CN1080863A - A kind of anti-alcoholic health care medicinal composition - Google Patents

Abstract

The invention discloses a medicinal composition for hangover, which consists of kudzu Composed of flowers, green bark and ginseng stem and leaf saponins, it has the effect of hangover health care, and can To make capsules, tablets, granules, teas, oral liquids.

Description

The invention relates to a medicine for hangover, which is a traditional Chinese medicine preparation made by using Chinese herbal medicine as a raw material through a specific processing technology.

Drinking alcohol is a hobby of most people, but excessive drinking can cause serious damage to the human body. After alcohol enters the human body, the alcohol is absorbed into the blood, and the alcohol concentration in the blood also increases correspondingly with the increase of the amount of drinking. When the alcohol concentration in the blood reaches more than 0.5%, high depression, drowsiness, disturbance of consciousness, and incontinence may occur, such as If timely rescue is not carried out, death may occur due to respiratory paralysis. Therefore for people who drink excessively, it is very necessary to have a kind of anti-alcoholic medicine to alleviate and treat its alcoholism. At present, there is not yet a kind of definite anti-alcoholic medicine for doctors to choose and use clinically.

The object of the present invention is to provide a drug preparation for anti-alcoholism.

Another object of the present invention is to provide a processing technology for the above-mentioned anti-alcohol preparation.

The prescription and the preparation process of the anti-alcoholic medicament of the present invention are as follows:

Prescription composition: kudzu flower, green bark, ginseng stem and leaf saponin.

The consumption ratio of each component in the above-mentioned prescription is (weight ratio):

Pueraria japonica: green bark: ginseng stem and leaf saponin=25-35:5-15:0.5-2.

The optimal weight ratio between each component is:

Pueraria japonica: green bark: ginseng stem and leaf saponins = 30:10:1.

The ginseng stem and leaf saponin used in the above prescription is a light brown powder extracted from the ginseng stem and leaf, and is a saponin extract with hygroscopicity [refer to: "Acta Pharmacologica" 1983, Volume 18, No. 10]. The ginseng stem and leaf saponins used in the present invention should meet the quality requirements of the approval document No. (84) 942-66 "Reply on Interim Quality Standards for Ginsenosides".

In the actual preparation process, conventional pharmaceutical excipients, such as starch and dextrin, can also be added to the above prescription. The amount of excipients added is not critical to the effect of the drug, and those skilled in the art can choose the usual amount according to actual needs.

The above-mentioned pharmaceutical composition can be prepared into different dosage forms, such as electuary, tea, tablet, capsule, oral liquid and the like.

Now combine the capsule dosage form to illustrate its processing technology.

2. Preparation process

(1) Process flow

Raw materials→decocting→filtering→concentrating→adding ginsenosides→drying→crushing→sieving→adding appropriate amount of starch and mixing→filling in capsules→packing.

(2) Operation process

According to the amount of raw materials in the composition of the prescription, weigh Pueraria japonica and Qingpi, moisten with 12 times of water, heat and boil for 1 hour and filter with gauze. Add 7-8 times of water to the dregs, boil for 40 minutes, and filter according to the above method. Combine the filtrates, concentrate under reduced pressure to a thin paste, add the prescribed amount of ginseng stem and leaf saponins, and dry under reduced pressure at 60-80°C. The dry matter is crushed and passed through an 80-mesh sieve, and the dry powder is mixed with an appropriate amount of starch and packed into capsules, and the capsule core is about 0.48 grams.

(3) Process Description

1. The basis for extraction by decoction

In this prescription, Pueraria lobata is the monarch drug. The main sobering active ingredients in kudzu flower are water-soluble ingredients, so decoction with water can better exert the medicinal effect. The main active ingredients in Qingpi are flavonoid glycosides, which also have good solubility in hot water, so the extraction of this prescription adopts the water decoction method.

2. Examination of cooking time

The main ingredients of this prescription are Pueraria japonica and Qingpi. They both contain isoflavones and flavanones respectively, and have the maximum absorption near 270nm in UV, which can be used as the main ingredients to examine the extraction process. The UV absorption spectrum of the total extract is shown in the accompanying drawing.

After feeding according to the prescription amount, extract three times in total, take samples every 20 minutes from the boiling time, and measure the UV absorbance at 275nm, the values are shown in Table 1 and Figure 1. Figure 1 is the dissolution rate curve.

