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CN108030800A - A kind of composition for improving mankind spermatozoon quality - Google Patents

A kind of composition for improving mankind spermatozoon quality Download PDF

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Publication number
CN108030800A
CN108030800A CN201810137019.9A CN201810137019A CN108030800A CN 108030800 A CN108030800 A CN 108030800A CN 201810137019 A CN201810137019 A CN 201810137019A CN 108030800 A CN108030800 A CN 108030800A
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parts
composition
lacquer tree
ginseng
mankind spermatozoon
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CN201810137019.9A
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王忠良
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/22—Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of composition for improving mankind spermatozoon quality, it is characterised in that it is made of the raw material of following parts by weight：15~40 parts of maca, 5~15 5~15 parts of Fen , china dodders of lacquer tree seed extract, 5~30 parts of cynomorium songaricum, 5~30 parts of ginseng.The composition of the present invention is capable of the function of tonifying kidney and strengthening yang strengthening the essence, effectively improvement kidney, improves the purpose of mankind spermatozoon quality and quantity.

Description

A kind of composition for improving mankind spermatozoon quality
Technical field
The invention belongs to pharmaceutical technology field, more particularly to a kind of composition for improving mankind spermatozoon quality.
Background technology
According to World Health Organization, worldwide, in married couple there are about 5%~30% cannot give birth to, it is infertile not The ratio educated is more prominent in developing country, incidence about 10% in China, and is gradually increasing trend.Wherein male sterility It is an important factor for causing human reproduction's obstacle, to account for 40%-60%.In recent years, auxiliary procreation technology and appearance, such as manually award Smart (IUI), in vitro fertilization-embryo transfer (IVF) and intracytoplasmic sperm injection（ICSI）Deng to solve human reproduction's obstacle Provide strong means.But the either maintenance of normal reproduction function, or the treatment of auxiliary procreation technology all refer to essence The quality of son, maintains the quality for even improving sperm to have for solving human reproduction's obstacle, the success rate for improving supplementary reproduction Important effect.
It can produce sperm in Infertility male more than 85%, but most poor quality, clinically it is usually expressed as few essence Sub- disease, asthénospermie and teen bra, i.e. sperm number are very few, or locomitivity is low, this causes male sterility Major reason.Spermatogenesis is an extremely complex process, is spermatogonium Growth and Differentiation and ripe one continuous dynamic Process.There are many cell factors and local adjusting to play important function during sperm development at the same time, production of sperm is thin The collective effect of born of the same parents, sertoli cell and interstitial cell maintain spermatogenetic particular surroundings.Appointing in spermatogenesis Obstacle occurs for what link, can influence the quality of sperm, cause male sterility.Except gene mutation and chromosome abnormality etc. Inherent cause, the disease factor such as environmental factor and infection is the major reason for causing spermatogenesis obstacle.
Maca, and translate agate card（Scientific name：Lepidium meyenii Walp.）,（It is Spanish：Maca）.It is to originate in South America A kind of Andean crucifer in continent.Leaf is oval, and rhizome likeness in form turnip radish, edible, is a kind of pure natural food Product, nutrition are enriched, and have the reputation of " South America ginseng ".Chemical composition composition in the dry root of agate card：Protein content for 10% with On, 59% carbohydrate；8.5% fiber, include abundant zinc, calcium, iron, titanium, rubidium, potassium, sodium, copper, manganese, magnesium, strontium, phosphorus, The mineral matters such as iodine, and containing vitamin C, B1, B2, B6, A, E, B12, B5, fat content is not high but is wherein mostly unsaturated lipid Fat acid, up to more than 53%, natural activity composition includes alkaloid, glucosinolate and its decomposes production the content of linoleic acid plus linolenic acid Thing benzyl isothiocyanate, sterol, polyphenols etc..
Lacquer tree, belongs to Anacardiaceae, deciduous tree, up to 20 meters, there is milk.Chinese lacquer tree is widely distributed, substantially in 25 ° of north latitude ~ 42 °, the mountain area between 95 ° ~ 125 ° of east longitude.The area that Qin-ba Mountains and the Yunnan-Guizhou Plateau are concentrated for lacquer tree distribution.China's lacquer tree money Source is enriched, a great variety, and China there are about 500,000,000 plants of lacquer trees according to investigations.It is ripe annual 9~October of autumn to paint seed, be divided into exocarp, Middle pericarp and kernel.Exocarp is film quality layer, and middle pericarp is wax coat, light yellow or celadon.Research shows, paints seed exocarp With the middle pericarp content of wax 40%~45%.Kernel is seed, generally by 2%~4% moisture, 18%~20% thick protein, 15%~18% thick Fatty (urushoil), 30%~35% carbohydrate, 25%~30% fiber and 1%~3% ash composition.Lacquer tree fat chemical composition by 90%~ 95% glyceryl ester, 3%~15% free fatty, 1%~2% free alkyl alcohol composition, wherein conjugated fatty acid is by 70%~75% palm fibre Palmitic acid acid, 3%~5% stearic acid, 15%~35% oleic acid, 2%~5% binary of fatty acids composition.Contain more than 70% palmitic acid in lacquer tree fat, 15%~35% oleic acid and 3%~5% stearic acid.Contain 60% linoleic acid and 20% oleic acid in urushoil, refined palm can be directly separated Acid, stearic acid, oleic acid and linoleic acid and its salt.Lacquer tree seed nucleolus oil comes from lacquer tree seed nuclei, recovery rate 10%~12%, in oil product Linoleic acid content is up to more than 80%, while also contains certain leukotrienes, is the very high woody edible oil of nutritive value.
