CN1078452A - Implantable porous ceramic anti-tuberculosis, anti-cancer, anti-inflammatory sustained-release body - Google Patents

Abstract

Implantable porous ceramic anti-tuberculosis, anti-cancer and anti-inflammatory sustained-release body, the invention relates to and bone tuberculosis, bone tumors, and implantable drugs that release drugs in lesions of osteomyelitis Sustained-release body, which mainly overcomes conventional treatment drugs, and its concentration in the lesion is low, It is difficult to control the survival and reproduction of residual bacteria, resulting in amputation of patients Residual problems, the present invention provides a kind of hydroxyapatite, aluminum phosphate as Main crystal phase, add appropriate amount of silicon oxide, calcium oxide, potassium carbonate, mix and calcined Sintered porous ceramic sustained-release body, the hollow cylindrical cavity of the slow-release body has drug implanted into the lesion of patients with bone disease, so that it can be released slowly, and the treatment The effective rate of bone tuberculosis is 95.4%, and the effective rate of bone tumor is 82%.

Description

The invention relates to an implantable slow-release body for releasing drugs in bone tuberculosis, bone swelling and pain, and osteomyelitis lesions.

At present, the treatment of common diseases such as bone tuberculosis, bone swelling and pain, osteomyelitis, etc. usually adopts conventional surgical focus debridement. It is easy to relapse, and even some patients have not healed for decades, and the concentration in the lesion is low due to frequent medication (injection, oral administration), making it difficult to control the growth and reproduction of residual bacteria. For the treatment of malignant bone tumors, amputation is often adopted, and the disability rate is high.

The purpose of the present invention is to provide a porous ceramic body, which can release the medicine in the ceramic body slowly, and can effectively kill the bacteria and tumor cells in the local lesion, and at the same time, the concentration in the lesion area is high, the concentration in the whole body is low, and the side effects of the medicine can be prevented. , in order to achieve the purpose of improving the treatment rate and rebuilding the functions of the limbs.

The specific technical solution for realizing the present invention is that the porous ceramic drug carrier is made of hydroxyapatite and aluminum phosphate as the main crystal phase, mixed and prepared by adding an appropriate amount of flux oxide, and is calcined at a high temperature to form a hollow cylinder , where the hollow cylinder is surrounded by evenly distributed release micropores.

Preparation and Examples of Porous Ceramic Carriers:

It is composed of hydroxyapatite, aluminum phosphate, silicon oxide, calcium oxide, potassium phosphate, its formula:

Using hydroxyapatite and aluminum phosphate as the main raw materials, adding an appropriate amount of flux oxides, the following two formulas are prepared:

Preparation Process:

配料→混合均匀 (950℃～1000℃)/(保温1hr) 煅烧→冷却 (120℃烘干2hr)/(加0.7%油酸) 球磨→加石腊和蜂蜡（干料量的30%）→加热熔化→搅拌→热压注成型→装钵（埋在Al₂O₃中烧成） (200～600℃)/() 排蜡 (1160～1200℃)/() 烧成→产品→超声波清洗→烘干→备用

Ingredients→mix evenly (950℃～1000℃)/(keep heat for 1hr) calcining→cooling (dry at 120℃ for 2hr)/(add 0.7% oleic acid) ball mill→add paraffin and beeswax (30% of dry material)→ Heating and melting→stirring→hot press injection molding→bottling (buried in Al ₂ O ₃ and firing) (200～600℃)/() wax removal (1160～1200℃)/() firing→product→ultrasonic cleaning →Drying→Standby

The drawings provided by the present invention are structural diagrams of implantable porous ceramic slow-release bodies. In the figure, (1) slow-release body, (2) cylindrical cavity, (3) cover.

Physicochemical properties and clinical effects of the porous ceramic drug carrier of the present invention:

Porosity (%) Pore Size (μm) Corrosion Resistance Biocompatibility Toxicity

10～20 <50 Good Good No

It has been clinically proven by the 200 series that as a carrier of anti-tuberculosis (ie anti-tuberculosis) anti-cancer and anti-inflammatory drugs, it can release high-concentration drugs in local lesions in the body for half a year without toxic side effects, and the effective rate of treating bone tuberculosis is 95.4%. 82%.

Claims (4)

1. A porous ceramic slow-release body for the treatment of bone tuberculosis, bone tumors, and osteomyelitis. It is composed of hydroxyapatite and aluminum phosphate as the main crystal phase, and an appropriate amount of flux oxide is added to mix and prepare. Under high-temperature calcination, A hollow cylinder is made, and release micropores are evenly distributed around the hollow cylinder. 2. The porous ceramic slow-release body according to claim 1, characterized in that hydroxyapatite is prepared from tricalcium phosphate and calcium hydroxide, and the ratio of tricalcium phosphate: calcium hydroxide is 92.63%: 7.37 %. 3. The porous ceramic slow-release body according to claim 1, characterized in that it is composed of hydroxyapatite and aluminum phosphate as the main crystal phase, adding an appropriate amount of silicon oxide, calcium oxide, and potassium carbonate, and its proportioning ratio is hydroxyphosphorus Limestone: aluminum phosphate: calcium oxide: potassium carbonate is 55%: 26.14%: 9.09%: 6.03%: 3.74%. 4. The porous ceramic slow-release body according to claim 1, 2, 3, characterized in that the calcination temperature is between 1160°C and 1200°C.

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