CN106924657A - 一种用于治疗老年性阴道炎的植物精油组合物及制备方法、应用 - Google Patents
一种用于治疗老年性阴道炎的植物精油组合物及制备方法、应用 Download PDFInfo
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- CN106924657A CN106924657A CN201710085738.6A CN201710085738A CN106924657A CN 106924657 A CN106924657 A CN 106924657A CN 201710085738 A CN201710085738 A CN 201710085738A CN 106924657 A CN106924657 A CN 106924657A
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Abstract
本发明公开了一种用于治疗老年性阴道炎的植物精油及制备方法。其技术领域属于植物提取物的应用技术领域。一种用于治疗老年性阴道炎的植物精油组合物，其特征在于：所述的植物精油由下列体积份的组分组成：荷荷巴精油，天竺葵精油，胡萝卜籽精油，洋甘菊精油，玉兰花精油，人参精油，白芷精油，茶树精油，印蒿精油，充分混匀，得到混合液A相备用，配置中药复方乙醇溶液为B相，将A相加入B相中，充分混匀后得到成品；所述的中药复方乙醇溶液由郁金、吴茱萸、木通、菟丝子、鹿角霜和桂枝制备而成。本发明的有益效果在于本发明制备的植物精油利用精油的高挥发性和高渗透性及多种精油的协同作用来达到治疗老年性阴道炎的目的。
Description
技术领域
本发明涉及一种用于老年性阴道炎的植物精油，属于植物提取物的应用技术领域。
背景技术
老年性阴道炎发生于绝经以后、卵巢切除者或盆腔放射治疗后，其发病率据报道高达98.5％，常见于绝经后的老年妇女。
老年性阴道炎主要症状为白带增多，多为黄水样，严重者可为脓性，有臭味，有时为淡血性，甚至发生少量阴道流血。常伴有下腹及阴道坠胀感或阴道皮肤受炎性分泌物影响，可产生轻度瘙痒。检查见阴道呈老年性改变，皱壁消失，上皮菲薄，黏膜充血，表面常有散在点状充血，严重时上皮剥脱形成表浅溃疡，子宫颈也有点状充血。老年性阴道炎如经久不愈，黏膜下结缔组织纤维化后，阴道弹性消失，使阴道狭窄，尤以穹隆部多见，以致暴露宫颈困难。
老年性阴道炎的病因是：因卵巢功能衰退，雌激素水平降低，阴道壁萎缩，黏膜变薄，上皮细胞内糖原含量减少，阴道内pH增高，局部抵抗力降低，致病菌容易入侵繁殖引起炎症。同时，由于阴道黏膜萎缩，上皮菲薄，血运不足，使阴道抵抗力降低，便于细菌侵入繁殖引起炎症病变。另外，个人卫生习惯不良，营养缺乏，尤其是B族维生素缺乏，可能与发病有关。此外，手术切除双侧卵巢、卵巢早衰、盆腔放疗后、长期闭经、长期哺乳等均可引起本病发生。
老年性阴道炎可以引起阴道壁溃疡，导致阴道粘连，严重时可导致阴道狭窄甚至闭锁，这时原本增多的分泌物会出现流出不畅的情况，形成阴道内甚至子宫内脓液堆积，使炎症加重。同时，老年是各种恶性疾病的好发年龄，如宫颈癌或子宫内膜癌等。这些疾病早期表现不典型，与老年性阴道炎症状可以有相似的地方。
目前治疗老年性阴道炎原则为补充雌激素，增强阴道抵抗力，抑制细菌生长。常规治疗药物及方法如下：
1.增强阴道抵抗力
针对病因给予雌激素制剂，可局部用药，也可全身给药。妊马雌酮软膏局部涂抹，每日2次，或雌三醇乳膏，第1周内局部，每天使用1次，然后根据缓解情况逐渐减低至维持量(如每周用2次)。
2.抑制细菌生长
