CN106730406A - A kind of dentistry laser therapeutic apparantus - Google Patents
A kind of dentistry laser therapeutic apparantus Download PDFInfo
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Abstract
Description
技术领域technical field
本发明涉及一种牙科激光治疗仪,属于医疗器械领域。The invention relates to a dental laser treatment instrument, which belongs to the field of medical equipment.
背景技术Background technique
口腔常见疾病包括感染类疾病(如慢性牙周疾病,种植体周围炎和口腔黏膜感染)和非感染性疾病(如牙齿磨耗导致的牙齿敏感类疾病)。流行病学调查显示,这两类疾病发病率分别高达90%和57%,迄今为止仍缺乏有效的治疗手段,治愈率低于两成,严重影响患者生活质量,可能诱发和加重心脑血管疾病风险,危及患者生命。疼痛、愈合缓慢、易复发是这两大疾病的共同临床难题。传统物理化学方法可以取得短期疗效,但长期复发率高。Common oral diseases include infectious diseases (such as chronic periodontal disease, peri-implantitis and oral mucosal infection) and non-infectious diseases (such as tooth sensitivity caused by tooth wear). Epidemiological surveys show that the incidence rates of these two types of diseases are as high as 90% and 57% respectively. So far, there is still a lack of effective treatment methods, and the cure rate is less than 20%, which seriously affects the quality of life of patients and may induce and aggravate cardiovascular and cerebrovascular diseases. risk, endangering the life of the patient. Pain, slow healing, and easy recurrence are the common clinical problems of these two diseases. Traditional physical and chemical methods can achieve short-term curative effect, but the long-term recurrence rate is high.
日常生活中,牙齿经常因为遇冷热酸甜影响而产生酸麻、疼痛现象,这就是我们所说的牙齿敏感。它是指暴露的牙本质在受到温度、化学、机械、渗透压等外界刺激时所引发的短暂而尖锐的牙齿酸痛症状,但不能将其归因于其他任何形式的牙体缺损或病变。造成牙齿敏感(DH)的原因很多,包括各种引起釉质或牙骨质缺失、导致牙本质暴露的病理、生理性因素,例如磨耗、牙龈退缩、不当的刷牙方式、摄取过多的酸性食物等。In daily life, teeth often experience numbness and pain due to the influence of cold, hot, sour and sweet. This is what we call tooth sensitivity. It refers to the transient and sharp tooth pain symptoms caused by exposed dentin being subjected to external stimuli such as temperature, chemical, mechanical, osmotic pressure, etc., but it cannot be attributed to any other form of tooth defect or lesion. There are many reasons for tooth sensitivity (DH), including various pathological and physiological factors that cause loss of enamel or cementum, and exposure of dentin, such as abrasion, gingival recession, improper brushing methods, excessive intake of acidic foods, etc. .
牙周炎主要是由局部因素引起的牙周支持组织的慢性炎症。如龈炎未能及时治疗,炎症可由牙龈向深层扩散到牙周膜、牙槽骨和牙骨质而发展为牙周炎。Periodontitis is mainly a chronic inflammation of periodontal supporting tissues caused by local factors. If gingivitis is not treated in time, the inflammation can spread from the gums to the deep layer of the periodontal ligament, alveolar bone and cementum and develop into periodontitis.
随着年龄的增长,牙齿敏感和牙周炎的频率愈发突出,严重影响了人们的生活品质,因此研究开发安全有效、标本兼治型激光治疗仪就显得十分必要。With the growth of age, the frequency of tooth sensitivity and periodontitis becomes more and more prominent, which seriously affects people's quality of life. Therefore, it is very necessary to research and develop a safe and effective laser treatment device that treats both symptoms and root causes.
发明内容Contents of the invention
鉴于背景技术中存在的问题,本发明的目的在于提供一种牙科激光治疗仪,其可将一定能量的光直接照射到牙齿处,起到治疗牙齿敏感和慢性牙周病的作用。In view of the problems existing in the background technology, the purpose of the present invention is to provide a dental laser therapy instrument, which can directly irradiate the light of a certain energy to the teeth, and play a role in treating tooth sensitivity and chronic periodontal disease.
光生物调节作用(Photobiomodulation,PBM)是一种通过不同的特定波长的低能量激光激活机体细胞线粒体、阻断疼痛传导、激光抗菌的共性技术,当机体细胞处于低营养的不良状态下效果更佳,因此该技术特别适合口腔常见疾病的临床治疗。Photobiomodulation (Photobiomodulation, PBM) is a common technology that uses low-energy lasers of different specific wavelengths to activate the mitochondria of body cells, block pain transmission, and laser antibacterial. When the body cells are in a poor state of low nutrition, the effect is better. , so this technology is especially suitable for the clinical treatment of common oral diseases.
经过大量实验研究发现,利用波长为540nm左右例如520-560nm的超低能量激光阻断牙本质小管中的神经突触中负责痛觉传导的蛋白TRPV1,提高牙本质的疼痛阈值,阻断疼痛传导,减轻DH患者疼痛,这样可实现短期疗效。After a lot of experimental research, it was found that using an ultra-low energy laser with a wavelength of about 540nm, such as 520-560nm, to block the protein TRPV1 responsible for pain transmission in the nerve synapses in the dentinal tubules, increase the pain threshold of the dentine, and block pain transmission. Reduce pain in DH patients, so that short-term efficacy can be achieved.
