CN107126411A - With cannabidiol gel for alleviating nervous headache effect and preparation method thereof - Google Patents
With cannabidiol gel for alleviating nervous headache effect and preparation method thereof Download PDFInfo
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- CN107126411A CN107126411A CN201710173288.6A CN201710173288A CN107126411A CN 107126411 A CN107126411 A CN 107126411A CN 201710173288 A CN201710173288 A CN 201710173288A CN 107126411 A CN107126411 A CN 107126411A
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- cannabidiol
- ethanol
- glycerine
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- QHMBSVQNZZTUGM-UHFFFAOYSA-N Trans-Cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-UHFFFAOYSA-N 0.000 title claims abstract description 69
- QHMBSVQNZZTUGM-ZWKOTPCHSA-N cannabidiol Chemical compound OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-ZWKOTPCHSA-N 0.000 title claims abstract description 69
- 229950011318 cannabidiol Drugs 0.000 title claims abstract description 69
- ZTGXAWYVTLUPDT-UHFFFAOYSA-N cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CC=C(C)C1 ZTGXAWYVTLUPDT-UHFFFAOYSA-N 0.000 title claims abstract description 69
- PCXRACLQFPRCBB-ZWKOTPCHSA-N dihydrocannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)C)CCC(C)=C1 PCXRACLQFPRCBB-ZWKOTPCHSA-N 0.000 title claims abstract description 69
- 206010019233 Headaches Diseases 0.000 title claims abstract description 35
- 231100000869 headache Toxicity 0.000 title claims abstract description 35
- 230000000694 effects Effects 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 80
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 54
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 40
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 39
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 39
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 39
- 235000011187 glycerol Nutrition 0.000 claims abstract description 27
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims abstract description 25
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims abstract description 25
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims abstract description 25
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims abstract description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000008213 purified water Substances 0.000 claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 18
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims description 18
- 244000025254 Cannabis sativa Species 0.000 claims description 11
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 claims description 11
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 claims description 11
- 235000009120 camo Nutrition 0.000 claims description 11
- 235000005607 chanvre indien Nutrition 0.000 claims description 11
- 239000011487 hemp Substances 0.000 claims description 11
- -1 after stirring Chemical compound 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 6
- 239000000835 fiber Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 125000004494 ethyl ester group Chemical group 0.000 claims 2
- 239000000499 gel Substances 0.000 description 15
- 208000002193 Pain Diseases 0.000 description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 239000000203 mixture Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- XKZQKPRCPNGNFR-UHFFFAOYSA-N 2-(3-hydroxyphenyl)phenol Chemical compound OC1=CC=CC(C=2C(=CC=CC=2)O)=C1 XKZQKPRCPNGNFR-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 206010043269 Tension headache Diseases 0.000 description 1
- 208000008548 Tension-Type Headache Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 230000000049 anti-anxiety effect Effects 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000008252 pharmaceutical gel Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
With cannabidiol gel for alleviating nervous headache effect and preparation method thereof, it is prepared from following components in parts by weight by raw material, 5 10 parts of cannabidiol, 60 70 parts of sodium carboxymethylcellulose, 150 160 parts of glycerine, 23 parts of ethylparaben, 80 90 parts of 95% ethanol, 667 703 parts of purified water；Its preparation method is concretely comprised the following steps：Step 1, get the raw materials ready；Step 2, dissolving；Step 3, mixing.The a kind of of the present invention has cannabidiol gel of alleviation nervous headache effect and preparation method thereof, can effectively alleviate nervous headache, evident in efficacy, safe and reliable.
Description
Technical field
It is more particularly to a kind of that there is the big of alleviation nervous headache effect the present invention relates to a kind of pharmaceutical gel preparation
Numb diphenol gel and preparation method thereof.
