CN1081025C - Macule-removing skin-whitening cosmetics containing hydroquinone monopropionate fat and alpha-hydroxy acid - Google Patents

Abstract

The invention relates to a speckle-removing and whitening cosmetic containing hydroquinone monopropionate and α-hydroxy acid, which mainly includes anti-wrinkle, skin repair promotion and whitening α- -Hydroxy acid, and antioxidant vitamin C and vitamin E and skin nutrition amino acid, together with other adjuvants (such as matrix, emulsifier, penetrating agent, preservative, fragrance, water, etc.), prepared by conventional emulsification method Stable paste. The cosmetic has stable performance, is not easy to be oxidized and discolored after long-term storage, has a remarkable effect of removing spots and whitening, and has anti-wrinkle and other functions.

Description

A kind of anti-freckle and whitening cosmetic containing hydroquinone monopropionate and alpha-hydroxy acid

The present invention relates to freckle-removing and whitening cosmetics, in particular to a freckle-removing and whitening cosmetic containing hydroquinone monopropionate and α-hydroxy acid

Various types of skin pigmentation disorders are mainly due to the action of tyrosinase, tyrosine metabolism disorder in the body, and abnormal deposition of pigments, resulting in age spots, brown spots, freckles, etc. To artificially prevent the formation of these brown spots, mainly to inhibit the activity of tyrosinase. It is known that hydroquinone monopropionate, a synthetic derivative of hydroquinone, has this function, has the characteristics of less irritation, good safety, and easy absorption by the skin, and is gradually being widely used. However, after being made into a cosmetic paste, hydroquinone monopropionate is unstable and easily oxidized and discolored, which directly affects the appearance quality of cosmetics and the curative effect of freckle removal. The traditional solution in the past is to add a large amount of low-priced sulfates (such as sodium sulfite, sodium pyrosulfite) as oxidation inhibitors, but such substances are irritating to the skin, and long-term use will cause damage to the skin.

It is known that one of the excretion pathways of melanin is through the skin, that is, melanin is transferred to keratin, migrates to the stratum corneum with the growth of the epidermis, and finally falls off with the metabolism of the stratum corneum. Alpha hydroxy acids have the characteristics of exfoliating dead skin cells, thereby promoting skin repair, delaying skin aging, and reducing pigmentation.

The object of the present invention is to provide a freckle-removing and whitening cosmetic containing hydroquinone monopropionate and α-hydroxy acid. White α-hydroxy acid, and antioxidant vitamin C and vitamin E and skin nutrition amino acid, together with other auxiliary agents (such as matrix, emulsifier, penetrant, preservative, spice, water, etc.), using conventional emulsification Methods A paste with stable properties was prepared.

The principle of the invention is that the addition of α-hydroxy acid in cosmetics can control the pH value of the paste in the range of 4-6.5. Under this condition, the chemical properties of hydroquinone monopropionate are stable and not easily oxidized. And α-hydroxy acid has the activities of activating skin cells, anti-wrinkle, whitening, etc., and the compound with hydroquinone monopropionate has a synergistic effect of removing spots and whitening. Vitamin C and vitamin E can be used as antioxidants in the cosmetic formula to inhibit the oxidation of hydroquinone monopropionate, and have the same effect of nourishing the skin as the amino acids added in the formula, and vitamin C also has the effect of whitening the skin.

A freckle-removing and whitening cosmetic containing hydroquinone monopropionate and α-hydroxy acid according to the present invention, the dosage of hydroquinone monopropionate in cosmetics is 0.5-20 parts, and α-hydroxy acid is lactic acid or hydroxyl Acetic acid or malic acid or citric acid or tartaric acid or their mixture, its consumption is 1-20 parts, vitamin is vitamin C, vitamin E, its consumption is 0-2 parts, amino acid is cystine or glycine, its consumption is 0 -1 part, mixed with other cosmetic auxiliary agents (such as base, emulsifier, penetrant, preservative, fragrance, water, etc.), prepared by conventional emulsification method, and the pH value is 4-6.5.