研究还发现,波长为980nm左右例如960-1000nm的激光与波长为540nm左右的激光在治疗牙齿敏感方面原理相同,同样可阻断疼痛传导,减轻DH患者疼痛,实现短期疗效。The study also found that lasers with a wavelength of about 980nm, such as 960-1000nm, have the same principle as lasers with a wavelength of about 540nm in the treatment of tooth sensitivity. They can also block pain transmission, relieve pain in DH patients, and achieve short-term curative effect.
研究表明,利用波长为808nm左右例如788-828nm低能量红外激光的组织再生功能及高穿透性,促进近髓处的牙髓细胞产生大量ATP,提高牙髓细胞有丝分裂及成骨向分化(向成牙本质细胞分化);大大增加血管内皮细胞增殖速度,保证牙髓血供,从而促进第三期牙本质的生成,达到治疗牙本质敏感症的目的,并且可维持长期疗效。Studies have shown that using the tissue regeneration function and high penetration of low-energy infrared lasers with a wavelength of about 808nm, such as 788-828nm, can promote the production of a large amount of ATP in the dental pulp cells near the pulp, and improve the mitosis and osteogenic differentiation of dental pulp cells (towards osteogenesis). Odontoblast differentiation); greatly increase the proliferation rate of vascular endothelial cells, ensure the blood supply of the dental pulp, thereby promoting the formation of the third phase of dentin, achieving the purpose of treating dentin hypersensitivity, and maintaining long-term efficacy.
研究还表明,利用波长为808nm左右例如788-828nm不但可激活牙髓干细胞形成第三期牙本质减少牙本质敏感复发率,还可激活牙周膜细胞及上皮细胞促进牙周组织再生。Studies have also shown that using a wavelength of about 808nm, such as 788-828nm, can not only activate dental pulp stem cells to form third-stage dentin and reduce the recurrence rate of dentin sensitivity, but also activate periodontal ligament cells and epithelial cells to promote periodontal tissue regeneration.
研究还表明,利用波长为1064nm左右例如1044-1084nm的低能量红外激光产生的热效应照射牙齿,可提高牙齿表面温度,而对牙髓不产生不利刺激,并在牙齿表面熔融再结晶,封闭牙本质小管,隔绝外界刺激同时不损伤牙髓,可保证中期疗效。Studies have also shown that irradiating teeth with the thermal effect generated by low-energy infrared lasers with a wavelength of about 1064nm, such as 1044-1084nm, can increase the surface temperature of the teeth without causing adverse stimulation to the dental pulp, and melt and recrystallize on the tooth surface to seal the dentin Small tubes, isolated from external stimuli without damaging the dental pulp, can guarantee the medium-term curative effect.
发明人通过研究还惊奇地发现,利用三波长(例如520-560nm优选540nm、788-828nm优选808nm和1044-1084nm优选1064nm或者960-1000nm优选980nm、788-828nm优选808nm和1044-1084nm优选1064nm)的激光对患者进行治疗牙齿敏感,也即将上述短、中以及长期的治疗手段结合起来,似乎是产生了某种协同效应,其作用并非简单的叠加,能够实现更好治疗效果。The inventor also surprisingly found through research that using three wavelengths (such as 520-560nm preferably 540nm, 788-828nm preferably 808nm and 1044-1084nm preferably 1064nm or 960-1000nm preferably 980nm, 788-828nm preferably 808nm and 1044-1084nm preferably 1064nm) The laser treatment of patients with tooth sensitivity, that is, the combination of the above short, medium and long-term treatment methods, seems to have a certain synergistic effect, and its effect is not simply superposition, which can achieve better treatment results.
发明人研究还发现,利用两波长的激光对患者进行治疗也可以产生某种协同作用。利用波长为540nm左右例如520-560nm和1064nm左右例如1044-1084nm可精确控制调控疼痛传导信号通路实现即刻止痛,其中,波长为980nm左右例如960-1000nm可替代波长为540nm左右例如520-560nm的激光发生器;利用波长为808nm左右例如788-828nm和415nm左右例如395-435nm可激活细胞免疫机制的同时有效杀灭致病菌达到治疗牙周炎的目的。The inventors have also found that using two-wavelength lasers to treat patients can also produce a certain synergistic effect. Using a wavelength of about 540nm, such as 520-560nm and 1064nm, such as 1044-1084nm, can precisely control and regulate the pain transmission signal pathway to achieve immediate pain relief. Among them, a wavelength of about 980nm, such as 960-1000nm, can replace lasers with a wavelength of about 540nm, such as 520-560nm Generator: The use of wavelengths around 808nm, such as 788-828nm and 415nm, such as 395-435nm, can activate the cellular immune mechanism and effectively kill pathogenic bacteria to achieve the purpose of treating periodontitis.