用1％乳酸或0.5％醋酸液冲洗阴道，每日1次，增加阴道酸度，抑制细菌生长繁殖。阴道冲洗后，局部应用抗生素治疗。
上述这些治疗方法单一，且多采用抗生素治疗法。长期使用抗生素会出现不良反应。甚至，由于长期使用抗生素，打破阴道正常的微生态环境的菌群平衡，从而导致双重感染，菌群失调，引发抗生素耐药等，最终导致顽固性的阴道炎，久治不愈。
本发明将精油有与中药提取物有机结合，制备成用于治疗老年性阴道炎的功效性方剂植物精油组合物，从而克服抗生素治疗老年性阴道炎的缺陷。
发明内容
为解决现有技术中抗生素治疗老年性阴道炎的问题，本发明提供一种的植物精油复合制剂，无人工合成制剂，治疗老年性阴道炎的作用。
本发明通过下列技术方案实现：一种用于老年性阴道炎的植物精油，由下列体积份的组分组成：荷荷巴精油，天竺葵精油，胡萝卜籽精油，洋甘菊精油，玉兰花精油，人参精油，白芷精油，茶树精油，印蒿精油，充分混匀，得到混合液A相备用，配置中药复方乙醇溶液为B相，将A相加入B相中，充分混匀后得到成品。所述的中药复方乙醇溶液由郁金、吴茱萸、木通、菟丝子、鹿角霜和桂枝制备而成。
本发明植物精油的制备方法按以下步骤进行：
1)采用蒸馏法，分别将荷荷巴，天竺葵花，胡萝卜籽，洋甘菊，玉兰花，人参，白芷，绿茶，印蒿进行蒸馏，制备出相应的粗制精油；
2)将所述的荷荷巴，天竺葵，胡萝卜籽，洋甘菊，玉兰花，人参，白芷，绿茶，印蒿的粗制精油分别进行二氧化碳超临界萃取，得到纯度更髙的二级精油；
3)将所述的二级精油根椐需要分别进行划段分馏萃取，其中，所述荷荷巴二级精油收集荷荷巴精油；所述天竺葵二级精油收集天竺葵精油；所述胡萝卜籽二级精油收集胡萝卜籽精油；所述洋甘菊二级精油收集洋甘菊精油；所述玉兰花二级精油收集玉兰花精油；所述人参二级精油收集人参精油；所述白芷二级精油收集白芷精油；所述绿茶二级精油收集绿茶精油；所述印蒿二级精油收集印蒿精油；分別得到划段分馏后的高純度单組份精油；
4)按体积份数称取荷荷巴精油6～8份，天竺葵精油4～6份，胡萝卜籽精油8～10份，洋甘菊精油6～8份，玉兰花精油5～7份，人参精油5～7份，白芷精油4～6份，茶树精油8～10份，印蒿精油6～8份，和10-25份所述中药复方乙醇溶液分别加入到密封混料罐中，常温下边搅拌边加入，加完后再继续搅拌3分钟；所述的中药复方乙醇溶液由如下步骤获得：按重量份数计，将郁金3-5份、吴茱萸1-2份、木通1-10份、菟丝子2-3份、鹿角霜0.1-1份和桂枝2-3份，用65％乙醇浸泡、过滤得到的滤液，获得中药复方乙醇溶液；
5)将密封混料罐中的精油混合液加入大混料罐后高速搅拌5分钟，混合均匀后进行灌装，灌装时边搅拌边灌装，经包装后即可得到产品。
本发明植物精油的应用：用于治疗老年性阴道炎，本发明治疗老年性阴道炎是通过调节阴道微环境菌群、酸碱度平衡和调节内分泌实现的。本发明可通过多重途径治疗老年性阴道炎，包括喷雾剂、洗剂。
有益效果：
本发明利用精油的高挥发性和高渗透性及多种精油与中药提取协同增效作用来达到治老年性阴道炎的目的，克服用单一精油抗菌效果差，易复发的缺陷。本发明的作用在于(1)本发明对杆菌、化脓性金黄色葡萄球菌、念珠菌、真菌等致病菌属的杀菌率大于99％；(2)有明显的除异味、止痒功效；(3)长期使用不改变阴道內的酸碱平衡，无抗药性，无毒副作用，对阴道粘膜仅有极轻微的刺激作用；(4)至今未发現有禁忌人群，对过敏体质人群也未发现有过敏作用；(5)具有促进雌激素分泌的作用；(6)同时具有治疗和保健的功效，对女性生殖系统及身心有一定的调节作用；
具体实施方式：
实施例1
