CN106818783A - A kind of microbicide compositions comprising BIT class and tetraconazole - Google Patents
A kind of microbicide compositions comprising BIT class and tetraconazole Download PDFInfo
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- CN106818783A CN106818783A CN201710009258.1A CN201710009258A CN106818783A CN 106818783 A CN106818783 A CN 106818783A CN 201710009258 A CN201710009258 A CN 201710009258A CN 106818783 A CN106818783 A CN 106818783A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a kind of microbicide compositions, said composition includes two kinds of effective constituents As and B, and active component A is the compound with formula (I) structure, and active component B is tetraconazole, and the weight ratio between two components is 20~1:1~20.Present invention also offers the Preparation method and use of said composition.Result of the test shows that the above-mentioned bactericidal composition synergy that the present invention is provided is obvious, it is often more important that amount of application is reduced, use cost reduction.The bactericidal composition can effectively prevent and treat some specific bacteriums or the fungal disease of crop.Compounded by by the bactericide of different mechanism of action and the mode of action, there is effect well for expanding fungicidal spectrum and delaying fungi, bacterial resistance and improve the aspects such as prevention effect.
Description
Technical field
It is more particularly to a kind of with the bactericidal composition for improving performance, tool the invention belongs to agriculture plant protection field
Say it is to be related to a kind of microbicide compositions comprising BIT class and tetraconazole body.
Background technology
BIT class compound is a kind of new, wide-spectrum bactericide, is mainly used in preventing and treating and treating Cereal
The various bacterias such as crop, veterinary antibiotics, fungal disease.Its bactericidal action mechanism, it is main to include destruction germ nucleus knot
Structure, makes it lose cardia and dead and interference germ cell the metabolism of exhaustion, makes its physiologic derangement, ultimately results in dead
Die two aspects.In disease early period of origination using can effectively protect plant not infected by pathogen, disease takes the circumstances into consideration to increase after occurring
Dosage can substantially control spreading for germ, so as to the double action for reaching protection and root out.
Tetraconazole (Tetraconazole) belongs to second generation triazole bactericidal agent, fluorine-containing in molecular structure, bactericidal activity
Than 2-3 times that is the first generation, wide sterilization spectrum, efficient, lasting period are up to 4-6 weeks, with protection and therapeutic action, and have well
Uptake and translocation performance.Suitable for crop cereal crop such as wheat, barley, oat, rye etc., fruit tree such as banana, grape, pears, apple
Fruit etc., vegetables are for example melon, beet, ornamental plant etc..Erysiphe, Puccinia, beak genuss, nuclear cavity Pseudomonas and shell can be prevented and treated
Pin spore belong to microbial disease for example wheat powdery mildew, loose smut of wheat, wheat rust, the bunt of wheat, wheat grain husk blessing disease,
Barley leaf blotch, loose smut of barley, barley banded sclerotial blight, maize head smut, head smut of sorghum, melon and fruit powdery mildew, banana
Leaf spot, alternaria leaf spot of apple, pear scab and uncinula necator etc..Both can cauline leaf process, can also be used as Seed Treatment.
Actual agricultural chemicals experience have shown that, repeat and single-minded apply a kind of reactive compound to prevent and treat harmful fungoid very
The fast selective of fungal bacterial strain will be caused in the case of many, to reduce the danger of refractory fungal bacterial strain selectivity, at present generally
Harmful fungoid is prevented and treated using the mixture of different activities compound.Enter by by the reactive compound with the different mechanisms of action
Row combination, can delaying drug resistance generation, reduction amount of application, reduction cost accounting.
The content of the invention
The purpose of the present invention is directed to bactericide resistance and pedo relict problem in actual applications, filters out difference and kills
The bactericide of bacterium principle is compounded, and obtains a kind of new microbicide compositions, to improve bactericidal agent for preventing and treating effect, delaying drug resistance
Produce, reduce amount of application, reduce cost accounting.
It is a further object to provide anti-in agriculture field comprising two kinds of effective constituents As and B microbicide compositions
Control the application in terms of corps diseases.
