CN107280810A - A kind of degradable mammary gland support - Google Patents

Abstract

A degradable breast stent, which consists of a three-dimensional border structure and an internal filling structure. The contour of the three-dimensional border structure matches the contour of the actual tumor in the implanted patient. The contour of the three-dimensional border structure is based on the actual tumor contour. The outer direction of the normal line extends 1 to 5 mm; the internal filling structure includes a three-dimensional elastic unit array, and the three-dimensional elastic unit array intersects with the three-dimensional boundary structure to form a degradable mammary gland scaffold; The overall elasticity is to simulate the deformation characteristics of natural breast tissue; its unique porous structure is conducive to the growth of tissue cells, which solves the risks of breast implant shedding and displacement; as the scaffold degrades, autologous tissue gradually replaces the scaffold structure, and eventually Achieve self-healing.

Description

A degradable mammary gland stent

technical field

The invention relates to the technical field of tissue engineering and biomanufacturing, in particular to a degradable breast bracket.

Background technique

In recent years, the incidence of cancer in my country has been increasing. Breast cancer is the most common cancer among Chinese women. The treatment of breast cancer generally requires mastectomy or mastectomy, combined with later radiation therapy. In addition to being unfavorable for the patient's physical health, mammary gland or mastectomy will directly affect the patient's physical appearance and mental health, and bring inconvenience to daily life. In response to this problem, breast reconstruction surgery can reconstruct breasts for patients, thereby improving the adverse effects of resection surgery.

Depending on the type of implant, breast reconstruction surgery can be divided into autologous tissue transplantation and prosthetic implantation. Among them, autologous tissue transplantation has the advantages of no rejection and strong sense of reality; however, the disadvantages are the absorption of autologous tissue and the need for multiple operations. Although prosthesis transplantation can achieve a better breast reconstruction effect, the existing prosthesis materials are mainly silicone gel and other materials, which cannot be degraded after implantation in the human body, and there are risks such as falling off and displacement, which will affect postoperative recovery. .

Contents of the invention

In order to overcome the shortcomings of the above-mentioned prior art, the purpose of the present invention is to provide a degradable breast stent, which can not only restore the shape of the breast after being implanted in the human body, but also has good overall elasticity to simulate the deformation characteristics of natural breast tissue; its unique The porous structure is conducive to the growth of tissue cells, which solves the risks of breast implant shedding and displacement; as the scaffold degrades, autologous tissue gradually replaces the scaffold structure, and finally realizes self-repair.

In order to achieve the above object, the technical solution of the present invention is:

A degradable breast stent, which consists of a three-dimensional border structure and an internal filling structure. The contour of the three-dimensional border structure matches the contour of the actual tumor in the implanted patient. The contour of the three-dimensional border structure is based on the actual tumor contour. The outer direction of the normal line extends 1-5 mm; the inner filling structure is a three-dimensional elastic unit array, and the three-dimensional elastic unit array intersects with the three-dimensional boundary structure to form a degradable mammary gland scaffold.

The actual tumor contour of the implanted patient is obtained by extracting medical image data of the patient.

The three-dimensional boundary structure is a closed surface structure formed by a porous grid, the angle between the grid structure is 30-150 degrees, the minimum line width of the grid unit is 0.2-2 mm, and the pore size is 2-10 mm;

The three-dimensional elastic unit is a three-dimensional unit formed by intersecting a scalable line structure in the three directions of XYZ, and the form of the line structure includes: trigonometric function, trigonometric function-like line structure or space spiral curved line structure; line structure The minimum line width is 0.2-2mm, the side length of the three-dimensional unit is 5-12mm; the amplitude of the trigonometric function or quasi-trigonometric function-shaped line structure is 0.3-4mm, and the helix diameter of the space spiral curve is 0.3-6mm.

The array direction of the three-dimensional elastic unit array is consistent with the grid array direction of the three-dimensional boundary structure, and intersects with the outer contour boundary of the degradable mammary gland stent to form a complete inner filling structure.

