CN1081056C - Anticancer injection and its preparation method - Google Patents
Anticancer injection and its preparation method Download PDFInfo
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- CN1081056C CN1081056C CN99103528A CN99103528A CN1081056C CN 1081056 C CN1081056 C CN 1081056C CN 99103528 A CN99103528 A CN 99103528A CN 99103528 A CN99103528 A CN 99103528A CN 1081056 C CN1081056 C CN 1081056C
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- 238000002347 injection Methods 0.000 title claims abstract description 32
- 239000007924 injection Substances 0.000 title claims abstract description 32
- 230000001093 anti-cancer Effects 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 34
- 241000237903 Hirudo Species 0.000 claims abstract description 9
- 239000009636 Huang Qi Substances 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 230000001954 sterilising effect Effects 0.000 claims abstract description 4
- 210000000582 semen Anatomy 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 239000006228 supernatant Substances 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 9
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- 244000153234 Hibiscus abelmoschus Species 0.000 claims description 8
- 244000044425 Quisqualis indica Species 0.000 claims description 8
- 241000131808 Scolopendra Species 0.000 claims description 8
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- 230000001066 destructive effect Effects 0.000 claims description 8
- 239000009490 scorpio Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000010298 pulverizing process Methods 0.000 claims description 6
- 235000021419 vinegar Nutrition 0.000 claims description 6
- 239000000052 vinegar Substances 0.000 claims description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
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- 238000007710 freezing Methods 0.000 claims description 3
- 241000411851 herbal medicine Species 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
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- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 235000012907 honey Nutrition 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 abstract description 14
- 229940079593 drug Drugs 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 5
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- 206010061218 Inflammation Diseases 0.000 abstract 1
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- 230000036737 immune function Effects 0.000 description 2
- 238000010255 intramuscular injection Methods 0.000 description 2
- 239000007927 intramuscular injection Substances 0.000 description 2
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Abstract
The invention relates to an anticancer injection, which is an injection prepared by taking traditional Chinese medicines as raw materials, and also relates to a preparation method of the injection. The invention aims to provide an anticancer injection which has ideal effects of resisting and eliminating tumor, diminishing inflammation and relieving pain and repairing body injury. Restoring physiological function and enhancing immunity. The invention also aims to provide the anticancer injection and a preparation method thereof. For this purpose, 21 kinds of medicines such as radix astragali, Moschus, calculus bovis, herba Portulacae, Hirudo, etc. are used. The injection is prepared by extracting effective components, concentrating, sterilizing, etc., and is injected into acupoints. The effective rate of the invention is 95%, and the anticancer effect is obvious.
Description
The present invention relates to a kind of anti-cancer injection, is to be the injection of feedstock production with Chinese medicine, the invention still further relates to the preparation method of this injection.
With the Chinese herbal treatment cancer is the work of studying always and exploring, and present this cancer compound recipe is remembered with ten thousand, presses the controlling way and the effect of these medicines, and can be divided into has direct inhibitory or killing effect to cancerous cell; Can alleviate the patient suffering, prolong life cycle; Can improve the antitumor immune function, enhancing body body constitution.So natural drug treatment cancer can reduce that counteracting toxic substances uncharms and tonification is set upright two aspects and carried out.Though the anticancer natural composition document of Chinese patent is more, effectively the scope of application is narrower, and therapeutic effect is also unsatisfactory.
The purpose of this invention is to provide a kind of anti-cancer injection, have and make us ideal anticancerization tumor, anti-inflammatory analgetic, reparation body injury.Recover physiological function and enhance immunity effect.
Another object of the present invention provides this anti-cancer injection and preparation method thereof.
Solution of the present invention is based on the cancer therapy drug of selecting in motherland's medical treasure-house, and the counteracting toxic substances in the theory of Chinese medical science combined with eliminating stagnation, melt eliminating evil and set upright and be one, reinforcement and elimination in combination, just do not hindering to attack, to attack, benefit dislike evil, cancerous protuberance is dissipated, pyretic toxicity is cleared up pain and is ended, healthy energy is multiple, improve body's immunological function, and short treating period, fast, the no side effects of curative effect, drug safety, satisfactory for result.
