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CN107027308A - 一种达比加群硫酯衍生物及其制备方法和在药学上的用途 - Google Patents

一种达比加群硫酯衍生物及其制备方法和在药学上的用途 Download PDF

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Publication number
CN107027308A
CN107027308A CN201580036779.5A CN201580036779A CN107027308A CN 107027308 A CN107027308 A CN 107027308A CN 201580036779 A CN201580036779 A CN 201580036779A CN 107027308 A CN107027308 A CN 107027308A
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CN
China
Prior art keywords
alkyl
pharmaceutically acceptable
compound
salt
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580036779.5A
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English (en)
Inventor
魏用刚
邱关鹏
雷柏林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sichuan Haisco Pharmaceutical Co Ltd
Original Assignee
Sichuan Haisco Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sichuan Haisco Pharmaceutical Co Ltd filed Critical Sichuan Haisco Pharmaceutical Co Ltd
Publication of CN107027308A publication Critical patent/CN107027308A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

一种如式(I)的达比加群硫酯衍生物及其立体异构体和药学上可接受的盐，以及在制备用于预防和治疗血栓栓塞疾病的药物中的用途，其中X1、X2、R1和R2如说明书所定义。

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN201580036779.5A 2014-08-06 2015-08-04 一种达比加群硫酯衍生物及其制备方法和在药学上的用途 Pending CN107027308A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201410383909 2014-08-06
CN201410383909X 2014-08-06
CN2015102015805 2015-04-27
CN201510201580 2015-04-27
PCT/CN2015/086021 WO2016019848A1 (zh) 2014-08-06 2015-08-04 一种达比加群硫酯衍生物及其制备方法和在药学上的用途

Publications (1)

Publication Number Publication Date
CN107027308A true CN107027308A (zh) 2017-08-08

Family

ID=55263150

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580036779.5A Pending CN107027308A (zh) 2014-08-06 2015-08-04 一种达比加群硫酯衍生物及其制备方法和在药学上的用途

Country Status (2)

Country Link
CN (1) CN107027308A (zh)
WO (1) WO2016019848A1 (zh)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1675193A (zh) * 2002-08-02 2005-09-28 贝林格尔英格海姆法玛两合公司 1－甲基－2－(4－脒基苯基氨甲基)－苯并咪唑－5－基－羧酸－(n－2－吡啶基－n－2－羟基羰基乙基－酰胺的新颖前药，其制法及其作为药物制剂的用途
CN102766134A (zh) * 2012-07-19 2012-11-07 北京普禄德医药科技有限公司 达比加群的酯衍生物及其制备方法和用途
CN102875533A (zh) * 2012-11-06 2013-01-16 中国药科大学 达比加群衍生物、其制法及抗血栓用途
CN103554087A (zh) * 2013-11-19 2014-02-05 南京工业大学 达比加群衍生物、及其制备方法和抗血栓用途
CN103945845A (zh) * 2011-07-25 2014-07-23 第三专利投资有限两合公司 作为前药的达比加群-偕胺肟酸酯及其作为药物的用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE121699A1 (es) * 1997-02-18 1999-12-08 Boehringer Ingelheim Pharma Heterociclos biciclicos disustituidos como inhibidores de la trombina
CN102838588B (zh) * 2011-06-24 2014-03-19 中国药科大学 一类可用于口服的凝血酶抑制剂、其制法以及医药用途

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1675193A (zh) * 2002-08-02 2005-09-28 贝林格尔英格海姆法玛两合公司 1－甲基－2－(4－脒基苯基氨甲基)－苯并咪唑－5－基－羧酸－(n－2－吡啶基－n－2－羟基羰基乙基－酰胺的新颖前药，其制法及其作为药物制剂的用途
CN103945845A (zh) * 2011-07-25 2014-07-23 第三专利投资有限两合公司 作为前药的达比加群-偕胺肟酸酯及其作为药物的用途
CN102766134A (zh) * 2012-07-19 2012-11-07 北京普禄德医药科技有限公司 达比加群的酯衍生物及其制备方法和用途
CN102875533A (zh) * 2012-11-06 2013-01-16 中国药科大学 达比加群衍生物、其制法及抗血栓用途
CN103554087A (zh) * 2013-11-19 2014-02-05 南京工业大学 达比加群衍生物、及其制备方法和抗血栓用途

Also Published As

Publication number Publication date
WO2016019848A1 (zh) 2016-02-11

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