本发明制备方法：分别将荷荷巴全草，天竺葵花，胡萝卜籽，洋甘菊，玉兰花，人参，白芷，绿茶，印蒿分別进行蒸馏，制备出相应的粗制精油；将所述的荷荷巴，天竺葵，胡萝卜籽，洋甘菊，玉兰花，人参，白芷，绿茶，印蒿的粗制精油分别进行二氧化碳超临界萃取，得到相应的二级精油；其中，二氧化碳超临界萃取的操作是：将粗制精油装入萃取器中，加热到40℃，萃取压力为20MPa，萃取流速为25L·h-1，连续萃取8h，二氧化碳和萃取出的精油的混合物输入分离器中，减至常压并降至室温，其中的二氧化碳与精油分离，得到二级精油；将所述的二级精油根据需要分别进行划段分馏，其中，荷荷巴二级精油在分馏时收集230-270℃的馏分；天竺葵二级精油在分馏时收集210-260℃的馏分；胡萝卜籽二级精油在分馏时收集260-300℃的馏分；洋甘菊二级精油在分馏时收集140-180℃的馏分；玉兰花二级精油在分馏时收集210-260℃的馏分；人参二级精油在分馏时收集240-300℃的馏分；白芷二级精油在分馏时收集150-200℃的馏分；绿茶二级精油在分馏时收集200℃的馏分；印蒿二级精油在分馏时收集170-200℃的馏分；分別得到划段分馏后的高純度单組份精油；
按体积份数称取荷荷巴精油6份，天竺葵精油4份，胡萝卜籽精油8份，洋甘菊精油6份，玉兰花精油5份，人参精油5份，白芷精油4份，茶树精油80份，印蒿精油6份，和10份所述中药复方乙醇溶液分别加入到密封混料罐中，常温下边搅拌边加入，加完后再继续搅拌3分钟；所述的中药复方乙醇溶液由如下步骤获得：按将郁金3kg、吴茱萸1kg、木通1kg份、菟丝子2kg、鹿角霜0.1kg和桂枝2kg份，用30L 65％乙醇浸泡、过滤得到的滤液，获得中药复方乙醇溶液；
5)将密封混料罐中的精油混合液加入大混料罐后高速搅拌5分钟，混合均匀后进行灌装，灌装时边搅拌边灌装，经包装后即可得到产品。
采用pH计测得制备得到的植物精油的pH值为4.1±0.2，接近人体正常的阴道酸碱度，起到平衡老年性阴道炎阴道局部酸碱值的作用。
实施例2
本实施例与实施例1不同的是按体积份数，称取荷荷巴精油8份，天竺葵精油6份，胡萝卜籽精油10份，洋甘菊精油8份，玉兰花精油7份，人参精油7份，白芷精油6份，茶树精油10份，印蒿精油8份，和10-25份所述中药复方乙醇溶液分别加入到密封混料罐中，常温下边搅拌边加入，加完后再继续搅拌3分钟；所述的中药复方乙醇溶液由如下步骤获得：按重量份数计，将郁金5kg、吴茱萸2kg、木通10kg、菟丝子3kg、鹿角霜1kg和桂枝3kg，用30L 65％乙醇浸泡、过滤得到的滤液，获得中药复方乙醇溶液；其他操作同实施例1。
实施例3
本实施例与实施例1不同的是按体积份数称取荷荷巴精油6～8份，天竺葵精油4～6份，胡萝卜籽精油8～10份，洋甘菊精油6～8份，玉兰花精油5～7份，人参精油5～7份，白芷精油4～6份，茶树精油8～10份，印蒿精油6～8份，和10-25份所述中药复方乙醇溶液分别加入到密封混料罐中，常温下边搅拌边加入，加完后再继续搅拌3分钟；所述的中药复方乙醇溶液由如下步骤获得：按重量份数计，将郁金4kg、吴茱萸1.5kg、木通8kg、菟丝子2.5kg、鹿角霜0.8kg和桂枝2.5kg，用30L 65％乙醇浸泡、过滤得到的滤液，获得中药复方乙醇溶液；其他操作同实施例1。
实施例4
本发明实施例1制备的植物精油复合物应用测试：
自2013年11月始，至2014年12月底止，公司分別在上海，江苏等地区，分別对已被珍断确定患老年性阴道炎的患者女性用本发明对临床效果进行了测试，年龄为55-60岁，参加试用总人数为97名。使用方法为：喷剂的使用方法：对准患者阴部內裤内侧的相应部位的护垫上，喷5-8下，喷后立即穿上，3次/日，症重者可4-6次/日，6天为一个疗程。洗剂的方法为：用本品2ml放进300ml温水中，用洁净纱布沾水清洗外阴及阴道，症轻者2次/日，重者3-4次/日，一般一个疗程即可痊愈。注意事项：本品不可直接喷到阴部。
