CN107007844A - A kind of developer composition and its preparation method and application - Google Patents
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- 239000000203 mixture Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000002872 contrast media Substances 0.000 claims abstract description 22
- 238000007408 cone-beam computed tomography Methods 0.000 claims abstract description 16
- 238000005259 measurement Methods 0.000 claims abstract description 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 5
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical group C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 claims description 17
- 229960004647 iopamidol Drugs 0.000 claims description 17
- 229920001817 Agar Polymers 0.000 claims description 16
- 239000008272 agar Substances 0.000 claims description 16
- 239000007924 injection Substances 0.000 claims description 16
- 238000002347 injection Methods 0.000 claims description 16
- 210000000988 bone and bone Anatomy 0.000 claims description 15
- 210000004195 gingiva Anatomy 0.000 claims description 15
- 239000000499 gel Substances 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 abstract description 3
- 239000000463 material Substances 0.000 description 7
- 239000011505 plaster Substances 0.000 description 5
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 238000003384 imaging method Methods 0.000 description 4
- 229920002379 silicone rubber Polymers 0.000 description 4
- 239000004945 silicone rubber Substances 0.000 description 4
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 3
- 229940072056 alginate Drugs 0.000 description 3
- 235000010443 alginic acid Nutrition 0.000 description 3
- 229920000615 alginic acid Polymers 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 210000004513 dentition Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 230000036346 tooth eruption Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 238000013170 computed tomography imaging Methods 0.000 description 1
- 201000005562 gingival recession Diseases 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000032724 odontogenesis Effects 0.000 description 1
- 230000008197 oral dentition Effects 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/25—Compositions for detecting or measuring, e.g. of irregularities on natural or artificial teeth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
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- Oral & Maxillofacial Surgery (AREA)
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- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
Abstract
本发明公开了一种显影组合物，包括以下重量份数的组分：赋形剂10‑25份、非离子型水溶性造影剂100‑150份。还公开了该显影组合物的制备方法以及作为牙龈厚度测量间接显影剂的应用。采用本显影剂进行CBCT拍照，CBCT拍照下可以清楚准确显影牙龈外侧表面与显影剂的界面，测量准确，在临床上可取得良好效果。
The invention discloses a developing composition, which comprises the following components in parts by weight: 10-25 parts of excipient, and 100-150 parts of non-ionic water-soluble contrast agent. The preparation method of the developing composition and the application as an indirect developing agent for gum thickness measurement are also disclosed. The contrast agent is used for CBCT photography. Under the CBCT photography, the interface between the outer surface of the gum and the contrast agent can be clearly and accurately developed, the measurement is accurate, and good clinical results can be achieved.
Description
技术领域technical field
本发明涉及牙科领域，具体涉及一种测量牙龈厚度的显影组合物，还涉及其制备方法和应用。The invention relates to the field of dentistry, in particular to a developing composition for measuring gum thickness, as well as its preparation method and application.
背景技术Background technique
牙龈厚度是决定牙龈生物型的一个主要标准，牙龈薄容易出现牙龈萎缩而影响种植及常规冠修复的美观效果。薄龈型比后龈型的美学修复风险要大很多。因此临床操作前需要对牙龈厚度进行客观准确的判断，以采用合适的方案（如软组织移植等）改善。Gingival thickness is a major criterion for determining gingival biotype. Thin gingiva is prone to gingival recession, which affects the aesthetic effect of implants and conventional crown restorations. Thin gingival type is much more risky for aesthetic restoration than posterior gingival type. Therefore, it is necessary to make an objective and accurate judgment on the thickness of the gingiva before clinical operation, so as to adopt an appropriate plan (such as soft tissue transplantation, etc.) to improve it.