The present invention has carried out rubbing test to the patient suffering from brown spots, freckles: rubbing test with the paste that contains 3.6% (weight ratio) hydroquinone monopropionate and 8.7% (weight ratio) α-hydroxy acid, continuous The result of using it for more than two months is as follows:

Embodiment 1 (in parts by weight)

First, 4 parts of petrolatum, 2 parts of glycerol monostearate, 1.5 parts of cetyl alcohol, 3.7 parts of stearic acid, 4.2 parts of liquid paraffin, 2.3 parts of castor oil, 2.6 parts of sorbitan monopalmitate, hydroquinone Mix 0.5 parts of monopropionate, 0.7 parts of vitamin E and 1.5 parts of commonly used preservatives, fragrances and penetrants, mix with 2.5 parts of glycolic acid, 12 parts of lactic acid, 4 parts of tartaric acid, 10 parts of glycerin, and 0.5 parts of vitamin C at 70 °C , 1 part of aminoacetic acid, the water phase of the remainder of water, and adjust the pH to 4 with aqueous potassium hydroxide solution, then emulsify and cool by conventional methods.

Embodiment 2 (in parts by weight)

First, 12 parts of solid paraffin, 5 parts of vaseline, 6 parts of hydrogenated lanolin, 19 parts of squalane, 2 parts of beeswax, 2.5 parts of glycerol monostearate, 1.2 parts of polyoxyethylene sorbitan monooleate, Mix 5 parts of hydroquinone monopropionate and 1.5 parts of commonly used preservatives, fragrances and penetrants, mix with 2 parts of lactic acid, 9.5 parts of malic acid, 1 part of tartaric acid, 1 part of vitamin C, 0.02 parts of cystine, water The remaining water phase is adjusted to pH 5.5 with potassium hydroxide aqueous solution, and then emulsified and cooled by conventional methods.

Embodiment 3 (in parts by weight)

First, 4 parts of stearyl alcohol, 5.5 parts of castor oil, 10 parts of glycerol monostearate, 2 parts of polyoxyethylene sorbitan monolaurate, 10 parts of hydroquinone monopropionate and commonly used preservatives, Mix 1.5 parts of spices and penetrants, mix with 1 part of glycolic acid, 1 part of vitamin C, and the rest of water at 70°C, and adjust the pH to 6.0 with aqueous potassium hydroxide solution, then emulsify and cool by conventional methods.

Embodiment 4 (in parts by weight)

First, 5 parts of isostearyl alcohol, 2 parts of safflower oil, 20 parts of glycerol monostearate, 6 parts of hydroquinone monopropionate, 2.8 parts of sorbitan monooleate, 0.5 parts of vitamin E and commonly used Mix 1.5 parts of preservatives, fragrances and penetrants, mix with 0.5 parts of glycolic acid, 2 parts of lactic acid, 2 parts of citric acid, and the rest of water at 70°C, adjust the pH to 6.5 with aqueous potassium hydroxide solution, and then use conventional methods Emulsify and cool.

Claims (2)

1, a kind of dispelling speckles and whitening face cosmetics that contain hydroquinone mono-propionate and 'alpha '-hydroxy acids, it is characterized in that, the consumption of hydroquinone mono-propionate is that 0.5-20 part, 'alpha '-hydroxy acids are lactic acid or hydroxyacetic acid or malic acid or citric acid or tartaric acid or its mixture in cosmetics, its consumption is 1-20 part, vitamin is vitamin C, vitamin E, its consumption is 0-2 part, aminoacid is cystine or glycine, its consumption is 0-1 part, be equipped with other cosmetics adjuvant again, adopt conventional emulsification method preparation, pH value is that 4-6.5 gets final product.

2, a kind of dispelling speckles and whitening face cosmetics that contain hydroquinone mono-propionate and 'alpha '-hydroxy acids according to claim 1 is characterized in that described adjuvant is substrate, emulsifying agent, penetrating agent, antiseptic, spice, water.