The purpose of the present invention can be reached by following measures：
A kind of microbicide compositions with synergistic effect, said composition includes two kinds of active components of A and B, wherein activity
Component A is the compound with formula (I) structure, and active component B is tetraconazole.
In formula (I), R is selected from H or C1~C8Alkyl.
C in the present invention1~C8Alkyl refers to that, containing 1 to 8 straight or branched alkyl of carbon atom, it includes C1Alkyl
(such as methyl), C2Alkyl (such as ethyl), C3Alkyl (such as n-propyl, isopropyl), C4Alkyl (such as normal-butyl, isobutyl group, the tert-butyl group,
Sec-butyl), C5Alkyl (such as n-pentyl), C6Alkyl, C7Alkyl, C8Alkyl.It includes but is not limited to C1~C6Alkyl, C1~C5
Alkyl, C1~C4Alkyl etc..
In a kind of preferred scheme, R is selected from H or C1~C4Alkyl.
In a kind of preferred scheme, R is selected from H ,-CH3Or-C4H9。
In formula (I), when R is H, A is BIT (abbreviation BIT in specification).
In formula (I), when R is CH3When, A is 2- methyl isophthalic acids, 2- benzisothiazole-3-ketones (abbreviation MBIT in specification).
In formula (I), when R is C4H9When, A is 2- butyl-BIT, and " butyl " in the formula is preferably
Normal-butyl (abbreviation BBIT in specification).
Inventor is found by experiment that composition of the invention is for preventing and treating crops bacterium or fungal disease preventing and treating
Synergy is obvious, it is often more important that amount of application is reduced, and reduces use cost.Compound structure type containing component A and component B is not
Together, mechanism of action is different, and both can expand fungicidal spectrum at compounding, and can to a certain extent delay the product of pathogen resistance
No interactions resistance between raw and development speed, and component A and component B.
Weight ratio between two components in microbicide compositions of the present invention is 20~1:1~20.Between to make two components
Drug effect synergistic effect is more notable, and the weight ratio between the component of weight two of component A and component B can further be optimized to 10~
1：1~10.
In a kind of preferred scheme, the weight ratio between A and the components of B two arbitrarily can enter in the range of following proportionings
Row adjustment 20:1、19:1、18:1、17:1、16:1、15:1、14:1、13:1、12:1、11:1、10:1、9:1、8:1、7:1、6:1、
5:1、4:1、3:1、2:1、1:1、1:2、1:3、1:4、1:5、1:6、1:7、1:8、1:9、1:10、1:11、1:12、1:13、1:14、
1:15、1:16、1:17、1:18、1:19、1:20, it is also possible to selected in the range of two proportionings of any of the above are constituted,
These ratios can be understood as weight ratio, it is also possible to including mol ratio.
Composition of the invention can be made the formulation allowed on agricultural chemicals by active component and insecticides adjuvant or auxiliary material.Enter one
Step, said composition is made up of the active component of 2~80% weight portions and the insecticides adjuvant of 98~20% weight portions and permit on agricultural chemicals
Perhaps formulation.
The invention provides the bactericidal composition comprising component A and component B in terms of agriculture field preventing and treating corps diseases
Purposes, particularly prevent and treat some crops fungi or bacterial disease in terms of purposes.
Above-mentioned composition can specifically include insecticides adjuvant or auxiliary material, for example carrier, solvent, dispersant, wetting agent, gluing
One or more in agent, thickener, adhesive, surfactant or fertilizer etc..Can mix during administration conventional
Auxiliary agent.
Suitable auxiliary agent or auxiliary material can be solid or liquid, and they are typically the material commonly used during formulation,
For example natural or regeneration mineral matter, solvent, dispersant, wetting agent, adhesive, thickener, adhesive.
The application process of the present composition includes being used for composition of the invention the aerial part of plant growth, especially
It is leaf portion or blade face.Can select to soak seed or be applied to controlling object surface.The frequency and amount of application of administration depend on pathogen
Biology and weather life condition.Can be by the growth place of plant, such as rice field is soaked with the liquid preparation of composition, or
In solid form be applied in soil composition by person, and such as in granular form (soil application), composition can be by soil through planting
Thing root enters in plant (systemic action).