Background technology
Nervous headache is primarily referred to as tension headache, feature headache and angioneurotic headache, more by it is nervous,
Anger causes, and cardinal symptom is the vexed pain in head, constriction, sense of heaviness of continuation；Most of patient is both sides headache, mostly two
Temporo side, rear pillow part and overhead or full head.With the quickening of modern life rhythm, the stress of people is also increasing,
Nervous headache generally occurs, and violent headache often makes one fidgety, agonizing, and the disease of nervous headache
People, because corticocerebral interior suppression declines, is difficult to cause extensive suppression diffusion, it is difficult to which sleep is not deep enough during sleep,
Easily wake up with a start or the length of one's sleep is too short, had difficulty in going to sleep after waking up, for a long time in this way, intractable aypnia can be formed, drastically influence people
Life, work and learn.
At present, medicine on the market only has lenitive effect mostly, can only respite pain symptom, but easily
Recurrence, and drug ingedient is complicated, is also easy to produce dependence, long-term taking has certain side effect, is unfavorable for the health of people.
The content of the invention
There is the cannabidiol gel for alleviating nervous headache effect and its preparation side it is an object of the invention to provide a kind of
Method, can effectively alleviate nervous headache, evident in efficacy, safe and reliable.
The purpose of the present invention is achieved through the following technical solutions：
With the cannabidiol gel for alleviating nervous headache effect, it is prepared from following components in parts by weight by raw material, hemp two
5-10 parts of phenol, 60-70 parts of sodium carboxymethylcellulose, 150-160 parts of glycerine, 2-3 parts of ethylparaben, 80-90 parts of 95% ethanol,
667-703 parts of purified water.
Described has the cannabidiol gel for alleviating nervous headache effect, and following preferred weight number system is pressed by raw material
It is standby to form, it is 5 parts of cannabidiol, 65 parts of sodium carboxymethylcellulose, 155 parts of glycerine, 2 parts of ethylparaben, 80 parts of 95% ethanol, pure
Change 693 parts of water.
Described has the cannabidiol gel for alleviating nervous headache effect, and following preferred weight number system is pressed by raw material
It is standby to form, it is 10 parts of cannabidiol, 70 parts of sodium carboxymethylcellulose, 150 parts of glycerine, 3 parts of ethylparaben, 90 parts of 95% ethanol, pure
Change 677 parts of water.
Described has the cannabidiol gel for alleviating nervous headache effect, and raw material presses optimum weight number, hemp two
5 parts of phenol, 60 parts of sodium carboxymethylcellulose, 150 parts of glycerine, 2 parts of ethylparaben, 80 parts of 95% ethanol, 703 parts of purified water.
The cannabidiol extracts from industrial hemp " cloud fiber crops No. 1 ".
It is described that there is the preparation method for alleviating the cannabidiol gel that nervous headache is acted on, the specific step of its preparation method
Suddenly it is：
Step 1, get the raw materials ready：
By weight, cannabidiol, sodium carboxymethylcellulose, glycerine, ethylparaben, 95% ethanol, purified water are weighed, it is standby
With；
Step 2, dissolving：
Sodium carboxymethylcellulose is taken, addition purifying is water-swellable, is completely dissolved, obtains taking sodium carboxymethyl cellulose solution, standby；
Cannabidiol is taken, is added into 95% ethanol, is stirred continuously dissolving, obtains cannabidiol ethanol solution, it is standby；
Step 3, mixing：
Cannabidiol ethanol solution is taken, is added in glycerine, after stirring, ethylparaben is added, after being again stirring for uniformly,
Add into sodium carboxymethyl cellulose solution, stir, finished product.
Cannabidiol (CBD) be extracted from hemp floral leaf a kind of it is nontoxic can be used for medicine, cosmetics, health food
A kind of high added value aldehydes matter.CBD is the non-additive composition in hemp, can hinder THC to nerve system of human body shadow
Ring, and with pharmacological activity such as anti-spasm, resisting rheumatoid arthritis, antianxiety, calm nerves.
Beneficial effects of the present invention：The present invention's has the cannabidiol gel for alleviating nervous headache effect, Neng Goubiao
Originally take into account, it is evident in efficacy, have no toxic side effect, no drug dependence has good therapeutic action to nervous headache；The present invention
Drug effect it is gentle, it is safe and reliable, can effective calm nerves, alleviate nervous headache, the sleep of promotion people.
