CN108114006A - A kind of preparation containing trinosin - Google Patents

Abstract

The invention discloses a kind of compositions containing trinosin, and by weight, the raw material composition of the composition containing trinosin includes：0.3 2 parts of 26 parts of trinosin, 0.5 2 parts of chlorogenic acid, 18 22 parts of inosine, 0.03 0.1 parts of yeast selenium and vitamin E.Pulvis, the preparation of three kinds of dosage forms of pre-mixing agent and granule can be made by being combined with auxiliary material in the above-mentioned composition containing trinosin.The preparation containing trinosin can be adjusted because epidemic disease causes animal body metabolic disorder, repair damaged tissues cell, enhance animal body resistance, promote physical recovery.

Description

A preparation containing disodium adenosine triphosphate

technical field

The invention belongs to the technical field of veterinary pharmaceutical preparations, in particular to a preparation containing disodium adenosine triphosphate.

Background technique

Epidemics in animals are often accompanied by abnormal metabolism, cell and tissue damage in the body, and decreased immunity. In addition, some sick animals show loss of appetite or even die, which further leads to excessive energy consumption of the animal body, which is not conducive to body recovery.

Adenosine triphosphate disodium is a nucleotide derivative, as a coenzyme involved in the body fat, protein, sugar, nucleic acid and nucleotide metabolism. When energy is needed for absorption, secretion, muscle contraction and biochemical synthesis reactions in the body, adenosine triphosphate is decomposed into adenosine diphosphate and phosphate groups, and energy is released at the same time. Therefore, adenosine triphosphate disodium can be used for adjuvant treatment and energy supplementation of various animal diseases. Most of the existing adenosine triphosphate disodium is injections and tablets, which cannot meet the requirements of mass administration of animal diseases in large-scale farming. Therefore, the present application aims at the problems existing in the prior art, and provides a preparation containing disodium adenosine triphosphate, which can regulate the metabolic disorder of the animal body caused by the epidemic, repair damaged tissue cells and enhance the resistance of the animal body.

Contents of the invention

The object of the present invention is to provide a preparation containing disodium adenosine triphosphate. The preparation containing disodium adenosine triphosphate can regulate the metabolic disorder of the animal body caused by the epidemic, repair damaged tissue cells, enhance the resistance of the animal body, and promote the recovery of the body.

In order to realize the purpose of the invention, the technical scheme adopted in the present invention is:

The present invention firstly provides a composition containing adenosine triphosphate disodium. In parts by weight, the raw material composition of the composition containing adenosine triphosphate disodium includes: 2-6 parts of adenosine triphosphate disodium, 0.5-2 parts of chlorogenic acid, 18-22 parts of inosine, 0.03-0.1 parts of yeast selenium and 0.3-2 parts of vitamin E.

According to the above composition containing adenosine triphosphate disodium, preferably, in parts by weight, the raw material composition of the composition containing adenosine triphosphate disodium includes: 4 parts of adenosine triphosphate disodium, 1 part of chlorogenic acid, 20 parts of inosine, Yeast selenium 0.05 part and vitamin E 0.5 part.

According to the above composition containing disodium adenosine triphosphate, preferably, the purity of the chlorogenic acid is 70%.

The above-mentioned composition containing disodium adenosine triphosphate can be used to regulate the metabolic disorder of the animal body caused by the epidemic, repair damaged tissue cells, enhance the resistance of the animal body, and promote the recovery of the body.

The present invention also provides a powder containing disodium adenosine triphosphate, the powder comprising the above-mentioned composition containing disodium adenosine triphosphate, an anti-caking agent and auxiliary materials; wherein, the pharmaceutical composition containing disodium adenosine triphosphate, anti-caking agent The mass ratio of the caking agent and the auxiliary material is (20-33):(0.5-1):(66-79).

According to the above-mentioned powder containing disodium adenosine triphosphate, preferably, the auxiliary material is any one of oral glucose, anhydrous glucose, maltodextrin, soluble starch, maltose and sucrose; the anti-caking agent is calcium phosphate, Any one of micronized silica gel, magnesium stearate and silicon dioxide.