Composition of the invention can be prepared into acceptable various formulations on agricultural chemicals, including but not limited to missible oil, suspension
Agent, wettable powder, water dispersible granules, pulvis, granula, aqua, aqueous emulsion, microemulsion, poison bait, mother liquor, female powder etc., in one kind
In preferred scheme, formulation of the invention uses wettable powder, suspending agent, water dispersible granules, aqueous emulsion or microemulsion.According to this
The property of a little compositions and the purpose to be reached using composition and ambient conditions, can select composition to spray,
Atomizing, dust, broadcast sowing or sprinkle the method poured or the like and apply.
Composition of the invention can be prepared into various formulations with known method, can by active ingredient with help
Agent, such as solvent, solid carrier, it is necessary to when can uniformly mix together with surfactant, grind, be prepared into required agent
Type.
Above-mentioned solvent may be selected from aromatic hydrocarbon, preferably containing 8-12 carbon atom, such as xylene mixture or substituted benzene, phthalein
The octanoic acid of esters of gallic acid, such as Dibutyl phthalate or phthalandione two, such as fat hydrocarbon, thiacyclohexane or paraffin, alcohol and ethylene glycol and their ether
And ester, such as ethanol, ethylene glycol, ethylene glycol monomethyl；Ketone, such as cyclohexanone, such as highly polar solvent, N- methyl -2- pyrrolidines
Ketone, dimethyl sulfoxide (DMSO) or dimethylformamide, and vegetable oil or vegetable oil, such as soybean oil.
Above-mentioned solid carrier, is such as used for pulvis and dispersibles the typically natural mineral fillers, such as talcum, kaolinite of agent
Soil, montmorillonite or atlapulgite.In order to manage the physical property of composition, it is also possible to add polymolecularity silicic acid or polymolecularity
Adsorpting polymerization thing carrier, such as granulated adsorptive carriers or non-adsorbed carrier, suitable granulated adsorptive carriers are porous types, such as floating
Stone, bentonite or bentonite；Suitable non-adsorbed carrier such as calcite or sand.Further, it is possible to use substantial amounts of inorganic in nature or having
The prefabricated material for granulating of machine property is used as carrier, particularly dolomite.
According to the chemical property of active ingredient in the present composition, suitable surfactant is lignin sulfonic acid, naphthalene
Sulfonic acid, phenolsulfonic acid, alkali salt or amine salt, alkylaryl sulfonates, alkyl sulfate, alkylsulfonate, fatty alcohol sulphur
The condensation product of hydrochlorate, aliphatic acid and sulphated fatty alcohol glycol ether, also sulfonated naphthalene and naphthalene derivatives and formaldehyde, naphthalene or naphthalene sulphur
Acid and phenol and the condensation product of formaldehyde, NONIN HS 240, ethoxylated isooctyl-phenol, octyl phenol, nonyl phenol, alkyl
Aryl polyglycol ether, tributyl benzene polyglycol ether, three stearyl phenyl polyglycol ethers, alkyl aryl polyether alcohol, ethoxy
Base castor oil, polyoxyethylene alkyl ether, ethylene oxide condensation product, ethoxylation polyoxypropylene, the contracting of laurate polyglycol ether
Aldehyde, sorbitol ester, lignin sulfite waste liquor and methylcellulose.
When liquid or solid dosage forms is prepared, active component A first can be dissolved in some specific alkaline matters, form benzene
And isothiazoline slaine, suitable alkaline matter includes：Alkali carbonate, alkali metal hydroxide (such as NaOH, hydrogen
Potassium oxide), alkali metal alkoxy carbonate, alkali metal alcoholates or magnesium methoxide.
Two kinds of active ingredients show as synergistic effect in composition of the invention, and the activity of said composition is than using individualized
The expected summation of activity of compound, and the independent activity of single compound is more notable.Synergistic effect shows as allowing amount of application
Reduce, broader antifungal control spectrum, instant effect, more longlasting prevention effect, by only once or minority is several times using more
Good control plant pest fungi and broaden the possible administration interval time.These characteristics are plant epiphyte control practices
During especially need.