结果显示：调查试用及统计结果见下表1：
表1 本发明的临床效果测试结果
调查结果显示本发明的产品对老年性阴道炎具有较好的疗效，平均治愈率是93.9％。是一种有潜力的治疗老年性阴道炎的消毒产品。
实施例6
实施例1制备的植物精油复合物复合物的抑菌试验。
1、材料
测试菌种：大肠杆菌，金色葡萄球菌，白色念珠菌。
待测样品：实施例1所得植物精油。
2、方法
按照QB/T 2738-2012《日化产品抗菌抑菌效果的评价方法》其中抗菌型日化产品的杀菌效果检验方法中的悬液定量法测定实施例1制备的用于老年性阴道炎的植物精油的杀菌率。
3、结果
按实施例1制备的植物精油复合物复合物的老年性阴道炎杀菌剂实验结果见表2所示。
表2 实施例1所得用于老年性阴道炎的天然植物精油的杀菌率结果
4、结论：
从表2可知实施例1所制备的植物精油对大肠杆菌，金色葡萄球菌，白色念珠菌均都有显著的杀菌作用，且使用于老年性阴道炎中不会改变阴道內的酸碱平衡，无抗药性，无毒副作用，对女性生殖系统和身心有一定的调节作用，适合使用在老年性阴道炎的杀菌中。
实施例7
皮肤刺激性试验包括急性皮肤刺激性试验和多次皮肤刺激性试验。
依据《化妆品卫生规范(2007版)》，对实施例1制备的植物精油复合物进行急性皮肤刺激性试验和多次皮肤刺激性试验。
(1)急性皮肤刺激性试验方法：取SD大鼠10只，试验前约24h，将大鼠背部脊柱两侧毛剪掉，不可损伤表皮，去毛范围左、右各约3cm×3cm。取实施例1制备的植物精油复合物约0.5mL直接涂在一侧皮肤上，然后用二层纱布(2.5cm×2.5cm)和一层玻璃纸或类似物覆盖，再用无刺激性胶布和绷带加以固定。另一侧皮肤作为对照。采用封闭试验，敷用时间为4h。试验结束后用温水清除残留实施例1制备的植物精油复合物。分别在清除实施例1制备的植物精油复合物后的1、24、48和72h观察大鼠涂抹部位皮肤的红斑和水肿反应情况。
结果显示，清除实施例1制备的植物精油复合物后1、24、48和72h大鼠皮肤均未出现红斑和水肿现象。由此可见，实施例1制备的植物精油复合物对皮肤无刺激性。
(2)多次皮肤刺激性试验方法：取SD大鼠10只，试验前约24h，将大鼠背部脊柱两侧被毛剪掉，去毛范围各为3cm×3cm，涂抹面积2.5cm×2.5cm。取实施例1制备的植物精油复合物约0.5mL直接涂在一侧皮肤上，另一侧涂溶剂作为对照，每天涂抹1次，连续涂抹14d。从第二天开始，每次涂抹前应剪毛，用水清除残留实施例1制备的植物精油复合物。一小时后观察大鼠涂抹部位皮肤的红斑和水肿反应情况。
结果显示，将实施例1制备的植物精油复合物连续14天涂布于大鼠一侧皮肤后，均未出现红斑和水肿现象。由此可见，实施例1制备的植物精油复合物对皮肤无刺激性。
实施例8
实施例1制备的植物精油复合物的抑菌环试验
1、材料
测试菌种：大肠杆菌，金色葡萄球菌，白色念珠菌菌悬液。
待测样品：实施例1所得植物精油复合物，中药复方乙醇溶液(按实施例1制备)荷荷巴精油，天竺葵精油，胡萝卜籽精油，洋甘菊精油，玉兰花精油，人参精油，白芷精油，茶树精油，印蒿精油。
培养基：营养琼脂培养基
2、方法
取无菌并干燥的滤纸片。每片滴加实际待测样品20μl，然后将滤纸片平放于清洁的无菌平皿内，置室温下自然干燥后备用。阴性对照样片的制备：取无菌干燥滤纸片，每片滴加无菌蒸馏水20μl，干燥后备用。
试验菌的接种：用无菌棉拭子蘸取浓度为5×105cfu/ml～5×106cfu/ml大肠杆菌，金色葡萄球菌，白色念珠菌菌悬液，在营养琼脂培养基平板表面均匀涂抹。盖好平皿，置室温干燥5min。