蓝光疗法是一种新的抗感染光学疗法。通常认为菌体内存在内源性的光敏物质,这些光敏物质能被蓝光激发,通过光化学反应产生活性氧,并作用于菌体的蛋白质、核酸等重要的功能大分子。与光动力相比,蓝光疗法无需使用外源性光敏剂,因而其不受光敏剂的吸收、渗透深度的限制;与短波紫外线UVC相比,蓝光并非直接作用于DNA,因此其诱导组织细胞基因突变的风险较小,并且其穿透皮肤及组织的能力比UVC强,作用范围较大。研究发现,波长为415nm的蓝光对口腔内的细菌有杀伤作用。Blue light therapy is a new anti-infection light therapy. It is generally believed that there are endogenous photosensitive substances in the bacteria, which can be excited by blue light, generate reactive oxygen species through photochemical reactions, and act on important functional macromolecules such as proteins and nucleic acids in the bacteria. Compared with photodynamics, blue light therapy does not require the use of exogenous photosensitizers, so it is not limited by the absorption and penetration depth of photosensitizers; compared with short-wave ultraviolet UVC, blue light does not directly act on DNA, so it induces tissue cell genes The risk of mutation is small, and its ability to penetrate skin and tissue is stronger than UVC, and its range of action is larger. Studies have found that blue light with a wavelength of 415nm has a killing effect on bacteria in the oral cavity.
发明人通过研究还惊奇地发现,利用三波长(例如788-828nm优选808nm、395-435nm优选415nm和520-560nm优选540nm)的激光对患者进行治疗慢性牙周病,似乎是产生了某种协同效应,其作用并非简单的叠加,能够实现更好治疗效果。The inventor also surprisingly found through research that using lasers with three wavelengths (such as 788-828nm, preferably 808nm, 395-435nm, preferably 415nm, and 520-560nm, preferably 540nm) to treat patients with chronic periodontal disease seems to produce some synergy. Effect, its function is not a simple superposition, can achieve better treatment effect.
基于上述发现,本发明提供一种牙科激光治疗仪,包括:激光发生器,能够发射520-560nm激光,优选为540nm。Based on the above findings, the present invention provides a dental laser treatment apparatus, comprising: a laser generator capable of emitting 520-560nm laser, preferably 540nm.
在根据本发明所述的一种牙科激光治疗仪中,所述激光发生器还能够发射788-828nm、优选为808nm激光,以及395-435nm、优选为415nm激光的激光发生器。In a dental laser therapeutic apparatus according to the present invention, the laser generator can also emit 788-828nm, preferably 808nm laser, and 395-435nm, preferably 415nm laser.
在根据本发明所述的一种牙科激光治疗仪中,所述激光发生器还能够发射788-828nm、优选为808nm激光,以及1044-1084nm、优选为1064nm激光的激光发生器。In a dental laser therapeutic apparatus according to the present invention, the laser generator can also emit 788-828nm, preferably 808nm laser, and 1044-1084nm, preferably 1064nm laser.
在根据本发明所述的一种牙科激光治疗仪中,所述激光发生器还能够发射960-1000nm激光的激光发生器,优选为980nm,或者包括能够发射960-1000nm、优选为980nm激光的激光发生器以替代所述能够发射520-560nm激光的激光发生器。In a dental laser treatment apparatus according to the present invention, the laser generator can also emit a laser generator of 960-1000nm laser, preferably 980nm, or include a laser capable of emitting 960-1000nm, preferably 980nm laser The generator can replace the laser generator capable of emitting 520-560nm laser.
在根据本发明所述的一种牙科激光治疗仪中,所述治疗仪还包括:电源模块,包括蓄电池和电源检测单元;显示屏及控制系统,包括:用以建立近距离无线通信的通信单元、用于依据所述执行请求输出波长激光束的执行单元以及触控显示单元;制冷系统,对应所述激光发生器设置;激光笔,用于将所述激光发生器输出的激光束照射至待操作区域。In a dental laser therapeutic apparatus according to the present invention, the therapeutic apparatus further includes: a power supply module, including a storage battery and a power detection unit; a display screen and a control system, including: a communication unit for establishing short-distance wireless communication , an execution unit and a touch display unit for outputting a laser beam of a wavelength according to the execution request; a cooling system, which is set corresponding to the laser generator; a laser pointer, which is used to irradiate the laser beam output by the laser generator to the operating area.
在根据本发明所述的一种牙科激光治疗仪中,所述治疗仪还包括:脚踏开关,与显示屏及控制系统的通信单元建立无线通信连接,用于触发激光发生器。In the dental laser therapeutic apparatus according to the present invention, the therapeutic apparatus further includes: a foot switch, which establishes a wireless communication connection with the display screen and the communication unit of the control system, and is used to trigger the laser generator.
在根据本发明所述的一种牙科激光治疗仪中,所述触控显示单元为7英寸的电阻式触摸屏。In a dental laser treatment apparatus according to the present invention, the touch display unit is a 7-inch resistive touch screen.
本发明的有益效果:Beneficial effects of the present invention:
发现的新的激光波段可用于治疗或缓解口腔疾病;所述激光治疗仪将三种波长的激光器同步使用用于治疗牙齿敏感,可显著减轻牙齿敏感带来的疼痛;The new laser waveband discovered can be used to treat or alleviate oral diseases; the laser therapy instrument uses lasers of three wavelengths synchronously for the treatment of tooth sensitivity, which can significantly reduce the pain caused by tooth sensitivity;
操作安全简单,值得临床推广使用。The operation is safe and simple, and it is worthy of clinical promotion and use.