Microbicide compositions of the invention can be applied to agriculture field preventing and treating corps diseases aspect, targeted specific disease
Disease includes but is not limited to wheat diseases (such as：Wheat scab, wheat powdery mildew, wheat rust etc.), rice disease (such as：Paddy rice
Banded sclerotial blight, rice green smut, rice blast, paddy bacterial streak etc.), maize diseases (such as：Smut of maize, corn are big
Pinta, corn southern leaf blight), cucumber disease (such as：The bacillary angle spot of cucumber downy mildew, powdery mildew of cucumber, cucumber anthracnose, cucumber
Disease etc.), tomato disease (such as：Anthracnose of tomato, graw mold of tomato, tomato bacterial angular leaf spot etc.), grape disease (such as：Grape
Downy mildew, grape grey mould, uncinula necator), apple disease (such as ring rot of apple, apple anthracnose), citrus disease (mandarin orange
Tangerine canker, oranges and tangerines scab simultaneously, citrus anthracnose), tobacco diseases (wildfire) etc..
Other features for showing of bactericidal composition of the invention are mainly shown as：1st, composition mixture tool of the invention
There is obvious synergistic effect；2nd, because two single dose chemical constitutions of this composition are widely different, the mechanism of action is entirely different, no
There is cross resistance, can delay two single doses that produced resistance problem is used alone；3rd, composition of the invention to crop safety,
Preventive effect is good.Tests prove that, microbicide compositions stable chemical nature of the present invention, synergy significantly, shows bright to controlling object
Aobvious synergy and complementation.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that specific embodiment described herein is only used to explain the present invention, limit is not used to
The fixed present invention, all any modification, equivalent and improvement made within the spirit and principles in the present invention etc., should be included in
Within protection scope of the present invention.
Percentage is weight percentage in all formulas of following examples.The processing work of the various preparations of the present composition
Skill is prior art, can be varied from according to different situations.
First, formulation prepares embodiment
(1) processing of aqueous emulsion and embodiment
Active components A and B activity composition and solvent, emulsifying agent, dispersant, antifreeze etc. are sufficiently mixed in proportion, plus
It is well mixed after water and can be prepared by aqueous emulsion.
(1) active component A (BIT) prepares aqueous emulsion with tetraconazole
Embodiment 1：16%BIT tetraconazoles aqueous emulsion (15:1)
BIT 15%, tetraconazole 1%, castor oil ethylene oxide adduct 6.35%, dimethylbenzene 12%, alkyl benzene sulphonate
Sodium 5.86%, glycerine 10%, water complements to 100%.
Embodiment 2：30%BIT tetraconazoles aqueous emulsion (1:5)
BIT 5%, tetraconazole 25%, APES formaldehyde condensation product 8.46%, toluene 16%, dodecane
Base sodium sulphate 7.49%, glycerine 12%, water complements to 100%.
Embodiment 3：42%BIT tetraconazoles aqueous emulsion (1:20)
BIT 2%, tetraconazole 40%, polyvinyl alcohol 10.47%, dimethylbenzene 15%, methyl anyl alcohol 10.21%, second two
Alcohol 10%, water complements to 100%.
(2) active component A (MBIT) prepares aqueous emulsion with tetraconazole
Embodiment 4：16%MBIT tetraconazole aqueous emulsions
MBIT 15%, tetraconazole 1%, remaining component is prepared according to the method for embodiment 1.
Embodiment 5：30%MBIT tetraconazole aqueous emulsions
MBIT 5%, tetraconazole 25%, remaining component is prepared according to the method for embodiment 2.
Embodiment 6：42%MBIT tetraconazole aqueous emulsions
MBIT 2%, tetraconazole 40%, remaining component is prepared according to the method for embodiment 3.
(3) active component A (BBIT) prepares aqueous emulsion with tetraconazole
Embodiment 7：16%BBIT tetraconazole aqueous emulsions
BBIT 15%, tetraconazole 1%, remaining component is prepared according to the method for embodiment 1.