The preparation method of the above-mentioned adenosine triphosphate disodium-containing powder is as follows: (1) weigh adenosine triphosphate disodium, chlorogenic acid, inosine, yeast selenium, vitamin E, anti-caking agent and auxiliary materials according to the raw material composition of the powder, and weigh the solid The raw materials are crushed and passed through an 80-mesh sieve; (2) vitamin E is mixed with auxiliary materials twice its weight to obtain a vitamin E mixture; (3) yeast selenium is mixed with chlorogenic acid to obtain a mixture A; (4) adenosine triphosphate Put the disodium, vitamin E mixture, mixture A and anti-caking agent into the mixer, mix evenly for 10-20min, then add inosine into the mixer, mix evenly for 15-30min, then add the total amount of auxiliary materials into the mixer Mix 10%-20% auxiliary materials uniformly for 15-30 minutes, and finally add all the remaining auxiliary materials into the mixer, and uniformly mix for 15-30 minutes to obtain the powder containing disodium adenosine triphosphate.

The present invention also provides a premix containing disodium adenosine triphosphate, which includes the above-mentioned composition containing disodium adenosine triphosphate, an anti-caking agent and auxiliary materials; wherein, the drug containing disodium adenosine triphosphate The mass ratio of the composition, the anti-caking agent and the auxiliary material is (20-33):(0.5-1):(66-79).

According to the above-mentioned premix containing adenosine triphosphate disodium, preferably, the auxiliary material is any one of corn starch, corncob powder, corn flour and bran; the anti-caking agent is calcium phosphate, micronized silica gel, hard Any one of magnesium fatty acid and silicon dioxide.

The preparation method of the above-mentioned adenosine triphosphate disodium-containing premix is as follows: (1) weigh adenosine triphosphate disodium, chlorogenic acid, inosine, yeast selenium, vitamin E, The anti-caking agent and auxiliary materials are crushed and passed through an 80-mesh sieve; (2) vitamin E is mixed with auxiliary materials twice its weight to obtain a vitamin E mixture; (3) yeast selenium is mixed with chlorogenic acid to obtain Mixture A; (4) Put adenosine triphosphate disodium, vitamin E mixture, mixture A and anti-caking agent into the mixer, mix evenly for 10-20min, then add inosine into the mixer, mix evenly for 15-30min, Then add auxiliary materials accounting for 10%-20% of the total weight of auxiliary materials into the mixer, and mix uniformly for 15-30 minutes, and finally add all the remaining auxiliary materials into the mixer, and mix uniformly for 15-30 minutes to obtain the preprepared product containing adenosine triphosphate disodium. Mixture.

The present invention also provides a granule containing disodium adenosine triphosphate, said granule comprising the pharmaceutical composition containing disodium adenosine triphosphate according to claim 1, sucrose and dextrin; wherein said disodium adenosine triphosphate contains The mass ratio of the pharmaceutical composition, sucrose and dextrin is (20-33):(48-52):(15-32).

The preparation method of the above-mentioned disodium adenosine triphosphate-containing granules is as follows: weighing disodium adenosine triphosphate, chlorogenic acid, inosine, yeast selenium, vitamin E, sucrose and dextrin according to the raw material composition of the disodium adenosine triphosphate-containing granules, The solid raw material is crushed and passed through an 80-mesh sieve; (2) vitamin E is mixed with sucrose twice its weight to obtain a vitamin E mixture; (3) yeast selenium is mixed with chlorogenic acid to obtain a mixture A; (4) Put the sucrose accounting for 10%-20% of the total weight of sucrose and the dextrin accounting for 10%-20% of the total weight of dextrin into a mixer and mix for 10-20min, then add disodium adenosine triphosphate, vitamin E mixture and Mixture A, stir evenly for 10-30min; then add inosine and the remaining amount of sucrose and dextrin into the mixer, and continue stirring for 15-30min to obtain Mixture B; (5) The added amount is 0.8%-1.5 %(volume of ethanol/weight of mixture B) add ethanol with a mass fraction of 70% to mixture B, and mix uniformly for 15-30min to obtain mixture C; put mixture C into an extruding granulator to produce Soft granules, dried, and granulated to obtain granules containing disodium adenosine triphosphate.