附图说明Description of drawings
图1是本发明的牙科激光治疗仪的结构框图;Fig. 1 is the structural block diagram of dental laser therapy instrument of the present invention;
图2是波长为415nm蓝光杀灭口腔病原菌的效果图;Figure 2 is an effect diagram of killing oral pathogenic bacteria by blue light with a wavelength of 415nm;
图3是为采用安慰剂、脱敏牙膏、不同波长以及多波长的激光治疗仪后的疼痛程度值变化;Fig. 3 is for adopting placebo, desensitizing toothpaste, different wavelength and multi-wavelength laser therapy instrument after the pain degree value change;
图4是采用单波长以及多波长的激光治疗仪治疗后的牙周探诊深度的变化值。Figure 4 shows the changes in periodontal probing depth after treatment with single-wavelength and multi-wavelength laser therapeutic instruments.
附图说明标记:Drawing description mark:
11-电源模块、111-蓄电池、113-电源检测单元、11-power supply module, 111-storage battery, 113-power detection unit,
12-激光发生器、13-制冷系统、17-脚踏开关、18-激光笔、12-laser generator, 13-refrigeration system, 17-foot switch, 18-laser pointer,
15-显示屏及控制系统、151-通信单元、153-执行单元、15-display screen and control system, 151-communication unit, 153-execution unit,
155-触控显示单元、19-指示灯。155-touch display unit, 19-indicator light.
具体实施方式detailed description
如图1所示,公开了本发明的激光治疗仪结构框图。所述牙科激光治疗仪1包括:电源模块11、激光发生器12、制冷系统13、显示屏及控制系统15、脚踏开关17以及激光笔18。As shown in FIG. 1 , a structural block diagram of the laser therapeutic apparatus of the present invention is disclosed. The dental laser therapy instrument 1 includes: a power module 11 , a laser generator 12 , a refrigeration system 13 , a display screen and a control system 15 , a foot switch 17 and a laser pointer 18 .
电源模块11包括蓄电池111和电源检测单元113。蓄电池111可以根据各个用电单元的状况而提供多种不同的直流供电电压。经过蓄电池111整流、滤波之后输出,这样可得到稳定的直流电流,可应用于激光发生器12、制冷系统13的供电。The power module 11 includes a battery 111 and a power detection unit 113 . The storage battery 111 can provide a variety of different DC power supply voltages according to the conditions of each power consumption unit. After being rectified and filtered by the storage battery 111 , a stable DC current can be obtained, which can be applied to the power supply of the laser generator 12 and the refrigeration system 13 .
另外,为确保工作正常,电源模块11中还包括与蓄电池111相连的电源检测单元113,用于检测蓄电池111的当前电量。电源检测单元113在检测到蓄电池111的当前电量小于预设值的情形下发出警告信息(在一实施例中,所述警告信息可以是采用灯闪烁或以特定颜色灯光显示),以提醒操作者蓄电池111的当前电量情况,从而使得操作者根据所述告警信息以决定是否对蓄电池111进行充电。In addition, to ensure normal operation, the power supply module 11 further includes a power detection unit 113 connected to the storage battery 111 for detecting the current power of the storage battery 111 . The power detection unit 113 sends out a warning message (in one embodiment, the warning message may be flashing or displayed in a specific color) when it detects that the current charge of the storage battery 111 is less than a preset value, to remind the operator The current power condition of the storage battery 111 , so that the operator can decide whether to charge the storage battery 111 according to the warning information.
激光发生器12,用于发出激光;与所述激光发生器12相连的传输光纤,用于传导所述激光发生器12产生的激光;位于所述传输光纤末端的激光笔18,与所述传输光纤相连,采用所述激光发生器12发射的激光对所述治疗对象实施治疗;在所述激光发生器12的输出功率设定之后,启动激光发生器12产生激光。所述激光经耦合装置耦合进入传输光纤;由传输光纤传导直到患处,对所述治疗对象实时治疗。在本发明中,激光发生器12可以为激光二极管。激光二极管是在发光二极管的基础上,在其内部加光学谐振腔,发出的光为单波长光,强度大,方向性好。The laser generator 12 is used to emit laser light; the transmission fiber connected to the laser generator 12 is used to conduct the laser light generated by the laser generator 12; the laser pointer 18 at the end of the transmission fiber is connected to the transmission fiber The laser beam emitted by the laser generator 12 is used to treat the treatment object; after the output power of the laser generator 12 is set, the laser generator 12 is started to generate laser light. The laser is coupled into the transmission fiber through the coupling device; it is guided to the affected part by the transmission fiber, and the treatment object is treated in real time. In the present invention, the laser generator 12 may be a laser diode. Laser diodes are based on light-emitting diodes, with an optical resonant cavity inside, and the light emitted is single-wavelength light with high intensity and good directionality.
