CN108114311A - 碘仿明胶海绵的制备方法 - Google Patents
碘仿明胶海绵的制备方法 Download PDFInfo
- Publication number
- CN108114311A CN108114311A CN201711380950.1A CN201711380950A CN108114311A CN 108114311 A CN108114311 A CN 108114311A CN 201711380950 A CN201711380950 A CN 201711380950A CN 108114311 A CN108114311 A CN 108114311A
- Authority
- CN
- China
- Prior art keywords
- gelatin
- iodoform
- preparation
- gelatin sponge
- carbon nano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OKJPEAGHQZHRQV-UHFFFAOYSA-N iodoform Chemical compound IC(I)I OKJPEAGHQZHRQV-UHFFFAOYSA-N 0.000 title claims abstract description 74
- 108010010803 Gelatin Proteins 0.000 title claims abstract description 60
- 229920000159 gelatin Polymers 0.000 title claims abstract description 60
- 239000008273 gelatin Substances 0.000 title claims abstract description 60
- 235000019322 gelatine Nutrition 0.000 title claims abstract description 60
- 235000011852 gelatine desserts Nutrition 0.000 title claims abstract description 60
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims abstract description 22
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 16
- 239000002086 nanomaterial Substances 0.000 claims abstract description 16
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 8
- 229910001629 magnesium chloride Inorganic materials 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims abstract 2
- 241000251468 Actinopterygii Species 0.000 claims description 5
- 229910021389 graphene Inorganic materials 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 230000000025 haemostatic effect Effects 0.000 abstract description 8
- 239000008367 deionised water Substances 0.000 abstract description 5
- 229910021641 deionized water Inorganic materials 0.000 abstract description 5
- 208000027418 Wounds and injury Diseases 0.000 abstract description 4
- 230000023597 hemostasis Effects 0.000 abstract description 4
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 229940030225 antihemorrhagics Drugs 0.000 abstract description 3
- 230000002209 hydrophobic effect Effects 0.000 abstract description 3
- 208000014674 injury Diseases 0.000 abstract description 3
- 230000001681 protective effect Effects 0.000 abstract description 3
- 230000008733 trauma Effects 0.000 abstract description 3
