CN106859800B - A kind of tumor planting device - Google Patents

Abstract

The invention provides a tumor implanter. The tumor implanter includes: an acupuncture device, which has a housing assembly and an acupuncture head. The internal space of the slicing unit is connected; the slicing device has a slicing head and a pressing part; part or all of the slicing head is arranged in the acupuncture head channel, and the slicing head is installed on the head end of the pressing part; the pressing part is slidably Installed in the housing assembly, configured to drive the slicing head to move along the axial direction of the needle-piercing head channel to obtain slices; and a slice pushing device, the slice pushing device includes a push head arranged in the cutting head channel of the slicing head, Configured to eject slices located within the slicer head. The tumor implanter is easy to operate, convenient to use, less traumatic, simple to implant, and high in reliability.

Description

a tumor implant

technical field

The invention relates to the technical field of tumor implantation, in particular to a tumor implanter.

Background technique

In the process of medical animal experiments, it is often necessary to establish animal tumor models, and local implantation of tumor tissue blocks is a common method. The existing method mainly relies on tweezers and other surgical instruments to place the tissue block into the site to be planted, which has the following disadvantages: it is difficult to unify the size of the tumor tissue block to be planted; for the tumor planting of subcutaneous and internal organs, the operation is complicated and surgery is often required. The tumor mass is implanted after exposing the subcutaneous tissue and viscera, and the trauma is large.

Contents of the invention

The present invention aims at overcoming at least one defect of the existing tumor implantation, and provides a tumor implanter, which is easy to operate, easy to use, less traumatic, simple to implant, and high in reliability.

In order to achieve the above object, the present invention provides a tumor implanter, which includes:

Acupuncture device, which has a housing assembly and an acupuncture head, the acupuncture head is arranged at the head end of the housing assembly, and the acupuncture head has an acupuncture head channel, the acupuncture head channel is connected to the acupuncture head The internal space of the shell assembly is communicated;

Slicing device, which has a slicing head and a pressing part; part or all of the slicing head is arranged in the channel of the acupuncture head, and the slicing head is installed at the head end of the pressing part; The pressing part is slidably mounted on the housing assembly, and is configured to drive the slicing head to move along the axial direction of the piercing head channel, so as to obtain slices; and

A slice push-out device, the slice push-out device includes a push head arranged in the cutter head channel of the slice cutter head, configured to push out the slices located in the slice cutter head.

Further, the slice pushing device also includes:

a connecting rod extending along the axial direction of the cutter head passage, and one end of the connecting rod is fixed to the push head, and the other end is arranged in the housing assembly; and

The pull rod is perpendicular to the connecting rod and is directly or indirectly fixedly connected to the other end of the connecting rod; moreover, the pull rod is slidably mounted on the housing assembly along the axial direction of the cutter head channel , and both ends of the pull rod protrude from the housing assembly.

Further, the head end face of the push head is flush with or outside the head end face of the slicer head at the initial position of the push head; and

The slice pushing device also includes:

a push head positioning device configured to keep the push head at the preset position when the pull rod drives the push head to move to a preset position in a direction pointing into the housing assembly; and

The return device is configured to provide an active force for urging the push head to move from the preset position to the initial position.

Further, the pressing part includes:

The pressing rod extends along the axial direction of the cutter head channel, and the pressing rod is a hollow structure, and the tail end of the pressing rod passes through the tail end of the housing assembly;

The slicing head is installed on the head end of the pressing rod;

The connecting rod is arranged in the pressing rod.

Further, the tumor implanter further includes: a protective cover, which is slidably arranged in the acupuncture head channel, and a part of the protective cover protrudes from the acupuncture head channel; and

The slicing head is slidably disposed in the protective cover.

Further, the return device is a first elastic device, which is arranged between the housing assembly and the pull rod;

The pressing part and the housing assembly are provided with a second elastic device, and the second elastic device is configured to urge the pressing part to return to the initial position of the pressing part after the pressing part captures a slice;

The protective sheath and the housing assembly are provided with a third elastic device, and the third elastic device is configured to allow the head end of the protective sheath to be resisted when the tumor implanter performs a piercing action. The protective cover moves in a direction pointing into the housing assembly, and the protective cover returns to the initial position of the protective cover after the resistance disappears.

Further, the housing assembly includes an outer shell and an inner shell disposed inside the outer shell;

The acupuncture head is arranged at the head end of the inner shell.