激光发生器12受执行单元153控制以生成并依次输出波长为540nm、808nm和1064nm的激光束或者980nm、808nm和1064nm的激光束。操作者踩踏所述踏板,所述踏板在受到向下的作用力后,激光发生器发出波长为540nm的激光,激光笔照射人体牙齿后,所述踏板在受到向上的作用力后,执行单元接受指示,激光发生器关闭发射540nm的激光;再次脚踏所述踏板,激光发生器发出波长为1064nm的激光,激光笔照射人体牙齿后,所述踏板在受到向上的作用力后,激光发生器关闭发射1064nm的激光;第三次脚踏所述踏板,激光发生器发出波长为808nm的激光,激光笔照射人体牙齿后,所述踏板在受到向上的作用力后,激光发生器关闭发射808nm的激光。在上述说明中,对各个波长的先后次序不作限制。本领域技术人员知晓执行单元153接受脚踏开关17的指示如何控制激光发生器12依次发出三波长的激光束。The laser generator 12 is controlled by the execution unit 153 to generate and sequentially output laser beams with wavelengths of 540nm, 808nm and 1064nm or laser beams of 980nm, 808nm and 1064nm. The operator steps on the pedal. After the pedal is subjected to a downward force, the laser generator emits laser light with a wavelength of 540nm. After the laser pointer irradiates the teeth of the human body, the execution unit receives Instructions, the laser generator shuts down and emits a 540nm laser; step on the pedal again, the laser generator emits a laser with a wavelength of 1064nm, after the laser pointer irradiates the teeth of the human body, the pedal is subjected to an upward force, and the laser generator is turned off Emit 1064nm laser; step on the pedal for the third time, the laser generator emits laser light with a wavelength of 808nm, after the laser pointer irradiates human teeth, the pedal is subjected to an upward force, the laser generator turns off and emits 808nm laser . In the above description, there is no limitation on the sequence of the wavelengths. Those skilled in the art know how to control the laser generator 12 to sequentially emit three-wavelength laser beams by the execution unit 153 under the instruction of the foot switch 17 .
激光二极管的发光机理是受激发光,即利用激光二极管中的谐振腔发生振荡而激发出许许多多的频率相同的光子,从而形成激光。用半导体工艺技术在PN结两侧加工出两个相互平行的反射镜面,这两个反射镜面与原来的两个解理面(晶体的天然晶面)构成了谐振腔结构。当在激光二极管两端加上正偏置电压时,在PN结区域内因电子与空穴的复合而释放光子。而其中的一部分光子沿着和反射镜面相垂直的方向运动时,会受到反射镜面的反射作用在谐振腔内往复运动。只要外加正偏置电流足够大,光子的往复运动会激射出更多的、与之频率相同的光子,即发生振荡现象,从而发出激光。The light-emitting mechanism of a laser diode is stimulated light, that is, the resonant cavity in the laser diode is used to oscillate to excite many photons of the same frequency, thereby forming laser light. Two mirrors parallel to each other are processed on both sides of the PN junction by semiconductor technology. These two mirrors and the original two cleavage planes (natural crystal planes of the crystal) form a resonant cavity structure. When a positive bias voltage is applied across the laser diode, photons are released due to the recombination of electrons and holes in the PN junction region. When some of the photons move along the direction perpendicular to the mirror surface, they will be reflected by the mirror surface and reciprocate in the resonant cavity. As long as the external positive bias current is large enough, the reciprocating motion of photons will excite more photons with the same frequency, that is, oscillation occurs, and laser light is emitted.
所述传输光纤在满足传输的情况下,有易耦合、轻便、易弯曲等特点。可以为一根,也可以为多根,考虑到整体装置的体积,本实施例也可以选择两根光导纤维,当其中一根光导纤维发生故障时,本装置仍可以正常使用,提高了本装置的稳定性。The transmission optical fiber has the characteristics of easy coupling, light weight, and easy bending under the condition of satisfying the transmission. It can be one or more. Considering the volume of the overall device, two optical fibers can also be selected in this embodiment. When one of the optical fibers fails, the device can still be used normally, which improves the performance of the device. stability.
制冷系统13用于对本发明牙科激光治疗仪1中的各个发热单元(例如激光发生器)进行散热,确保正常工作。牙科激光治疗仪1开机进入后,制冷系统13就开始执行制冷程序;无论激光发生器12工作与否,实时检测激光发生器12的反馈输出;检测到的激光发生器12的反馈输出的变化,即,判断激光发生器12的反馈输出的变化量是否超出预设的阈值;若判断得到激光发生器12的反馈输出的变化量没有超出预设的阈值,则继续检测;若判断得到激光发生器12的反馈输出的变化量超出预设的阈值,则根据激光发生器12的反馈输出的变化量自适应地调整制冷系统13的输出功率。所述自适应地调整制冷系统13的输出功率包括:当激光发生器12所反馈的输出变大时,则由显示屏及控制系统15控制制冷系统13增大输出功率;当激光发生器12所反馈的输出值变小时,则由显示屏及控制系统15控制制冷系统13减小输出功率。The refrigeration system 13 is used to dissipate heat from each heating unit (such as a laser generator) in the dental laser treatment apparatus 1 of the present invention, so as to ensure normal operation. After the dental laser therapy instrument 1 is turned on and entered, the refrigeration system 13 begins to execute the refrigeration program; no matter whether the laser generator 12 works or not, the feedback output of the laser generator 12 is detected in real time; the detected feedback output of the laser generator 12 changes, That is, it is judged whether the amount of change of the feedback output of the laser generator 12 exceeds the preset threshold value; if it is judged that the amount of change of the feedback output of the laser generator 12 does not exceed the preset threshold value, then continue to detect; If the variation of the feedback output of laser generator 12 exceeds the preset threshold, the output power of refrigeration system 13 is adaptively adjusted according to the variation of feedback output of laser generator 12 . The adaptive adjustment of the output power of the refrigeration system 13 includes: when the output fed back by the laser generator 12 becomes larger, the display screen and the control system 15 control the refrigeration system 13 to increase the output power; When the output value of the feedback becomes smaller, the display screen and the control system 15 control the refrigeration system 13 to reduce the output power.