Embodiment 8：30%BBIT tetraconazole aqueous emulsions
BBIT 5%, tetraconazole 25%, remaining component is prepared according to the method for embodiment 2.
Embodiment 9：42%BBIT tetraconazole aqueous emulsions
BBIT 2%, tetraconazole 40%, remaining component is prepared according to the method for embodiment 3.
(2) processing of suspending agent and embodiment
By active component activity packet A and active component B, with each component such as dispersant, wetting agent, thickener and water by matching somebody with somebody
Side ratio be well mixed, through sand milling and/or high speed shear after, obtain semi-finished product, after analysis mend be mixed with water filtering i.e.
Obtain finished product.
(1) active component A (BIT) prepares suspending agent with tetraconazole
Embodiment 10：10.5%BIT tetraconazoles suspending agent (20:1)
BIT 10%, tetraconazole 0.5%, spaonin powder 4.58%, aluminium-magnesium silicate 1.46%, ethylene glycol 6%, silicone oil
0.01%, water complements to 100%.
Embodiment 11：3%BIT tetraconazoles suspending agent (5:1)
BIT 2.5%, tetraconazole 0.5%, lignin sulfonic acid sodium salt 2.36%, xanthans 1.65%, ethylene glycol 5%,
Dimethyl silicone polymer 0.01%, water complements to 100%.
Embodiment 12：22%BIT tetraconazoles suspending agent (1:10)
BIT 2%, tetraconazole 20%, AEO 8.45%, xanthans 5.33%, glycerine 12%,
Silicone oil 0.02%, water complements to 100%.
(2) active component A (MBIT) prepares suspending agent with tetraconazole
Embodiment 13：10.5%MBIT tetraconazole suspending agents
MBIT 10%, tetraconazole 0.5%, remaining component is prepared according to the method for embodiment 10.
Embodiment 14：3%MBIT tetraconazole suspending agents
MBIT 2.5%, tetraconazole 0.5%, remaining component is prepared according to the method for embodiment 11.
Embodiment 15：22%MBIT tetraconazole suspending agents
MBIT 2%, tetraconazole 20%, remaining component is prepared according to the method for embodiment 12.
(3) active component A (BBIT) prepares suspending agent with tetraconazole
Embodiment 16：10.5%BBIT tetraconazole suspending agents
BBIT 10%, tetraconazole 0.5%, remaining component is prepared according to the method for embodiment 10.
Embodiment 17：3%BBIT tetraconazole suspending agents
BBIT 2.5%, tetraconazole 0.5%, remaining component is prepared according to the method for embodiment 11.
Embodiment 18：22%BBIT tetraconazole suspending agents
BBIT 2%, tetraconazole 20%, remaining component is prepared according to the method for embodiment 12.
(3) processing of wettable powder and embodiment
Active components A and B activity composition and various auxiliary agents and filler etc. are sufficiently mixed in proportion, through ultrafine crusher powder
Prepared wettable powder after broken.
(1) active component A (BIT) prepares wettable powder with tetraconazole
Embodiment 19:55%BIT tetraconazoles wettable powder (10:1)
BIT 50%, tetraconazole 5%, naphthalene sulfonate 1.73%, lauryl sodium sulfate 1.53%, bentonite
3.50%, kaolin complements to 100%.
Embodiment 20:15%BIT tetraconazoles wettable powder (1:1)
BIT 7.5%, tetraconazole 7.5%, lignin sulfonic acid sodium salt 6.64%, Nekal BX 4.05%, bentonite
4.73%, white carbon supply to 100%.
Embodiment 21:24%BIT tetraconazoles wettable powder (1:15)
BIT 1.5%, tetraconazole 22.5%, spaonin powder 9.84%, APES 11.29%, ammonium sulfate
6.08%, kaolin complements to 100%.
(2) active component A (MBIT) prepares wettable powder with tetraconazole
Embodiment 22：55%MBIT tetraconazole wettable powders
MBIT 50%, tetraconazole 5%, remaining component is prepared according to the method for embodiment 19.
Embodiment 23：15%MBIT tetraconazole wettable powders
MBIT 7.5%, tetraconazole 7.5%, remaining component is prepared according to the method for embodiment 20.
