CN107802836B - 一种肿瘤靶向光热药剂及制备方法和应用 - Google Patents
一种肿瘤靶向光热药剂及制备方法和应用 Download PDFInfo
- Publication number
- CN107802836B CN107802836B CN201711311833.XA CN201711311833A CN107802836B CN 107802836 B CN107802836 B CN 107802836B CN 201711311833 A CN201711311833 A CN 201711311833A CN 107802836 B CN107802836 B CN 107802836B
- Authority
- CN
- China
- Prior art keywords
- tumor
- photothermal
- preparation
- medicament
- mote
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000003814 drug Substances 0.000 title claims abstract description 6
- HITXEXPSQXNMAN-UHFFFAOYSA-N bis(tellanylidene)molybdenum Chemical compound [Te]=[Mo]=[Te] HITXEXPSQXNMAN-UHFFFAOYSA-N 0.000 claims abstract description 13
- 230000008685 targeting Effects 0.000 claims abstract description 7
- 239000012221 photothermal agent Substances 0.000 claims description 19
- 239000002135 nanosheet Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 239000002246 antineoplastic agent Substances 0.000 claims description 4
- 239000002060 nanoflake Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 229910016021 MoTe2 Inorganic materials 0.000 claims description 3
- 230000009471 action Effects 0.000 claims description 3
- 239000013078 crystal Substances 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000002052 molecular layer Substances 0.000 claims description 3
- 229940041181 antineoplastic drug Drugs 0.000 claims description 2
- 238000000498 ball milling Methods 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 230000000259 anti-tumor effect Effects 0.000 abstract description 6
- 210000004881 tumor cell Anatomy 0.000 abstract description 6
- 230000002401 inhibitory effect Effects 0.000 abstract description 2
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 15
- 239000000463 material Substances 0.000 description 12
- 206010006187 Breast cancer Diseases 0.000 description 7
- 208000026310 Breast neoplasm Diseases 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 4
- 230000006907 apoptotic process Effects 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 238000011534 incubation Methods 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 239000002086 nanomaterial Substances 0.000 description 3
- 238000007626 photothermal therapy Methods 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 229910052723 transition metal Inorganic materials 0.000 description 3
- 150000003624 transition metals Chemical class 0.000 description 3
- 238000002371 ultraviolet--visible spectrum Methods 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 206010034972 Photosensitivity reaction Diseases 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 208000007578 phototoxic dermatitis Diseases 0.000 description 2
- 231100000018 phototoxicity Toxicity 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 238000000527 sonication Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 102000000412 Annexin Human genes 0.000 description 1
