CN106824005A - Prepare the process system of ebutol - Google Patents
Prepare the process system of ebutol Download PDFInfo
- Publication number
- CN106824005A CN106824005A CN201710074764.9A CN201710074764A CN106824005A CN 106824005 A CN106824005 A CN 106824005A CN 201710074764 A CN201710074764 A CN 201710074764A CN 106824005 A CN106824005 A CN 106824005A
- Authority
- CN
- China
- Prior art keywords
- reactor
- ebutol
- pipe
- nitrogen
- recycling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 16
- AUAHHJJRFHRVPV-BZDVOYDHSA-N ethambutol dihydrochloride Chemical compound [Cl-].[Cl-].CC[C@@H](CO)[NH2+]CC[NH2+][C@@H](CC)CO AUAHHJJRFHRVPV-BZDVOYDHSA-N 0.000 title claims abstract description 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 66
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 33
- 238000004064 recycling Methods 0.000 claims abstract description 14
- 238000004821 distillation Methods 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims abstract description 8
- 238000004090 dissolution Methods 0.000 claims abstract description 4
- 238000011144 upstream manufacturing Methods 0.000 claims abstract description 4
- JCBPETKZIGVZRE-UHFFFAOYSA-N 2-aminobutan-1-ol Chemical compound CCC(N)CO JCBPETKZIGVZRE-UHFFFAOYSA-N 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000002360 explosive Substances 0.000 description 3
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- 238000005660 chlorination reaction Methods 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 229960003350 isoniazid Drugs 0.000 description 2
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 230000006819 RNA synthesis Effects 0.000 description 1
- 208000036981 active tuberculosis Diseases 0.000 description 1
- 229940124976 antitubercular drug Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 150000005826 halohydrocarbons Chemical class 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 239000000814 tuberculostatic agent Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/008—Feed or outlet control devices
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention relates to a kind of process system for preparing ebutol, reactor is included from upstream to arranged downstream（1）, distillation still（2）, dissolution kettle（3）, filtering equipment（4）；Also include recycling can（5）, the recycling can（5）Positioned at the distillation still（2）Downstream；Also include collecting tank（6）, the collecting tank（6）Positioned at the filtering equipment（4）Downstream；Also include nitrogen protection device, the nitrogen protection device is included into nitrogen tube（7）, pressure warning unit（10）, this enters nitrogen tube（7）With the reactor（1）Top duct connection, and with the reactor（1）Blow-off pipe（8）And discharge nozzle（9）Pipeline is connected, the pressure warning unit（10）Enter nitrogen tube described in being located at respectively（7）With the blow-off pipe（8）, discharge nozzle（9）Between connecting pipe at.The present invention is prepared suitable for the technique of ebutol.
Description
Technical field
The present invention relates to chemical process, the process unit of ebutol is particularly prepared.
Background technology
DNA and the RNA synthesis of ebutol interference tubercle bacillus, have stronger suppression to growth breeding period tubercle bacillus
Make and use, with other anti-tubercular drugs without cross resistance.Long-term taking can slowly produce drug resistance.Be clinically used for streptomysin or
Isoniazid produces the patient of resistance.It is combined with rifampin or isoniazid, can heightens the effect of a treatment and delay the generation of drug resistance, treatment is each
Type active tuberculosis.In the technique for preparing ebutol, there is chloro danger technique, chlorohydrocarbon and air and oxygen
Explosive mixture can be formed, easily generation is exploded, poisonous material leaks, tight or misoperation does not cause reaction mistake for technic index control
Control accident.
The content of the invention
Goal of the invention：Above-mentioned in order to overcome the shortcomings of, mesh of the invention is to provide a kind of safety, easy-operating one kind and prepares
The process system of ebutol.
Technical scheme：A kind of process system for preparing ebutol, reactor is included from upstream to arranged downstream
（1）, distillation still（2）, dissolution kettle（3）, filtering equipment（4）；Also include recycling can（5）, the recycling can（5）Positioned at the distillation still
（2）Downstream；Also include collecting tank（6）, the collecting tank（6）Positioned at the filtering equipment（4）Downstream；Also protected including nitrogen
Device, the nitrogen protection device is included into nitrogen tube（7）, pressure warning unit（10）, this enters nitrogen tube（7）With the reactor
（1）Top duct connection, and with the reactor（1）Blow-off pipe（8）And discharge nozzle（9）Pipeline is connected, the pressure alarm
Device（10）Enter nitrogen tube described in being located at respectively（7）With the blow-off pipe（8）, discharge nozzle（9）Between connecting pipe at.
Preferably, described enters nitrogen tube（7）With the reactor（1）Top connecting pipe have 2, and set respectively
Put check valve.
Preferably, described recycling can（5）It is dextrorotation amino butanol recycling can.
Preferably, described collecting tank（6）It is portable transparent vessel.
Beneficial effect：The present invention uses nitrogen protection device, when chlorination is carried out, opens nitrogen protection device,
It is connected with 2 and enters nitrogen tube with reactor top, quickly will can be effectively prevented in course of reaction because of halogen in reactor full of nitrogen
Acutely there is inflammable and explosive accident for hydrocarbon reaction.At discharging and blow-off pipe, also with enter nitrogen tube and be connected, it is ensured that whole process is pacified
It is complete reliable.
