcium-ion absorption performance test：

The preparation method of carboxymethyl oligosaccharide malt sugar calcium：

2) 10- parts of chloroacetic acid is added in the pure type oligomeric maltose of above-mentioned alkali carries, and slurry temperature is made to maintain 40 DEG C, insulation reaction 6 hours obtains oligomeric maltose crude product after being cooled to room temperature；

3) the complete chloroacetic acid of unreacted in step (2) is removed using vacuum distillation, be then dried in vacuo at 50-60 DEG C 20 hours to get the carboxymethyl oligosaccharide malt sugar calcium；

The preparation method of product that common oligomeric maltose is directly mixed to get with calcium ion is：

10 parts of oligomeric maltoses, 45 parts of edible calcium chloride are mixed, stirred evenly；

Volunteer 100, men and women is fifty-fifty, and the age, points 2 groups, every group of 50 people, men and women was fifty-fifty all for 20 years old；

Before experiment starts, it is 10.78mmol/l to measure calcium ion mean concentration in a group volunteers seras, measures b groups aspiration Person's Determination of Calcium in Serum ion mean concentration is 13.05mmol/l；

Everyone carboxymethyl oligosaccharide malt sugar calcium 20g, b group volunteer for taking the present invention of a groups volunteer takes common oligomeric The product 20g that maltose is directly mixed to get with calcium ion；

After 6 hours, it is 314.11mmol/l to measure calcium ion mean concentration in a group volunteers seras, measures b group volunteers Determination of Calcium in Serum ion mean concentration is 207.3mmol/l；

As can be seen that the carboxymethyl oligosaccharide malt sugar calcium of the present invention, direct relative to common oligomeric maltose and calcium ion The product being mixed to get is compared, and is had and is preferably promoted Calcium-ion absorption effect.

Functional form powder preparation in the embodiment of the present invention 1 is substituted for the common oligomeric maltose and calcium ion of similary quality Two kinds of toothpaste are made in the product being directly mixed to get, and are 45 years old to the age, the good women population of health status is tested： As a result it is：

The crowd that the daily toothpaste using the embodiment of the present invention 1 is brushed teeth, after 1 year, tooth bone mineral Content reduced rate is 0.0058g/cm；

And the crowd of product toothpaste being directly mixed to get with calcium ion containing common oligomeric maltose is used, by 1 Nian Hou, tooth bone mineral content reduced rate are 0.0101g/cm；

Carboxymethyl oligosaccharide malt sugar calcium of the present invention is can be seen that, it is directly mixed relative to common oligomeric maltose and calcium ion It closes obtained product to compare, has and preferably promote Calcium-ion absorption effect.

Test example 3：Stability test

According to QB 8372-2008 standards, the obtained products of embodiment 1-11 are tested, indices are as follows：

13 stability study of the embodiment of the present invention of table

As can be seen from the above table, toothpaste of the invention, every organoleptic indicator, physical and chemical index, sanitary index accord with completely QB 8372-2008 standards are closed, while the sample of embodiment 1,5,7 is also placed in the environment of -10 DEG C, 48 DEG C and respectively stores by we 48 hours, restore after taking-up to room temperature, find the uniform foreign of lotion, it is seen that its resistance to jelly, heat resistance are also very good.

Toothpaste made of the present embodiment can still remain round when uniform color and luster and the paste via tube body extrusion is presented The lotion of column type strip, even if after 45 minutes carry out centrifugal test with 3500 revs/min of rotating speed, which water outlet is not presented Phenomenon；And after 45 DEG C of constant temperature 60 days or 5 DEG C of constant temperature caloric test of 60 days, it can all maintain cylindrical type strip lotion, it was demonstrated that Toothpaste provided by the invention has splendid stability.

Test example 4：Clinical trial

1. general information

Randomly select the Patients with RAU 420 for meeting diagnostic criteria, man 198, female 222；Age 19~64 Year, the recurrence 1 time 113 of aphtha 1 month, recurrence in 2 months 1 time 106, recur within 1 week 1 time 84, the Non-intermittent phase 117；It is light-duty Recurrent aphthous ulcer 193；Heavy recurrent aphthous ulcer (periglandular aphtha) 116, bleb sample aphtha (mouth tip aphtha) 111, with Machine is divided into treatment group 120, control group 1,2 and 3 each 100, and the differences such as three groups of patient ages, sex composition ratio, course of disease are without aobvious Write meaning.Reference《Oral mucosal disease》In diagnostic criteria about canker sore and indexing.

2. therapy

1 conventional vitamin B of control group₂, vitamin C three times/d, and with water melon frost spray in 6 times/d on ulcer surface, Average 7d is 1 course for the treatment of.

Control group 2 applies affected part in the toothpaste that morbidity takes reference examples 1 of the present invention to prepare on the 2nd day, early, middle and late each 1 time.