Further, the push head positioning device includes at least one positioning protrusion and at least one positioning through hole;

Each positioning protrusion is fixedly connected to the pull rod through a connecting rod;

Each of the connecting rods is disposed between the inner shell and the outer shell;

Each of the positioning through holes is disposed on the housing;

Each of the positioning protrusions is matched with one of the positioning through holes.

Further, a mounting plate is provided in the inner shell, and the mounting plate is located between the pull rod and the protective sleeve;

The first elastic device includes at least one first spring, and the two ends of each first spring are respectively installed on the pull rod and the mounting plate;

The second elastic device includes a second spring, the second spring is sleeved on the pressing rod, and the second spring is located between the pull rod and the mounting plate, and one end of the second spring is fixed on the The other end of the pressing rod is fixed to the mounting plate;

The third elastic device includes a third spring, and the two ends of the third spring are installed on the mounting plate and the rear end of the protective sleeve respectively.

Further, the slicing head is detachably mounted on the pressing part, and the inner surface of the slicing head is a non-slip inner surface.

The tumor implanter provided by the present invention is very convenient for taking slices. After the slices are taken, the slices can be sent to the planting site by acupuncture, and then the slices can be pushed out from the tumor implanter. It is easy to operate, easy to use, less traumatic and easy to implant. Simple, the slices will not come out of the implantation site again with the tumor implanter, the reliability is high, and the size of the tumor tissue block to be implanted can be uniform.

Description of drawings

Hereinafter, some specific embodiments of the present invention will be described in detail by way of illustration and not limitation with reference to the accompanying drawings. The same reference numerals in the drawings designate the same or similar parts or parts. Those skilled in the art will appreciate that the drawings are not necessarily drawn to scale. In the attached picture:

Fig. 1 is a schematic structural diagram of a tumor implanter according to an embodiment of the present invention;

Fig. 2 is a schematic cross-sectional view of the tumor implanter shown in Fig. 1;

Fig. 3 is a partial enlarged view of A in Fig. 2 .

Detailed ways

Those skilled in the art will be more aware of the above and other objects, advantages and features of the present invention according to the following detailed description of specific embodiments of the present invention in conjunction with the accompanying drawings.

Fig. 1 is a schematic structural view of a tumor implanter according to an embodiment of the present invention. As shown in FIG. 1 and referring to FIG. 2 and FIG. 3 , an embodiment of the present invention provides a tumor implanter. The tumor implanter may include an acupuncture device 20 , a slice taking device 30 and a slice pushing device 40 . The needling device 20 has a housing assembly 21 and a needling head 22 . The acupuncture head 22 is arranged at the head end of the housing assembly 21 , and the acupuncture head 22 has an acupuncture head channel, and the acupuncture head channel communicates with the inner space of the housing assembly 21 . The slicer 30 has a slicer head 31 and a pressing portion 32 . Part or all of the slicer head 31 is disposed in the passage of the needle head, and the slicer head 31 is mounted on the head end of the pressing portion 32 . The pressing part 32 is slidably mounted on the housing assembly 21 and is configured to drive the slicing head 31 to move along the axial direction of the acupuncture head channel to obtain slices. The slice ejecting device 40 includes a pusher 41 disposed in the cutter head channel of the slicer head 31 , configured to push out the slices located in the slicer head 31 .

When the tumor implanter in this embodiment of the present invention is in use, first of all, the slicer head 31 can have a certain accommodation space by moving the pusher head 41 (or the pusher head 41 is at the initial position so that the slicer head 31 has a certain space). Then take the pressing part 32 of the slicing device 30 to drive the slicing head 31 to move to cut the slices. After cutting the slices, the acupuncture device 20 can pierce the planting site, and then use the slice pushing device 40 to push the slices out. The slice cutter head 31 makes the slice enter the planting site. Finally, the tumor implanter can be pulled out. It is easy to use, simple and reliable, and has high planting success rate and efficiency. The head end face of the acupuncture head 22 can preferably be designed as an inclined plane, so as to facilitate piercing, of course, it can also be designed as a plane or the like.