Embodiment 24：24%MBIT tetraconazole wettable powders
MBIT 1.5%, tetraconazole 22.5%, remaining component is prepared according to the method for embodiment 21.
(3) active component A (BBIT) prepares wettable powder with tetraconazole
Embodiment 25：55%BBIT tetraconazole wettable powders
BBIT 50%, tetraconazole 5%, remaining component is prepared according to the method for embodiment 19.
Embodiment 26：15%BBIT tetraconazole wettable powders
BBIT 7.5%, tetraconazole 7.5%, remaining component is prepared according to the method for embodiment 20.
Embodiment 27：24%BBIT tetraconazole wettable powders
BBIT 1.5%, tetraconazole 22.5%, remaining component is prepared according to the method for embodiment 21.
2nd, drug effect checking test
(1) Assays Example
The incidence of whole strain blade is investigated according to experiment grade scale, disease index and prevention effect is calculated.
Prevention effect is converted into niqueMin (y), liquor strength (μ g/ml) is converted into logarithm value (x), with least square method
Concentration EC50 in calculating virulence equation and suppressing, the toxicity index and co-toxicity coefficient (CTC) of medicament are calculated according to the abundant methods of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) * 100
Percentage composition+B medicament toxicity index * the mixtures of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixtures
The percentage composition of middle B
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI)/mixture theoretical toxicity index (TTI)] * 100
CTC≤80, composition shows as antagonism, 80 ＜ CTC ＜ 120, and composition shows as summation action, and CTC >=
120, composition shows as synergistic effect.
1st, BIT and tetraconazole compounding are tested Kiwi berry powdery mildew toxicity test
Table 1.BIT is compounded to Kiwi berry powdery mildew toxicity test interpretation of result with tetraconazole
As a result (table 1) shows that BIT is compounded with tetraconazole and the prevention effect of Kiwi berry powdery mildew is significantly improved, especially
In its proportioning 20~1：1~20 virulence coefficient is more than 132.85.Illustrate both compoundings to Kiwi berry controlling powdery mildew
There is significant synergistic effect.
2nd, MBIT and tetraconazole compounding are tested gray mold of cucumber toxicity test
Table 2.MBIT is compounded to gray mold of cucumber toxicity test interpretation of result with tetraconazole
As a result (table 2) shows that BIT is compounded with tetraconazole and the prevention effect of gray mold of cucumber is significantly improved, and is especially existed
Its proportioning is 20~1：1~20 virulence coefficient is more than 162.21.Illustrate that both compoundings have aobvious to gray mold of cucumber preventing and treating
The synergistic effect of work.
3rd, BBIT and tetraconazole are tested sclerotinia of tomato toxicity test
Table 3.BBIT is compounded to sclerotinia of tomato toxicity test interpretation of result with tetraconazole
As a result (table 3) shows that BBIT is compounded with tetraconazole and the prevention effect of sclerotinia of tomato is significantly improved, and illustrates two
Person's compounding has significant synergistic effect to sclerotinia of tomato preventing and treating.
(2) field efficacy checking test
Test method：At the initial stage of a disease, first time spraying is carried out immediately, and second dispenser is carried out after 7 days, each treatment 4
Individual cell, each square meter of cell 20.In 11 days investigation statisticses incidences before medicine and after second medicine, 5 points of each cell is random
Sampling, 5 plants of crops of every investigation, investigates the lesion area in whole strain per blade and accounts for the percentage of blade area and be classified, and calculates
Disease index and prevention effect.
Expected preventive effect (%)=X+Y-XY/100 (wherein, X, Y are single dose preventive effect)
Grade scale：
0 grade：Disease-free spot；
1 grade：Leaf spot lesion is less than 5, and length is less than 1cm；
3 grades：Leaf spot lesion 6-10, part scab length is more than 1cm；
5 grades：Leaf spot lesion 11-25, part scab is linked to be piece, and lesion area accounts for the 10-25% of leaf area；
7 grades：Leaf spot lesion more than 26, scab is linked to be piece, and lesion area accounts for the 26-50% of leaf area；
9 grades：Scab is linked to be piece, and more than 50% or the full leaf that lesion area accounts for leaf area are withered.