The experimental result of table 1 extraction number of times and extraction percentage Extraction times 1 2 3 The absorbance of each extraction solution at equilibrium 0.51 0.21 0.10 Extraction percentage (%) 64.8 23.9 11.4

Conclusion The following conclusions can be drawn from the experimental results in the above table and diagrams:

(1) It is advisable to decoct and extract for the first time for 1 hour. Because the absorbance has reached equilibrium in 60 minutes during the first extraction and no longer increases, indicating that the maximum extraction rate has been reached, and the solvent should be renewed.

(2) When decocting and extracting for the second time, the extraction absorbency does not change after 40 minutes, which also shows that the extraction is relatively complete.

3. Determination of the number of times of decoction

After feeding according to the prescription amount, it was extracted three times in total, and the absorbance of purple part was measured. The absorbance shown in Table 2 represents the extraction rate. The extraction rates of the first, second and third decoctions are 64.8%, 23.9% and 11.4% respectively. Among them, the first and second decoctions account for 88.7% of the total extraction rate, and most of the active ingredients in the crude drug have been extracted, so it is determined to only extract twice in consideration of various factors such as cost and energy consumption.

4. Examination of the ointment rate:

We conducted a total of three batches of raw materials to examine the yield of the extract, and the yield of the extract was about 17%→20% after the two extractions were concentrated. The results are shown in the table below:

batch number Feed amount (g) Amount of extract (g) Paste yield (%) 920417 240 40 16.7 920418 240 42 17.5 920419 240 47 19.6

The anti-alcoholic drug of the invention has good anti-alcoholic and sober functions. When it is shown by rolling rod test and recovery test, the medicament of the present invention has better anti-acute alcoholism ability, and obviously delays the time for animals to start getting drunk, and shortens the animals' drowsiness. It is a definite anti-alcoholic medicine.

Example 1

Take 1500g of kudzu flower and 500g of green skin, add 12 times of water to infiltrate, heat and boil for 1 hour, filter with gauze, add 7-8 times of water to the dregs and boil for 40 minutes, then filter with gauze, combine the filtrates, concentrate under reduced pressure to dilute Paste, add 50g of ginseng stem and leaf saponins, dry under reduced pressure at 60-80°C, crush the dry matter and pass through an 80-mesh sieve, add an appropriate amount of starch and mix to make a total of 500g, put it into a capsule, and the capsule content is about 0.5g.

Claims (9)

1. A medicinal composition for hangover, characterized in that it is made up of the following components: kudzu flower, green bark, ginseng stem and leaf saponin, and the weight ratio between each component is kudzu flower: green bark: ginseng stem and leaf saponin= 25-35:5-15:0.5-2. 2. The pharmaceutical composition according to claim 1, characterized in that the weight ratio between the components is: Pueraria japonica: green bark: ginseng stem and leaf saponins = 30:10:1. 3. The pharmaceutical composition according to claim 1, characterized in that pharmaceutically acceptable excipients can also be added. 4. Pharmaceutical composition according to claim 3, characterized in that said excipient is starch. 5. A preparation method of a hangover medicinal composition, which is characterized in that kudzu flower, green bark, ginseng stem and leaf saponin=0.5-35:5-15:0.5-2 (weight ratio) are used as raw materials, first kudzu flower, Add water to decoct green bark, filter and concentrate, add ginsenoside, dry and pulverize, sieve, add appropriate amount of starch and mix well to make medicinal dosage form. 6, according to the preparation method of claim 5, it is characterized in that take kudzu flower and Qingpi and moisten with 12 times of water, heat and boil for 1 hour and filter with gauze, add 7-8 times of water to the dregs and boil for 40 minutes, according to the above method Filtrate, combine the filtrates, concentrate under reduced pressure to a thin paste, add the prescribed amount of ginseng stem and leaf saponins, dry under reduced pressure at 60-80°C, crush the dry matter and pass through an 80-mesh sieve, add an appropriate amount of starch to the dry powder and mix well, and make it into a medicinal product dosage form. 7. The preparation method according to claim 6, said pharmaceutical dosage forms are capsules, tablets and granules. 8. The preparation method according to claim 6, said pharmaceutical dosage form is tea. 9. The preparation method according to claim 6, characterized in that said dosage form is oral liquid.

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