In some embodiments of the present invention, the slice pushing device 40 further includes a connecting rod 42 and a pull rod 43 . The connecting rod 42 extends along the axial direction of the cutter head channel, and one end of the connecting rod 42 is fixed to the push head 41 , and the other end is disposed in the housing assembly 21 . The pull rod 43 is perpendicular to the connecting rod 42, and is directly or indirectly fixedly connected with the other end of the connecting rod 42; moreover, the pull rod 43 is slidably installed in the housing assembly 21 along the axial direction of the cutter head channel, and the two ends of the pull rod 43 One end extends out of the housing assembly 21, so that the experimenter etc. can use two fingers to pull back the push head 41, and the two ends of the pull rod 43 should be humanized to make it comfortable to touch with hands. The pull rod 43 and the connecting rod 42 are convenient for the experimenter to pull back the push head 41 .

In some embodiments of the present invention, the housing assembly 21 includes an outer shell 211 and an inner shell 212 disposed inside the outer shell 211 . The inner shell 212 and the outer shell 211 can be fixedly connected. The acupuncture head 22 is disposed at the head end of the inner casing 212 . The pressing part 32 may include a pressing rod 321 . The pressing rod 321 extends along the axial direction of the cutter head channel, and the pressing rod 321 is a hollow structure, and the tail end of the pressing rod 321 passes through the tail end of the housing assembly 21 . The slicer head 31 can be installed on the head end of the pressing rod 321, especially detachably installed on the head end of the pressing rod 321, so that different types of slicer heads 31 can be replaced, such as the circular slicer head 31, square slicer The first 31 and so on. Moreover, the push head 41 in the slicing head 31 can also be adapted to different types of slicing heads 31 , and can be circular or square, and can also be a passing structure such as a polygon. Further, in some embodiments, the tail end of the slicer head 31 can be inserted into the head end of the pressing rod 321, specifically, the slicer head 31 can be inserted into the pressing rod 321 from the inside of the head end of the pressing rod 321, optionally , the slicing head 31 can also be designed to be inserted into the pressing rod 321 from the outside of the head end of the pressing rod 321 , that is, the head end of the pressing rod 321 is inserted into the tail end of the slicing head 31 . In some alternative embodiments, the tail end of the slicer head 31 can be screwed to the head end of the pressing rod 321 .

The connecting rod 42 can be disposed in the pressing rod 321 . The pull rod 43 can be vertically arranged at the tail end of the connecting rod 42, and the pressing rod 321, the inner shell 212 and the outer shell 211 are all provided with a path channel that allows the pull rod 43 to move, so that the push head 41 can move along the axis of the cutter head passage. Swipe in direction. Further, the pressing part 32 and the housing assembly 21 are provided with a second elastic device 33 configured to urge the pressing part 32 to return to the initial position of the pressing part 32 after the pressing part 32 captures a slice.

In some embodiments of the present invention, in order to further improve the operation convenience of the tumor implanter, when designing, the head end face of the push head 41 can be aligned with the head end face of the slicer head 31 at the initial position of the push head 41. flush with or on the outside of the head end surface of the slicer head 31 . The slice pushing device 40 may also include a pushing head positioning device and a returning device 44 . The push head positioning device can be configured to keep the push head 41 at the preset position when the pull rod 43 drives the push head 41 to move to a preset position in a direction pointing to the inside of the housing assembly 21, so that there is an accommodation space in the slicer head 31, to hold the fetched slices. The return device 44 can be configured to provide a force to move the push head 41 from a preset position to an initial position. When pushing out the slices in the slicing cutter head 31, after the pusher positioning device is de-positioned, the pusher 41 can be returned under the action of the return device 44 to automatically push out the slices.

Specifically, the push head positioning device may include at least one positioning protrusion 45 and at least one positioning through hole. Each positioning protrusion 45 is fixedly connected with the pull rod 43 through a connecting rod 46 . Each connecting rod 46 is disposed between the inner shell 212 and the outer shell 211 . Each positioning through hole is disposed on the housing 211; each positioning protrusion 45 is matched with one positioning through hole. When in use, the experimenter pulls the pull rod 43 to move toward the tail end of the housing assembly 21, and stops pulling after the positioning protrusion 45 extends into the positioning through hole. When the section needs to be released, the medical personnel can press the positioning protrusion 45 into the inside of the housing 211, and the return device 44 can make the pushing head 41 go back and push out the section. Further, the return device 44 is a first elastic device, which is arranged between the housing assembly 21 and the pull rod 43 .