显示屏及控制系统15包括通信单元151、执行单元153和触控显示单元155。触控显示单元155作为输出输入界面,用于提供显示相关的系统参数信息,并在接收到相应的设置和/或操控的动作之后发出执行和/或更新请求。在本发明中,通过显示屏及控制系统15可实现设备参数的设置。在本实施例中,显示屏及控制系统15为7英寸的电阻式触摸屏。本发明可利用触控显示单元155自适应地进行设备参数的设置,提供了更大的选择性和更好的针对性。The display screen and control system 15 includes a communication unit 151 , an execution unit 153 and a touch display unit 155 . The touch display unit 155 is used as an input and output interface for providing and displaying relevant system parameter information, and issuing execution and/or update requests after receiving corresponding setting and/or manipulation actions. In the present invention, the setting of equipment parameters can be realized through the display screen and the control system 15 . In this embodiment, the display screen and control system 15 is a 7-inch resistive touch screen. The present invention can use the touch display unit 155 to adaptively set device parameters, providing greater selectivity and better pertinence.
激光发生器的触发可以通过外置的开关来发出指令而进行,例如可以为脚踏开关的形式。脚踏开关17与显示屏及控制系统15建立无线通信连接,用于触发激光发生器。在本实施例中,显示屏及控制系统15中具有用以建立近距离无线通信的通信单元151,通信单元151与脚踏开关17建立无线通信连接,所述无线通信单元可以是例如WLAN、WiMax或蓝牙技术。脚踏开关17通过开关而发出指令,通信单元151接收信息指令,然后发送给执行单元来执行命令,开关激光发生器12。The triggering of the laser generator can be performed through an external switch, for example, in the form of a foot switch. The foot switch 17 establishes a wireless communication connection with the display screen and the control system 15 for triggering the laser generator. In this embodiment, there is a communication unit 151 for establishing short-range wireless communication in the display screen and control system 15, and the communication unit 151 establishes a wireless communication connection with the foot switch 17. The wireless communication unit can be, for example, WLAN, WiMax or Bluetooth technology. The foot switch 17 sends an instruction through the switch, and the communication unit 151 receives the information instruction, and then sends it to the execution unit to execute the instruction to switch the laser generator 12 on and off.
脚踏开关17用于触发激光发生器12。脚踏开关17可提供一踏板,操作者可以用脚踩踏所述踏板,利用所述踏板的下,上动作以分别实现激光发生器12的开启、关闭。具体地,所述踏板保持初始静止状态,则激光发生器12关闭;所述踏板在受力后向下动作,则触发激光发生器12输出激光束。另外,脚踏开关17中的踏板进行上、下动作的频率则决定了激光发生器12执行开启或关闭的频率。The foot switch 17 is used to trigger the laser generator 12 . The foot switch 17 can provide a pedal, and the operator can step on the pedal with his foot, and utilize the down and up movements of the pedal to respectively realize the opening and closing of the laser generator 12 . Specifically, if the pedal remains in an initial static state, the laser generator 12 is turned off; when the pedal moves downward after being stressed, the laser generator 12 is triggered to output a laser beam. In addition, the frequency at which the pedal in the foot switch 17 moves up and down determines the frequency at which the laser generator 12 is turned on or off.
激光笔18可通过光纤与激光发生器12相连,用于将激光发生器12输出的激光束照射至口腔中的待操作区域。在本实施例中,激光笔18的末端连接有一光纤,所述光纤的另一端则配置有一转接口,利用所述转接口与激光发生器12相连。在实际操作中,当操作者将光纤的转接口与激光发生器12的端口相接合时,若它们之间连接正常,则会给出配置正确的提示(例如指示灯提示中的指示灯19显绿色),若它们之间连接不当或连接不正常,则也会给出配置错误需重新再连接的指示(例如指示灯提示中的指示灯19显黄色)。具体地,所述激光笔18的末端光纤为可支持同光孔径为200μm,300μm,400μm,600μm,800μm或1000μm直径的光纤。The laser pointer 18 can be connected with the laser generator 12 through an optical fiber, and is used for irradiating the laser beam output by the laser generator 12 to the area to be operated in the oral cavity. In this embodiment, the end of the laser pointer 18 is connected to an optical fiber, and the other end of the optical fiber is configured with an adapter, and the laser generator 12 is connected to the laser generator 12 through the adapter. In actual operation, when the operator connects the adapter port of the optical fiber with the port of the laser generator 12, if the connection between them is normal, a prompt of correct configuration will be given (for example, the indicator light 19 in the indicator light prompt shows green), if they are improperly connected or abnormally connected, an indication that a configuration error needs to be reconnected will also be given (for example, the indicator light 19 in the indicator light prompts is yellow). Specifically, the end optical fiber of the laser pointer 18 is an optical fiber that can support an optical aperture with a diameter of 200 μm, 300 μm, 400 μm, 600 μm, 800 μm or 1000 μm.