Control group 3 applies affected part in the toothpaste that morbidity takes reference examples 2 of the present invention to prepare on the 2nd day, early, middle and late each 1 time.

Treatment group applies affected part in the toothpaste that morbidity takes the embodiment of the present invention 2 to prepare on the 2nd day, early, middle and late each 1 time.

3. the standard of curative effect evaluation

Using Chinese Medical Association's mucous membrane disease special interest group 2001 by recurrent aphthous ulcer (RAU) the effect of the tentative mark of evaluation Quasi- IN stagings.Effective is total backlash time lengthening, and total ulcer number is reduced；It is effectively total backlash time lengthening, total ulcer number Mesh does not have significant change or total ulcer number to reduce, and the total backlash time is without significant change；When being total ulcer number and total backlash in vain Between without significant change.Total effective rate=(effective number of cases+effective number of cases)/total number of cases × 100%.

It is counted according to Chi-square Test method.

4. result

Two groups of curative effects compare, and have significant difference (P ＜ 0.01) (table 14)

14 two groups of curative effects of table compare

Group	Recovery from illness/example	Effective/example	Effectively/example	In vain/example	Total effective rate/%
						Treatment group	57	41	20	2	98.3
Control group 1	11	37	25	27	66.3
						Control group 2	41	33	16	10	90.0
Control group 3	40	32	15	13	87.0

The above is only the preferred embodiment of the invention, it is impossible to the implementation model of the invention is limited with this It encloses, i.e., every simple equivalent changes and modifications made according to the invention claim and innovation and creation description, All still fall within the range that the invention is covered.

Claims

1. a kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function, it is characterised in that：The toothpaste includes tooth Cream base material, bismuth glycyrrhetate and functional form powder preparation；The Radix Glycyrrhizae for including a concentration of 0.01% weight to 5% weight in the toothpaste Sour bismuth；Preferably, the bismuth glycyrrhetate for including a concentration of 0.5% weight to 3% weight in the toothpaste；It is included in the toothpaste A concentration of 0.5% weight to 2% weight functional form powder preparation.

2. the toothpaste of oral cavity helicobacter pylori resistant according to claim 1 and anti-caries stomach strengthening function, it is characterised in that： The bismuth glycyrrhetate is by licorice root ointment solution and bismuth nitrate solution precipitation gained, and this product contains bismuth glycyrrhetate, by dry product with bismuth (Bi) It calculates, should be 11.0%~15.0%.

3. the toothpaste of oral cavity helicobacter pylori resistant according to claim 1 and anti-caries stomach strengthening function, which is characterized in that What the functional form powder preparation was made of the raw material of following weight parts：Edible 2-4 parts of rosin glycerides, 10-15 parts of starch, 0.5-1 parts of carboxymethyl oligosaccharide malt sugar calcium；

The preparation method of the functional form powder preparation is：Feeding rosin glycerides are added to the anhydrous second of 3-5 times of its weight In alcohol, stir evenly；Starch is added in the deionized water of 20-30 times of its weight, stirred evenly, it is sweet with above-mentioned edible rosin The ethanol solution mixing of grease, insulated and stirred 3-4 hours at 60-70 DEG C, adds in carboxymethyl oligosaccharide malt sugar calcium, continues to keep the temperature Stirring 20-30 minute, is distilled off ethyl alcohol, is sent into baking oven, at 50-60 DEG C drying to water content within 2% to get；

The carboxymethyl oligosaccharide malt sugar calcium structural formula is following (wherein n is 1-3)：

(1) 10-15 parts of commercially available food grade maltodextrins are added in into 30-50 parts of calcium hydroxide saturated solutions, is heated to 40- 70 DEG C, then insulation reaction 2-4 hours filters to obtain the pure type oligomeric maltose of alkali carries；

(2) 10-20 parts of chloroacetic acid is added in the pure type oligomeric maltose of above-mentioned alkali carries, and slurry temperature is made to maintain 40- 70 DEG C, insulation reaction 6-12 hours obtains oligomeric maltose crude product after being cooled to room temperature；

(3) the complete chloroacetic acid of unreacted in step (2) is removed using vacuum distillation, is then dried in vacuo 20- at 50-60 DEG C 25 hours to get the carboxymethyl oligosaccharide malt sugar calcium.