目前临床上没有测量牙龈厚度统一确定的办法。现有测量牙龈厚度的方法有以下三种： 1、牙龈型临床中多用牙周探针插入龈下1mm处 ,如能看见探针轮廓则为薄龈型，如无法看见则为厚龈型。缺点：无法客观准确测定厚度。2、硅橡胶印模材料制取印模,均与除去最内一层约1mm左右以此作为个性托盘备用。再用藻酸盐印模材料混合硫酸钡（显影剂）与水搅拌均匀，放入处理好的硅橡胶个性托盘内，带有放射剂的托盘放入口内重新就位。再拍CBCT（锥形CT），利用间接显影法可以显示出牙龈表面，CBCT显示的骨组织影像与牙龈表面间的距离即为牙龈厚度。缺点：此法制作复杂，另外制备好的硅橡胶个性托盘内的带有放射剂硫酸钡的藻酸盐印模材料在重新就位时容易压迫牙龈，至牙龈移位，影响测量精度。另外硅橡胶个性托盘加上带有放射印模材料厚度较厚，影响CBCT显影精确度。3、用印模材料制取口腔牙列印模，在印模内灌注石膏制作牙列石膏模型，在石膏模型上需测量牙龈厚度的位置用石蜡加热软化涂布，用熟塑胶在带有石蜡石膏牙列模型上压制个性托盘（类似矫正治疗的透明保持器），再把带有显影剂的印模材料藻酸盐放入透明熟塑胶保持器内以备用。带有显影印模材料保持器放入口内拍CBCT，显影剂可以显示牙龈表面，与CBCT显示的牙槽骨表面之间间距即为牙龈厚度。缺点：个性托盘同样存在重新就位精确度难，有压迫牙龈可能性，影响测量精度。At present, there is no uniform method for measuring gingival thickness clinically. There are three existing methods for measuring gingival thickness: 1. In gingival type, a periodontal probe is often inserted 1 mm below the gum in clinical practice. If the outline of the probe can be seen, it is a thin gingival type, and if it cannot be seen, it is a thick gingival type. Disadvantages: It is impossible to measure the thickness objectively and accurately. 2. The silicone rubber impression material is used to make the impression, and the innermost layer of about 1mm is removed to use it as a personalized tray for backup. Then mix barium sulfate (developer) and water with alginate impression material and stir evenly, put it into the treated silicone rubber personalized tray, put the tray with radioactive agent into the mouth and reset it in place. Take CBCT (cone CT) again, and use the indirect imaging method to display the surface of the gums. The distance between the bone tissue image displayed by the CBCT and the surface of the gums is the thickness of the gums. Disadvantages: This method is complicated to make. In addition, the alginate impression material with radioactive barium sulfate in the prepared silicone rubber personality tray is easy to compress the gingiva when it is repositioned, and the gingiva shifts, which affects the measurement accuracy. In addition, the silicone rubber personalized tray and the thickness of the radiation impression material are thick, which affects the accuracy of CBCT development. 3. Use the impression material to make an impression of the oral dentition, pour plaster into the impression to make a plaster model of the dentition, heat and soften the gingiva on the plaster model where the thickness of the gums needs to be measured, and apply cooked plastic on the plaster with paraffin plaster A personalized tray (similar to a transparent retainer for orthodontic treatment) is pressed on the dentition model, and then the impression material alginate with developer is put into the transparent cooked plastic retainer for later use. Put the developed impression material holder into the mouth to take CBCT, the contrast agent can show the surface of the gums, and the distance between the surface of the alveolar bone and the surface of the alveolar bone shown by the CBCT is the thickness of the gums. Disadvantages: Personalized trays also have difficulties in repositioning accuracy, and may compress the gums, affecting measurement accuracy.
发明内容Contents of the invention
本发明所要解决的技术问题是提供一种测量牙龈厚度的显影组合物，并提供其制备方法及应用，该显影组合物用于测量牙龈的厚度，可以克服以上现有技术的缺陷，在临床上可取得良好效果。The technical problem to be solved by the present invention is to provide a developing composition for measuring gum thickness, and provide its preparation method and application. Can achieve good results.
本发明所要解决的技术问题通过以下技术方案予以实现：The technical problem to be solved by the present invention is realized through the following technical solutions:
本发明公开了一种显影组合物，其特征在于，包括以下重量份数的组分：The invention discloses a developing composition, which is characterized in that it comprises the following components in parts by weight:
赋形剂10-25份、非离子型水溶性造影剂100-150份。10-25 parts of excipient, 100-150 parts of non-ionic water-soluble contrast agent.