1st, BIT and tetraconazole compounding field efficacy experiment
The BIT of table 4 is with tetraconazole mixture to powdery mildew of strawberry prevention effect
Measurement result (table 4) shows that BIT is significantly improved with the compounding of tetraconazole to powdery mildew of strawberry preventive effect, illustrates two
Person's compounding has significant synergistic effect to powdery mildew of strawberry.
2nd, MBIT and tetraconazole compounding field efficacy experiment
The MBIT of table 5 is with tetraconazole mixture to fruit white rot of grape prevention effect
Measurement result (table 5) shows that MBIT is significantly improved with tetraconazole mixture to the preventive effect of fruit white rot of grape, illustrates two
Person's compounding has significant synergistic effect to fruit white rot of grape.
3rd, BBIT and tetraconazole compounding field efficacy experiment
The BBIT of table 6 is with tetraconazole mixture to Powdery Mildew in Tobacco prevention effect
Measurement result (table 6) shows that BBIT is significantly improved with tetraconazole mixture to the preventive effect of Powdery Mildew in Tobacco, illustrates two
Person's compounding has significant synergistic effect to Powdery Mildew in Tobacco.
Claims (8)
1. a kind of microbicide compositions, it is characterised in that described composition includes two kinds of active components of A and B, wherein activearm
A is divided to be the compound with formula (I) structure, active component B is tetraconazole, and the weight ratio between two components is 20~1:1~
20
In formula (I), R is selected from H or C1~C8Alkyl.
2. microbicide compositions according to claim 1, it is characterised in that in formula (I), R is selected from H or C1~C4Alkyl.
3. microbicide compositions according to claim 2, it is characterised in that in formula (I), R is preferably selected from H ,-CH3Or-
C4H9, corresponding active component A is respectively BIT, 2- methyl isophthalic acids, 2- benzisothiazole-3-ketones or
2- butyl -1,2- benzisothiazole-3-ketones.
4. microbicide compositions according to claim 1, it is characterised in that the weight ratio of active component A and active component B
It is 10~1:1~10.
5. microbicide compositions according to any one in Claims 1 to 4, it is characterised in that said composition by activity into
Divide the formulation for being made with insecticides adjuvant or auxiliary material and being allowed on agricultural chemicals.
6. microbicide compositions according to claim 5, it is characterised in that described formulation is wettable powder, suspending agent
Or aqueous emulsion.
7. microbicide compositions according to claim 5 or 6, it is characterised in that the insecticides adjuvant or auxiliary material are selected from and carry
One or more in body, solvent, dispersant, wetting agent, adhesive, thickener, adhesive, surfactant or fertilizer.
8. the microbicide compositions in claim 1~7 described in any one are in terms of agriculture field preventing and treating corps diseases
Purposes.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710009258.1A CN106818783A (en) | 2017-01-06 | 2017-01-06 | A kind of microbicide compositions comprising BIT class and tetraconazole |
| PCT/CN2017/116817 WO2018126878A1 (en) | 2017-01-06 | 2017-12-18 | Fungicide composition containing benzisothiazolinone and tetraconazole |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710009258.1A CN106818783A (en) | 2017-01-06 | 2017-01-06 | A kind of microbicide compositions comprising BIT class and tetraconazole |
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| Publication Number | Publication Date |
|---|---|
| CN106818783A true CN106818783A (en) | 2017-06-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710009258.1A Withdrawn CN106818783A (en) | 2017-01-06 | 2017-01-06 | A kind of microbicide compositions comprising BIT class and tetraconazole |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN106818783A (en) |