Semen Cuscutae is convolvulaceous dry mature seed, and property is sweet, warm, returns kidney, liver, warp, has nourishing liver and kidney, controlling nocturnal emission with astringent drugs The effect of contracting urine, tocolysis, improving eyesight, antidiarrheal.《Sheng Nong's herbal classic》It is classified as top grade.Semen Cuscutae has tonic effect, Gan Xinwei Temperature, examines gas neutralization, not only can yang-tonifying, but also can benefit it is cloudy, have it is warm but not dry, mend without it is stagnant the characteristics of.Semen Cuscutae be flat kidney tonifying simply, Liver, the good medicine of spleen, clinic are mainly used in lumbago due to the kidney deficiency, positive paralysis seminal emission, frequent micturition, uterus cold infertile, the mesh secretly just kidney yin deficiency of yang such as pool Disease.Experimental studies have found that Semen Cuscutae seemingly plays the role of protecting human sperm.Such as：Freezing people is added with Semen Cuscutae water extracting liquid The protection liquid of sperm, living spermatozoa percentage and vigor significantly improve.Another research also found Semen Cuscutae Aqueous extracts to active oxygen institute The sperm ultrastrueture damage of cause has protective effect.Zoopery also confirms that the class androgen-like action of Semen Cuscutae, which has, to be protected Protect the reproductive organs of buck, promote the functions such as testicualr development, the oxidative damage for preventing androgone and apoptosis.
Cynomorium songaricum（Scientific name：Cynomorium songaricum Rupr.）, nature and flavor are sweet；It is warm-natured.Effect kidney-replenishing, benefiting essence-blood, Relax bowel.The more provinces and regions of China are distributed in, the Central Asia, Iran, Mongolia are also distributed.It is born in desert steppe, steppificated desert and famine The habitats such as the river bank in unconcerned area, lakeside, pool side and there are white thorn, batch varieties in saline-alkali areas that bavin is grown.The kidney tonifying of cynomorium songaricum energy, strengthening the essence, profit It is dry, impotence and seminal emission, soreness and weakness of waist and knees, dry constipation of intestines are cured mainly, sexual performance is weak has certain effect to paralysing and improving.
Ginseng（Panax ginseng C. A. Mey）For herbaceos perennial, it is grown between 33 ° ~ 48 ° of north latitude The theropencedrymion based on Korean pine of hundreds of meters of height above sea level or broad leaved and deciduous broad leaved hayashishita, originate in Northeast China, Korea, South Korea, Japan, Russian east.The nickname of ginseng is yellow ginseng, it is smart, god is careless, the king of hundred grass, be one of well-known " northeast Triratna ".People Ginseng nature and flavor are sweet in flavor, slight bitter, warm-natured, flat.Returns spleen, lung channel, the heart channel of Hang-Shaoyin.Tonifying Qi, prevent prolapse, promotes the production of body fluid, and calms the nerves, intelligence development.The fleshy root of ginseng For famous strong tonic, suitable for adjustment blood pressure, recover cardiac function, neurasthenia and the disease such as in poor health, also have eliminating the phlegm, Stomach invigorating, diuresis, excitement and other effects.Contain panaxoside 0.4%, a small amount of volatile oil in root.Main ingredient is panacene in oil （Panacen, C15H24）0.072%.Soaping agents are isolated from root according to reports：Panaxoside A, B, C, D, E and F （panaxosideA、B、C、D、E、F）Deng.Panaxoside A（C42H72O14）, it is panaxoside A（ginsenosideRg1）.People Panaxatriol is produced after ginseng saponin B and C hydrolysis（panaxatriol）Sapogenin, 20- tables are obtained after panaxoside D, E and F hydrolysis Panoxadiol（20-epiprotopanaxo-diol）Sapogenin.Again from the low boiling point of ether extract be partially separated out β- Elemene（β-elemene, C15H24）.High-boiling fration isolates Panaxynol（Panaxynol, C17H26O）.In addition still contain Monosaccharide：Glucose, fructose, sugarcane candy, three kinds of trisaccharides：Glucose-Fructose-fructose, three polydextroses, glucose-grape Sugar-fructose, panax acid（For palmitic acid, stearic acid and linoleic mixture）, more clock vitamins（B1, B2, Yan acid, Yan acyls Amine, pantothenic acid）, a variety of amino acid, choline, enzyme（Maltose, invertase, esterase）, spermine（spermine）And cholamine （cholamine）.The aerial part of ginseng contains flavone compound, and people claims ginseng Huang glucoside（panasenoside）, trilobatin （trifolin）, kaempferol, panaxoside, cupreol and carbohydrate.
The content of the invention