- 108050008874 Annexin Proteins 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229910016001 MoSe Inorganic materials 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 238000003917 TEM image Methods 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000032912 absorption of UV light Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940034982 antineoplastic agent Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 150000001491 aromatic compounds Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002041 carbon nanotube Substances 0.000 description 1
- 229910021393 carbon nanotube Inorganic materials 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000004146 energy storage Methods 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 231100000225 lethality Toxicity 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052961 molybdenite Inorganic materials 0.000 description 1
- CWQXQMHSOZUFJS-UHFFFAOYSA-N molybdenum disulfide Chemical compound S=[Mo]=S CWQXQMHSOZUFJS-UHFFFAOYSA-N 0.000 description 1
- 229910052982 molybdenum disulfide Inorganic materials 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 125000000962 organic group Chemical group 0.000 description 1
- 230000001699 photocatalysis Effects 0.000 description 1
- 238000007146 photocatalysis Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 125000003396 thiol group Chemical class [H]S* 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明公开了一种肿瘤靶向光热药剂及制备方法和应用。本发明通过巯基改性带有靶向基团的PEG对碲化钼进行亲水性改性，合成出具有光热抗肿瘤作用的药剂。此类药剂具有肿瘤细胞靶向的特点，并且可以通过光热作用实现抑制肿瘤细胞的增殖的疗效。
Description
技术领域
本发明属于纳米材料技术领域，具体涉及一种肿瘤靶向光热药剂及制备方法和应用。
背景技术
光热疗法是一种新兴的基于由光激发材料产生远红外波的治疗方法。随着共轭有机基团、碳纳米管、金纳米棒等光热试剂的发展，光热疗法已经广泛的用于肿瘤成像和治疗。光热药剂的特异性和选择性在诊断和治疗的过程中起着关键的作用。纳米材料的几何结构对其光热效果有很大的影响。近年来，具有纳米级厚度的MoS2，MoSe2，WS2，WSe2等过渡性金属双硫属化合物引起了广泛的关注。由于其独特的物理和化学性质，过渡性金属双硫属化合物在电子元器件和光催化和能量储存方面具有很强的应用潜力。受到电化学应用的启发，越来越多的研究者倾向于研究那些具有优异的光学和电子性质的过渡性金属双硫属化合物在癌症成像和治疗方面的应用。例如，在最近的一项光热与化疗联合治疗的研究中刘[ Advanced materials 2014, 26, 3433.]与他的同事们制备了一种MoS2纳米薄片。
二碲化钼是一种灰色六角形粉末状固体。能在碱中分解，不溶于水，可溶于硝酸，在空气中较稳定。可以代替硅成为新型的半导体材料。目前未见将MoTe2用于癌症的多功能疗法中。
发明内容
本发明药解决的第一技术问题是提供一种肿瘤靶向光热药剂的制备方法。该方法第一次将二碲化钼用于癌症的多功能疗法，通过机械球磨法制备了MoTe2纳米薄片，并利用硫醇反应功能化，赋予其肿瘤靶向性与生物相容性。本发明提供了一种生物相容性优良的MoTe2纳米薄片展现出了较强的近红外吸收，低毒性和体内可降解的性质，这使得它们成为光热疗法的一个很有前景的试剂。
本发明要解决的第二个技术问题是提供上述方法制得的肿瘤靶向光热药剂的应用。
为解决上述第一个技术问题，发明一种肿瘤靶向光热药剂的制备方法，步骤如下：
a）将碲化钼晶体在高速球磨机中球磨24-36 h，球磨时旋转速度为200-800 rpm，然后使用声波降解法在冰浴中将球磨后的粉末均匀分散在去离子水中，
b）将分散在水中的碲化钼与巯基改性带有靶向基团的PEG按质量比1:1的比例混合搅拌反应48 h，之后在8000 rpm下离心分离，得到生物相容性优良的MoTe2纳米薄片。
所述的声波降解法为：0-10 oC条件下将球磨后的粉末在细胞粉碎仪的作用下剥离，粉碎时间为6-12 h，得到的纳米片层为1~10层的分子层组成。
优选地，步骤b）中，靶向基团为RGD、cRGD、HA、PAA。
优选地，步骤b）中，PEG的分子量可以是200-5000。
进一步地，本发明提供有上述方法制备的肿瘤靶向光热药剂。
为解决上述第二个技术问题，本发明肿瘤靶向光热药剂在制备抗肿瘤药物中的应用。
如无特殊说明，本发明中的各原料均可通过市售购买获得，本发明中所用的设备可采用所属领域中的常规设备或参照所属领域的现有技术进行。
与现有技术相比较，本发明具有如下有益效果：
本发明选用了高光热转化率的碲化钼纳米材料作为光热试剂，避免了重金属与高毒性芳香类化合物的使用，相对市场同类产品成本低廉，体内代谢快。本发明所述的新型肿瘤靶向光热药剂，对近红外光有强的吸收；对肿瘤细胞的生长具有良好的抑制作用，并且对肿瘤细胞具有更高的杀伤力；有高效的光热转化效率；可以诱导细胞凋亡。
附图说明