研究发现,一定波长的蓝光例如395-435nm对金黄色葡萄球菌、口腔病原菌、幽门螺杆菌及其他重要的病原菌等都有杀伤作用。如图2所示,采用波长为415nm蓝光杀灭口腔病原菌,随着蓝光照射量的增加,牙龈卟啉单胞菌(图2中的曲线1)、变形链球菌(图2中的曲线2)以及伴放线放线杆菌(图2中的曲线3)的存活数一直下降直到10*(-7)。Studies have found that blue light of a certain wavelength, such as 395-435nm, has a killing effect on Staphylococcus aureus, oral pathogens, Helicobacter pylori and other important pathogens. As shown in Figure 2, using a wavelength of 415nm blue light to kill oral pathogens, with the increase of blue light exposure, Porphyromonas gingivalis (curve 1 in Figure 2), Streptococcus mutans (curve 2 in Figure 2) And the surviving numbers of A. actinomycetes (curve 3 in FIG. 2 ) decrease until 10*(-7).
实验:experiment:
本发明征集了40例牙齿敏感患者作为试验的志愿者,于2015年12月-2016年12月间进行了试验,40例患者中,年龄在27-88岁之间,平均年龄57.64岁。随机分为:对比组1为5例,对比组2为5例,治疗组30例。其中治疗组分为6组,各组性别、年龄、病情等资料均无显著性差异,具有可比性。The present invention recruited 40 patients with tooth sensitivity as test volunteers. The test was carried out between December 2015 and December 2016. Among the 40 patients, they were between 27 and 88 years old, with an average age of 57.64 years. Randomly divided into: 5 cases in the comparison group 1, 5 cases in the comparison group 2, and 30 cases in the treatment group. Among them, the treatment group is divided into 6 groups, and there is no significant difference in gender, age, disease condition and other data among each group, which are comparable.
试验结果如图3所示,坐标轴纵轴的一端为0,表示无痛;另一端为10,表示剧痛;中间部分表示不同程度的疼痛。轻度疼痛平均值为2.57±1.04;中度疼痛平均值为5.18±1.41;重度疼痛平均值为8.41±1.35。疼痛值的分级与测试方法为本领域技术人员所熟知。The test results are shown in Figure 3. One end of the vertical axis of the coordinate axis is 0, indicating no pain; the other end is 10, indicating severe pain; the middle part indicates different degrees of pain. The average value of mild pain was 2.57±1.04; the average value of moderate pain was 5.18±1.41; the average value of severe pain was 8.41±1.35. The grading and testing methods of pain scores are well known to those skilled in the art.
各组患者起初均为重度疼痛患者,在经过治疗后,定期跟踪患者,过程如下:The patients in each group were all patients with severe pain at the beginning. After treatment, the patients were followed up regularly. The process is as follows:
对比组1的方法:患者服用安慰剂,每次1粒药,早晚各1次,观察效果。防治效果:如图3中的曲线1,患者3个月内疼痛程度值基本保持不变,一直为重度疼痛。Compared with the method of group 1: patients took placebo, one pill each time, once in the morning and once in the evening, and observed the effect. Prevention and treatment effect: as shown in curve 1 in Figure 3, the pain degree value of the patient remained basically unchanged within 3 months, and it was always severe pain.
对比组2的方法:采用脱敏牙膏,其余与常规刷牙一样操作,每次刷牙5分钟,早晚各一次,观察效果。防治效果:如图3中的曲线2,对比组2的患者在使用脱敏牙膏1天后,疼痛程度由重度疼痛降为中度疼痛,但是在随后的3个月内,疼痛程度值一直升高,达到重度疼痛,因此可证明脱敏牙膏仅可保持短期疗效。The method of comparison group 2: use desensitizing toothpaste, the rest is the same as conventional tooth brushing, brush your teeth for 5 minutes each time, once in the morning and in the evening, and observe the effect. Prevention and treatment effect: as shown in curve 2 in Figure 3, the pain level of patients in the comparison group 2 decreased from severe pain to moderate pain after using the desensitizing toothpaste for 1 day, but in the following 3 months, the pain level value continued to increase , to severe pain, so it can be proven that the desensitizing toothpaste only maintains a short-term effect.
治疗组1的方法:激光治疗仪的激光波长为980nm,终端输出功率不超过300毫瓦,每次照射6min,早晚各一次,观察效果。防治效果:如图3中的曲线3,采用波长为980nm的激光治疗仪治疗,1天后疼痛程度值降为中度疼痛,但是在随后的3个月内,疼痛程度值呈直线一直升高,达到重度疼痛,因此可知,980nm的激光治疗仪可实现短期疗效。The method of treatment group 1: the laser wavelength of the laser therapy instrument is 980nm, the terminal output power does not exceed 300 mW, each irradiation is 6 minutes, once in the morning and evening, and the effect is observed. Prevention and treatment effect: as shown in curve 3 in Figure 3, the pain level value decreased to moderate pain after 1 day after treatment with a laser therapeutic instrument with a wavelength of 980nm, but in the following 3 months, the pain level value continued to rise in a straight line. Severe pain is achieved, so it can be seen that the 980nm laser therapy instrument can achieve short-term curative effect.