待测样品贴放：每次试验贴放1个染菌平板，每个平板贴放4片试验样片，1片阴性对照样片，共5片。用无菌镊子取样片贴放于平板表面。各样片中心之间相距25mm以上，与平板的周缘相距15mm以上。贴放好后，用无菌镊子轻压样片，使其紧贴于平板表面。盖好平皿，置37℃温箱，在24、48小时分别培养观察结果。用游标卡尺测量抑菌环的直径(包括贴片)并记录。试验重复3次。抑菌环宽度＝抑菌环的直径-贴片直径。
实施例1制备的植物精油复合物的可用于治疗老年性阴道炎，其抑菌效果符合表3的规定。
表3 实施例1制备的植物精油复合物的抗(抑)菌效果
可见，本发明治疗老年性阴道炎效果显著，与单味精油或中药复方相比，其抑制真菌作用显著，且有效作用时间较长。
实施例9
评价实施例1制备的植物精油复合物对白色念珠菌阴道炎模型动物炎症的影响。建立白色念珠菌阴道炎动物模型：雌性新西兰大白兔，用5号头皮针硅胶管凃无菌石蜡油，缓慢插入大白兔阴道约5～8cm，注入白色念珠菌悬液0.25mL，原位停留2～3min，防止菌悬液溢出，每天1次，连续3d。分组与给药：将白色念珠菌阴道炎模型大白兔随机分成12组：模型组，阳性组，实施例1制备的植物精油复合物组，中药复方乙醇溶液(按实施例1制备)，荷荷巴精油，天竺葵精油，胡萝卜籽精油，洋甘菊精油，玉兰花精油，人参精油，白芷精油，茶树精油，印蒿精油组。每组6只。每天阴道给药1次，连续7d。分别在给药第7、14、60天判断标准阴道清洁度分级，显微镜下观察细菌数，计算有效率。有效率(％)＝好转的动物数/各组总动物数×100％。Ⅰ级、Ⅱ级清洁度表示正常，Ⅲ级表示有炎症，Ⅳ级表示有严重炎症。阴道炎治愈、好转标准：阴道外观正常，清洁度Ⅰ级，无杂菌生长，病理检查无炎性细胞浸润为治愈；阴道外观正常，清洁度Ⅱ级或Ⅰ级，无或每平皿1～2个致病菌落，病理检查大致正常为好转。
结果显示：如表4。实施例1制备的植物精油复合物能显著性抑制阴道炎模型动物的炎症，有效率达100％，与单味精油相比，其抑菌作用显著。且与阳性组相比，有效作用时间较长，在60日内无复发。
表4 实施例1制备的植物精油复合物对白色念珠菌阴道炎模型动物炎症的影响
实施例10
评价实施例2制备的植物精油对雌激素分泌的影响。雌性ICR小鼠，随机分成3组：空白组，阳性组，实施例2制备的植物精油组。每组10只。每天阴道给药1次，剂量为空白组按照20μl/只的生理盐水；阳性对照组5μl/只的雌激素；实施例1制备的植物精油复合物组10μl/只，连续10d。分别在最后一次给药后，眼球取血，采用放射免疫法检测小鼠血浆中雌激素的含量。
结果显示：如表5。实施例2制备的植物精油能显著性促进小鼠血浆中，与空白组相比，有显著性差异(p＜0.01)，效果优于阳性雌激素组。
表5 实施例1制备的植物精油复合物对血浆雌激素含量的影响
| 雌二醇含量(pmol/L) | |
| 空白组 | 57.5±18.1 |
| 雌激素 | 504.1±73.2* |
| 实施例1植物精油 | 662.0±94.1** |
Claims (4)
1.一种用于治疗老年性阴道炎的植物精油组合物，其特征在于：所述的植物精油由下列体积份的组分组成：荷荷巴精油，天竺葵精油，胡萝卜籽精油，洋甘菊精油，玉兰花精油，人参精油，白芷精油，茶树精油，印蒿精油，充分混匀，得到混合液A相备用，配置中药复方乙醇溶液为B相，将A相加入B相中，充分混匀后得到成品；所述的中药复方乙醇溶液由郁金、吴茱萸、木通、菟丝子、鹿角霜和桂枝制备而成。
2.根据权利要求书1所述植物精油组合物的制备方法，其特征在于：步骤包括：
1)采用蒸馏法，分别将荷荷巴，天竺葵花，胡萝卜籽，洋甘菊，玉兰花，人参，白芷，绿茶，印蒿进行蒸馏，制备出相应的粗制精油；