The present invention is through two groups of clinical verifications, and one of which is cannabidiol gel of the treatment group using the present invention, per angel
With the present invention once, 7 days are a course for the treatment of, and another group of control group uses tablet for alleviating pain, are used once daily, are within 7 days a course for the treatment of,
Per group selection outpatient 110, wherein man 55, female 55, max age 75 years old, minimal ages 35 years old, clinical manifestation is
Headache, dizzy, palpitation and short breath, table one are to take the contrasting data after a course for the treatment of：
Table 1 takes front and rear two groups of courses for the treatment of and compares (unit:People)
There were significant differences for treatment group and control group, it will thus be seen that the application of the present invention clinically has significant curative effect.
Embodiment
Embodiment 1
With the cannabidiol gel for alleviating nervous headache effect, it is prepared from following components in parts by weight by raw material, hemp two
5-10 parts of phenol, 60-70 parts of sodium carboxymethylcellulose, 150-160 parts of glycerine, 2-3 parts of ethylparaben, 80-90 parts of 95% ethanol,
667-703 parts of purified water.
The cannabidiol extracts from industrial hemp " cloud fiber crops No. 1 ".
Its preparation method is concretely comprised the following steps：
Step 1, get the raw materials ready：
By weight, cannabidiol, sodium carboxymethylcellulose, glycerine, ethylparaben, 95% ethanol, purified water are weighed, it is standby
With；
Step 2, dissolving：
Sodium carboxymethylcellulose is taken, addition purifying is water-swellable, is completely dissolved, obtains taking sodium carboxymethyl cellulose solution, standby；
Cannabidiol is taken, is added into 95% ethanol, is stirred continuously dissolving, obtains cannabidiol ethanol solution, it is standby；
Step 3, mixing：
Cannabidiol ethanol solution is taken, is added in glycerine, after stirring, ethylparaben is added, after being again stirring for uniformly,
Add into sodium carboxymethyl cellulose solution, stir, finished product.
Embodiment 2
Described has the cannabidiol gel for alleviating nervous headache effect, by raw material by the preparation of following preferred weight number
Into 5 parts of cannabidiol, 65 parts of sodium carboxymethylcellulose, 155 parts of glycerine, 2 parts of ethylparaben, 80 parts of 95% ethanol, purified water
693 parts.
The cannabidiol extracts from industrial hemp " cloud fiber crops No. 1 ".
Its preparation method is concretely comprised the following steps：
Step 1, get the raw materials ready：
By weight, cannabidiol, sodium carboxymethylcellulose, glycerine, ethylparaben, 95% ethanol, purified water are weighed, it is standby
With；
Step 2, dissolving：
Sodium carboxymethylcellulose is taken, addition purifying is water-swellable, is completely dissolved, obtains taking sodium carboxymethyl cellulose solution, standby；
Cannabidiol is taken, is added into 95% ethanol, is stirred continuously dissolving, obtains cannabidiol ethanol solution, it is standby；
Step 3, mixing：
Cannabidiol ethanol solution is taken, is added in glycerine, after stirring, ethylparaben is added, after being again stirring for uniformly,
Add into sodium carboxymethyl cellulose solution, stir, finished product.
Embodiment 3
Described has the cannabidiol gel for alleviating nervous headache effect, by raw material by the preparation of following preferred weight number
Into 10 parts of cannabidiol, 70 parts of sodium carboxymethylcellulose, 150 parts of glycerine, 3 parts of ethylparaben, 90 parts of 95% ethanol, purified water
677 parts.
The cannabidiol extracts from industrial hemp " cloud fiber crops No. 1 ".
Its preparation method is concretely comprised the following steps：
Step 1, get the raw materials ready：
By weight, cannabidiol, sodium carboxymethylcellulose, glycerine, ethylparaben, 95% ethanol, purified water are weighed, it is standby
With；
Step 2, dissolving：
Sodium carboxymethylcellulose is taken, addition purifying is water-swellable, is completely dissolved, obtains taking sodium carboxymethyl cellulose solution, standby；
Cannabidiol is taken, is added into 95% ethanol, is stirred continuously dissolving, obtains cannabidiol ethanol solution, it is standby；
Step 3, mixing：
Cannabidiol ethanol solution is taken, is added in glycerine, after stirring, ethylparaben is added, after being again stirring for uniformly,
Add into sodium carboxymethyl cellulose solution, stir, finished product.