The method of using the powder containing disodium adenosine triphosphate of the present invention is as follows: after 1 kg of the powder containing disodium adenosine triphosphate of the present invention is mixed with 2000 kg of water or 1000 kg of feed, animals are allowed to drink water or eat food freely.

The using method of the premix containing disodium adenosine triphosphate of the present invention is as follows: after 1000 kg of the premixed feed containing disodium adenosine triphosphate of the present invention is mixed, animals eat freely.

The usage method of the granule containing disodium adenosine triphosphate of the present invention is as follows: After 1 kg of the granule containing disodium adenosine triphosphate of the present invention is mixed with 2000 kg of water or 1000 kg of feed, the animals are allowed to drink water or eat food freely.

The effect of each component in the composition containing adenosine triphosphate disodium of the present invention is:

Chlorogenic acid has the functions of scavenging free radicals and anti-lipid peroxidation, can protect vascular endothelial cells, and at the same time has the functions of immune regulation, reducing inflammation, antibacterial and antiviral, liver protection and gallbladder.

Inosine is a component of ATP, coenzyme A, ribonucleic acid and deoxyribonucleic acid in the body. It can directly enter the body cells through the cell membrane and activate pyruvate oxidase, so that the cells in the state of low energy and hypoxia can continue to develop smoothly. Metabolism, and participate in human energy metabolism and protein synthesis. Inosine increases ATP levels and can be converted into various nucleotides. It can stimulate the production of antibodies in the body, improve the intestinal absorption of iron, activate liver function, and accelerate the repair of liver cells. It has the effect of enhancing the proliferation of white blood cells.

Vitamin E has a good anti-oxidation function. It binds to the biofilm to protect the membrane from free radical attack and oxidative damage; it can enhance the body's immune function, improve the body's tolerance to various stresses, and promote the recovery of diseases , Improve animal survival rate and relative weight gain, thereby improving the economic benefits of animal production.

The physiological effects of selenium mainly include anti-oxidation (free radical damage), improving immunity and mediating thyroid hormones. Yeast selenium is a microbial fermentation product produced by enriching organic forms (selenomethionine, selenocystine) in yeast. It is a high-quality organic selenium source, and its bioavailability is much higher than that of inorganic selenium. Selenium is easy to be absorbed in animals, has no toxic side effects, causes little pollution to the environment, and is more suitable for animal production.

In terms of anti-free radical damage, VE and Se have mutual promotion and mutual compensation effects. VE binds to the biofilm to protect the membrane from free radical attack and oxidative damage; while Se destroys peroxide through GSH-Px, preventing the formation of harmful free radicals and their attack on unsaturated fatty acids, so the relationship between the two Exhibit a "mutual saving" effect.

The positive beneficial effect that the present invention obtains:

(1) In the preparation containing adenosine triphosphate disodium of the present invention, disodium adenosine triphosphate participates in body tissue metabolism, provides energy, assists the repair of tissue damage, and provides energy; Cells can continue to metabolize smoothly, indirectly synergizing or strengthening the effect of ATP. Chlorogenic acid is an active ingredient of many traditional Chinese medicines, which has the functions of scavenging free radicals and anti-lipid peroxidation, and at the same time has the functions of immune regulation and reducing inflammation; VE and Se are antioxidants, and appropriate amounts of Se and VE can reduce tissue internal The level of peroxide can reduce the damage of peroxide to body tissue, so as to maintain the balance of peroxide generation and elimination process in the body. Therefore, the preparation containing disodium adenosine triphosphate of the present invention can effectively regulate the metabolic disorder of animal body caused by epidemic disease, Repair damaged tissue cells, enhance animal body resistance, and promote body recovery.