- 239000007787 solid Substances 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 206010001889 Alveolitis Diseases 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/104—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/202—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with halogen atoms, e.g. triclosan, povidone-iodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
本发明涉及医疗用品技术领域，尤其是一种碘仿明胶海绵的制备方法；所述方法包括以下步骤：将明胶与去离子水按固液比30‑75kg/m3混合，在75℃条件下搅拌混合均匀得到明胶溶液，将明胶溶液与纳米炭材料、碘仿、甲醛溶液、氯化镁按质量比100:1‑5:10‑20:0.2‑3混合，得到混合液，然后在‑30～‑20℃条件下冷冻8‑12h，最后在冷冻干燥机中干燥24‑48h得到碘仿明胶海绵；本发明外伤止血用明胶海绵制备方法简单，绿色环保，所选原理造价低廉，所制备的碘仿明胶海绵孔径分布均匀、疏水亲油性好，强度高，而且对外伤止血效果十分显著，能很好的杀菌止血。
Description
技术领域
本发明涉及医疗用品技术领域，尤其是一种碘仿明胶海绵的制备方法。
背景技术
现有技术中，由三种主要的口腔外科手术用的消毒用品：1、明胶海绵在口腔颌面外科拔牙术及颌骨手术填塞止血应用很广泛，明胶止血效果佳，易于吸收，但是没有抗感染功效；2、碘仿纱条可用于拔牙窝创口止血剂干槽症治疗，碘仿纱条使用后需要取出来，使用不方便。
发明内容
本发明的目的是：提供一种使用方便、止血效果好的碘仿明胶海绵的制备方法。
为解决上述技术问题，本发明采用的技术方案如下：
一种碘仿明胶海绵的制备方法，所述方法包括以下步骤：将明胶与去离子水按固液比30-75kg/m3混合，在75℃条件下搅拌混合均匀得到明胶溶液，将明胶溶液与纳米炭材料、碘仿、甲醛溶液、氯化镁按质量比100:1-5:10-20:0.2-3混合，得到混合液，然后在-30～-20℃条件下冷冻8-12h，最后在冷冻干燥机中干燥24-48h得到碘仿明胶海绵。
优选的，所述甲醛溶液的质量分数为30％。
优选的，所述明胶选用水产鱼皮明胶或家养动物明胶中的一种。
优选的，所述纳米炭材料选用石墨烯，纳米炭材料的粒径大小为100-200nm。
优选的，所述方法还包括对碘仿明胶海绵进行切割、密封包装及紫外线灭菌操作。
采用本发明的技术方案的有益效果是：
本发明外伤止血用明胶海绵制备方法简单，绿色环保，所选原理造价低廉，所制备的碘仿明胶海绵孔径分布均匀、疏水亲油性好，强度高，而且对外伤止血效果十分显著，能很好的杀菌止血。
本发明中的碘仿明胶海绵可以被人体自动吸收，不用二次手术重新取出，使用更安全。
具体实施方式
下面结合具体实施方式对本发明作进一步说明。
实施例1
一种碘仿明胶海绵的制备方法，所述方法包括以下步骤：将明胶与去离子水按固液比30kg/m3混合，在75℃条件下搅拌混合均匀得到明胶溶液，将明胶溶液与纳米炭材料、碘仿、甲醛溶液、氯化镁按质量比100:1:10:0.2混合，得到混合液，然后在-30℃条件下冷冻8h，最后在冷冻干燥机中干燥24h得到碘仿明胶海绵，甲醛溶液的质量分数为30％，本实施例中明胶选用水产鱼皮明胶，纳米炭材料选用石墨烯，纳米炭材料的粒径大小为100nm，还包括对碘仿明胶海绵进行切割、密封包装及紫外线灭菌操作。
实施例2
一种碘仿明胶海绵的制备方法，所述方法包括以下步骤：将明胶与去离子水按固液比60kg/m3混合，在75℃条件下搅拌混合均匀得到明胶溶液，将明胶溶液与纳米炭材料、碘仿、甲醛溶液、氯化镁按质量比100:3:15:1.8混合，得到混合液，然后在-30℃条件下冷冻10h，最后在冷冻干燥机中干燥36h得到碘仿明胶海绵，甲醛溶液的质量分数为30％，本实施例中明胶选用水产鱼皮明胶，纳米炭材料选用石墨烯，纳米炭材料的粒径大小为200nm，还包括对碘仿明胶海绵进行切割、密封包装及紫外线灭菌操作。
实施例3
一种碘仿明胶海绵的制备方法，所述方法包括以下步骤：将明胶与去离子水按固液比75kg/m3混合，在75℃条件下搅拌混合均匀得到明胶溶液，将明胶溶液与纳米炭材料、碘仿、甲醛溶液、氯化镁按质量比100:5:20:3混合，得到混合液，然后在-20℃条件下冷冻12h，最后在冷冻干燥机中干燥48h得到碘仿明胶海绵，甲醛溶液的质量分数为30％，本实施例中明胶选用水产鱼皮明胶，纳米炭材料选用石墨烯，纳米炭材料的粒径大小为200nm，还包括对碘仿明胶海绵进行切割、密封包装及紫外线灭菌操作。
本发明外伤止血用明胶海绵制备方法简单，绿色环保，所选原理造价低廉，所制备的碘仿明胶海绵孔径分布均匀、疏水亲油性好，强度高，而且对外伤止血效果十分显著，能很好的杀菌止血。
本发明中的碘仿明胶海绵可以被人体自动吸收，不用二次手术重新取出，使用更安全。
以上述依据本发明的理想实施例为启示，通过上述的说明内容，相关工作人员完全可以在不偏离本项发明技术思想的范围内，进行多样的变更以及修改。本项发明的技术性范围并不局限于说明书上的内容，必须要根据权利要求范围来确定其技术性范围。
Claims (5)
1.一种碘仿明胶海绵的制备方法，其特征在于，所述方法包括以下步骤：将明胶与去离子水按固液比30-75kg/m3混合，在75℃条件下搅拌混合均匀得到明胶溶液，将明胶溶液与纳米炭材料、碘仿、甲醛溶液、氯化镁按质量比100:1-5:10-20:0.2-3混合，得到混合液，然后在-30～-20℃条件下冷冻8-12h，最后在冷冻干燥机中干燥24-48h得到碘仿明胶海绵。