进一步的，所述的非离子型水溶性造影剂为碘帕醇注射液。Further, the non-ionic water-soluble contrast agent is iopamidol injection.
进一步的，所述碘帕醇注射液优选37 g（I）/100 ml/瓶浓度规格。碘帕醇作为一种新型的造影剂，在临床上具有良好的安全性和造影效果。Further, the iopamidol injection preferably has a concentration specification of 37 g (I)/100 ml/bottle. As a new type of contrast agent, iopamidol has good safety and contrast effect in clinical practice.
进一步的，所述的赋形剂为琼脂。Further, the excipient is agar.
本发明公开了一种所述显影组合物的制备方法，包括以下步骤：The invention discloses a preparation method of the developing composition, comprising the following steps:
（a）将常温下的琼脂加热至95-100℃，维持5-10分钟直到其变为溶胶状，其中，在加热条件下溶解琼脂的同时混入非离子型水溶性造影剂，均匀混合得混合物；(a) Heat the agar at room temperature to 95-100°C and keep it for 5-10 minutes until it turns into a sol, wherein, while dissolving the agar under heating conditions, mix in a non-ionic water-soluble contrast agent and mix evenly to obtain a mixture ;
（b）混合物降温至凝胶状，得到显影组合物。进一步的，所述的非离子型水溶性造影剂为碘帕醇注射液。(b) The temperature of the mixture is cooled to a gel state to obtain a developing composition. Further, the non-ionic water-soluble contrast agent is iopamidol injection.
进一步的，所述显影组合物是作为牙龈厚度测量用的间接显影剂。Further, the developing composition is used as an indirect developer for gum thickness measurement.
本发明还公开了一种使用所述测量牙龈厚度的间接显影剂测量牙龈厚度的方法：首先将所述显影剂加热至溶胶状，然后涂布于牙龈表面，降温后显影剂凝固成凝胶状均匀附着于牙龈表面，然后进行CBCT拍照，CBCT拍照下可以清楚准确显影牙龈外侧表面与显影剂的界面，此界面即为牙龈外侧面，同时CBCT可以让高密度的牙齿与牙槽骨外表面显影，牙齿或牙槽骨的外侧表面与牙龈内侧接触位置即为牙龈的内侧界面，测量牙龈外表面与显影剂接触的界面至牙齿或牙槽骨外表面与牙龈内界面的距离就是牙龈准确厚度。The invention also discloses a method for measuring gum thickness using the indirect developer for measuring gum thickness: first, the developer is heated to a sol state, and then coated on the surface of the gum, and the developer is solidified into a gel after cooling down Evenly adhere to the surface of the gums, and then take a CBCT photo. Under the CBCT photo, the interface between the outer surface of the gums and the contrast agent can be clearly and accurately developed. This interface is the outer surface of the gums. At the same time, CBCT can visualize the high-density teeth and the outer surface of the alveolar bone The contact position between the outer surface of the tooth or alveolar bone and the inner gingiva is the inner interface of the gingiva, and the distance between the outer surface of the gingiva and the interface in contact with the contrast agent to the outer surface of the tooth or alveolar bone and the inner interface of the gingiva is the exact thickness of the gingiva.
本发明具有如下有益效果：The present invention has following beneficial effect:
本发明公开的显影组合物采用的碘帕醇注射液，CT显影效果确切。采用的琼脂为热可逆性凝胶，加热可以溶解，流动性好。二者混合加热后成为溶胶状即可用于口腔牙龈拍摄CBCT （锥形CT）显影，在需要使用的时候加热变成溶解状涂布于牙龈表面，降温后拍摄CBCT即可显示出牙龈表面及牙龈边缘精确位置，测量精度高，不压迫牙龈，无需辅助工具，同时易于重新就位。本发明涉及的显影组合物易于制备、保存和操作，在临床上可取得良好效果。The iopamidol injection used in the imaging composition disclosed by the invention has a definite CT imaging effect. The agar used is a thermoreversible gel, which can be dissolved by heating and has good fluidity. The two are mixed and heated to form a sol, which can be used for CBCT (cone CT) imaging of the oral cavity and gums. When needed, it is heated to dissolve and spread on the surface of the gums. After cooling down, the CBCT can show the gum surface and the gums. Precise edge positioning, high measurement accuracy, no pressure on the gums, no need for auxiliary tools, and easy repositioning. The developing composition involved in the invention is easy to prepare, preserve and operate, and can achieve good clinical effects.
附图说明Description of drawings
图1为本发明所述测量牙龈厚度的显影组合物测量牙龈厚度的显影图。Fig. 1 is a development diagram of measuring gum thickness with the developing composition for measuring gum thickness according to the present invention.
图2为本发明所述测量牙龈厚度的显影组合物测量牙龈厚度的显影示意图。Fig. 2 is a development schematic diagram of measuring gum thickness with the developing composition for measuring gum thickness according to the present invention.
具体实施方式detailed description
下面结合实施例对本发明进行详细的说明，实施例仅是本发明的优选实施方式，不是对本发明的限定。The present invention will be described in detail below in conjunction with examples, which are only preferred implementations of the present invention, and are not limitations of the present invention.
实施例1Example 1
一种测量牙龈厚度的间接显影剂，包括以下重量份数的组分：碘帕醇注射液100份，琼脂20份。An indirect contrast agent for measuring gum thickness, comprising the following components in parts by weight: 100 parts of iopamidol injection and 20 parts of agar.
该间接显影剂的制备方法包括以下步骤：The preparation method of this indirect developer comprises the following steps:
（a）将常温下的琼脂加热至98℃，维持7分钟直到其变为溶胶状，在加热条件下溶解琼脂的同时混入水溶性的碘帕醇注射液，均匀混合得混合物。所用碘帕醇注射液的规格为37g（I）/100 ml/瓶；(a) Heat the agar at room temperature to 98°C for 7 minutes until it becomes a sol, dissolve the agar under heating conditions and mix in water-soluble iopamidol injection, and mix evenly to obtain a mixture. The specification of the iopamidol injection used is 37g (I)/100 ml/bottle;
（b）混合物降温至凝胶状，得到显影组合物。(b) The temperature of the mixture is cooled to a gel state to obtain a developing composition.
实施例2Example 2
一种测量牙龈厚度的间接显影剂，包括以下重量份数的组分：碘帕醇注射液150份，琼脂20份。An indirect contrast agent for measuring gum thickness, comprising the following components in parts by weight: 150 parts of iopamidol injection and 20 parts of agar.
该间接显影剂的制备方法包括以下步骤：The preparation method of this indirect developer comprises the following steps:
（a）将常温下的琼脂加热至95℃，维持9分钟直到其变为溶胶状，在加热条件下溶解琼脂的同时混入水溶性的碘帕醇注射液，均匀混合得混合物。所用碘帕醇注射液的规格为37g（I）/100 ml/瓶；(a) Heat the agar at room temperature to 95°C for 9 minutes until it becomes a sol, dissolve the agar under heating conditions and mix in water-soluble iopamidol injection, and mix evenly to obtain a mixture. The specification of the iopamidol injection used is 37g (I)/100 ml/bottle;
（b）混合物降温至凝胶状，得到显影组合物。(b) The temperature of the mixture is cooled to a gel state to obtain a developing composition.
实施例3Example 3
一种测量牙龈厚度的间接显影剂，包括以下重量份数的组分：碘帕醇注射液100份，琼脂10份。An indirect contrast agent for measuring gum thickness, comprising the following components in parts by weight: 100 parts of iopamidol injection and 10 parts of agar.
该间接显影剂的制备方法包括以下步骤：The preparation method of this indirect developer comprises the following steps:
（a）将常温下的琼脂加热至99℃，维持5分钟直到其变为溶胶状，在加热条件下溶解琼脂的同时混入水溶性的碘帕醇注射液，均匀混合得混合物。所用碘帕醇注射液的规格为37g（I）/100 ml/瓶；(a) Heat the agar at room temperature to 99°C and keep it for 5 minutes until it turns into a sol, dissolve the agar under heating conditions and mix it with water-soluble iopamidol injection, and mix evenly to obtain a mixture. The specification of the iopamidol injection used is 37g (I)/100 ml/bottle;
（b）混合物降温至凝胶状，得到显影组合物。(b) The temperature of the mixture is cooled to a gel state to obtain a developing composition.