(2) The preparation containing disodium adenosine triphosphate of the present invention has simple preparation process, low price, convenient use and easy popularization and application.

Detailed ways

The present invention will be described in further detail below through specific examples, but the scope of the present invention will not be limited. Without departing from the spirit and essence of the present invention, any modifications or substitutions made to the methods, steps or conditions of the present invention fall within the scope of the present invention.

Unless otherwise specified, the technical means used in the examples are conventional means well known to those skilled in the art, and the reagents used are also conventional reagents in the art.

Example 1:

A composition containing disodium adenosine triphosphate, in parts by weight, the raw materials of the composition containing disodium adenosine triphosphate consist of 4 parts of disodium adenosine triphosphate, 1 part of chlorogenic acid, 20 parts of inosine, 0.05 parts of yeast selenium and Vitamin E 0.5 part.

Example 2:

A composition containing disodium adenosine triphosphate, in parts by weight, the raw materials of the composition containing disodium adenosine triphosphate consist of 2 parts of disodium adenosine triphosphate, 1.5 parts of chlorogenic acid, 18 parts of inosine, 0.1 part of yeast selenium and Vitamin E 1.0 parts.

Example 3:

A composition containing disodium adenosine triphosphate, in parts by weight, the raw materials of the composition containing disodium adenosine triphosphate consist of 6 parts of disodium adenosine triphosphate, 2 parts of chlorogenic acid, 22 parts of inosine, 0.03 parts of yeast selenium and Vitamin E 2 parts.

Example 4:

A composition containing disodium adenosine triphosphate, in parts by weight, the raw materials of the composition containing disodium adenosine triphosphate consist of 5 parts of disodium adenosine triphosphate, 0.5 parts of chlorogenic acid, 20 parts of inosine, 0.08 parts of yeast selenium and Vitamin E 0.3 parts.

Example 5:

A composition containing disodium adenosine triphosphate, in parts by weight, the raw materials of the composition containing disodium adenosine triphosphate consist of 4 parts of disodium adenosine triphosphate, 2 parts of chlorogenic acid, 18 parts of inosine, 0.05 parts of yeast selenium and Vitamin E 1.5 parts.

Embodiment 6:

A composition containing disodium adenosine triphosphate, in parts by weight, the raw materials of the composition containing disodium adenosine triphosphate are 5 parts of disodium adenosine triphosphate, 1.5 parts of chlorogenic acid, 20 parts of inosine, 0.1 part of yeast selenium and Vitamin E 1 part.

Embodiment 7:

A powder containing disodium adenosine triphosphate, said powder is prepared from the composition containing disodium adenosine triphosphate described in Example 1, an anti-caking agent and auxiliary materials; wherein, the pharmaceutical composition containing disodium adenosine triphosphate 1. The mass ratio of the anti-caking agent to the auxiliary material is 25.55:1:73.45; the anti-caking agent is calcium phosphate; the auxiliary material is oral glucose.

The preparation method of the above-mentioned adenosine triphosphate disodium-containing powder is as follows: (1) weigh adenosine triphosphate disodium, chlorogenic acid, inosine, yeast selenium, vitamin E, anti-caking agent and auxiliary materials according to the raw material composition of the powder, and weigh the solid The raw materials are crushed and passed through an 80-mesh sieve; (2) vitamin E is mixed with auxiliary materials twice its weight to obtain a vitamin E mixture; (3) yeast selenium is mixed with chlorogenic acid to obtain a mixture A; (4) adenosine triphosphate Put the disodium, vitamin E mixture, mixture A and anti-caking agent into the mixer, mix evenly for 10-20min, then add inosine into the mixer, mix evenly for 15-30min, then add the total amount of auxiliary materials into the mixer Mix 10%-20% auxiliary materials uniformly for 15-30 minutes, and finally add all the remaining auxiliary materials into the mixer, and uniformly mix for 15-30 minutes to obtain the powder containing disodium adenosine triphosphate.