2)将所述的荷荷巴，天竺葵，胡萝卜籽，洋甘菊，玉兰花，人参，白芷，绿茶，印蒿的粗制精油分别进行二氧化碳超临界萃取，得到纯度更髙的二级精油；
3)将所述的二级精油根椐需要分别进行划段分馏萃取，其中，所述荷荷巴二级精油收集荷荷巴精油；所述天竺葵二级精油收集天竺葵精油；所述胡萝卜籽二级精油收集胡萝卜籽精油；所述洋甘菊二级精油收集洋甘菊精油；所述玉兰花二级精油收集玉兰花精油；所述人参二级精油收集人参精油；所述白芷二级精油收集白芷精油；所述绿茶二级精油收集绿茶精油；所述印蒿二级精油收集印蒿精油；分別得到划段分馏后的高純度单組份精油；
4)按体积份数称取荷荷巴精油6~8份，天竺葵精油4~6份，胡萝卜籽精油8~10份，洋甘菊精油6~8份，玉兰花精油5~7份，人参精油5~7份，白芷精油4~6份，茶树精油8~10份，印蒿精油6~8份，和10-25份所述中药复方乙醇溶液分别加入到密封混料罐中，常温下边搅拌边加入，加完后再继续搅拌3分钟；所述的中药复方乙醇溶液由如下步骤获得：按重量份数计，将郁金3-5份、吴茱萸1-2份、木通1-10份、菟丝子2-3份、鹿角霜0.1-1份和桂枝2-3份，用65%乙醇浸泡、过滤得到的滤液，获得中药复方乙醇溶液；
5)将密封混料罐中的精油混合液加入大混料罐后高速搅拌5分钟，混合均匀后进行灌装，灌装时边搅拌边灌装，经包装后即可得到产品。
3.根据权利要求书1所述组合物，其特征在于：用于治疗老年性阴道炎。
4.根据权利要求书3所述植物精油，其特征在于：所述的老年性阴道炎可通过多重途径治疗老年性阴道炎，包括喷雾剂、洗剂。
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| CN107595947A (zh) * | 2017-02-17 | 2018-01-19 | 云南同方科技有限公司 | 一种用于治疗痛经的植物精油组合物及制备方法、应用 |
| CN110585418A (zh) * | 2018-06-13 | 2019-12-20 | 广州合伊美生物科技有限公司 | 女性外用消毒精油乳及其生产工艺 |
| CN113717791A (zh) * | 2021-09-30 | 2021-11-30 | 梵申兰科技(上海)有限公司 | 一种治疗足癣和头屑的白茶精油及其用途 |
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| CN102512490A (zh) * | 2012-01-10 | 2012-06-27 | 唐嗣信 | 一种治疗妇科炎症的香薰精油及其精油香薰贴 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107595947A (zh) * | 2017-02-17 | 2018-01-19 | 云南同方科技有限公司 | 一种用于治疗痛经的植物精油组合物及制备方法、应用 |
| CN107595947B (zh) * | 2017-02-17 | 2021-01-12 | 云南同方科技有限公司 | 一种用于治疗痛经的植物精油组合物及制备方法、应用 |
| CN110585418A (zh) * | 2018-06-13 | 2019-12-20 | 广州合伊美生物科技有限公司 | 女性外用消毒精油乳及其生产工艺 |
| CN113717791A (zh) * | 2021-09-30 | 2021-11-30 | 梵申兰科技(上海)有限公司 | 一种治疗足癣和头屑的白茶精油及其用途 |
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