| WO (1) | WO2018126878A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018126878A1 (en) * | 2017-01-06 | 2018-07-12 | 江苏辉丰生物农业股份有限公司 | Fungicide composition containing benzisothiazolinone and tetraconazole |
| CN108338173A (en) * | 2017-08-08 | 2018-07-31 | 江苏辉丰农化股份有限公司 | A kind of bactericidal composition including benzoisothiazolinone class and fluorine thiazole pyrrole ethyl ketone |
| CN113273577A (en) * | 2021-06-18 | 2021-08-20 | 上海迈肯生物科技有限公司 | 1, 2-benzisothiazolin-3-one aqueous suspension preparation and preparation method thereof |
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| CN101326915A (en) * | 2007-06-21 | 2008-12-24 | 罗门哈斯公司 | microbicide composition |
| CN101984809A (en) * | 2010-07-22 | 2011-03-16 | 福建诺德生物科技有限责任公司 | Oil suspension preparation using resin-based vegetable oil as carrier and preparation method thereof |
| CN101999372A (en) * | 2010-12-14 | 2011-04-06 | 陕西西大华特科技实业有限公司 | Bactericidal composition containing benziothiazolinone and difenoconazole |
| CN102172240A (en) * | 2011-03-01 | 2011-09-07 | 陕西西大华特科技实业有限公司 | Bactericidal composition containing benziothiazolinone and methoxyl acrylic ester type bactericides |
| CN105685061A (en) * | 2016-02-29 | 2016-06-22 | 陕西西大华特科技实业有限公司 | Application of benziothiazolinone in preventing and treating potato seed-borne diseases and promoting rooting and germination |
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| CN101530099B (en) * | 2009-04-27 | 2012-04-25 | 陕西上格之路生物科学有限公司 | Isothiazolinone-containing bactericidal composition |
| GB2479556A (en) * | 2010-04-13 | 2011-10-19 | Arch Timber Protection Ltd | Wood preservative formulation |
| CN102860309A (en) * | 2011-07-07 | 2013-01-09 | 爱环吴世(苏州)环保有限公司 | Corrosion mitigation sterilization composite medicament and processing technique thereof |
| CN102771488B (en) * | 2012-07-31 | 2014-07-23 | 陕西上格之路生物科学有限公司 | Bactericidal composition containing isothiazolone |
| CN104472505B (en) * | 2014-12-15 | 2016-03-23 | 上海万厚生物科技有限公司 | A kind of mould inhibitor and application thereof |
| CN106818783A (en) * | 2017-01-06 | 2017-06-13 | 江苏辉丰农化股份有限公司 | A kind of microbicide compositions comprising BIT class and tetraconazole |
-
2017
- 2017-01-06 CN CN201710009258.1A patent/CN106818783A/en not_active Withdrawn
- 2017-12-18 WO PCT/CN2017/116817 patent/WO2018126878A1/en not_active Ceased
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101326915A (en) * | 2007-06-21 | 2008-12-24 | 罗门哈斯公司 | microbicide composition |
| CN101984809A (en) * | 2010-07-22 | 2011-03-16 | 福建诺德生物科技有限责任公司 | Oil suspension preparation using resin-based vegetable oil as carrier and preparation method thereof |
| CN101999372A (en) * | 2010-12-14 | 2011-04-06 | 陕西西大华特科技实业有限公司 | Bactericidal composition containing benziothiazolinone and difenoconazole |
| CN102172240A (en) * | 2011-03-01 | 2011-09-07 | 陕西西大华特科技实业有限公司 | Bactericidal composition containing benziothiazolinone and methoxyl acrylic ester type bactericides |
| CN105685061A (en) * | 2016-02-29 | 2016-06-22 | 陕西西大华特科技实业有限公司 | Application of benziothiazolinone in preventing and treating potato seed-borne diseases and promoting rooting and germination |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018126878A1 (en) * | 2017-01-06 | 2018-07-12 | 江苏辉丰生物农业股份有限公司 | Fungicide composition containing benzisothiazolinone and tetraconazole |
| CN108338173A (en) * | 2017-08-08 | 2018-07-31 | 江苏辉丰农化股份有限公司 | A kind of bactericidal composition including benzoisothiazolinone class and fluorine thiazole pyrrole ethyl ketone |
| CN113273577A (en) * | 2021-06-18 | 2021-08-20 | 上海迈肯生物科技有限公司 | 1, 2-benzisothiazolin-3-one aqueous suspension preparation and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018126878A1 (en) | 2018-07-12 |
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Application publication date: 20170613 |