Embodiment 8:

A powder containing adenosine triphosphate disodium, said powder is prepared from the composition containing adenosine triphosphate disodium described in Example 2, an anti-caking agent and auxiliary materials; wherein, said pharmaceutical composition containing adenosine triphosphate disodium , The mass ratio of the anti-caking agent and the auxiliary material is 33:1:66, the anti-caking agent is micropowder silica gel; the auxiliary material is anhydrous glucose.

The preparation method of the above-mentioned powder containing disodium adenosine triphosphate is the same as that of Example 7.

Embodiment 9:

A powder containing disodium adenosine triphosphate, which is prepared from the composition containing disodium adenosine triphosphate described in Example 3, an anti-caking agent and auxiliary materials; wherein, the pharmaceutical composition containing disodium adenosine triphosphate 1. The mass ratio of the anti-caking agent to the auxiliary material is 20:1:79; the anti-caking agent is magnesium stearate; the auxiliary material is maltodextrin.

The preparation method of the above-mentioned powder containing disodium adenosine triphosphate is the same as that of Example 7.

Example 10:

A powder containing adenosine triphosphate disodium, characterized in that the powder is prepared from the composition containing adenosine triphosphate disodium described in Example 4, an anti-caking agent and auxiliary materials; wherein, the adenosine triphosphate-containing disodium The mass ratio of the pharmaceutical composition, anti-caking agent and auxiliary material is 28:0.8:71.2; the anti-caking agent is silicon dioxide; and the auxiliary material is soluble starch.

The preparation method of the above-mentioned powder containing disodium adenosine triphosphate is the same as that of Example 7.

Example 11:

A powder containing adenosine triphosphate disodium, characterized in that the powder is prepared from the composition containing adenosine triphosphate disodium described in Example 6, an anti-caking agent and auxiliary materials; wherein, the described adenosine triphosphate-containing disodium The mass ratio of the pharmaceutical composition, anti-caking agent and auxiliary material is 30:1:69; the anti-caking agent is calcium phosphate; and the auxiliary material is maltose.

The preparation method of the above-mentioned powder containing disodium adenosine triphosphate is the same as that of Example 7.

Example 12:

A powder containing adenosine triphosphate disodium, characterized in that the powder is prepared from the composition containing adenosine triphosphate disodium described in Example 1, an anti-caking agent and auxiliary materials; wherein, the adenosine triphosphate-containing disodium The mass ratio of the pharmaceutical composition, anti-caking agent and auxiliary material is 25:0.5:74.5; the anti-caking agent is silicon dioxide; the auxiliary material is sucrose.

The preparation method of the above-mentioned powder containing disodium adenosine triphosphate is the same as that of Example 7.

Example 13:

A premix containing adenosine triphosphate disodium, said premix is prepared from the composition containing adenosine triphosphate disodium described in Example 1, an anti-caking agent and auxiliary materials; wherein said adenosine triphosphate-containing disodium The mass ratio of the pharmaceutical composition, anti-caking agent and auxiliary material is 25.55:1:73.45; the anti-caking agent is calcium phosphate; and the auxiliary material is corn starch.

The preparation method of the above-mentioned adenosine triphosphate disodium-containing premix is as follows: (1) weigh adenosine triphosphate disodium, chlorogenic acid, inosine, yeast selenium, vitamin E, The anti-caking agent and auxiliary materials are crushed and passed through an 80-mesh sieve; (2) vitamin E is mixed with auxiliary materials twice its weight to obtain a vitamin E mixture; (3) yeast selenium is mixed with chlorogenic acid to obtain Mixture A; (4) Put adenosine triphosphate disodium, vitamin E mixture, mixture A and anti-caking agent into the mixer, mix evenly for 10-20min, then add inosine into the mixer, mix evenly for 15-30min, Then add auxiliary materials accounting for 10%-20% of the total weight of auxiliary materials into the mixer, and mix uniformly for 15-30 minutes, and finally add all the remaining auxiliary materials into the mixer, and mix uniformly for 15-30 minutes to obtain the preprepared product containing adenosine triphosphate disodium. Mixture.