4. toothpaste according to claim 1, it is characterised in that：The toothpaste base-material includes moisturizer, thickener, friction Agent, foaming agent, essence, preservative and other additives；The thickener is sodium carboxymethylcellulose, hydroxyethyl cellulose, card One or more of mixing of wave nurse, xanthans, hydroxypropyl melon glue, carragheen；The moisturizer is sorbierite, glycerine, the third two The mixing of one or more of alcohol or polyethylene glycol；The rubbing agent is titanium dioxide, calcium carbonate, calcium phosphate dibasic dihydrate, nothing One in water calcium monohydrogen phosphate, calcium pyrophosphate, silica, aluminium hydroxide, hibbsite, calcite in powder, leuchtenbergite Kind or several mixing；The foaming agent is lauryl sodium sulfate, Cocoamidopropyl betaine or dodecanoyl sodium sarcosinate； The preservative is the mixing of one or more of triclosan, methyl hydroxybenzoate, ethylparaben, sodium benzoate；The essence For peppermint oil, lemon sesame oil, spearmint oil, orange oil, mandarin oil, wintergreen, caryophyllus oil, cinnamon oil, fennel oil, menthol, dragon The mixing of one or more of brain, citral, lauryl aldehyde, vanillic aldehyde, pentyl acetate；Other additives are colorant, resist One or more of mixing of oxidant, pH adjusting agent, taste-modifier, functional additive.

5. toothpaste according to claim 1, it is characterised in that：The taste-modifier is xylitol, saccharin sodium, A Siba One or more of mixing of sweet tea, Sucralose, sodium chloride；The colorant is chlorophyll, titanium dioxide, allured red pigment, bright orchid At least one of pigment, lemon yellow pigment, pearl powder；The pH adjusting agent is sodium pyrophosphate, sodium dihydrogen phosphate, phosphoric acid hydrogen two One or more of mixing of sodium, sodium carbonate, sodium bicarbonate, sodium metasilicate；The antioxidant for butylated hydroxy anisole (BHA), One or more of mixing of dibutyl hydroxy toluene (BHT), stannous chloride, phytic acid, vitamin C, vitamin E；Described effect adds Add agent for caries preventive agent, desensitizer, antibacterial anti-inflammatory hemostat, except stain brightening agent, calculus dentalis inhibitor, flavorants one kind or Several mixing.

6. toothpaste according to claim 1, it is characterised in that：The weight percent of each component is in the toothpaste prescription 0.001%~10% bismuth glycyrrhetate, 0.5%~2% are functional form powder preparation, 10%~30% moisturizer, 1%~2% Thickener, 40%~60% rubbing agent, 1%~3% foaming agent, 0.5%~1.5% fragrance, 0.1%~0.5% it is anti- Rotten agent, other additives 0%~5%, surplus are water.

7. toothpaste according to claim 1, it is characterised in that：The weight percent of each component is in the toothpaste prescription 0.001%~10% bismuth glycyrrhetate, 0.5%~2% for functional form powder preparation, 35%~65% moisturizer, 0.2%~ 1% thickener, 10%~25% rubbing agent, 1%~2% foaming agent, 0.5%~2% essence, 0.1%~0.5% it is anti- Rotten agent, other additives 0%~5%, surplus are water.

8. toothpaste according to claim 1, it is characterised in that：The weight percent of each component is in the toothpaste prescription 0.001%~10% bismuth glycyrrhetate, 0.5%~2% for functional form powder preparation, 40%~80% moisturizer, 0.5%~ 1% thickener, 15%~50% rubbing agent, 1%~2% foaming agent, 0.5%~1.5% essence, 0.1%~0.5% Preservative, other additives 0%~5%, water 0%；The thickener is carbomer；The moisturizer is polyethylene glycol, sweet The mixed liquor of oil, propylene glycol.

9. the preparation method of a kind of toothpaste as described in claim 6-7 is any, it is characterised in that include the following steps：

1) bismuth glycyrrhetate is crushed, crosses 150-200 mesh sieve；

2) above-mentioned bismuth glycyrrhetate powder, moisturizer and preservative are mixed and is put into deionized water deionized water made of stirring Solution then adds in functional form powder preparation, thickener, rubbing agent, foaming agent, the mixing of other additives, is sent into three-in-one vacuum Manufacturing medicine extract machine, high-speed stirred are milled 25~40 minutes, vacuum outgas, are then added in essence and are stirred for 10~25 minutes mixings of milling, Lotion of toothpaste is obtained, passes through sterile filling, packaging.

10. a kind of preparation method of toothpaste as claimed in claim 8, it is characterised in that include the following steps：

1) bismuth glycyrrhetate is crushed, crosses 150-200 mesh sieve；

2) carbomer Carbopol is distributed in polyethylene glycol；Glycerine, propylene glycol moisturizer are added in into carbomer Carbopol- In polyglycol solution, liquid material is made in moderate-speed mixer 5-10 minutes；Then by above-mentioned bismuth glycyrrhetate powder, functional form powder preparation, Thickener, rubbing agent, foaming agent, the mixing of other additives, are sent into three-in-one vacuum Manufacturing medicine extract machine, high-speed stirred is milled 25~40 points Clock, vacuum outgas then add in essence and are stirred for 10~25 minutes mixings of milling, obtain lotion of toothpaste, pass through sterile filling, packet Dress.