In some embodiments of the present invention, the tumor implant may further include a protective sheath 50 . The protective cover 50 is slidably disposed in the acupuncture head channel, and a part of the protective cover 50 protrudes from the acupuncture head channel. The slicer head 31 is slidably disposed in the protective cover 50 . Preferably, the protective sheath 50 and the housing assembly 21 are provided with a third elastic device 51, and the third elastic device 51 is configured to allow the head end of the protective sheath 50 to make the protective sheath 50 when the tumor implanter performs a piercing action. Move along the direction pointing into the housing assembly 21, and make the protective cover 50 return to the initial position of the protective cover 50 after the resistance disappears.

In some embodiments of the present invention, a mounting plate 213 is disposed inside the inner shell 212 , and the mounting plate 213 is located between the pull rod 43 and the protective cover 50 . The first elastic device includes at least one first spring, and the two ends of each first spring are installed on the pull rod 43 and the mounting plate 213 respectively. The second elastic device 33 includes a second spring, the second spring is sleeved on the pressing rod 321, and the second spring is located between the pull rod 43 and the mounting plate 213, one end of the second spring is fixed to the pressing rod 321, and the other end is fixed to the mounting plate 213. The third elastic device 51 includes a third spring, and the two ends of the third spring are installed on the mounting plate 213 and the rear end of the protective cover 50 respectively. Further, a limiting device 322 is also provided on the pressing rod 321, which is located between the mounting plate 213 and the slicer head 31, so as to prevent the switchable head from continuing to the tail of the housing assembly 21 after the switchable head returns to its initial position. terminal moves.

When the protective cover 50 is in its initial position, the head end face of the protective cover 50 can be in front of the head end face of the slicer head 31 when it is in the initial position of the slicer head 31, that is to say, when the protective cover 50 and the slicer When the heads 31 are in their respective initial positions, the end face of the head end of the protective cover 50 is in front of the end face of the head end of the slicer head 31 . When the protective sheath 50 is in its initial position, the head end face of the protective sheath 50 is still in front of the head end face of the acupuncture head 22 . The head end face of the acupuncture head 22 can be in front of the head end face of the slicer head 31 when it is in the initial position of the slicer head 31 or flush, that is to say, when the slicer head 31 is in the initial position, the needle head The head end face of 22 may be in front of or flush with the head end face of slicer head 31 . The inner surface of the slicing cutter head 31 is a non-slip inner surface, which can prevent the slices from falling off freely.

Further, the distance between the pull rod 43 and the positioning protrusion 45 is 100 to 120 mm, which is convenient for hand holding and other operations. The outer diameter of the housing 211 may be 20 to 25 mm. The distance between the positioning through hole and the head end of the housing 211 may be 40 to 60 mm, and the total length of the housing 211 may be 160 to 210 mm.

In some embodiments of the present invention, there may be a certain gap between the pushing head 41 and the inner wall of the cutting head channel of the slicing head 31 . In some other embodiments, the push head 41 has at least one channel extending along the axial direction of the cutter head passage or a through groove formed on the peripheral wall of the push head 41 , and there may be 1 to 2 channels. The gap or channel or channel can balance the pressure on both sides of the slice when the slice is taken, preventing the pressure between the slice and the pusher head 41 from being too large, and the slice cannot be effectively taken. Further, valves, one-way valves and other devices can be arranged in the gap, channel or channel, which are configured to only allow the gas between the push head 41 and the slice to flow out towards the tail end of the push head 41, which can further prevent the obtained Slices slip off. The head end face of the acupuncture head can preferably be designed as a bevel to facilitate penetration.

When in use, the experimenter can obtain smaller slices from the prepared, larger and uniformly thick tissue slices (also known as slice bases, which can be made by using tumor tissue slice molds, etc.) for planting. Specifically, the experimenter first pulls the pull rod 43 to move the push head 41 inward to a preset position, so that there is an accommodation space in the slicer head 31 . Then press the pressing part 32, so that the slicer head 31 stretches out the protective cover 50 and the acupuncture head 22, the slicer head 31 cuts a section from the slice substrate, releases the presser part 32, and the second spring can make the slicer head 31 automatically Return to the initial position. Hold the housing assembly 21 to make the acupuncture part puncture the planting site. During the puncture, due to the action of the skin, the protective cover 50 retracts to expose the acupuncture head 22, and the acupuncture head 22 penetrates; the acupuncture head 22 pierces. After entering, because there is no resistance, the third spring can make the protective cover 50 stretch out. Finally, the experimenter presses the positioning protrusion 45 to contact the positioning of the pushing head 41, and the first spring moves the pushing head 41 to withdraw from the slice. Then pull out the tumor implanter to complete the tumor implantation.

