CN106806187A - 一种抗菌牙膏 - Google Patents
一种抗菌牙膏 Download PDFInfo
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- 239000000606 toothpaste Substances 0.000 title claims abstract description 11
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 11
- 230000002421 anti-septic effect Effects 0.000 title claims abstract description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000001736 Calcium glycerylphosphate Substances 0.000 claims abstract description 6
- 241001148782 Davallia Species 0.000 claims abstract description 6
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 6
- 244000068988 Glycine max Species 0.000 claims abstract description 6
- 239000009636 Huang Qi Substances 0.000 claims abstract description 6
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 6
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 claims abstract description 6
- 229940095618 calcium glycerophosphate Drugs 0.000 claims abstract description 6
- 235000019299 calcium glycerylphosphate Nutrition 0.000 claims abstract description 6
- 239000008367 deionised water Substances 0.000 claims abstract description 6
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 6
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims abstract description 6
- 150000003271 galactooligosaccharides Chemical class 0.000 claims abstract description 6
- 235000011187 glycerol Nutrition 0.000 claims abstract description 6
- 229920001542 oligosaccharide Polymers 0.000 claims abstract description 6
- 150000002482 oligosaccharides Chemical class 0.000 claims abstract description 6
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims abstract description 6
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims abstract description 6
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000001506 calcium phosphate Substances 0.000 claims description 5
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 5
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 2
- 235000019738 Limestone Nutrition 0.000 claims 1
- MSBKSDYSQOAXAW-UHFFFAOYSA-N O[P].[Sr] Chemical compound O[P].[Sr] MSBKSDYSQOAXAW-UHFFFAOYSA-N 0.000 claims 1
- 239000006028 limestone Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract description 5
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract description 5
- 241000894006 Bacteria Species 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 abstract description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 abstract description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 abstract description 2
- 230000003266 anti-allergic effect Effects 0.000 abstract description 2
- 230000000675 anti-caries Effects 0.000 abstract description 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 2
- 235000019155 vitamin A Nutrition 0.000 abstract description 2
- 239000011719 vitamin A Substances 0.000 abstract description 2
- 229940045997 vitamin a Drugs 0.000 abstract description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract 1
- 235000019731 tricalcium phosphate Nutrition 0.000 abstract 1