A kind of anti-cancer injection, it is the injection of being made by the following weight proportion raw material:
Radix Astragali 5-15 part Moschus 5-15 part
Calculus Bovis 5-15 part Periostracum Serpentis 5-15 part
Hirudo 5-15 part Scolopendra 1-8 part
Scorpio 0.5-6 part speckle insect destructive of the roots of seedlings 0.5-6 part
Rhizoma Coptidis 5-15 part Radix Rhapontici 5-15 part
Semen Hydnocarpi 5-15 part Semen Armeniacae Amarum 5-15 part
Fructus Cnidii 5-15 part Plantula Papaveris 5-15 part
Fructus Quisqualis 5-15 part Semen Strychni 0.1-0.7 part
Herba Portulacae 5-15 part Cornu Saigae Tataricae 10-20 part
Radix Stellariae 5-15 part Cornu Bubali 25-35 part
Fel Ursi 5-15 part
Preparing injection prescription optimum weight proportioning of the present invention is:
10 parts in 10 parts of Moschus of the Radix Astragali
10 parts of 10 parts of Periostracum Serpentiss of Calculus Bovis
4 parts of 10 parts of Scolopendras of Hirudo
1.2 parts of 2 parts of speckle insect destructive of the roots of seedlings of Scorpio
10 parts of 10 parts of Radix Rhapontici of Rhizoma Coptidis
10 parts in 10 parts of Semen Armeniacae Amarums of Semen Hydnocarpi
10 parts of 10 parts of Plantula Papaveris of Fructus Cnidii
0.2 part of 10 parts of Semen Strychni of Fructus Quisqualis
15 parts of 10 parts of Cornu Saigae Tataricae of Herba Portulacae
30 parts of 10 parts of Cornu Bubalis of Radix Stellariae
10 parts of Fel Ursis
The production method of above-mentioned each component being made injection of the present invention is:
(1) with Rhizoma Coptidis, Radix Rhapontici, Semen Hydnocarpi, Semen Armeniacae Amarum, Fructus Cnidii, Plantula Papaveris, Herba Portulacae, Cornu Saigae Tataricae, Radix Stellariae and Cornu Bubali, clean dry chopping or section; The Radix Astragali honey parch; Moschus is put into 100 ℃ of water and is stirred into paste and insert 100 ℃ of water again and soak after 3 hours and get supernatant, and twice filtration is standby repeatedly; The Calculus Bovis levigation was got supernatant in eight hours with 80 ℃ of water loggings bubble, and to fry in shallow oil into extractum three times standby; Periostracum Serpentis Testa Tritici parching to brown; Hirudo vinegar system 30 minutes, reuse Chinese liquor are boiled to take out in 10 minutes and are used as medicine; Behind the little Huang of Scolopendra fire preparing, parched with bran vinegar boils and is used as medicine; Scorpio fire preparing salt is fried and is used as medicine; Reuse Chinese liquor boils and is used as medicine half an hour after the fire preparing of the speckle insect destructive of the roots of seedlings; The Fructus Quisqualis parching to brown is used as medicine, and Semen Strychni Oleum sesami parching to brown pulverizing is used as medicine; The Fel Ursi pulverizing is used as medicine;
(2) Chinese medicine and the extract of above-mentioned preparation are inserted adding 2.4-2.7 premium on currency in the container, 100 ℃ of water temperatures are boiled and were taken out clear liquid in 40 minutes, repeat to add water logging once more and boil 2 times, and 3 decocting liquids are merged freezing precipitation 20 hours; Get the Chinese herbal medicine extractum that supernatant concentration becomes water content 45-50%; Add 1000 milliliters in water by every 50g extractum, heat 100 ℃, fried in shallow oil 30-50 minute, plate-and-frame filtration, filtrate adding, account for the active carbon of volume ratio 0.05%-0.08% and the tween 80 of 0.03-0.05% volume ratio, and with 20%HaOH accent pH to 6-8, add 1000 ml distilled waters after the filtration again, behind the fine straining, filtrate is through fill, the sealing by fusing sterilization is distributed into 2ml peace bottle injection.
Contain active ingredient 0.02g in 1 milliliter of injection of the present invention.
The clinical result of use of injection of the present invention is obvious, and various cancers of available treatment and scrofula sore, carbuncle are treated skin ulcer, medication every day once, 21 days is a course of treatment, a 2ml adopts intramuscular injection or acupoint injection therapy.
Injection of the present invention is through Heilongjiang Prov. Tumour Hospital, Heilongjiang Province Academy of Traditional Chinese Medicine Pharmaceutical Manufacturing Plant, Beijing treatment and prevention of tumour institute, Sichuan tumour hospital institute is made poison of drug, pharmacological effect experimental results show that, the animal experiment effective percentage is 95.2%, tumour inhibiting rate 62.7%, and remission rate is more than 70%.
For showing therapeutic effect of the present invention, select body weight 18-20g Switzerland male mice for use, select random packet, 10 every group, every group of average body method of double differences is less than 0.5g.