So far, those skilled in the art should appreciate that, although a number of exemplary embodiments of the present invention have been shown and described in detail herein, without departing from the spirit and scope of the present invention, the disclosed embodiments of the present invention can still be used. Many other variations or modifications consistent with the principles of the invention are directly identified or derived from the content. Accordingly, the scope of the present invention should be understood and deemed to cover all such other variations or modifications.

Claims (8)

1. A tumor implanter, characterized in that, comprising: Acupuncture device, which has a housing assembly and an acupuncture head, the acupuncture head is arranged at the head end of the housing assembly, and the acupuncture head has an acupuncture head channel, the acupuncture head channel is connected to the acupuncture head The internal space of the shell assembly is communicated; Slicing device, which has a slicing head and a pressing part; part or all of the slicing head is arranged in the channel of the acupuncture head, and the slicing head is installed at the head end of the pressing part; The pressing part is slidably mounted on the housing assembly, and is configured to drive the slicing head to move along the axial direction of the piercing head channel, so as to obtain slices; and a slice push-out device, the slice push-out device includes a push head arranged in the cutter head channel of the slice cutter head, configured to push out the slice located in the slice cutter head; The slice pushing device also includes: a connecting rod extending along the axial direction of the cutter head passage, and one end of the connecting rod is fixed to the push head, and the other end is arranged in the housing assembly; and The pull rod is perpendicular to the connecting rod and is directly or indirectly fixedly connected to the other end of the connecting rod; moreover, the pull rod is slidably mounted on the housing assembly along the axial direction of the cutter head channel , and both ends of the pull rod protrude from the housing assembly; The head end face of the push head is flush with or outside the head end face of the slicer head at the initial position of the push head; and The slice pushing device also includes: a push head positioning device configured to keep the push head at the preset position when the pull rod drives the push head to move to a preset position in a direction pointing into the housing assembly; and The return device is configured to provide an active force for urging the push head to move from the preset position to the initial position. 2. The tumor implanter according to claim 1, wherein the pressing part comprises: The pressing rod extends along the axial direction of the cutter head channel, and the pressing rod is a hollow structure, and the tail end of the pressing rod passes through the tail end of the housing assembly; The slicing head is installed on the head end of the pressing rod; The connecting rod is arranged in the pressing rod. 3. The tumor implanter according to claim 2, further comprising: A protective cover is slidably disposed in the acupuncture head channel, and a part of the protective cover protrudes from the acupuncture head channel; and The slicing head is slidably disposed in the protective cover. 4. The tumor implanter according to claim 3, characterized in that, The return device is a first elastic device, which is arranged between the housing assembly and the pull rod; The pressing part and the housing assembly are provided with a second elastic device, and the second elastic device is configured to urge the pressing part to return to the initial position of the pressing part after the pressing part captures a slice; The protective sheath and the housing assembly are provided with a third elastic device, and the third elastic device is configured to allow the head end of the protective sheath to be resisted when the tumor implanter performs a piercing action. The protective cover moves in a direction pointing into the housing assembly, and the protective cover returns to the initial position of the protective cover after the resistance disappears. 5. The tumor implanter according to claim 4, characterized in that, The housing assembly includes an outer shell and an inner shell disposed inside the outer shell; The acupuncture head is arranged at the head end of the inner shell. 6. The tumor implanter according to claim 5, characterized in that, The push head positioning device includes at least one positioning protrusion and at least one positioning through hole; Each positioning protrusion is fixedly connected to the pull rod through a connecting rod; Each of the connecting rods is disposed between the inner shell and the outer shell; Each of the positioning through holes is disposed on the housing; Each of the positioning protrusions is matched with one of the positioning through holes. 7. The tumor implanter according to claim 6, characterized in that, A mounting plate is arranged in the inner shell, and the mounting plate is located between the pull rod and the protective sleeve; The first elastic device includes at least one first spring, and the two ends of each first spring are respectively installed on the pull rod and the mounting plate; The second elastic device includes a second spring, the second spring is sleeved on the pressing rod, and the second spring is located between the pull rod and the mounting plate, and one end of the second spring is fixed on the The other end of the pressing rod is fixed to the mounting plate; The third elastic device includes a third spring, and the two ends of the third spring are installed on the mounting plate and the rear end of the protective sleeve respectively. 8. The tumor implanter according to claim 1, characterized in that, The slicing head is detachably installed on the pressing part, and the inner surface of the slicing head is a non-slip inner surface.