- 229920001661 Chitosan Polymers 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- RZYKUPXRYIOEME-UHFFFAOYSA-N CCCCCCCCCCCC[S] Chemical compound CCCCCCCCCCCC[S] RZYKUPXRYIOEME-UHFFFAOYSA-N 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000233866 Fungi Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 229940058573 b-d glucose Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 238000009941 weaving Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
一种抗菌牙膏，属于日用品技术领域。掺锶羟基磷灰石2‑6份，β‑磷酸三钙8‑16份，骨碎补0.5‑1份，黄芪0.1‑0.5份，壳聚糖0.1‑0.3份，维生素A 0.05‑0.2份，甘油磷酸钙1‑5份，山梨醇15‑13份，甘油15‑35份，羟甲基纤维素钠0.8‑1.5份，十二烷基硫酸钠1.5‑2.5份，去离子水为18‑30份，焦磷酸四钠1‑5份，低聚半乳糖10‑20份，大豆低聚糖10‑20份。本发明抗菌牙膏可有效清除口腔细菌，并具有抑菌作用，同时兼具抗敏、防龋齿和消炎的作用。
Description
技术领域
本发明涉及一种抗菌牙膏，属于日用品技术领域。
背景技术
壳聚糖(chitosan)又称脱乙酰甲壳素，是由自然界广泛存在的几丁质(chitin)经过脱乙酰作用得到的，化学名称为聚葡萄糖胺(1-4)-2-氨基-B-D葡萄糖。自1859年，法国人Rouget首先得到壳聚糖后，这种天然高分子的生物官能性和相容性、血液相容性、安全性、微生物降解性等优良性能被各行各业广泛关注，在医药、食品、化工、化妆品、水处理、金属提取及回收、生化和生物医学工程等诸多领域的应用研究取得了重大进展。
壳聚糖在弱酸溶剂中易于溶解，特别值得指出的是溶解后的溶液中含有氨基(NH2+)，这些氨基通过结合负电子来抑制细菌。壳聚糖的抑制细菌活性，使其在医药、纺织和食品等领域有着广泛的应用。壳聚糖及其衍生物有较好的抗菌活性，能抑制一些真菌、细菌、和病毒的生长繁殖。截止到2013年认为其可能的机制有三：一是由于壳聚糖的多聚阳离子，易于真菌细胞表面带负电荷的基团作用，从而改变病原菌细胞膜的流动性和通透性；二是干扰DNA的复制与转录；三是阻断病原菌代谢。
将壳聚糖的抗菌作用应用到牙膏中。
发明内容
本发明的目的是提供一种抗菌牙膏。
本发明的技术方案包括如下：
本发明抗菌牙膏由以下重量份的原料制成：掺锶羟基磷灰石2-6份，β-磷酸三钙8-16份，骨碎补0.5-1份，黄芪0.1-0.5份，壳聚糖0.1-0.3份，维生素A 0.05-0.2份，甘油磷酸钙1-5份，山梨醇15-13份，甘油15-35份，羟甲基纤维素钠0.8-1.5份，十二烷基硫酸钠1.5-2.5份，去离子水为18-30份，焦磷酸四钠1-5份，低聚半乳糖10-20份，大豆低聚糖10-20份。
本发明的有益效果是：
本发明抗菌牙膏可有效清除口腔细菌，并具有抑菌作用，同时兼具抗敏、防龋齿和消炎的作用。
具体实施方式
以下结合技术方案详细叙述本发明的具体实施方式。
实施例1
掺锶羟基磷灰石6份，β-磷酸三钙16份，骨碎补1份，黄芪0.5份，壳聚糖0.3份，维生素A0.2份，甘油磷酸钙5份，山梨醇13份，甘油35份，羟甲基纤维素钠1.5份，十二烷基硫酸钠2.5份，去离子水为30份，焦磷酸四钠5份，低聚半乳糖20份，大豆低聚糖20份。
实施例2
掺锶羟基磷灰石2份，β-磷酸三钙8份，骨碎补0.5份，黄芪0.1份，壳聚糖0.1份，维生素A 0.05份，甘油磷酸钙1份，山梨醇15份，甘油15份，羟甲基纤维素钠0.8份，十二烷基硫酸钠1.5份，去离子水为18份，焦磷酸四钠1份，低聚半乳糖10份，大豆低聚糖10份。
实施例3
掺锶羟基磷灰石4份，β-磷酸三钙10份，骨碎补0.7份，黄芪0.3份，壳聚糖0.2份，维生素A 0.1份，甘油磷酸钙3份，山梨醇14份，甘油20份，羟甲基纤维素钠1.2份，十二烷基硫酸钠2.1份，去离子水为22份，焦磷酸四钠3份，低聚半乳糖15份，大豆低聚糖18份。
Claims (1)
1.一种抗菌牙膏，其特征在于，所述的抗菌牙膏由以下重量份的原料制成：掺锶羟基磷灰石2-6份，β-磷酸三钙8-16份，骨碎补0.5-1份，黄芪0.1-0.5份，壳聚糖0.1-0.3份，维生素A 0.05-0.2份，甘油磷酸钙1-5份，山梨醇15-13份，甘油15-35份，羟甲基纤维素钠0.8-1.5份，十二烷基硫酸钠1.5-2.5份，去离子水为18-30份，焦磷酸四钠1-5份，低聚半乳糖10-20份，大豆低聚糖10-20份。
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510855474.9A CN106806187A (zh) | 2015-11-30 | 2015-11-30 | 一种抗菌牙膏 |
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| CN201510855474.9A CN106806187A (zh) | 2015-11-30 | 2015-11-30 | 一种抗菌牙膏 |
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| CN106806187A true CN106806187A (zh) | 2017-06-09 |
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| CN201510855474.9A Pending CN106806187A (zh) | 2015-11-30 | 2015-11-30 | 一种抗菌牙膏 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107693569A (zh) * | 2017-09-26 | 2018-02-16 | 广西达庆生物科技股份有限公司 | 一种口腔抑菌组合物 |
| CN115869228A (zh) * | 2022-12-07 | 2023-03-31 | 苏州猫尔科技有限公司 | 一种纳米缓释微囊及其制备方法 |
-
2015
- 2015-11-30 CN CN201510855474.9A patent/CN106806187A/zh active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107693569A (zh) * | 2017-09-26 | 2018-02-16 | 广西达庆生物科技股份有限公司 | 一种口腔抑菌组合物 |
| CN115869228A (zh) * | 2022-12-07 | 2023-03-31 | 苏州猫尔科技有限公司 | 一种纳米缓释微囊及其制备方法 |
| CN115869228B (zh) * | 2022-12-07 | 2023-11-21 | 苏州猫尔科技有限公司 | 一种纳米缓释微囊及其制备方法 |
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Application publication date: 20170609 |