Regarding the issue above, the present invention provides a kind of composition for improving mankind spermatozoon quality, it can be mended Kidney and enhancing body strengthening the essence, effectively improves the function of kidney, improves the quality of sperm.
To achieve the above object, the present invention adopts the following technical scheme that：
A kind of composition for improving mankind spermatozoon quality, it is characterised in that its component is made of the raw material of following parts by weight：Maca 15~40 parts, 5~15 5~15 parts of Fen , china dodders of lacquer tree seed extract, 5~30 parts of cynomorium songaricum, 5~30 parts of ginseng.
Above raw material can reach tonifying kidney and benefiting sperm, improve the effect of mankind spermatozoon quality after affiliated parts by weight of composition.
Preferably, it is of the present invention it is a kind of improve mankind spermatozoon quality composition by following parts by weight raw material group Into：15~40 parts of maca, 5~15 5~15 parts of Fen , china dodders of lacquer tree seed extract, 5~30 parts of cynomorium songaricum, 5~30 parts of ginseng.
Preferably, it is of the present invention it is a kind of improve mankind spermatozoon quality composition by following parts by weight raw material group Into：30 parts of maca, 5 10 parts of Fen , china dodders of lacquer tree seed extract, 10 parts of cynomorium songaricum, 10 parts of ginseng.
Lacquer tree seed extract in composition of the present invention in lacquer tree seed wax or/and lacquer tree seed nucleolus oil at least It is a kind of
Composition of the present invention can prepare the oral formulations such as pelletization, granule, capsule, tablet.
Preparation method, can use conventional method in pharmaceutics to be prepared.
It is as follows that the present invention provides a kind of preparation method of tablet herein：Raw material of the present invention is weighed, is cleaned respectively, 60 DEG C It dry, pulverize, after crossing 100 mesh sieves, be uniformly mixed below.Mixed medicinal powder is added into appropriate distilled water and microcrystalline cellulose again Element, is put into tablet press machine and can be made into tablet, is finished product after dry.The usage and dosage of tablet of the present invention is：It is oral, often Secondary 2~4 ball.Two times a day or follow the doctor's advice.Usual a month as a treatment course.When ball, granule, capsule is such as made, it can join The taking dose of photo agent.Pungent and tobacco and wine should be avoided during taking the present composition.Medicine of the present invention has tonifying kidney and benefiting sperm, disappears Stagnation resolvation heat, the effect for promoting testicular spermatogenic and cell development, are remarkably improved sperm quantity and sperm survival rate and sperm is lived Power.The present composition can be used for treating aspermia or oligospermia, particularly suitable for the male caused by few smart, weak essence or sperm quality be not good enough not Educate disease.Medicine of the present invention can also be used to treat the diseases such as impotence and premature ejaculation, the weak, dizziness and tinnitus of the soreness of waist.
The beneficial effects of the present invention are：Composition of the present invention can reach tonifying kidney and benefiting sperm, improve male Sperm quality（It is good to improve living spermatozoa percentage, motility of sperm）Effect；Except good, the sperm that can make male's kidney qi after taking Quality is high.Male often takes, and can play strengthening spleen, tonifying kidney, Yang strengthening and life essence tonifying, life quality is high, the effect promoted longevity.This The invention composition has the advantages that quick, safe and reliable, without any side effects, informal dress is uneasy to recur at the same time, passes through Thousands of related disorder patients' takes verification, efficient up to 98%, and success rate is up to more than 80%.
Embodiment
To better illustrate the content in the present invention, it is described further with reference to specific embodiment.
Embodiment 1
Weigh following raw material：40 parts of maca, 5 10 parts of Fen , china dodders of lacquer tree seed extract, 5 parts of cynomorium songaricum, 5 parts of ginseng.
Preparation method：Raw material of the present invention is weighed, is cleaned respectively, less than 60 DEG C dry, pulverize, and after crossing 100 mesh sieves, mix Close uniform.Mixed medicinal powder is added into lacquer tree seed extract again（Lacquer tree seed nucleolus oil）Mix thoroughly, then add appropriate distilled water and micro- Crystalline cellulose is put into tabletting in tablet press machine after mixing thoroughly can be made tablet, be finished product after dry.
Embodiment 2
Weigh following raw material：15 parts of maca, 85 parts of Fen , china dodders of lacquer tree seed extract, 5 parts of cynomorium songaricum, 5 parts of ginseng.
Preparation method：Raw material of the present invention is weighed, is cleaned respectively, less than 60 DEG C dry, pulverize, and after crossing 100 mesh sieves, mix Close uniform.Again by lacquer tree seed extract（Lacquer tree seed wax and lacquer tree seed nucleolus oil, mass ratio 1:1）After mixing being added after heating fusing Medicinal powder mix thoroughly, add appropriate distilled water and microcrystalline cellulose, tablet can be made by being put into tabletting in tablet press machine, after dry, i.e., For finished product.