The material used in the degradable mammary gland stent is a biodegradable material, and the biodegradable material includes polycaprolactone (PCL), polylactic acid (PLA) and polylactic acid-glycolic acid copolymer (PLGA).

The degradable mammary gland stent is made by 3D printing technology or mold perfusion method.

The advantages of the present invention are:

1. The degradable breast stent structure of the present invention can perfectly match the actual tumor of the patient, and completely cover the tumor area under the condition of causing minimal harm to the patient;

2. The degradable breast stent structure of the present invention not only has a good supporting capacity, but also has the elastic characteristics of simulating real breast tissue, meeting the aesthetic and practical needs of patients for breast reconstruction;

3. The porous network structure adopted by the degradable mammary gland scaffold of the present invention is suitable for the growth of tissue cells, which can effectively solve the problems of mammary gland implant shedding and displacement;

4. The degradable mammary gland stent of the present invention has good biodegradability. With the degradation of the stent, autologous tissue can completely replace the stent, and the breast repair is finally completed.

Description of drawings

Figure 1 is a tumor model extracted from medical image data taken by patients.

Fig. 2 is a degradable mammary gland stent grid shell matched with a tumor model in Embodiment 1.

Fig. 3 is a three-dimensional elastic unit with a sinusoidal line structure in Embodiment 1.

Fig. 4 is a sinusoidal internal filling structure of the degradable mammary gland stent in Embodiment 1.

Fig. 5 is a degradable mammary gland stent of Embodiment 1.

Fig. 6 is a degradable mammary gland stent grid shell matched with a tumor model in Example 2.

Fig. 7 is a three-dimensional elastic unit with a helical curve structure in the second embodiment.

Fig. 8 is a helical curve internal filling structure of the degradable mammary gland stent in Example 2.

Fig. 9 is the degradable mammary gland stent of the second embodiment.

detailed description

The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments.

Embodiment one

A degradable breast stent, which consists of a three-dimensional border structure and an internal filling structure. The contour of the three-dimensional border structure matches the contour of the actual tumor in the implanted patient. In order to ensure that the stent completely covers the tumor area, the contour of the three-dimensional border structure is The actual tumor outer contour is used as the reference, extending 2mm along the normal direction; the internal filling structure includes a three-dimensional elastic unit array, and the three-dimensional elastic unit array intersects with the three-dimensional boundary structure to form a degradable breast scaffold.

The actual tumor outline of the implanted patient is obtained by extracting the medical image data of the patient, as shown in FIG. 1 ;

The three-dimensional boundary structure is a closed surface structure formed by a porous grid, the angle between the grid structure is 90 degrees, the minimum line width of the grid unit is 1mm, and the pore size is 8mm, as shown in Figure 2;

The three-dimensional elastic unit is a three-dimensional unit formed by intersecting a scalable line structure in the three directions of XYZ. The line structure is a sinusoidal line structure intersecting in the three directions of XYZ. The amplitude of the sinusoidal curve is 2 mm, and the line width is 1 mm. , the peripheral size of the unit structure is 9mm*9mm*9mm, as shown in Figure 3;

The array direction of the three-dimensional elastic unit array is consistent with the grid array direction of the three-dimensional boundary structure, and intersects with the outer contour boundary of the degradable breast stent to form a complete internal filling structure, as shown in Figure 4;

The degradable mammary gland stent is composed of a three-dimensional boundary structure of the degradable mammary gland stent intersecting with an internal filling structure, as shown in Figure 5;

The material used in the degradable mammary gland stent is a biodegradable material, and the biodegradable material includes polycaprolactone (PCL), polylactic acid (PLA) and polylactic acid-glycolic acid copolymer (PLGA).

The degradable mammary gland stent is made by 3D printing technology or mold perfusion method.