Be divided into experimental group and matched group, the experimental group administration once a day, 52mg/kg, successive administration 7 days, control group administered physiological saline 0.4ml, color Pu EAC tumor pearl will grow on the 8th day under aseptic condition, with 1: 3 times (about 2,500 ten thousand cancerous cell) of normal saline dilution, inoculate 0.2ml in mice right fore subcutaneous abdomen, the inoculation back is normal raised 7 days, the 8th day execution mice, weigh respectively and get tumor and weigh, experimental group and matched group relatively have significant inhibitory effect, average tumour inhibiting rate 50%, P＜0.05-0.001.
Injection of the present invention is tested through allergy, and hemolytic test, abnormal toxicity test show that injection is nontoxic, have no side effect drug safety.The present invention is 50% to hepatocarcinoma and patients with lung cancer cure rate, to other cancer patient cure and effective percentage about 40%.In clinical hundreds of cancer patients, in being, terminal cancer shifts the patient, except that cure rate, coefficient of stabilization reaches that survival rate reaches more than 90% more than 52%, one year.
Injection of the present invention adopts the acupoint injection therapy method, or intramuscular injection, is convenient to treatment, makes things convenient for treatment, short treating period, curative effect be fast, the medication handy and safe.
Embodiment
Take by weighing raw material by following proportioning:
Radix Astragali 12g Moschus 12g
Calculus Bovis 11g Periostracum Serpentis 12g
Hirudo 11g Scolopendra 4g
Scorpio 2g speckle insect destructive of the roots of seedlings 1.9g
Rhizoma Coptidis 12g Radix Rhapontici 12g
Semen Hydnocarpi 12g Semen Armeniacae Amarum 12g
Fructus Cnidii 12g Plantula Papaveris 12g
Fructus Quisqualis 12g Semen Strychni 0.6g
Herba Portulacae 12g Cornu Saigae Tataricae 15g
Radix Stellariae 12g Cornu Bubali 25g
Fel Ursi 10g
With Rhizoma Coptidis, Radix Rhapontici, Semen Hydnocarpi, Semen Armeniacae Amarum, Fructus Cnidii, Plantula Papaveris, Herba Portulacae, Cornu Saigae Tataricae, Radix Stellariae and Cornu Bubali chopping section.The close parch of the Radix Astragali.Moschus, 100 ℃ of water are made paste, 100 ℃ of insulations 3 hours, get supernatant, and repeatedly twice, it is standby to merge 3 supernatant, and supernatant was got in 80 ℃ of water loggings of Calculus Bovis levigation in 8 hours, and to fry in shallow oil into paste three times standby.Serpentis takes off the Testa Tritici parching to brown, and Hirudo vinegar system wine boils.Parched with bran vinegar boils and is used as medicine after the Scolopendra fire preparing.Scorpio fire preparing salt is fried and is used as medicine.Speckle insect destructive of the roots of seedlings fire preparing wine boils and is used as medicine.The Fructus Quisqualis parching to brown is used as medicine, and Semen Strychni Oleum sesami parching to brown pulverizing is used as medicine.The Fel Ursi pulverizing is used as medicine.
Above-mentioned Chinese medicine for preparing and extract are inserted adding 2.6 premium on currency in the container.Water temperature was boiled 40 minutes for 100 ℃, took out clear liquid, added 2.6 boiled water again and boiled, and took out clear liquid, and repeated once in 40 minutes.3 decocting liquids are merged, freezing precipitation 20 hours is got the Chinese herbal medicine extractum that supernatant concentration becomes water content 45-50%, adds aquae destillata 1000ml by every 50g extractum, heat 100 ℃, fried in shallow oil 45 minutes, plate-and-frame filtration, filtrate adds and the activated carbon of volume ratio 0.05% and the tween 80 of 0.03% volume ratio, and with 20%NaOH accent pH7, add 1000 ml distilled waters after the filtration again, G filter stick, the low and silk C3 filter bulb 0.45 μ filtering with microporous membrane of outsourcing filter.Filtrate is through fill, sealing by fusing sterilization, and packing 2ml pacifies the bottle injection.
Claims (3)
1, a kind of anti-cancer injection is characterized in that: it is the injection of being made by the following weight proportion raw material:
Radix Astragali 5-15 part Moschus 5-15 part
Calculus Bovis 5-15 part Periostracum Serpentis 5-15 part
Hirudo 5-15 part Scolopendra 1-8 part
Scorpio 0.5-6 part speckle insect destructive of the roots of seedlings 0.5-6 part
Rhizoma Coptidis 5-15 part Radix Rhapontici 5-15 part
Semen Hydnocarpi 5-15 part Semen Armeniacae Amarum 5-15 part
Fructus Cnidii 5-15 part Plantula Papaveris 5-15 part
Fructus Quisqualis 5-15 part Semen Strychni 0.1-0.7 part
Herba Portulacae 5-15 part Cornu Saigae Tataricae 10-20 part
Radix Stellariae 5-15 part Cornu Bubali 25-35 part
Fel Ursi 5-15 part.