2.根据权利要求1所述的碘仿明胶海绵的制备方法，其特征在于：所述甲醛溶液的质量分数为30％。
3.根据权利要求1所述的碘仿明胶海绵的制备方法，其特征在于：所述明胶选用水产鱼皮明胶或家养动物明胶中的一种。
4.根据权利要求1所述的碘仿明胶海绵的制备方法，其特征在于：所述纳米炭材料选用石墨烯，纳米炭材料的粒径大小为100-200nm。
5.根据权利要求1所述的碘仿明胶海绵的制备方法，其特征在于：所述方法还包括对碘仿明胶海绵进行切割、密封包装及紫外线灭菌操作。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711380950.1A CN108114311A (zh) | 2017-12-20 | 2017-12-20 | 碘仿明胶海绵的制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711380950.1A CN108114311A (zh) | 2017-12-20 | 2017-12-20 | 碘仿明胶海绵的制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108114311A true CN108114311A (zh) | 2018-06-05 |
Family
ID=62229650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711380950.1A Pending CN108114311A (zh) | 2017-12-20 | 2017-12-20 | 碘仿明胶海绵的制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108114311A (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112190599A (zh) * | 2020-10-09 | 2021-01-08 | 徐州医科大学 | 一种制备治疗干槽症的复合海绵的方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020153632A1 (en) * | 2001-01-25 | 2002-10-24 | Alfred Schaufler | Method of preparing a collagen sponge, a device for extracting a part of a collagen foam, and an elongated collagen sponge |
| CN101854960A (zh) * | 2006-12-15 | 2010-10-06 | 生命连结有限公司 | 明胶-转谷氨酰胺酶止血敷料和密封材料 |
| CN103908351A (zh) * | 2012-12-31 | 2014-07-09 | 江苏省健尔康医用敷料有限公司 | 一种含碘广谱杀菌医用手术用巾 |
| CN103937023A (zh) * | 2014-04-04 | 2014-07-23 | 青岛大学 | 一种轻体海藻酸钙基海绵体功能材料的制备方法 |
| CN106983904A (zh) * | 2017-04-10 | 2017-07-28 | 惠州市口腔医院有限公司 | 一种碘仿明胶海绵的制备方法 |
| CN107349912A (zh) * | 2017-08-10 | 2017-11-17 | 武汉科技大学 | 一种碳复合明胶海绵及其制备方法 |
-
2017
- 2017-12-20 CN CN201711380950.1A patent/CN108114311A/zh active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020153632A1 (en) * | 2001-01-25 | 2002-10-24 | Alfred Schaufler | Method of preparing a collagen sponge, a device for extracting a part of a collagen foam, and an elongated collagen sponge |
| CN101854960A (zh) * | 2006-12-15 | 2010-10-06 | 生命连结有限公司 | 明胶-转谷氨酰胺酶止血敷料和密封材料 |
| CN103908351A (zh) * | 2012-12-31 | 2014-07-09 | 江苏省健尔康医用敷料有限公司 | 一种含碘广谱杀菌医用手术用巾 |
| CN103937023A (zh) * | 2014-04-04 | 2014-07-23 | 青岛大学 | 一种轻体海藻酸钙基海绵体功能材料的制备方法 |
| CN106983904A (zh) * | 2017-04-10 | 2017-07-28 | 惠州市口腔医院有限公司 | 一种碘仿明胶海绵的制备方法 |
