CN107007629A - A kind of pearl powder zinc ointment - Google Patents
A kind of pearl powder zinc ointment Download PDFInfo
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- CN107007629A CN107007629A CN201710183718.2A CN201710183718A CN107007629A CN 107007629 A CN107007629 A CN 107007629A CN 201710183718 A CN201710183718 A CN 201710183718A CN 107007629 A CN107007629 A CN 107007629A
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- 239000000843 powder Substances 0.000 title claims abstract description 58
- 239000002674 ointment Substances 0.000 title claims abstract description 35
- 239000011701 zinc Substances 0.000 title claims abstract description 14
- 229910052725 zinc Inorganic materials 0.000 title claims abstract description 14
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title claims abstract 13
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 80
- 239000011787 zinc oxide Substances 0.000 claims abstract description 40
- 239000003814 drug Substances 0.000 claims abstract description 20
- 201000004624 Dermatitis Diseases 0.000 claims abstract description 16
- 206010021639 Incontinence Diseases 0.000 claims abstract description 14
- 229940099259 vaseline Drugs 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims abstract description 10
- 238000010438 heat treatment Methods 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 239000011812 mixed powder Substances 0.000 claims abstract description 5
- 238000007873 sieving Methods 0.000 claims abstract description 4
- 230000000694 effects Effects 0.000 abstract description 9
- 230000035876 healing Effects 0.000 abstract description 3
- 239000011049 pearl Substances 0.000 description 32
- 210000003491 skin Anatomy 0.000 description 23
- 235000019271 petrolatum Nutrition 0.000 description 8
- 239000004264 Petrolatum Substances 0.000 description 7
- 229940066842 petrolatum Drugs 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 206010015150 Erythema Diseases 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000001142 anti-diarrhea Effects 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- 230000000474 nursing effect Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 208000014644 Brain disease Diseases 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 208000032274 Encephalopathy Diseases 0.000 description 2
- 208000010201 Exanthema Diseases 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 208000000386 Hypertensive Intracranial Hemorrhage Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 201000005884 exanthem Diseases 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 230000002485 urinary effect Effects 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 102000011931 Nucleoproteins Human genes 0.000 description 1
- 108010061100 Nucleoproteins Proteins 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000006059 cover glass Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
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- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000037257 muscle growth Effects 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 210000002640 perineum Anatomy 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000011814 protection agent Substances 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- -1 zinc fatty acid Chemical class 0.000 description 1
- LPEBYPDZMWMCLZ-CVBJKYQLSA-L zinc;(z)-octadec-9-enoate Chemical compound [Zn+2].CCCCCCCC\C=C/CCCCCCCC([O-])=O.CCCCCCCC\C=C/CCCCCCCC([O-])=O LPEBYPDZMWMCLZ-CVBJKYQLSA-L 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
Description
技术领域technical field
本发明涉及一种珍珠粉氧化锌软膏。The invention relates to a pearl powder zinc oxide ointment.
背景技术Background technique
失禁性皮炎（incontinence-associated dermatitis, IAD）是失禁病人常见的并发症，临床表现为肛周和会阴部瘙痒及不适感，甚至皮肤破溃及感染等。失禁病人要承受极大的身心压力，同时增加了护理工作量。因此，IAD 的治疗、护理已成为医疗和护理工作中亟待解决的问题。皮肤保护剂，就是临床被广泛应用于预防和治疗IAD的发生，用来隔离和保护皮肤远离过度潮湿、尿液和粪的产品。皮肤保护剂的使用可以有效预防IAD的发生，降低IAD发生率。同时临床的皮肤保护剂种类繁多，目前为止，尚无一种有效的工具可以评价不同产品预防IAD的效果。Incontinence-associated dermatitis (IAD) is a common complication of incontinence patients, clinically manifested as perianal and perineal itching and discomfort, and even skin ulceration and infection. Incontinent patients are under great physical and mental stress, while increasing the workload of nursing. Therefore, the treatment and nursing of IAD has become an urgent problem to be solved in medical and nursing work. Skin protectants are products that are widely used clinically to prevent and treat the occurrence of IAD, to isolate and protect the skin from excessive moisture, urine and feces. The use of skin protectants can effectively prevent the occurrence of IAD and reduce the incidence of IAD. At the same time, there are many kinds of clinical skin protection agents. So far, there is no effective tool to evaluate the effect of different products on IAD prevention.
氧化锌是皮肤保护剂，由氧化锌和凡士林配制而成，具有收敛和抗菌作用，它能与油脂中游离脂肪酸生成油酸锌及脂酸锌，既滋润、保护皮肤，又有吸着、干燥功能。此外，还可通过毛囊被吸收到细胞内，促进核酸和核蛋白的合成，参与细胞的能量代谢，起到促进组织修复的作用。具有祛腐生肌、抗感染、收敛创口、促进创面愈合等作用，可起到预防和治疗肛周红肿、皮疹、糜烂的作用。Zinc oxide is a skin protectant, which is formulated from zinc oxide and vaseline. It has astringent and antibacterial effects. It can form zinc oleate and zinc fatty acid with free fatty acids in oil, which not only moisturizes and protects the skin, but also has the functions of adsorption and drying. . In addition, it can also be absorbed into cells through hair follicles, promote the synthesis of nucleic acids and nucleoproteins, participate in the energy metabolism of cells, and play a role in promoting tissue repair. It has the effects of removing putrefaction and promoting muscle growth, anti-infection, astringent wounds, and promoting wound healing. It can prevent and treat perianal redness, rashes, and erosions.
珍珠作为一种名贵中药材，在中国已有两千余年药用历史，其性味甘、咸、寒，归心、肝经，具有安神定惊、明目消翳、解毒生肌的功效。珍珠内所含的碳酸钙对细菌有很强的抑制作用，外用有增加细胞增生分化、改善血液循环、促进肉芽生长、加速创口愈合作用。珍珠粉末在治疗肛周皮肤受损方面有利于创面的血液循环、创面收敛及溃疡面肉芽生长，能加速红肿消退、创面的结痂和愈合，利于患者肛周受损皮肤的康复。As a precious Chinese herbal medicine, pearls have been used in China for more than two thousand years. Its nature is sweet, salty, and cold. The calcium carbonate contained in the pearl has a strong inhibitory effect on bacteria. External use can increase cell proliferation and differentiation, improve blood circulation, promote granulation growth, and accelerate wound healing. In the treatment of damaged perianal skin, pearl powder is beneficial to the blood circulation of the wound surface, the convergence of the wound surface and the growth of granulation on the ulcer surface.
发明内容Contents of the invention
本发明的目的在于提供一种珍珠粉氧化锌软膏。The object of the present invention is to provide a kind of pearl powder zinc oxide ointment.
本发明所采取的技术方案是：The technical scheme that the present invention takes is:
一种珍珠粉氧化锌软膏，包括氧化锌、珍珠粉和凡士林。A pearl powder zinc oxide ointment, comprising zinc oxide, pearl powder and petrolatum.
氧化锌和珍珠粉混合质量与凡士林的质量比为1：（17~19）。The mass ratio of the mixed mass of zinc oxide and pearl powder to petrolatum is 1: (17~19).
氧化锌与珍珠粉的质量比为（0.5~2）：（0.1~1.5）。The mass ratio of zinc oxide to pearl powder is (0.5~2): (0.1~1.5).
氧化锌与珍珠粉的质量比为1:1。The mass ratio of zinc oxide to pearl powder is 1:1.
氧化锌≥0.3g，珍珠粉≥0.3g。Zinc oxide ≥ 0.3g, pearl powder ≥ 0.3g.
所述的一种珍珠粉氧化锌软膏的制备方法，包括以下步骤：The preparation method of described a kind of pearl powder zinc oxide ointment, comprises the following steps:
1）将氧化锌和珍珠粉分别研磨成粉，过筛后，按配比称量、混合，备用；1) Grind zinc oxide and pearl powder into powder respectively, after sieving, weigh and mix according to the proportion, and set aside;
2）把凡士林加热熔化后，加入上述的混合粉料搅拌，制成软膏。2) After heating and melting the vaseline, add the above mixed powder and stir to make an ointment.
所述的氧化锌和珍珠粉分别过100目筛。The zinc oxide and pearl powder are respectively passed through a 100-mesh sieve.
所述凡士林的加热温度为55~65℃。The heating temperature of the petrolatum is 55-65°C.
所述的一种珍珠粉氧化锌软膏在制备治疗皮肤炎症药物中的应用。The application of the pearl powder zinc oxide ointment in the preparation of medicine for treating skin inflammation.
所述的皮肤炎症为失禁性皮炎。Described skin inflammation is incontinent dermatitis.
本发明的有益效果是：The beneficial effects of the present invention are:
本发明的药物具有显著的皮肤保护，促进皮肤愈合的功效，对于轻、中、重度失禁性皮炎均有较好的效果，且治疗时间短，治愈率高。The medicament of the invention has remarkable effects of skin protection and skin healing promotion, has better effects on mild, medium and severe incontinence dermatitis, and has short treatment time and high cure rate.
具体实施方式detailed description
一种珍珠粉氧化锌软膏，包括氧化锌、珍珠粉和凡士林。A pearl powder zinc oxide ointment, comprising zinc oxide, pearl powder and petrolatum.
优选的，氧化锌和珍珠粉混合质量与凡士林的质量比为1：（17~19）。Preferably, the mass ratio of zinc oxide and pearl powder to petrolatum is 1: (17-19).
优选的，氧化锌与珍珠粉的质量比为（0.5~2）：（0.1~1.5）；进一步优选的，氧化锌与珍珠粉的质量比为1:1。Preferably, the mass ratio of zinc oxide to pearl powder is (0.5-2): (0.1-1.5); further preferably, the mass ratio of zinc oxide to pearl powder is 1:1.
进一步的，氧化锌≥0.3g，珍珠粉≥0.3g。Further, zinc oxide≥0.3g, pearl powder≥0.3g.
所述的一种珍珠粉氧化锌软膏的制备方法，包括以下步骤：The preparation method of described a kind of pearl powder zinc oxide ointment, comprises the following steps:
1）将氧化锌和珍珠粉分别研磨成粉，过筛后，按配比称量、混合，备用；1) Grind zinc oxide and pearl powder into powder respectively, after sieving, weigh and mix according to the proportion, and set aside;
2）把凡士林加热熔化后，加入上述的混合粉料搅拌，制成软膏。2) After heating and melting the vaseline, add the above mixed powder and stir to make an ointment.
优选的，所述的氧化锌和珍珠粉分别过100目筛。Preferably, the zinc oxide and pearl powder are respectively passed through a 100-mesh sieve.
优选的，所述凡士林的加热温度为55~65℃；进一步优选的，所述的凡士林的加热温度为58~62℃。Preferably, the heating temperature of the petrolatum is 55-65°C; further preferably, the heating temperature of the petrolatum is 58-62°C.
所述的一种珍珠粉氧化锌软膏在制备治疗皮肤炎症药物中的应用。The application of the pearl powder zinc oxide ointment in the preparation of medicine for treating skin inflammation.
优选的，所述的皮肤炎症为失禁性皮炎。Preferably, the skin inflammation is incontinent dermatitis.
以下通过具体的实施例对本发明的内容作进一步详细的说明。The content of the present invention will be described in further detail below through specific examples.
实施例1：Example 1:
一种珍珠粉氧化锌软膏，其中氧化锌1g，珍珠粉1g，凡士林34g。该软膏的制备方法如下：1）将氧化锌和珍珠粉分别研磨成粉，过100目筛后，按配比称量、混合，备用；2）把凡士林加热至60℃熔化后，加入上述的混合粉料搅拌，制成软膏。A pearl powder zinc oxide ointment, wherein zinc oxide 1g, pearl powder 1g, vaseline 34g. The preparation method of the ointment is as follows: 1) Grind zinc oxide and pearl powder into powder respectively, pass through a 100-mesh sieve, weigh and mix according to the proportion, and set aside; Stir the powder to make an ointment.
实施例2：Example 2:
一种珍珠粉氧化锌软膏，其中氧化锌2.5g，珍珠粉2.5g，凡士林90g。该软膏的制备方法如下：1）将氧化锌和珍珠粉分别研磨成粉，过100目筛后，按配比称量、混合，备用；2）把凡士林加热至62℃熔化后，加入上述的混合粉料搅拌，制成软膏。A pearl powder zinc oxide ointment, wherein zinc oxide 2.5g, pearl powder 2.5g, vaseline 90g. The preparation method of the ointment is as follows: 1) Grind zinc oxide and pearl powder into powder respectively, pass through a 100-mesh sieve, weigh and mix according to the proportion, and set aside; Stir the powder to make an ointment.
本药物为细腻柔软的乳白色软膏剂，具有适当的黏稠度，应易涂布于皮肤或黏膜上，不融化，黏稠度随季节变化应很小；应无酸败、异臭、变色、变硬等变质现象；氧化锌与珍珠粉的混合粉应均匀分散在凡士林中形成细腻的软膏。This drug is a delicate and soft milky white ointment with appropriate viscosity, which should be easy to spread on the skin or mucous membrane without melting, and the viscosity should change little with the seasons; there should be no rancidity, odor, discoloration, hardening, etc. Deterioration phenomenon; the mixed powder of zinc oxide and pearl powder should be evenly dispersed in petroleum jelly to form a fine ointment.
本发明的质量检查应符合《中国药典》2015版四部通则0109软膏剂项下有关的各项规定：The quality inspection of the present invention should meet the relevant regulations under the "Chinese Pharmacopoeia" 2015 edition four general rules 0109 ointment item:
粒度：取供试品适量，置于载玻片上涂成薄层，薄层面积相当于盖玻片面积，共涂3片，照粒度和粒度分布测定法(通则0982第一法)测定，均不得检出大于180μm的粒子。Particle size: take an appropriate amount of the test product, put it on a glass slide and apply it as a thin layer, the area of the thin layer is equivalent to the area of the cover glass, apply 3 pieces in total, measure according to the particle size and particle size distribution method (the first method of General Rules 0982), and the average Particles larger than 180 μm shall not be detected.
装量：照最低装量检査法（通则0942)检查，应符合规定。Loading volume: check according to the minimum loading volume inspection method (general rule 0942), and it should meet the regulations.
微生物限度：照微生物计数法（通则1105)、控制菌检查法（通则1106)以及非无菌药品微生物限度标准（通则1107)检査，应符合规定。Microbial limit: check according to microbial enumeration method (general rule 1105), control bacteria inspection method (general rule 1106) and non-sterile drug microbial limit standard (general rule 1107), and it should meet the regulations.
效果：Effect:
本药物具有良好的治疗效果，对于轻、中、重度失禁性皮炎均有较好的效果。The medicine has a good therapeutic effect, and has a good effect on mild, moderate and severe incontinence dermatitis.
轻度：皮肤完整，有轻度发红和不适。常规清洗皮肤后直接涂药，一般2-3天痊愈。Mild: Intact skin with mild redness and discomfort. Apply the medicine directly after routine skin cleansing, and usually recover within 2-3 days.
中度：中度发红，皮肤剥脱，小水疱或小范围部分皮层受损，伴有疼痛或不适。Moderate: Moderate redness, peeling skin, small blisters or damage to a small area of partial skin, with pain or discomfort.
生理盐水清洗抹干，直接涂药，一般3-5天痊愈。Wash with normal saline and wipe dry, apply the medicine directly, and usually recover within 3-5 days.
重度：皮肤变暗或深红色，大面积皮肤剥脱受损，水疱和渗出。生理盐水清洗抹干，直接涂药，一般7-10天痊愈。Severe: Darkening or dark red skin, extensive exfoliation of damaged skin, blistering and oozing. Wash with normal saline and wipe dry, apply the medicine directly, and usually recover within 7-10 days.
本药物具有显著的皮肤保护，促进皮肤愈合的效果。治疗时间短，治愈率高。其用法是将其涂于失禁性皮炎患处，范围大于红疹、红斑或破损处2cm，厚度为0.5mm，每日3-4次。This medicine has remarkable skin protection, promotes the effect of skin healing. The treatment time is short and the cure rate is high. Its usage is to apply it on the affected part of incontinence dermatitis, the range is 2cm larger than the rash, erythema or damaged part, and the thickness is 0.5mm, 3-4 times a day.
以下病例可作为例证。The following cases serve as illustrations.
（1）脑病科患者甲某诊断：急性脑梗塞。患者留置有气管切开置管、胃管、尿管。患者解稀烂便多次，肛周皮肤呈深红色，大面积皮肤剥脱受损，并且有渗出和渗血，部分皮肤呈现白色或黄色水疱和渗出。为重度失禁性皮炎。使用本药物，结合止泻药物配合鼻饲，8天痊愈。(1) Diagnosis of patient A in the department of encephalopathy: acute cerebral infarction. The patient had indwelling tracheostomy tubes, gastric tubes, and urinary catheters. The patient defecated many times, the skin around the anus was dark red, the skin was peeled off and damaged in a large area, and there was oozing and bleeding, and part of the skin showed white or yellow blisters and oozing. For severe incontinent dermatitis. Use this medicine, cooperate nasal feeding in conjunction with antidiarrheal medicine, 8 days recovery from illness.
（2）心血管科患者乙某诊断：冠状动脉粥样硬化性心脏病。患者时咳嗽咳痰，腹胀腹痛，小便失禁，皮肤完整，会阴部周围皮肤轻度发红。为轻度失禁性皮炎，使用本药物，结合留置导尿管，2天痊愈。(2) Diagnosis of patient B in cardiovascular department: coronary atherosclerotic heart disease. The patient had cough and expectoration, abdominal distension and abdominal pain, urinary incontinence, intact skin, and mild redness of the skin around the perineum. For mild incontinence dermatitis, use this medicine, in conjunction with indwelling catheter, fully recovered in 2 days.
（3）脑病科患者丙某诊断：高血压脑出血。患者留置鼻肠管、胃管、气管切开套管、PICC管及尿管。现肛周持续潮湿，时有溢出黄褐色烂便，肛周糜烂潮红，伴有少许渗血。为重度失禁性皮炎。使用本药物，结合止泻药物配合鼻饲，8天痊愈。(3) Diagnosis of B, a patient in the department of encephalopathy: hypertensive cerebral hemorrhage. Nasointestinal tube, gastric tube, tracheostomy tube, PICC tube and urinary catheter were placed in the patient. Now the perianal area continues to be moist, with yellowish-brown rotten stool overflowing from time to time, perianal erosion and flushing, accompanied by a little bleeding. For severe incontinent dermatitis. Use this medicine, cooperate nasal feeding in conjunction with antidiarrheal medicine, 8 days recovery from illness.
（4）颅脑科患者丁某诊断：高血压脑出血。患者左侧肢体乏力，留置腰大池置管引流，。患者每日解稀便4次后，出现肛周潮红，可见部分皮受损。为中度失禁性皮炎。使用本药物，结合止泻药物配合食疗，5天痊愈。(4) Diagnosis of Ding, a craniocerebral patient: hypertensive cerebral hemorrhage. The patient's left limb was weak, and a catheter was placed in the lumbar pool for drainage. After the patient defecated 4 times a day, perianal flushing occurred, and some skin damage could be seen. For moderate incontinent dermatitis. Use this medicine, cooperate dietotherapy in conjunction with antidiarrheal medicine, 5 days recovery from illness.
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| CN117815283A (en) * | 2023-06-30 | 2024-04-05 | 河池市人民医院 | A drug application method for treating IAD patients |
| WO2025199841A1 (en) * | 2024-03-28 | 2025-10-02 | 吴睿纮 | Compound capable of killing bacteria and viruses and manufacturing method therefor |
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| WO2009046116A1 (en) * | 2007-10-01 | 2009-04-09 | Dennis Gross | Skin care products containing multiple enhancers |
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| WO2009046116A1 (en) * | 2007-10-01 | 2009-04-09 | Dennis Gross | Skin care products containing multiple enhancers |
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| 吴德莲等: ""珍珠末外涂治疗重型颅脑损伤并发腹泻患者肛周皮肤受损的疗效观察"", 《当代护士》 * |
| 柯泽春等: ""氧化锌软膏治疗危重症患者肛周皮肤损伤89例效果观察"", 《齐鲁护理杂志》 * |
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| CN117815283A (en) * | 2023-06-30 | 2024-04-05 | 河池市人民医院 | A drug application method for treating IAD patients |
| WO2025199841A1 (en) * | 2024-03-28 | 2025-10-02 | 吴睿纮 | Compound capable of killing bacteria and viruses and manufacturing method therefor |
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