Claims (4)

1. a kind of composition for improving mankind spermatozoon quality, it is characterised in that its component is made of the raw material of following parts by weight：Agate 15~40 parts of coffee, 5~15 5~15 parts of Fen , china dodders of lacquer tree seed extract, 5~30 parts of cynomorium songaricum, 5~30 parts of ginseng.
2. a kind of composition for improving mankind spermatozoon quality according to claim 1, it is characterised in that by following parts by weight Raw material composition：30 parts of maca, 5 10 parts of Fen , china dodders of lacquer tree seed extract, 10 parts of cynomorium songaricum, 10 parts of ginseng.
3. a kind of composition for improving mankind spermatozoon quality according to claim 1, it is characterised in that contain maca.
4. a kind of composition for improving mankind spermatozoon quality according to claim 1, it is characterised in that carried containing lacquer tree seed Take thing.
CN201810137019.9A 2018-02-09 2018-02-09 A kind of composition for improving mankind spermatozoon quality Withdrawn CN108030800A (en)

Priority Applications (1)

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CN201810137019.9A CN108030800A (en) 2018-02-09 2018-02-09 A kind of composition for improving mankind spermatozoon quality

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CN201810137019.9A CN108030800A (en) 2018-02-09 2018-02-09 A kind of composition for improving mankind spermatozoon quality

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109674833A (en) * 2019-03-01 2019-04-26 广东香山堂制药有限公司 A kind of medicinal external emulsifiable paste and preparation method thereof for treating erectile dysfunction

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WO2007087667A3 (en) * 2006-02-03 2008-02-28 Fapa Vital Anstalt Combination preparation for improving sperm quality
CN104560570A (en) * 2015-01-09 2015-04-29 杨昊军 Maca juice liquor and preparation method thereof
CN105434576A (en) * 2015-11-27 2016-03-30 天津天狮生物发展有限公司 Composition with male healthcare function and preparation method thereof
CN106578899A (en) * 2016-12-30 2017-04-26 贝克尔（天津）药业有限公司 Instant cereal powder for improving male sperm motility
CN107557136A (en) * 2017-07-31 2018-01-09 长沙爱扬医药科技有限公司 Rhus succedanea seed oil method is extracted from Rhus succedanea seed

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007087667A3 (en) * 2006-02-03 2008-02-28 Fapa Vital Anstalt Combination preparation for improving sperm quality
CN104560570A (en) * 2015-01-09 2015-04-29 杨昊军 Maca juice liquor and preparation method thereof
CN105434576A (en) * 2015-11-27 2016-03-30 天津天狮生物发展有限公司 Composition with male healthcare function and preparation method thereof
CN106578899A (en) * 2016-12-30 2017-04-26 贝克尔（天津）药业有限公司 Instant cereal powder for improving male sperm motility
CN107557136A (en) * 2017-07-31 2018-01-09 长沙爱扬医药科技有限公司 Rhus succedanea seed oil method is extracted from Rhus succedanea seed

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Title
徐波等: "弱精子症的中医证治研究", 《中国当代医药》 *
徐福松: "《徐福松实用中医男科学》", 31 January 2009, 中国中医药出版社 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109674833A (en) * 2019-03-01 2019-04-26 广东香山堂制药有限公司 A kind of medicinal external emulsifiable paste and preparation method thereof for treating erectile dysfunction
CN109674833B (en) * 2019-03-01 2021-10-12 广东香山堂制药有限公司 External cream for treating erectile dysfunction and preparation method thereof

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