Embodiment 4
Described has the cannabidiol gel for alleviating nervous headache effect, and raw material presses optimum weight number, cannabidiol 5
Part, 60 parts of sodium carboxymethylcellulose, 150 parts of glycerine, 2 parts of ethylparaben, 80 parts of 95% ethanol, 703 parts of purified water.
The cannabidiol extracts from industrial hemp " cloud fiber crops No. 1 ".
Its preparation method is concretely comprised the following steps：
Step 1, get the raw materials ready：
By weight, cannabidiol, sodium carboxymethylcellulose, glycerine, ethylparaben, 95% ethanol, purified water are weighed, it is standby
With；
Step 2, dissolving：
Sodium carboxymethylcellulose is taken, addition purifying is water-swellable, is completely dissolved, obtains taking sodium carboxymethyl cellulose solution, standby；
Cannabidiol is taken, is added into 95% ethanol, is stirred continuously dissolving, obtains cannabidiol ethanol solution, it is standby；
Step 3, mixing：
Cannabidiol ethanol solution is taken, is added in glycerine, after stirring, ethylparaben is added, after being again stirring for uniformly,
Add into sodium carboxymethyl cellulose solution, stir, finished product.
Embodiment 5
With the cannabidiol gel for alleviating nervous headache effect, it is prepared from the following materials：
Sodium carboxymethylcellulose 60g
Glycerine 150g
Ethylparaben 2g
The g of cannabidiol 5
95% ethanol 80ml
Purified Water q. s
It is configured to 1000g.
Preparation method：Sodium carboxymethylcellulose plus purifying is water-swellable, it is completely dissolved, cannabidiol is added in ethanol and stirred
Mix dissolving；Cannabidiol ethanol solution is added to after being stirred in glycerine with ethylparaben, be added to carboxymethyl cellulose
Stirred in plain sodium water solution.
Claims (6)
1. with the cannabidiol gel for alleviating nervous headache effect, it is characterised in that：Following parts by weight numeral system is pressed by raw material
It is standby to form, 5-10 parts of cannabidiol, 60-70 parts of sodium carboxymethylcellulose, 150-160 parts of glycerine, 2-3 parts of ethylparaben, 95%
80-90 parts of ethanol, 667-703 parts of purified water.
2. according to claim 1 have the cannabidiol gel for alleviating nervous headache effect, it is characterised in that：By original
Material is prepared from by following preferred weight number, 5 parts of cannabidiol, 65 parts of sodium carboxymethylcellulose, 155 parts of glycerine, nipalgin
2 parts of ethyl ester, 80 parts of 95% ethanol, 693 parts of purified water.
3. according to claim 1 have the cannabidiol gel for alleviating nervous headache effect, it is characterised in that：By original
Material is prepared from by following preferred weight number, 10 parts of cannabidiol, 70 parts of sodium carboxymethylcellulose, 150 parts of glycerine, nipalgin
3 parts of ethyl ester, 90 parts of 95% ethanol, 677 parts of purified water.
4. according to claim 1 have the cannabidiol gel for alleviating nervous headache effect, it is characterised in that：Raw material
By optimum weight number, 5 parts of cannabidiol, 60 parts of sodium carboxymethylcellulose, 150 parts of glycerine, 2 parts of ethylparaben, 95% ethanol
80 parts, 703 parts of purified water.
5. having the cannabidiol gel for alleviating nervous headache effect according to claim 1-4 any one, it is special
Levy and be：The cannabidiol extracts from industrial hemp " cloud fiber crops No. 1 ".