2, anti-cancer injection according to claim 1 is characterized in that: each proportion of raw materials is:
10 parts in 10 parts of Moschus of the Radix Astragali
10 parts of 10 parts of Periostracum Serpentiss of Calculus Bovis
4 parts of 10 parts of Scolopendras of Hirudo
1.2 parts of 2 parts of speckle insect destructive of the roots of seedlings of Scorpio
10 parts of 10 parts of Radix Rhapontici of Rhizoma Coptidis
10 parts in 10 parts of Semen Armeniacae Amarums of Semen Hydnocarpi
10 parts of 10 parts of Plantula Papaveris of Fructus Cnidii
0.2 part of 10 parts of Semen Strychni of Fructus Quisqualis
15 parts of 10 parts of Cornu Saigae Tataricae of Herba Portulacae
30 parts of 10 parts of Cornu Bubalis of Radix Stellariae
10 parts of Fel Ursis.
3, a kind of method for preparing the described anti-cancer injection of claim 1 is characterized in that:
(1) with Rhizoma Coptidis, Radix Rhapontici, Semen Hydnocarpi, Semen Armeniacae Amarum, Fructus Cnidii, Plantula Papaveris, Herba Portulacae, Cornu Saigae Tataricae, Radix Stellariae and Cornu Bubali, clean dry chopping or section; The Radix Astragali honey parch; Moschus is put into 100 ℃ of water and is stirred into paste and insert 100 ℃ of water again and soak after 3 hours and get supernatant, and twice filtration is standby repeatedly; The Calculus Bovis levigation was got supernatant in eight hours with 80 ℃ of water loggings bubble, and to fry in shallow oil into extractum three times standby; Periostracum Serpentis Testa Tritici parching to brown; Hirudo vinegar system 30 minutes, reuse Chinese liquor are boiled to take out in 10 minutes and are used as medicine; Behind the little Huang of Scolopendra fire preparing, parched with bran vinegar boils and is used as medicine; Scorpio fire preparing salt is fried and is used as medicine; Reuse Chinese liquor boils and is used as medicine half an hour after the fire preparing of the speckle insect destructive of the roots of seedlings; The Fructus Quisqualis parching to brown is used as medicine, and Semen Strychni Oleum sesami parching to brown pulverizing is used as medicine; The Fel Ursi pulverizing is used as medicine;
(2) Chinese medicine and the extract of above-mentioned preparation are inserted adding 2.4-2.7 premium on currency in the container, 100 ℃ of water temperatures are boiled and were taken out clear liquid in 40 minutes, repeat to add water logging once more and boil 2 times, and 3 decocting liquids are merged freezing precipitation 20 hours; Get the Chinese herbal medicine extractum that supernatant concentration becomes water content 45-50%; Add 1000 milliliters in water by every 50g extractum, heat 100 ℃, fried in shallow oil 30-50 minute, plate-and-frame filtration, filtrate adding, account for the active carbon of volume ratio 0.05%-0.08% and the tween 80 of 0.03-0.05% volume ratio, and with 1.20%HaOH accent pH to 6-8, add 1000 ml distilled waters after the filtration again, behind the fine straining, filtrate is through fill, the sealing by fusing sterilization is distributed into 2ml peace bottle injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99103528A CN1081056C (en) | 1999-04-02 | 1999-04-02 | Anticancer injection and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99103528A CN1081056C (en) | 1999-04-02 | 1999-04-02 | Anticancer injection and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1269221A CN1269221A (en) | 2000-10-11 |
| CN1081056C true CN1081056C (en) | 2002-03-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99103528A Expired - Fee Related CN1081056C (en) | 1999-04-02 | 1999-04-02 | Anticancer injection and its preparation method |
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| Country | Link |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1034985A (en) * | 1988-02-12 | 1989-08-23 | 德利信电机株式会社 | Worm and worm-wheel gearing |
| CN1130088A (en) * | 1995-12-28 | 1996-09-04 | 安徽药都药业有限公司 | Pure traditional Chinese medicinal anti-cancer drug |
-
1999
- 1999-04-02 CN CN99103528A patent/CN1081056C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1034985A (en) * | 1988-02-12 | 1989-08-23 | 德利信电机株式会社 | Worm and worm-wheel gearing |
| CN1130088A (en) * | 1995-12-28 | 1996-09-04 | 安徽药都药业有限公司 | Pure traditional Chinese medicinal anti-cancer drug |
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| Publication number | Publication date |
|---|---|
| CN1269221A (en) | 2000-10-11 |
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Granted publication date: 20020320 Termination date: 20110402 |