| CN107349912A (zh) * | 2017-08-10 | 2017-11-17 | 武汉科技大学 | 一种碳复合明胶海绵及其制备方法 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112190599A (zh) * | 2020-10-09 | 2021-01-08 | 徐州医科大学 | 一种制备治疗干槽症的复合海绵的方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL275206B2 (en) | Dry implant composition and aqueous injection formulation of the implant | |
| CN101879324A (zh) | 壳聚糖复合医用敷料的制备方法 | |
| CN102274493B (zh) | 一种可用于微创美容疗法的止血消炎镇痛复合功效纳米乳及其制备方法 | |
| CN102614496A (zh) | 林蛙骨高钙片及其制作方法 | |
| CN108114311A (zh) | 碘仿明胶海绵的制备方法 | |
| CN105126152A (zh) | 一种明胶壳聚糖复合止血粉 | |
| CN105617452A (zh) | 一种医用生物新材料 | |
| CN101695583B (zh) | 一种用于组织修复的颗粒状生物材料及其制备方法 | |
| CN103830159A (zh) | 一种去粉刺凝胶 | |
| CN103263380B (zh) | 一种山葵面膜及其制备方法 | |
| ES2416804A1 (es) | Composición de productos naturales para aplicación tópica | |
| CN106267328B (zh) | 一种聚己内酯-胎牛皮胶原纤维复合止血凝胶的制备方法 | |
| CN105534787A (zh) | 草本植物苎麻根和羊蹄根提取物在口腔护理产品中的应用 | |
| CN105796769A (zh) | 一种医用伤口消毒液及其制作方法 | |
| CN103719328A (zh) | 一种三七损伤保健茶 | |
| CN103535368A (zh) | 一种植物愈合贴的制作方法 | |
| CN102429825B (zh) | 天然生物矿化粉及其制备方法和应用 | |
| CN104368032A (zh) | 一种创面修复用生物凝胶材料及其制备方法 | |
| CN101623511A (zh) | 一种生物敷料用保湿剂及其制备方法 | |
| CN106344960B (zh) | 利用微晶纤维素接枝改性胎牛皮胶原纤维制备的止血凝胶 | |
| CN104106626A (zh) | 一种酢浆草提取物保鲜剂的制备方法 | |
| CN104667332A (zh) | 冰箱除臭剂 | |
| CN104257682B (zh) | 一种创面修护组合物及制剂 | |
| JP6931437B1 (ja) | 抗ウイルス溶液 | |
| Ngoubinah Pretty | Evaluation of Antimicrobial and Cytotoxic Properties of Hyaluronic Acid based injectable Hydrogel incorporated with Dihydroxyacetone Phosphate, Magnesium Nanoparticles and Cissus Quadrangularis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 213200 Jiangsu city of Changzhou province Jintan District Town Industrial Zone jianerkang Road No. 1 Applicant after: Jianerkang Medical Technology Co.,Ltd. Address before: 213200 Jiangsu city of Changzhou province Jintan District Town Industrial Zone jianerkang Road No. 1 Applicant before: Jiangsu jianerkang Medical Technology Co.,Ltd. Address after: 213200 Jiangsu city of Changzhou province Jintan District Town Industrial Zone jianerkang Road No. 1 Applicant after: Jiangsu jianerkang Medical Technology Co.,Ltd. Address before: 213200 Jiangsu city of Changzhou province Jintan District Town Industrial Zone jianerkang Road No. 1 Applicant before: JIANGSU PROVINCE JIANERKANG MADICAL DRESSING CO.,LTD. |
|
| CB02 | Change of applicant information | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180605 |
|
| RJ01 | Rejection of invention patent application after publication |