Brief description of the drawings
Fig. 1 is structural representation of the invention.
Specific embodiment
With reference to specific embodiment, the present invention is expanded on further.It should be understood that these embodiments are merely to illustrate the present invention
Rather than limitation the scope of the present invention.
Embodiment 1
Such as Fig. 1, a kind of process system for preparing ebutol, include from upstream to arranged downstream reactor 1, distillation still 2,
Dissolution kettle 3, filtering equipment 4；Also include recycling can 5, the recycling can 5 is located at the downstream of the distillation still 2；Also include collecting tank 6,
The collecting tank 6 is located at the downstream of the filtering equipment 4；Also include nitrogen protection device, the nitrogen protection device is included into nitrogen
Pipe 7, pressure warning unit 10, this enters nitrogen tube 7 and is connected with the top duct of the reactor 1, and with the blowdown of the reactor 1
Pipe 8 and the pipeline of discharge nozzle 9 are connected, the pressure warning unit 10 be located at respectively it is described enter nitrogen tube 7 and the blow-off pipe 8, go out
At connecting pipe between expects pipe 9.
In the present embodiment, described nitrogen tube 7 of entering has 2 with the top connecting pipe of the reactor 1, and is respectively provided with
Check valve.
Described recycling can 5 is dextrorotation amino butanol recycling can.Described collecting tank 6 is portable transparent vessel.
The present invention uses nitrogen protection device, when chlorination is carried out, opens nitrogen protection device, with reactor top
It is connected with 2 and enters nitrogen tube, nitrogen can will be quickly full of in reactor, effectively prevents in course of reaction because halohydrocarbons reaction is violent
The inflammable and explosive accident of generation.At discharging and blow-off pipe, also with enter nitrogen tube and be connected, it is ensured that whole process is safe and reliable.
Claims (4)
1. a kind of process system for preparing ebutol, it is characterised in that：Include reactor from upstream to arranged downstream
（1）, distillation still（2）, dissolution kettle（3）, filtering equipment（4）；Also include recycling can（5）, the recycling can（5）Positioned at the distillation still
（2）Downstream；Also include collecting tank（6）, the collecting tank（6）Positioned at the filtering equipment（4）Downstream；Also protected including nitrogen
Device, the nitrogen protection device is included into nitrogen tube（7）, pressure warning unit（10）, this enters nitrogen tube（7）With the reactor
（1）Top duct connection, and with the reactor（1）Blow-off pipe（8）And discharge nozzle（9）Pipeline is connected, the pressure alarm
Device（10）Enter nitrogen tube described in being located at respectively（7）With the blow-off pipe（8）, discharge nozzle（9）Between connecting pipe at.
2. a kind of as claimed in claim 1 process system for preparing ebutol, it is characterised in that：Described enters nitrogen
Pipe（7）With the reactor（1）Top connecting pipe have 2, and be respectively provided with check valve.
3. a kind of as claimed in claim 1 process system for preparing ebutol, it is characterised in that：Described recycling can
（5）It is dextrorotation amino butanol recycling can.
4. a kind of as claimed in claim 1 process system for preparing ebutol, it is characterised in that：Described collecting tank
（6）It is portable transparent vessel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710074764.9A CN106824005A (en) | 2017-02-12 | 2017-02-12 | Prepare the process system of ebutol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710074764.9A CN106824005A (en) | 2017-02-12 | 2017-02-12 | Prepare the process system of ebutol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106824005A true CN106824005A (en) | 2017-06-13 |
Family
ID=59127884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710074764.9A Pending CN106824005A (en) | 2017-02-12 | 2017-02-12 | Prepare the process system of ebutol |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106824005A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101171217A (en) * | 2005-05-04 | 2008-04-30 | 陶氏环球技术公司 | Oxidative halogenation of C1 hydrocarbons to halogenated C1 hydrocarbons |
| CN101367708A (en) * | 2008-08-27 | 2009-02-18 | 王传华 | Preparation of chloro-cyclohexane under nitrogen protection |
| CN101759574A (en) * | 2009-12-25 | 2010-06-30 | 张中法 | Synthesizing method of 3-methylamino-1, 2-propanediol |
| CN206500127U (en) * | 2017-02-12 | 2017-09-19 | 江苏诚信药业有限公司 | Prepare the process system of ebutol |
-
2017
- 2017-02-12 CN CN201710074764.9A patent/CN106824005A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101171217A (en) * | 2005-05-04 | 2008-04-30 | 陶氏环球技术公司 | Oxidative halogenation of C1 hydrocarbons to halogenated C1 hydrocarbons |
| CN101367708A (en) * | 2008-08-27 | 2009-02-18 | 王传华 | Preparation of chloro-cyclohexane under nitrogen protection |
| CN101759574A (en) * | 2009-12-25 | 2010-06-30 | 张中法 | Synthesizing method of 3-methylamino-1, 2-propanediol |
| CN206500127U (en) * | 2017-02-12 | 2017-09-19 | 江苏诚信药业有限公司 | Prepare the process system of ebutol |
Non-Patent Citations (2)
| Title |
|---|
| 张会欣等: "浅析盐酸乙胺丁醇的合成工艺改进", 《山东工业技术》 * |
| 王广亮等: "《企业防爆安全》", 31 March 1997 * |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170613 |