图1：碲化钼光热抗肿瘤药剂的TEM图。
图2：抗肿瘤药剂对紫外光的吸收。
图3：a. 抗肿瘤光热药剂对小鼠乳腺癌细胞的生长抑制实验。b. 抗肿瘤光热药剂受远红外辐照后对小鼠乳腺癌细胞的生长抑制实验。
图4：远红外辐照下的抗肿瘤光热药剂对水体系温度的温度分布图。
图5：远红外辐照抗肿瘤光热药剂对体系温度的影响随时间的变化以及水对体系温度的影响比较。
图6：在不同作用条件下癌细胞的凋亡分析。
具体实施方式
通过以下详细说明结合附图可以进一步理解本发明的特点和优点。所提供的实施例仅是对本发明方法的说明，而不以任何方式限制本发明揭示的其余内容。
【实施例1】肿瘤靶向光热药剂1的合成：
（1）将碲化钼晶体在高速球磨机中球磨48 h，转速为400 rmp。
（2）使用细胞粉碎仪将球磨后的粉末均匀分散在去离子水中，粉碎时间为12 h，温度为0~4 oC。
（3）将分散在水中的碲化钼与HS-PEG-cRGD (Mn = 25.7 kg/mol) 按质量比1:1的比例混合搅拌反应48 h，之后在8000 rpm下离心分离，得到生物相容性优良的MoTe2纳米薄片。
（4）用投射电子显微镜表征材料结构（图1），并将获得的产品在-18℃避光条件下保存。
【实施例2】肿瘤靶向光热药剂1的紫外可见吸收光谱
MoTe2纳米薄片水溶液的紫外可见吸收光谱是由UV-Vis分光光度计（ThermoScientific, Waltham, MA）测得。结果如图2所示，MoTe2纳米薄片紫外可见吸收光谱在800~950 nm处显示出强的近红外吸收，从而证明MoTe2纳米薄片是一种有光热转化潜能的化合物，最优吸收波长范围为800~950 nm。
【实施例3】肿瘤靶向光热药剂1作用于小鼠乳腺癌细胞
小鼠乳腺癌细胞以6000个细胞/孔的密度分别接种在2个96孔板中，用0.1毫升培养基培养24小时。然后，将用培养基配制成不同浓度的 MoTe2纳米薄片PBS溶液分别加入到各孔中。在避光条件下保持37摄氏度培养48小时。暗毒性组在避光条件下继续培养24小时。为了评估材料的光毒性，在培养6小时后用新鲜的培养基置换还没有被內吞的材料，然后使用NIR激光进行辐照。每个孔使用808 nm的近红外光，功率为1 W cm-1的激光照射1分钟 。再继续培养24个小时。然后，再在每个孔中加入20微升的 MTT（MTT溶解在5毫克/毫升的PBS缓冲液中）。共培养4小时，吸出培养基，加入150微升二甲亚砜。酶标仪测量每个孔中570纳米处的吸光值，计算细胞存活率，进而得到实施例1所得材料对小鼠乳腺癌细胞的光毒性与暗毒性。
结果如图3所示，光照后的材料对小鼠乳腺癌细胞具有极大的毒性，从而证明光热抗肿瘤化合物对肿瘤细胞具有选择性杀死的特点。
【实施例4】测试亲水的碲化钼纳米薄片的光热性能
为了测试亲水的碲化钼纳米薄片的光热性能，采用808 nm的远红外激光辐照亲水性纳米薄片与空白对照组。用红外热成像仪记录了激光辐照的过程。
结果如图4和图5所示，随着辐照时间的增长，碲化钼薄片组的温度明显提高，空白对照组则几乎没有温度变化。
【实施例5】肿瘤靶向光热药剂1诱导肿瘤细胞凋亡
将小鼠乳腺癌细胞以1×105个细胞/孔的密度接种在六孔板中培养，37℃条件下在2毫升培养基中培养。24小时后，加入溶解有材料的培养基与空白培养基到六孔板中。继续培养6小时后，用808 nm的激光辐照。与不进行任何处理、仅用激光辐照或仅加入材料进行对照。经过进一步培养18小时后，所有的细胞通过胰蛋白酶消化，并离心收集。使用PBS和膜联蛋白缓冲液清洗后，所有细胞都用FITC染色30分钟，通过流式细胞仪进行测试分析。
结果如图6所示，远红外辐照后的材料组呈现出明显的细胞凋亡，这很好的验证了材料具有优异的光热效应。
Claims (5)
1.一种肿瘤靶向光热药剂的制备方法，其特征在于，包括步骤如下：
a）MoTe2纳米薄片的制备：将碲化钼晶体在高速球磨机中球磨24-36 h，球磨时旋转速度为200-800 rpm，然后将球磨后的粉末在细胞粉碎仪的作用下剥离，得到的纳米片层为1~10层的分子层组成，均匀分散在去离子水中，粉碎时间为6-12 h，温度为0-10 oC；
b）肿瘤靶向光热药剂的制备：将分散在水中的MoTe2纳米薄片与巯基改性带有靶向基团的PEG按质量比1:1的比例混合搅拌反应48 h，之后在8000 rpm下离心分离，得到生物相容性优良的MoTe2纳米薄片。
2.根据权利要求1所述的制备方法，其特征在于，步骤b）中，靶向基团为RGD、cRGD、HA、PAA。
3.根据权利要求1所述的制备方法，其特征在于，步骤b）中，PEG的分子量是200-5000。
4.一种肿瘤靶向光热药剂，其特征在于，由权利要求1所述的方法制备获得。
5.权利要求4所述的肿瘤靶向光热药剂在制备抗肿瘤药物中的应用。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711311833.XA CN107802836B (zh) | 2017-12-11 | 2017-12-11 | 一种肿瘤靶向光热药剂及制备方法和应用 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711311833.XA CN107802836B (zh) | 2017-12-11 | 2017-12-11 | 一种肿瘤靶向光热药剂及制备方法和应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107802836A CN107802836A (zh) | 2018-03-16 |
| CN107802836B true CN107802836B (zh) | 2020-09-08 |
Family
ID=61589896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711311833.XA Active CN107802836B (zh) | 2017-12-11 | 2017-12-11 | 一种肿瘤靶向光热药剂及制备方法和应用 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107802836B (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113265763B (zh) * | 2021-05-12 | 2022-12-13 | 广西医科大学 | 一种近红外光响应的静电纺丝PCL/MoS2纳米纤维膜及其制备方法 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705928A (zh) * | 2013-12-27 | 2014-04-09 | 中国科学院高能物理研究所 | 单层MoS2纳米片、制备方法以及纳米药物载体 |