Example 14:

A premix containing adenosine triphosphate disodium, said premix is composed of the composition containing adenosine triphosphate disodium described in embodiment 2, anti-caking agent and adjuvant; wherein, said drug combination containing adenosine triphosphate disodium The mass ratio of compound, anti-caking agent and auxiliary material is 33:1:66; the anti-caking agent is micronized silica gel; the auxiliary material is corncob powder.

The preparation method of the above-mentioned premix containing disodium adenosine triphosphate is the same as that in Example 13.

Example 15:

A premix containing adenosine triphosphate disodium, said premix is composed of the composition containing adenosine triphosphate disodium described in embodiment 3, anti-caking agent and adjuvant; wherein, said drug combination containing adenosine triphosphate disodium The mass ratio of the substance, the anti-caking agent and the auxiliary material is 20:1:79; the anti-caking agent is magnesium stearate; the auxiliary material is corn flour.

The preparation method of the above-mentioned premix containing disodium adenosine triphosphate is the same as that in Example 13.

Example 16:

A premix containing adenosine triphosphate disodium, said premix is composed of the composition containing adenosine triphosphate disodium described in embodiment 4, anti-caking agent and adjuvant; wherein, said drug combination containing adenosine triphosphate disodium The mass ratio of compound, anti-caking agent and auxiliary material is 30:0.8:69.2; the anti-caking agent is silicon dioxide; the auxiliary material is bran.

The preparation method of the above-mentioned premix containing disodium adenosine triphosphate is the same as that in Example 13.

Example 17:

A premix containing adenosine triphosphate disodium, said premix is composed of the composition containing adenosine triphosphate disodium described in embodiment 5, anti-caking agent and adjuvant; wherein, said drug combination containing adenosine triphosphate disodium The mass ratio of compound, anti-caking agent and auxiliary material is 25:0.5:74.5; the anti-caking agent is calcium phosphate; the auxiliary material is corncob powder.

The preparation method of the above-mentioned premix containing disodium adenosine triphosphate is the same as that in Example 13.

Example 18:

A premix containing adenosine triphosphate disodium, said premix is composed of the composition containing adenosine triphosphate disodium described in embodiment 6, anti-caking agent and adjuvant; wherein, said drug combination containing adenosine triphosphate disodium The mass ratio of substance, anti-caking agent and auxiliary material is 28:1:71; the anti-caking agent is magnesium stearate; and the auxiliary material is corn starch.

The preparation method of the above-mentioned premix containing disodium adenosine triphosphate is the same as that in Example 13.

Example 19:

A granule containing disodium adenosine triphosphate, which is prepared from the pharmaceutical composition containing disodium adenosine triphosphate described in Example 1, sucrose and dextrin; wherein, the pharmaceutical composition containing disodium adenosine triphosphate The mass ratio of sugar, sucrose and dextrin is 25.55:50:24.45.

The preparation method of the above-mentioned disodium adenosine triphosphate-containing granules is as follows: weighing disodium adenosine triphosphate, chlorogenic acid, inosine, yeast selenium, vitamin E, sucrose and dextrin according to the raw material composition of the disodium adenosine triphosphate-containing granules, The solid raw material is crushed and passed through an 80-mesh sieve; (2) vitamin E is mixed with sucrose twice its weight to obtain a vitamin E mixture; (3) yeast selenium is mixed with chlorogenic acid to obtain a mixture A; (4) Put the sucrose accounting for 10%-20% of the total weight of sucrose and the dextrin accounting for 10%-20% of the total weight of dextrin into a mixer and mix for 10-20min, then add disodium adenosine triphosphate, vitamin E mixture and Mixture A, stir evenly for 10-30min; then add inosine and the remaining amount of sucrose and dextrin into the mixer, and continue stirring for 15-30min to obtain Mixture B; (5) The added amount is 0.8%-1.5 %(volume of ethanol/weight of mixture B) add ethanol with a mass fraction of 70% to mixture B, and mix uniformly for 15-30min to obtain mixture C; put mixture C into an extruding granulator to produce Soft granules, dried, and granulated to obtain granules containing disodium adenosine triphosphate.