结合附图说明实施例1、2、3的牙龈厚度测量临床应用：The gingival thickness measurement clinical application of embodiment 1,2,3 is illustrated in conjunction with accompanying drawing:
附图标号为：牙齿显影1，牙齿外侧面11，牙槽骨2，牙槽骨外侧面21，间接显影剂显影3，间接显影剂内侧面31，牙颈部处牙龈厚度4，牙槽骨处牙龈厚度5。The reference numerals are: tooth development 1, tooth outer surface 11, alveolar bone 2, alveolar bone outer surface 21, indirect developer development 3, indirect developer inner surface 31, gingiva thickness at the neck of the tooth 4, alveolar bone The thickness of the gums is 5.
如图1和2所示，本显影组合物加热后为溶胶状可直接涂布于牙龈表面，降温后能凝固成凝胶状均匀附于牙龈表面，CBCT拍照下可以清楚准确显影牙龈表面与显影剂的界面。同时CBCT可以让高密度的牙齿1和牙槽骨2显影以及让牙齿1和牙龈的外侧表面的间接显影剂3显影，间接显影剂内侧面31即为牙龈的外侧面，牙齿的外侧面11和牙槽骨的外侧面21与牙龈内侧接触位置即为牙龈的内侧面，测量牙龈的外侧面至牙龈的内侧面的距离就是牙龈准确厚度，此方法可准确测量牙龈厚度，可得到牙颈部处牙龈厚度4以及牙槽骨处牙龈厚度5。As shown in Figures 1 and 2, the developing composition is in the form of a sol after heating and can be directly applied on the surface of the gums. After cooling down, it can solidify into a gel and evenly attach to the surface of the gums. The gum surface and imaging can be clearly and accurately developed by CBCT photography. agent interface. At the same time, CBCT can visualize the high-density teeth 1 and alveolar bone 2 and develop the indirect contrast agent 3 on the outer surface of the teeth 1 and gums. The inner surface 31 of the indirect contrast agent is the outer surface of the gum, and the outer surface 11 and The contact position between the outer surface 21 of the alveolar bone and the inner surface of the gum is the inner surface of the gum. The distance from the outer surface of the gum to the inner surface of the gum is the exact thickness of the gum. This method can accurately measure the thickness of the gum and can obtain the Gingival thickness 4 and gingival thickness 5 at the alveolar bone.
以上内容是结合具体的优选实施方式对本发明所作的进一步详细说明，不能认定本发明的具体实施只局限于这些说明。对于本发明所属技术领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干简单推演或替换，都应当视为属于本发明的保护范围。The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be assumed that the specific implementation of the present invention is limited to these descriptions. For those of ordinary skill in the technical field of the present invention, without departing from the concept of the present invention, some simple deduction or replacement can be made, which should be regarded as belonging to the protection scope of the present invention.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109965894A (en) * | 2019-03-11 | 2019-07-05 | 南京市口腔医院 | A method of crack odontoclasis line is detected using image enhancing agents and conical beam CT imaging technique |
| CN114931654A (en) * | 2022-04-26 | 2022-08-23 | 乌鲁木齐市口腔医院 | A developing composition for gingiva |
| CN115500855A (en) * | 2022-10-08 | 2022-12-23 | 上海慧丰牙科技术有限公司 | A method for collecting and adhering radiation-blocking points of guide plate information |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109965894A (en) * | 2019-03-11 | 2019-07-05 | 南京市口腔医院 | A method of crack odontoclasis line is detected using image enhancing agents and conical beam CT imaging technique |
| CN114931654A (en) * | 2022-04-26 | 2022-08-23 | 乌鲁木齐市口腔医院 | A developing composition for gingiva |
| CN115500855A (en) * | 2022-10-08 | 2022-12-23 | 上海慧丰牙科技术有限公司 | A method for collecting and adhering radiation-blocking points of guide plate information |
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