| CN103896222A (zh) * | 2012-12-24 | 2014-07-02 | 中国科学技术大学 | 超薄纳米片半导体材料及其制备方法和应用 |
| CN106188590A (zh) * | 2016-07-14 | 2016-12-07 | 复旦大学 | 金属有机骨架结构改性的聚合物杂化质子交换膜及其制备方法 |
| CN106512002A (zh) * | 2016-10-21 | 2017-03-22 | 天津大学 | 集ct成像与光疗于一体的多功能纳米杂化物及制备方法 |
| CN106563130A (zh) * | 2016-10-31 | 2017-04-19 | 深圳先进技术研究院 | 一种二硫化钼纳米片的剥离制备方法及二硫化钼纳米片的应用 |
| WO2017194955A1 (en) * | 2016-05-13 | 2017-11-16 | Nanoco Technologies Ltd | Chemical vapor deposition method for fabricating two-dimensional materials |
| CN107375928A (zh) * | 2017-07-28 | 2017-11-24 | 北京化工大学 | 一种肿瘤靶向光热疗法纳米载体的制备方法及应用 |
-
2017
- 2017-12-11 CN CN201711311833.XA patent/CN107802836B/zh active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103896222A (zh) * | 2012-12-24 | 2014-07-02 | 中国科学技术大学 | 超薄纳米片半导体材料及其制备方法和应用 |
| CN103705928A (zh) * | 2013-12-27 | 2014-04-09 | 中国科学院高能物理研究所 | 单层MoS2纳米片、制备方法以及纳米药物载体 |
| WO2017194955A1 (en) * | 2016-05-13 | 2017-11-16 | Nanoco Technologies Ltd | Chemical vapor deposition method for fabricating two-dimensional materials |
| CN106188590A (zh) * | 2016-07-14 | 2016-12-07 | 复旦大学 | 金属有机骨架结构改性的聚合物杂化质子交换膜及其制备方法 |
| CN106512002A (zh) * | 2016-10-21 | 2017-03-22 | 天津大学 | 集ct成像与光疗于一体的多功能纳米杂化物及制备方法 |
| CN106563130A (zh) * | 2016-10-31 | 2017-04-19 | 深圳先进技术研究院 | 一种二硫化钼纳米片的剥离制备方法及二硫化钼纳米片的应用 |
| CN107375928A (zh) * | 2017-07-28 | 2017-11-24 | 北京化工大学 | 一种肿瘤靶向光热疗法纳米载体的制备方法及应用 |
Non-Patent Citations (7)
| Title |
|---|
| Drug Delivery with PEGylated MoS 2 Nano-sheets for Combined Photothermal and Chemotherapy of Cancer;Teng Liu et al;《Advanced. Materials》;20140220;3433页左栏第2段、右栏第2段，3435页右栏第3段、第5段，3438页左栏第2段，supporting information第2页第1段 * |
| Facile synthesis of biocompatible MoSe2 nanoparticles for efficient targeted photothermal therapy of human lung cancer;Chunlei Zhong et al;《RSC Advances》;20170123;7382–7391 * |
| Graphene-Like Two-Dimensional Materials;Mingsheng Xu et al;《CHEMICAL REVIEWS》;20130103;3766-3798 * |
| NIR Light-Triggered Degradable MoTe2 Nanosheets for Combined Photothermal and Chemotherapy of Cancer;Ning Ma et al;《Advanced Functional Materials》;20180622;1-11 * |
| Polydopamine Coated Selenide Molybdenum: A New Photothermal Nanocarrier for Highly Effective Chemo-Photothermal Synergistic Therapy;Chao Wang et al;《ACS Biomaterials Science & Engineering》;20160916;2011-2017 * |
| Size effect on near infrared photothermal conversion properties of liquid-exfoliated MoS2 and MoSe2;Yanbang Zhang et al;《Superlattices and Microstructures》;20161128;22-27 * |
| 二维过渡金属硫族化合物在生物医学中的应用;刘腾 等;《化学学报》;20150626;902-912 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107802836A (zh) | 2018-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kadian et al. | Recent advancements in synthesis and property control of graphene quantum dots for biomedical and optoelectronic applications | |
| He et al. | Recent developments of inorganic nanosensitizers for sonodynamic therapy | |
| Luo et al. | 2D black phosphorus–based biomedical applications | |
