CN107303254A - A kind of biotin anticreep nutrient solution - Google Patents

Abstract

The present invention relates to cosmetic technical field, a kind of biotin anticreep nutrient solution is specifically disclosed.It comprising following weight than active ingredient：D panthenols 0.1 1%；Extract solution from aloe 1 5%；Hair growing fluid solution 3 10%.The effectively prevention and treatment of described biotin anticreep nutrition liquid energy by（1）Insufficient blood circulation, scalp microcirculation is bad；（2）Cortisol is changed into male sex hormone dihydrotestosterone by 5 alpha-reductases（DHT）Caused by hair follicle atrophy；（3）Hair caused by hair follicle aging could not be anchored in corium hair breast；Etc. baldness caused by reason, to reach confrontation hair follicle aging, the purpose that anti-alopecia-stopping comes off.

Description

A kind of biotin anticreep nutrient solution

Technical field

The present invention relates to cosmetic technical field, and in particular to a kind of biotin anticreep nutrient solution.

Background technology

The required composition of natural on-off cycles of hair growth is the result of epiderm skin and the mutual physical action of corium, keratinocyte and into fiber Cell is compressed in corium hair breast.Moreover, the corium hair collagen that is rich in of breast and mucopolysaccharide and keratinocyte with into Fibrocyte group is in close contact, and promotes the necessary chemical reaction carried out for the generation of hair shaft.It is emphasized that collagen Matter IV and laminin importance, because these matrix constitute the matrix membrane of epidermis dermis junction（Hyaline membrane）With it is many Several corium hair breasts, these corium hair breast is considered as the matrix engine of natural on-off cycles of hair growth.

Alopecia refers to the phenomenon of epilation.The hair normally come off is at catagen and the hair of stand-down, excellent Continuous dynamic equilibrium is in the hair for newly entering growth period in entrance catagen, therefore the hair of normal quantity can be maintained.Disease Rationality alopecia refers to that hair is abnormal or excessively comes off, and its reason has a lot：As endocrinopathy alopecia, nutritional deficiency alopecia, Nervous baldness etc. caused by stress is big.

For alopecia caused by different reasons, there are different therapeutic schemes.We are with generally can select Minoxidil minots You are outer to wipe, and Finasteroid oral, severe patient can select hair of scalp Implant and be treated.In cosmetic industry, occurred Many anticreep shampoos, such as overlord, Suo Fu top grades.Typically toward adding Chinese medicinal herb essence in hair washing system, such as fleece-flower root, when Return, ginkgo leaf, ginseng, matrimony vine etc., matrimony vine can support profit scalp, nourish root of hair；Ginseng can increase the elasticity of hair；Fleece-flower root energy The nutrition that continually such as healthy hair is lost in, makes hair pitch-black beautiful；Radix Angelicae Sinensis and ginkgo leaf can activate the work of scalp and root of hair Power etc., so as to play effect of phalacrosis prevention and hair generation.

But anticreep shampoo is hair products, booster action can only be played at most, and must not fundamentally be solved Alopecia problem.And as " washout hair, the wash-in hair follicle " exaggerated in advertisement, expert points out：Hair follicle is hidden in below cortex, is not So easily wash what is obtained, in addition rest on scalp mostly let alone shampoo and there was only a few minutes clock time, water is once rushing, more It can not possibly penetrate into hair follicle.

The content of the invention

The technical problems to be solved by the invention are that there is provided one kind in order to overcome the above-mentioned problems in the prior art Biotin anticreep nutrient solution.

The technical problems to be solved by the invention are achieved by the following technical programs：

A kind of biotin anticreep nutrient solution, includes following active ingredient：D panthenols, extract solution from aloe and hair growing fluid solution.

Preferably, described biotin anticreep nutrient solution, comprising following weight than active ingredient：D panthenols 0.1-1%；Reed Luxuriant growth extract solution 1-5%；Hair growing fluid solution 3-10%.

It is highly preferred that described biotin anticreep nutrient solution, comprising following weight than active ingredient：D panthenols 0.1- 0.5%；Extract solution from aloe 1-3%；Hair growing fluid solution 3-5%.

Preferably, described hair growing fluid solution is the biotin acyl tripeptides -1 containing 200 ~ 300ppm, 300 ~ 400ppm The apiolin solution of oleanolic acid and 400 ~ 600ppm.

Most preferably, described hair growing fluid solution is the biotin acyl tripeptides -1 containing 250ppm, 300ppm olive The apiolin solution of acid and 500ppm.

Described hair growing fluid solution is prepared via a method which to obtain：First by biotin acyl tripeptides -1, oleanolic acid and Apiolin is fully dispersed with CO40, then adds water dissolving, stirs to form uniform solution adding 1,3-BDO.

Preferably, the volume ratio of described water and 1,3-BDO is 2 ~ 3:8~7.

Most preferably, the volume ratio of described water and 1,3-BDO is 2:8.

The hair growing fluid prepared by the above method is a kind of hair activity of fighting against senium polypeptide complex and had

Effect prevention and treatment baldness as caused by following reason, to reach confrontation hair follicle aging, the purpose that anti-alopecia-stopping comes off. Such as：（1）Insufficient blood circulation, scalp microcirculation is bad；（2）5α-reductase, male sex hormone dihydro is changed into by cortisol Testosterone（DHT）Caused by hair follicle atrophy；（3）Hair caused by hair follicle aging could not be anchored in corium hair breast.

Preferably, described biotin anticreep nutrient solution, also containing following matrix components：IPIS greases, tea oil, spermaceti are hard It is lipidol, EDETATE SODIUM, citric acid, glycerine, double（13-15 alkoxies）Polyoxyethylene aminomethyl siloxanes, preservative 0, two palms Acyloxyethyl alkyl dimethyl ammonium chloride, hydroxyethyl cellulose.

It is highly preferred that described biotin anticreep nutrient solution, also containing following weight than matrix components：

IPIS greases 0.5-2%；Tea oil 1-3%；Cetostearyl alcohol；EDETATE SODIUM 0.1-0.5%；Citric acid 0.2-1%；Glycerine 1- 5%；It is double（13-15 alkoxies）Polyoxyethylene aminomethyl siloxanes 0.5-1%；Preservative 0.1-0.3%；Two palm acyloxyethyls Alkyl dimethyl ammonium chloride 1-3%；Hydroxyethyl cellulose 0.5-1%.

Described preservative is selected from：Phenmethylol, methylchloroisothiazandnone or/and methylisothiazolinone.

（1）Aqueous phase is warming up to 85 DEG C, high speed homogenization 3-5min, it is ensured that material, which is completely dissolved, to be uniformly dispersed；

（2）Add macromolecule raw material scattered in advance, insulated and stirred；

（3）Low temperature material body is added when being cooled to 30 ~ 40 DEG C, is stirred；

（4）It can discharge after the assay was approved, material body placement is stable between standing, can be filling after micro- inspection etc. is qualified, finished product storage.

Preferably, described low temperature material body is hair growing fluid solution.

Beneficial effect：（1）The present invention provides a kind of anti-hair loss products being completely newly formulated, described biotin anticreep nutrient solution In contain natural component, can obvious stimulation natural on-off cycles of hair growth；（2）This product can effectively suppress 5α-reductase and change into cortisol Male sex hormone dihydrotestosterone（DHT）, improve hair follicle atrophy caused by DHT；（3）This product can fundamentally improve that hair follicle is micro- to follow Ring, stimulates cell metabolism.

Embodiment

The present invention is explained further below in conjunction with specific embodiment, but embodiment does not do any type of limit to the present invention It is fixed.

Embodiment 1

Active ingredient weight proportion：

D panthenols 0.5%；Extract solution from aloe 3%；Hair growing fluid solution 5%.

The preparation method of the hair growing fluid solution is as follows：Biotin acyl tripeptides -1, oleanolic acid and apiolin are used first CO40 is fully dispersed, then adds water dissolving, stirs to form the homogeneous biotin acyl containing 250ppm adding 1,3-BDO The solution of the apiolin of tripeptides -1,300ppm oleanolic acid and 500ppm.The volumetric usage of solution reclaimed water and 1,3 butylene glycol Than for 2:8.

The weight proportion of matrix components：IPIS greases 0.5%；Tea oil 1%；Cetostearyl alcohol；EDETATE SODIUM 0.1%；Lemon Acid 0.2%；Glycerine 1%；It is double（13-15 alkoxies）Polyoxyethylene aminomethyl siloxanes 0.5%；Preservative（By phenmethylol, methyl chloride OIT and methylisothiazolinone composition）0.1%；Two palm acyloxyethyl alkyl dimethyl ammonium chlorides 1%；Hydroxyethyl cellulose 0.5%.Surplus is deionized water.

Preparation method：Aqueous Phase Raw Material is heated to 80-85 DEG C, homogeneous 3-5min adds high score scattered in advance Sub- raw material etc., stirring insulation；Low temperature material body is added when being cooled to 40 DEG C（Hair growing fluid solution）, stir.It is after the assay was approved It can discharge, material body displays filling after 72h, and then finished product is put in storage.

Embodiment 2

Active ingredient weight proportion：

D panthenols 0.1%；Extract solution from aloe 1%；Hair growing fluid solution 3%.

The preparation method of the hair growing fluid solution is as follows：Biotin acyl tripeptides -1, oleanolic acid and apiolin are used first CO40 is fully dispersed, then adds water dissolving, stirs to form the homogeneous biotin acyl containing 250ppm adding 1,3-BDO The solution of the apiolin of tripeptides -1,300ppm oleanolic acid and 500ppm.The volumetric usage of solution reclaimed water and 1,3 butylene glycol Than for 2:8.

The weight proportion of matrix components：IPIS greases 2%；Tea oil 3%；Cetostearyl alcohol；EDETATE SODIUM 0.5%；Citric acid 1%；Glycerine 5%；It is double（13-15 alkoxies）Polyoxyethylene aminomethyl siloxanes 1%；Preservative（By phenmethylol, methyl chloroisothiazole Quinoline ketone and methylisothiazolinone composition）0.3%；Two palm acyloxyethyl alkyl dimethyl ammonium chlorides 3%；Hydroxyethyl cellulose 1%.It is remaining Measure as deionized water.

Preparation method：Aqueous Phase Raw Material is heated to 80-85 DEG C, homogeneous 3-5min adds high score scattered in advance Sub- raw material etc., stirring insulation；Low temperature material body is added when being cooled to 40 DEG C（Hair growing fluid solution）, stir.It is after the assay was approved It can discharge, material body displays filling after 72h, and then finished product is put in storage.

Embodiment 2

Active ingredient weight proportion：

D panthenols 1%；Extract solution from aloe 5%；Hair growing fluid solution 10%.

The preparation method of the hair growing fluid solution is as follows：Biotin acyl tripeptides -1, oleanolic acid and apiolin are used first CO40 is fully dispersed, then adds water dissolving, stirs to form the homogeneous biotin acyl containing 250ppm adding 1,3-BDO The solution of the apiolin of tripeptides -1,300ppm oleanolic acid and 500ppm.The volumetric usage of solution reclaimed water and 1,3 butylene glycol Than for 2:8.

The weight proportion of matrix components：IPIS greases 2%；Tea oil 3%；Cetostearyl alcohol；EDETATE SODIUM 0.5%；Citric acid 1%；Glycerine 5%；It is double（13-15 alkoxies）Polyoxyethylene aminomethyl siloxanes 1%；Preservative（By phenmethylol, methyl chloroisothiazole Quinoline ketone and methylisothiazolinone composition）0.3%；Two palm acyloxyethyl alkyl dimethyl ammonium chlorides 3%；Hydroxyethyl cellulose 1%.It is remaining Measure as deionized water.

Preparation method：Aqueous Phase Raw Material is heated to 80-85 DEG C, homogeneous 3-5min adds high score scattered in advance Sub- raw material etc., stirring insulation；Low temperature material body is added when being cooled to 40 DEG C（Hair growing fluid solution）, stir.It is after the assay was approved It can discharge, material body displays filling after 72h, and then finished product is put in storage.

[this embodiment is that whether PLSCONFM data below in order to prove the embodiment of this experiment effect supplement to embodiment 4 It is feasibleIf any other data, other experimental datas can also be supplemented and carry out verification the verifying results.

2000 hair loss patients between 30 ~ 40 years old are chosen in Guangdong Province；It is divided into two groups, every group is randomly selected 1000 people, First group of this product on probation（The product prepared with embodiment 1）, second group is that positive controls use minoxidil.Use Method is smears three medicines to be measured in scalp daily, and effect is as shown in table 1：

The product measure of merit tables of data of table 1.

Effectively（Number）It is efficient（%）

After 30 days（First group） 468 46.8

After 30 days（Second group） 244 24.4

After 60 days（First group） 609 60.9

After 60 days（Second group） 349 34.9

After 90 days（First group） 817 81.7

After 90 days（Second group） 423 42.3

The criterion of " effective " is in table 1：Without depilation phenomenon and there is obvious hair to grow.

From table 1 it follows that continuous, using this product, product effective percentage has reached 81.7% after 90 days,

Illustrate that the product that the present invention is prepared has good anti-alopecia-stopping and promotes scalp metabolism and hair regrowth.With Positive control drug is compared, and product of the present invention, which has, to be obviously improved.

Claims (10)

1. a kind of biotin anticreep nutrient solution, it is characterised in that include following active ingredient：D panthenols, extract solution from aloe and hair tonic Plain solution.

2. biotin anticreep nutrient solution according to claim 1, it is characterised in that comprising following weight than it is effective into Point：D panthenols 0.1-1%；Extract solution from aloe 1-5%；Hair growing fluid solution 3-10%.

3. biotin anticreep nutrient solution according to claim 2, it is characterised in that comprising following weight than it is effective into Point：D panthenols 0.1-0.5%；Extract solution from aloe 1-3%；Hair growing fluid solution 3-5%.

4. biotin anticreep nutrient solution according to claim 1, it is characterised in that described hair growing fluid solution be containing The apiolin solution of 200 ~ 300ppm biotin acyl tripeptides -1,300 ~ 400ppm oleanolic acid and 400 ~ 600ppm.

5. biotin anticreep nutrient solution according to claim 4, it is characterised in that described hair growing fluid solution be containing The apiolin solution of 250ppm biotin acyl tripeptides -1,300ppm oleanolic acid and 500ppm.

6. biotin anticreep nutrient solution according to claim 4, it is characterised in that described hair growing fluid solution passes through as follows Method is prepared：It is first that biotin acyl tripeptides -1, oleanolic acid and apiolin is fully dispersed with CO40, then add water Dissolving, stirs to form uniform solution adding 1,3-BDO.

7. biotin anticreep nutrient solution according to claim 6, it is characterised in that described water and the body of 1,3-BDO Product is than being 2 ~ 3:8~7.

8. biotin anticreep nutrient solution according to claim 7, it is characterised in that described water and the body of 1,3-BDO Product is than being 2:8.

9. biotin anticreep nutrient solution according to claim 1, it is characterised in that also containing following matrix components：IPIS It is grease, tea oil, cetostearyl alcohol, EDETATE SODIUM, citric acid, glycerine, double（13-15 alkoxies）Polyoxyethylene aminomethyl silica Alkane, preservative 0, two palm acyloxyethyl alkyl dimethyl ammonium chlorides, hydroxyethyl cellulose.

10. biotin anticreep nutrient solution according to claim 1, it is characterised in that also containing following weight than matrix Composition：

IPIS greases 0.5-2%；Tea oil 1-3%；Cetostearyl alcohol；EDETATE SODIUM 0.1-0.5%；Citric acid 0.2-1%；Glycerine 1- 5%；It is double（13-15 alkoxies）Polyoxyethylene aminomethyl siloxanes 0.5-1%；Preservative 0.1-0.3%；Two palm acyloxyethyls Alkyl dimethyl ammonium chloride 1-3%；Hydroxyethyl cellulose 0.5-1%.