Embodiment two:

A degradable breast stent, which consists of a three-dimensional border structure and an internal filling structure. The contour of the three-dimensional border structure matches the contour of the actual tumor in the implanted patient. In order to ensure that the stent completely covers the tumor area, the contour of the three-dimensional border structure is The actual tumor outer contour is used as the reference, extending 2mm along the normal direction; the internal filling structure includes a three-dimensional elastic unit array, and the three-dimensional elastic unit array intersects with the three-dimensional boundary structure to form a degradable breast scaffold.

The actual tumor outline of the implanted patient is obtained by extracting the medical image data of the patient, as shown in FIG. 1 ;

The three-dimensional boundary structure is a closed surface structure formed by a porous grid, the angle between the grid structure is 90 degrees, the minimum line width of the grid unit is 1.5mm, and the pore size is 10mm, as shown in Figure 6;

The three-dimensional elastic unit is a three-dimensional unit formed by intersecting a stretchable line structure in the three directions of XYZ, the line structure is a space spiral curve structure intersecting in the three directions of XYZ, the helix diameter is 5 mm, and the line width is 1 mm. The peripheral size of the unit structure is 12mm*12mm*12mm, as shown in Figure 7;

The array direction of the three-dimensional elastic unit array is consistent with the grid array direction of the three-dimensional boundary structure, and intersects with the outer contour boundary of the degradable breast stent to form a complete internal filling structure, as shown in Figure 8;

The degradable mammary gland stent is composed of a three-dimensional boundary structure of the degradable mammary gland stent intersecting with an internal filling structure, as shown in FIG. 9 ;

The material used in the degradable mammary gland stent is a biodegradable material, and the biodegradable material includes polycaprolactone (PCL), polylactic acid (PLA) and polylactic acid-glycolic acid copolymer (PLGA).

The degradable mammary gland stent is made by 3D printing technology or mold perfusion method.

Claims (7)

1. A degradable breast stent, characterized in that: it is composed of a three-dimensional boundary structure and an internal filling structure, the outline of the three-dimensional boundary structure matches the actual tumor outline of the implanted patient, and the outline of the three-dimensional boundary structure is based on the actual tumor outline. The outer contour is used as a reference, extending 1 to 5 mm along the outer direction of the normal; the inner filling structure includes a three-dimensional elastic unit array, and the three-dimensional elastic unit array intersects with the three-dimensional boundary structure to form a degradable mammary gland scaffold. 2 . The degradable breast stent according to claim 1 , wherein the actual tumor contour of the implanted patient is obtained by extracting medical image data of the patient. 3 . 3. A degradable mammary gland stent according to claim 1, characterized in that: the three-dimensional boundary structure is a closed curved surface structure formed by a porous grid, the included angle of the grid structure is 30-150 degrees, and the grid unit The minimum line width is 0.2-2mm, and the pore size is 2-10mm. 4. A degradable mammary gland stent according to claim 1, characterized in that: the three-dimensional elastic unit is a three-dimensional unit formed by a stretchable line structure intersecting in three directions of XYZ, and the form of the line structure includes : Trigonometric function, trigonometric function-like line structure or space spiral curved line structure; the minimum line width of the line structure is 0.2-2mm, and the side length of the three-dimensional unit is 5-12mm; trigonometric function or trigonometric function-like line structure The amplitude is 0.3-4mm, and the helix diameter of the space helical curve is 0.3-6mm. 5. A kind of degradable breast stent according to claim 1, characterized in that: the array direction of the three-dimensional elastic unit array is consistent with the grid array direction of the three-dimensional boundary structure, and is consistent with the outer contour of the degradable breast stent The boundaries intersect to form a complete interior fill structure. 6. A kind of degradable mammary gland stent according to claim 1, is characterized in that: the material that described degradable mammary gland stent adopts is biodegradable material, and biodegradable material comprises polycaprolactone (PCL), poly Lactic acid (PLA) and poly(lactic-co-glycolic acid) (PLGA). 7. A degradable mammary gland stent according to claim 1, characterized in that: said degradable mammary gland stent is made by 3D printing technology or mold perfusion method.