| Wang et al. | In-vitro photothermal therapy using plant extract polyphenols functionalized graphene sheets for treatment of lung cancer | |
| Wang et al. | Ultrathin black phosphorus nanosheets for efficient singlet oxygen generation | |
| Liu et al. | Synthesis and optimization of MoS2@ Fe3O4‐ICG/Pt (IV) nanoflowers for MR/IR/PA bioimaging and combined PTT/PDT/chemotherapy triggered by 808 nm laser | |
| Wang et al. | 2D nanostructures beyond graphene: preparation, biocompatibility and biodegradation behaviors | |
| Choi et al. | Black phosphorus and its biomedical applications | |
| Zhang et al. | Highly photoluminescent carbon dots derived from egg white: facile and green synthesis, photoluminescence properties, and multiple applications | |
| Dong et al. | Poly (ethylene glycol) conjugated nano-graphene oxide for photodynamic therapy | |
| CN106267204B (zh) | 一种黑磷纳米片-抗肿瘤化合物的复合材料及其制备方法和应用 | |
| Gan et al. | Mn2+-bonded reduced graphene oxide with strong radiative recombination in broad visible range caused by resonant energy transfer | |
| Bai et al. | Photosensitizer-conjugated Bi2Te3 nanosheets as theranostic agent for synergistic photothermal and photodynamic therapy | |
| Zhou et al. | Bacteria-mediated ultrathin Bi2Se3 nanosheets fabrication and their application in photothermal cancer therapy | |
| Einafshar et al. | Recent advances in MXene quantum dots: A platform with unique properties for general-purpose functional materials with novel biomedical applications | |
| Xia et al. | Selenium-functionalized graphene oxide that can modulate the balance of reactive oxygen species | |
| Rajasekar et al. | Chitosan coated molybdenum sulphide nanosheet incorporated with tantalum oxide nanomaterials for improving cancer photothermal therapy | |
| Yang et al. | Application and prospect of antimonene: A new two-dimensional nanomaterial in cancer theranostics | |
| Tufano et al. | Methods to scale down graphene oxide size and size implication in anti-cancer applications | |
| Chen et al. | Recent progress on transition metal dichalcogenide-based composites for cancer therapy | |
| Zhang et al. | Sonoactivated cascade Fenton reaction enhanced by synergistic modulation of electron–hole separation for improved tumor therapy | |
| Li et al. | Advances of bioactive tellurium nanomaterials in anti-cancer phototherapy | |
| Tolou-Shikhzadeh-Yazdi et al. | High-efficient synthesis of carbon quantum dots from orange pericarp as fluorescence turn-on probes for Ca2+ and Zn2+ ion detection and their application in trypsin activity characterization | |
| Tiwari et al. | Sustainable graphene production: New insights into cannabis sativa engineered carbon dots based exfoliating agent for facile production of graphene | |
| Bahadur et al. | Influence of PEGylation on WS2 nanosheets and its application in photothermal therapy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |