CN1070070C - 一种治疗痛风病的中药 - Google Patents
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Abstract
一种治疗痛风的中药，它由乌梢蛇(酒制)、炒地龙、菝葜、丹参、生大黄、络石藤、伸筋草、榆树根皮、千年健、五加皮、当归、赤芍、蚕沙、木通、苍术、木瓜、滑石、知母、青黛、黄柏、牛膝按剂量组方后，经粉碎，再过60目筛，然后与炼密混合制成丸剂，或将原药末装入胶囊制成胶囊剂。该药对治疗痛风、祛风除湿、活血、消肿止痛、促进血尿酸排泄有显著疗效，总有效率为94.74%，无毒副作用，可长期服用。
Description
本发明涉及以植物为原材料的医药配制品，特别是用于治疗痛风病的中药。
痛风，是由于嘌呤代谢紊乱引起血中尿酸过高，并沉积于全身大小关节、软组织、软骨、肾脏等处而引起的疾病，在祖国医学上又称之为痹症。痛风可分为原发性痛风和继发性痛风，原发性痛风一般由遗传因素所致，主要表现为人体的磷酸核糖焦磷酰胺转移酶增加，谷氨酰胺酶活性降低，次黄嘌呤氧化酶增加，谷胱甘肽还原酶增加。继发性痛风主要表现为人体伴有嘌呤合成增多，核糖核酸转换增加，肾脏清除率的下降。
痛风的特有病理性改变主要是尿酸钠盐在体内的沉积，它可以引起关节软骨、骨骺、滑膜、关节周围软组织及肾脏等部位的病变，当尿酸盐结晶沉着时，可以引起局部的炎症性反应：红肿、热、痛及功能障碍。
现有治疗痛风病主要是采用甾体类抗炎药，糖皮质激素、丙磺舒、别嘌呤醇、秋水仙碱、痛风灵仙等西药。上述药物虽能迅速终止痛风的急性发作，缓解尿酸盐在体内的沉积，预防痛风性关节炎的发作和痛风性肾结石的形成，但是，此类药物对胃肠道有不同程度的损害作用，严重时可以引起肝、肾功能的异常，病人长时间服药后，可引起不同程度的骨髓抑制，肝细胞坏死，精子减少，伸舌样白痴，神经毒性反应及胃肠道反应。因此，由于此类药物毒副作用较大，不宜长期服用。
中国专利局的发明专利公报上1997年3月12日公开了一种名称为“痛风灵药酒及其制备工艺”，申请号96102851.3，公开号CN1144676A的专利申请文件，该药酒全部采用中草药制成，具有一定的疗效，但需要经白酒浸渍后制成药酒，不适宜不饮酒患者、孕妇、心脏病、高血压患者服用。
本发明的目的在于：提供一种全部由中草药，经干燥、去渣、粉碎、过筛后用炼蜜制成的，适用于各种痛风病患者，具有祛风除湿、活血、凉血通络、消肿止痛、促进血尿酸的排泄功能，且疗效可靠，长期服用无毒副作用的治疗痛风病的中药。
本发明的技术解决方案是：一种治疗痛风病的中药，由虫药和草药配伍后加工成丸剂或胶囊剂，其特征在于，所述的虫药和草药的原料及其用量为(按重量百分比计)，乌梢蛇(酒制)3.3-5％，炒地龙3.3-5％，菝葜6.7-10％，丹参6.7-10％，生大黄3.3-5％，络石藤3.3-5％，伸筋草3.3-5％，榆树根皮6.7-10％，千年健3.3-5％，五加皮3.3-5％，当归6.7-10％，赤芍3.3-5％，蚕沙6.7-10％，木通3.3-5％，苍术3.3-5％，木瓜3.3-5％，滑石3.3-5％，知母3.3-5％，青黛1-1.7％，黄柏3.3-5％，牛膝3.3-5％。将上述二十一味药干燥、去渣后，均研为细末，过60目筛，加以炼蜜做成丸剂，或者将原药末装入胶囊内做成胶囊剂。
本发明的优点是：经临床施治，该药具有祛风除湿，活血，凉血通络，消肿止痛，促进血尿酸的排泄，减少嘌呤物质在体内的蓄积作用，并且有控制类风湿关节炎的急性发作期的特点，治愈后不复发，达到标本兼治的临床效果，总有效率为94.74％，且无毒副作用。
下面结合实施例对本发明作进一步的叙述如下：
以加工300克丸剂或胶囊剂为例：
实施例1：取干燥，去渣后的乌梢蛇(酒制)12克，炒地龙10克，菝葜23克，丹参26克，生大黄10克，络石藤14克，伸筋草12克，榆树根皮30克，千年健10克，五加皮11克，当归20克，赤芍12克，蚕沙24克，木通10克，苍术12克，木瓜14克，滑石12克，知母10克，青黛5克，黄柏13克，牛膝10克，其中乌梢蛇，炒地龙为虫药，其余为草药，先将以上二十一味药粉碎后，过60目的筛，再与炼蜜混合后制成丸剂，每粒含原药末为3.5克，每日服3次，每次1粒，28天为一疗程。若加工成胶囊剂则将原药末装入胶囊内，每粒内装原药末0.6克，每日服3次，第次6粒，28天为一疗程。一个疗程病人即可基本控制临床症状及体症，3-6个疗程即可痊愈。
实施例2：取干燥，去渣后的乌梢蛇(酒制)10克，炒地龙10克，菝葜26克，丹参28克，生大黄12克，络石藤12克，伸筋草12克，榆树根皮25克，千年健10克，五加皮15克，当归22克，赤芍12克，蚕沙26克，木通12克，苍术10克，木瓜10克，滑石10克，知母12克，青黛4克，黄柏10克，牛膝12克，加工与服用方法同实施例1。
服用该药期间尽量避免饮酒、食生冷、腥、辣及含嘌呤高的食物。
本发明临床治疗不同程度的痛风病人100例，治疗效果统计如下：