Example 20:

A granule containing disodium adenosine triphosphate, which is prepared from the pharmaceutical composition containing disodium adenosine triphosphate described in Example 3, sucrose and dextrin; wherein, the pharmaceutical composition containing disodium adenosine triphosphate The mass ratio of sugar, sucrose and dextrin is 20:48:32.

The preparation method of the above-mentioned granules containing disodium adenosine triphosphate is the same as that in Example 19.

Example 21:

A granule containing disodium adenosine triphosphate, which is prepared from the pharmaceutical composition containing disodium adenosine triphosphate described in Example 4, sucrose and dextrin; wherein, the pharmaceutical composition containing disodium adenosine triphosphate The mass ratio of sugar, sucrose and dextrin is 33:52:15.

The preparation method of the above-mentioned granules containing disodium adenosine triphosphate is the same as that in Example 19.

Example 22:

A granule containing disodium adenosine triphosphate, which is prepared from the pharmaceutical composition containing disodium adenosine triphosphate described in Example 6, sucrose and dextrin; wherein, the pharmaceutical composition containing disodium adenosine triphosphate The mass ratio of sugar, sucrose and dextrin is 30:50:20.

The preparation method of the above-mentioned granules containing disodium adenosine triphosphate is the same as that in Example 19.

Example 23:

A granule containing disodium adenosine triphosphate, which is prepared from the pharmaceutical composition containing disodium adenosine triphosphate described in Example 1, sucrose and dextrin; wherein, the pharmaceutical composition containing disodium adenosine triphosphate The mass ratio of sugar, sucrose and dextrin is 25:50:25.

The preparation method of the above-mentioned granules containing disodium adenosine triphosphate is the same as that in Example 19.

Example 24:

A granule containing disodium adenosine triphosphate, which is prepared from the pharmaceutical composition containing disodium adenosine triphosphate described in Example 6, sucrose and dextrin; wherein, the pharmaceutical composition containing disodium adenosine triphosphate The mass ratio of sugar, sucrose and dextrin is 28:50:22.

The preparation method of the above-mentioned granules containing disodium adenosine triphosphate is the same as that in Example 19.

Example 25: Validation of the effect of the preparation containing adenosine triphosphate disodium of the present invention

Taking the treatment of chicken cecal coccidiosis as an example, the powder containing disodium adenosine triphosphate prepared in Example 7 was used to verify the effect of the preparation containing disodium adenosine triphosphate of the present invention. The specific method is as follows:

Select 11-day-old healthy young chicks, number them one by one and weigh them on an empty stomach, eliminate underweight and overweight chicks, and randomly divide them into four groups A, B, C, and D according to the dispersion of body weight, with 18 chicks in each group. Chicks in groups A, B, and C were challenged at 12 days of age—each chick was orally administered with sporulated oocysts of E. tenella (see Table 1 for the amount of challenge), and group D was not given oocysts orally as a control. The chicks in groups A, B, C, and D were all fed the chick basal feed normally, and the rearing conditions were the same. Among them, the A group and the B group began to feed the chick basal feed mixed with the drug 72h after the challenge (the specific mixing of the drug) Intake see Table 1) to the end of the test. During the test period, the mental state, feeding situation, bloody stool, morbidity and death of the chickens were observed every day, and the feces on the 5th, 6th, and 7th days were collected for gram fecal oocyst count (OPG). On the 8th day after infection, the rats were weighed, dissected, and the cecal lesions were observed and scored. The body weight before challenge, body weight before dissection, survival rate, and cecal lesion score were recorded, and the anticoccidial index (ACI) was calculated. ACI=(relative weight gain rate+survival rate)-(lesion value+oocyst value), see Table 2 for the results. According to the method of Merck, ACI ≥ 180 is considered sensitive, 160 ≤ ACI < 180 is good, 120 ≤ ACI < 160 is poor, and ACI < 120 is invalid.

Table 1 The methods of attacking poison and medication in each group

group Attacking amount (×10 ⁴ oocysts) Drug and dose (per kg feed) A 5.5 30mg Toltrazuril+1g powder containing adenosine triphosphate disodium of the present invention B 5.5 30mg Toltrazuril + 1g anhydrous sugar C 5.5 -- D. 0 --

The treatment effect of each group in table 2

As can be seen from Table 2, the relative weight gain of the group of the present invention (group A) (can partly reflect the metabolic state of the body) is 4 percentage points higher than that of the drug control group B, and the repairing ability to body tissue damage (the smaller the lesion value, the better) is also Better than group B, the overall therapeutic effect (anti-coccidiostat index ACI) is better than the simple use of anticoccidial drugs. This also shows that using the powder containing adenosine triphosphate disodium of the present invention to assist the treatment of chicken cecal coccidiosis can effectively improve the repair level of body tissue damage, enhance the resistance of the animal body, and promote the recovery of the body.

The above examples are only used to illustrate the technical implementation of the present invention without limitation. Although the present invention has been described in detail with reference to the preferred embodiments, any modifications and equivalent replacements made within the spirit and principles of the present invention , improvements, etc., should be included within the protection scope of the present invention.

Claims (9)

1. A composition containing disodium adenosine triphosphate, characterized in that, in parts by weight, the composition of raw materials containing disodium adenosine triphosphate comprises: 2-6 parts of disodium adenosine triphosphate, 0.5-2 parts of chlorogenic acid , 18-22 parts of inosine, 0.03-0.1 parts of yeast selenium and 0.3-2 parts of vitamin E. 2. the composition containing adenosine triphosphate disodium according to claim 1, is characterized in that, by weight, the raw material composition of described composition containing adenosine triphosphate disodium comprises: 4 parts of adenosine triphosphate disodium, chlorogenic acid 1 20 parts of inosine, 0.05 parts of yeast selenium and 0.5 parts of vitamin E. 3. A powder containing disodium adenosine triphosphate, characterized in that, the powder comprises the composition of claim 1 containing disodium adenosine triphosphate, anti-caking agent and adjuvant; wherein, the powder containing disodium adenosine triphosphate The mass ratio of the pharmaceutical composition, the anti-caking agent and the auxiliary material is (20-33):(0.5-1):(66-79). 4. The powder according to claim 3, wherein the auxiliary material is any one of oral glucose, anhydrous glucose, maltodextrin, soluble starch, maltose and sucrose. 5. The powder according to claim 3, wherein the anti-caking agent is any one of calcium phosphate, micronized silica gel, magnesium stearate and silicon dioxide. 6. A premix containing disodium adenosine triphosphate, characterized in that, said premix comprises the composition, anti-caking agent and adjuvant containing adenosine triphosphate disodium described in claim 1; wherein said premix containing The mass ratio of the pharmaceutical composition of adenosine triphosphate disodium, the anti-caking agent and the auxiliary material is (20-33):(0.5-1):(66-79). 7. The premix according to claim 6, characterized in that, the auxiliary material is any one of cornstarch, corn cob powder, corn flour and bran. 8. The premix according to claim 6, wherein the anti-caking agent is any one of calcium phosphate, micronized silica gel, magnesium stearate and silicon dioxide. 9. A granule containing disodium adenosine triphosphate, characterized in that, the granule comprises the pharmaceutical composition containing disodium adenosine triphosphate according to claim 1, sucrose and dextrin; wherein, said disodium adenosine triphosphate contains The mass ratio of the pharmaceutical composition, sucrose and dextrin is (20-33):(48-52):(15-32).