6. there is the preparation side for the cannabidiol gel for alleviating nervous headache effect according to claim 1-4 any one
Method, it is characterised in that：Its preparation method is concretely comprised the following steps：
Step 1, get the raw materials ready：
By weight, cannabidiol, sodium carboxymethylcellulose, glycerine, ethylparaben, 95% ethanol, purified water are weighed, it is standby
With；
Step 2, dissolving：
Sodium carboxymethylcellulose is taken, addition purifying is water-swellable, is completely dissolved, obtains taking sodium carboxymethyl cellulose solution, standby；
Cannabidiol is taken, is added into 95% ethanol, is stirred continuously dissolving, obtains cannabidiol ethanol solution, it is standby；
Step 3, mixing：
Cannabidiol ethanol solution is taken, is added in glycerine, after stirring, ethylparaben is added, after being again stirring for uniformly,
Add into sodium carboxymethyl cellulose solution, stir, finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710173288.6A CN107126411A (en) | 2017-03-22 | 2017-03-22 | With cannabidiol gel for alleviating nervous headache effect and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710173288.6A CN107126411A (en) | 2017-03-22 | 2017-03-22 | With cannabidiol gel for alleviating nervous headache effect and preparation method thereof |
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| CN107126411A true CN107126411A (en) | 2017-09-05 |
Family
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| CN201710173288.6A Pending CN107126411A (en) | 2017-03-22 | 2017-03-22 | With cannabidiol gel for alleviating nervous headache effect and preparation method thereof |
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| WO2019193210A1 (en) * | 2018-04-06 | 2019-10-10 | Philip Morris Products S.A. | Nicotine gel |
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| CN119215099A (en) * | 2024-10-16 | 2024-12-31 | 广东云曌医疗科技有限公司 | A gel containing cannabidiol and its preparation method and application |
| US12186282B2 (en) | 2018-12-14 | 2025-01-07 | Harmony Biosciences Management, Inc. | Treatment of 22Q11.2 deletion syndrome with cannabidiol |
| US12514279B2 (en) | 2019-11-04 | 2026-01-06 | Philip Morris Products S.A. | Modified aerosol-generating element for use in an aerosol-generating article or system |
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Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023040166A (en) * | 2017-09-28 | 2023-03-22 | ジナーバ・ファーマシューティカルズ・インコーポレイテッド | Treatment of fragile X syndrome with cannabidiol |
| US12226373B2 (en) | 2017-09-28 | 2025-02-18 | Harmony Biosciences Management, Inc. | Treatment of fragile X syndrome with cannabidiol |
| US12213951B2 (en) | 2017-09-28 | 2025-02-04 | Harmony Biosciences Management, Inc. | Treatment of autism with cannabidiol |
| RU2812254C2 (en) * | 2018-04-06 | 2024-01-26 | Филип Моррис Продактс С.А. | Nicotine gel |
| CN111836557A (en) * | 2018-04-06 | 2020-10-27 | 菲利普莫里斯生产公司 | Nicotine gel |
| CN111867405A (en) * | 2018-04-06 | 2020-10-30 | 菲利普莫里斯生产公司 | Nicotine gel |
| RU2800618C2 (en) * | 2018-04-06 | 2023-07-25 | Филип Моррис Продактс С.А. | Nicotine gel |
| RU2809761C2 (en) * | 2018-04-06 | 2023-12-18 | Филип Моррис Продактс С.А. | Nicotine gel |
| WO2019193210A1 (en) * | 2018-04-06 | 2019-10-10 | Philip Morris Products S.A. | Nicotine gel |
| US11980219B2 (en) | 2018-04-06 | 2024-05-14 | Philip Morris Products S.A. | Nicotine gel |
| US12357018B2 (en) | 2018-04-06 | 2025-07-15 | Philip Morris Products S.A. | Nicotine gel |
| WO2019193209A1 (en) * | 2018-04-06 | 2019-10-10 | Philip Morris Products S.A. | Nicotine gel |
| US11589607B2 (en) | 2018-04-06 | 2023-02-28 | Philip Morris Products S.A. | Nicotine gel |
| US12186282B2 (en) | 2018-12-14 | 2025-01-07 | Harmony Biosciences Management, Inc. | Treatment of 22Q11.2 deletion syndrome with cannabidiol |
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| CN119215099A (en) * | 2024-10-16 | 2024-12-31 | 广东云曌医疗科技有限公司 | A gel containing cannabidiol and its preparation method and application |
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Application publication date: 20170905 |