| 有 时间效率临床指标 | 一月后 | 二月后 | 三月后 | 四月后 | 五月后 |
| 症状消失 | 86.3％ | 91.6％ | 94.74％ | 94.74％ | 94.74％ |
| 体症消失 | 79％ | 84.2％ | 94.7％ | 94.74％ | 94.74％ |
| 血尿酸(正常范围) | 2l％ | 52.7％ | 94.74％ | 94.74％ | 94.74％ |
| 甘油三酯(正常范围) | 10.5％ | l5.8％ | 21.1％ | 28.4％ | 35.8％ |
病例1.杨××，男，52岁，湖北省荆州市荆州区水利局干部；一九九四年五月出差时，夜间突发右侧大拇趾关节红、肿、热、痛功能障碍，血尿酸明显高于正常范围(570umol/L)，服用本药40天后，复查血尿酸恢复正常范围(327umol/L)，服用本药五个月后痊愈，且在服药期间，饮食未特别限制。随访多年，至今未见复发，多次复查血尿酸均在正常范围内。
病例2.蔡××，男，62岁，湖北省荆州市荆州区马山镇粮管所干部，现住荆州区御河新村3组4号。患者反复发作左右大拇趾关节、第一脚趾关节红、肿、热、痛、功能障碍3年余，每年反复多次发病，发病时应用抗生素、糖皮质激素、抗痛风药物(丙磺舒、别嘌呤醇等)而得以缓解，但未取得明显疗效。一九九四年十月十五日查血尿酸为480umol/L，并开始服用本药四个月，服药期间未出现上述症状及体症，于一九九五年三月十一日复查血尿酸39umol/L，并在当月停用本药，饮食恢复如常人，随访至今，未见复发，经多次复查血尿酸均在正常范围内。
Claims (2)
1．一种治疗痛风病的中药，其特征在于是以下列重量百分比的原料制成的：酒制乌梢蛇3.3-5％，炒地龙3.3-5％，菝葜6.7-10％，丹参6.7-10％，生大黄3.3-5％，络石藤3.3-5％，伸筋草3.3-5％，榆树根皮6.7-10％，千年健3.3-5％，五加皮3.3-5％，当归6.7-10％，赤芍3.3-5％，蚕沙6.7-10％，木通3.3-5％，苍术3.3-5％，木瓜3.3-5％，滑石3.3-5％，知母3.3-5％，青黛1-1.7％，黄柏3.3-5％，牛膝3.3-5％。
2．一种如权利要求1所述的药物，其特征在于是丸剂或胶囊剂。
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| CN98121618A CN1070070C (zh) | 1998-09-30 | 1998-09-30 | 一种治疗痛风病的中药 |
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| CN98121618A CN1070070C (zh) | 1998-09-30 | 1998-09-30 | 一种治疗痛风病的中药 |
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| CN1249192A CN1249192A (zh) | 2000-04-05 |
| CN1070070C true CN1070070C (zh) | 2001-08-29 |
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| CN100342889C (zh) * | 2005-03-14 | 2007-10-17 | 庹元斌 | 一种治疗痛风的中药制剂及其制备方法和应用 |
| CN103908603B (zh) * | 2014-04-15 | 2016-07-13 | 刘德喜 | 一种治疗痛风的中药组合物及其制备方法 |
| CN103948837A (zh) * | 2014-05-04 | 2014-07-30 | 三亚市中医院 | 治疗湿热痹阻所致痛风的中药组合物及其制备方法 |
| CN105833025A (zh) * | 2016-05-04 | 2016-08-10 | 包莉丽 | 一种用于治疗痛风的药物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1116528A (zh) * | 1994-08-10 | 1996-02-14 | 陈三立 | 一种治疗坐骨神经痛和痛风病的中药 |
| CN1192916A (zh) * | 1997-03-12 | 1998-09-16 | 李航海 | 治疗痛风病的中药 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1116528A (zh) * | 1994-08-10 | 1996-02-14 | 陈三立 | 一种治疗坐骨神经痛和痛风病的中药 |
| CN1192916A (zh) * | 1997-03-12 | 1998-09-16 | 李航海 | 治疗痛风病的中药 |
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