治疗组2的方法:激光治疗仪的激光波长为540nm,终端输出功率不超过300毫瓦,每次照射6min,早晚各一次,观察效果。防治效果:如图3中的曲线4,采用波长为540nm的激光治疗仪治疗,1天后疼痛程度值降为轻度疼痛,但是在随后的3个月内,疼痛程度值呈直线一直升高,达到重度疼痛,因此可知,540nm的激光治疗仪可实现短期疗效;因此可知,采用波长540nm与波长为980nm的激光牙刷机理类似,可实现短期疗效。The method of treatment group 2: the laser wavelength of the laser therapy instrument is 540nm, the terminal output power does not exceed 300 milliwatts, each irradiation is 6 minutes, once in the morning and evening, and the effect is observed. Prevention and treatment effect: as shown in curve 4 in Figure 3, using a laser therapy device with a wavelength of 540nm for treatment, the pain level decreased to mild pain after 1 day, but within the next 3 months, the pain level increased linearly. It can be seen that the 540nm laser therapy instrument can achieve short-term curative effect; therefore, it can be seen that the mechanism of using a laser toothbrush with a wavelength of 540nm and a wavelength of 980nm is similar, and a short-term curative effect can be achieved.
治疗组3的方法:激光治疗仪的激光波长为808nm,终端输出功率不超过300毫瓦,每次照射6min,早晚各一次,观察效果。防治效果:如图3中的曲线5,采用波长为808nm的激光治疗仪治疗,1天后疼痛程度值降为中度疼痛,此疼痛值可保持1个月,接下来至3个月内疼痛程度值降低,达到轻度疼痛;因此可知,808nm的激光治疗仪可保证长期疗效。The method of treatment group 3: the laser wavelength of the laser therapy instrument is 808nm, the terminal output power does not exceed 300 milliwatts, each irradiation is 6 minutes, once in the morning and evening, and the effect is observed. Prevention and treatment effect: as shown in curve 5 in Figure 3, using a laser therapy device with a wavelength of 808nm for treatment, the pain level decreased to moderate pain after 1 day, and this pain level can be maintained for 1 month, and the pain level within 3 months The value is reduced to achieve mild pain; therefore, it can be seen that the 808nm laser therapy device can guarantee long-term curative effect.
治疗组4的方法:激光治疗仪的激光波长为1064nm,终端输出功率不超过300毫瓦,每次照射6min,早晚各一次,观察效果。防治效果:如图3中的曲线6,采用波长为1064nm的激光治疗仪治疗,1天后疼痛程度值降为轻度疼痛,此疼痛值可保持7天,接下来至3个月内疼痛程度值升高,达到中度疼痛;因此可知,1064nm的激光治疗仪可保证中期疗效。The method of treatment group 4: the laser wavelength of the laser therapy instrument is 1064nm, the terminal output power does not exceed 300 mW, and each irradiation is 6 minutes, once in the morning and evening, and the effect is observed. Prevention and treatment effect: as shown in curve 6 in Figure 3, using a laser therapy device with a wavelength of 1064nm for treatment, the pain level will be reduced to mild pain after 1 day, and this pain level can be maintained for 7 days, and the pain level will be reduced to 3 months later. It can be seen that the 1064nm laser therapy device can guarantee the medium-term curative effect.
治疗组5的方法:激光治疗仪的激光波长为540nm、1064nm和808nm,终端输出功率不超过300毫瓦,操作者用脚踩踏所述踏板,所述踏板在受到向下的作用力后,激光发生器发出波长为540nm的激光,激光笔照射人体牙齿2min,所述踏板在受到向上的作用力后,激光发生器关闭发射540nm的激光;再次脚踏所述踏板,激光发生器发出波长为1064nm的激光,激光笔照射人体牙齿2min,所述踏板在受到向上的作用力后,激光发生器关闭发射1064nm的激光;第三次脚踏所述踏板,激光发生器发出波长为808nm的激光,激光笔照射人体牙齿2min,所述踏板在受到向上的作用力后,激光发生器关闭发射808nm的激光。早晚各一次,观察效果。防治效果:如图3中的曲线7,患者经采用多波长激光治疗仪治疗后,疼痛程度值降为轻度疼痛,并保持不变,因此可知,激光治疗仪对患者具有长期疗效。The method of treatment group 5: the laser wavelength of the laser therapy instrument is 540nm, 1064nm and 808nm, and the terminal output power is not more than 300 milliwatts. The generator emits a laser with a wavelength of 540nm, and the laser pointer irradiates the teeth of the human body for 2 minutes. After the pedal receives an upward force, the laser generator turns off and emits a 540nm laser; step on the pedal again, and the laser generator emits a laser with a wavelength of 1064nm The laser pointer irradiates the human teeth for 2 minutes. After the pedal is subjected to an upward force, the laser generator turns off and emits a 1064nm laser; the third time the pedal is stepped on, the laser generator emits a laser with a wavelength of 808nm. The pen irradiates the teeth of the human body for 2 minutes. After the pedal is subjected to an upward force, the laser generator turns off and emits 808nm laser light. Once in the morning and evening, observe the effect. Prevention and treatment effect: as shown in curve 7 in Figure 3, after the patient is treated with the multi-wavelength laser therapy device, the pain level value is reduced to mild pain and remains unchanged. Therefore, it can be seen that the laser therapy device has long-term curative effect on patients.
治疗组6的方法:激光治疗仪的激光波长为980nm、1064nm和808nm,终端输出功率不超过300毫瓦,操作者用脚踩踏所述踏板,所述踏板在受到向下的作用力后,激光发生器发出波长为980nm的激光,激光笔照射人体牙齿2min,所述踏板在受到向上的作用力后,激光发生器关闭发射980nm的激光;再次脚踏所述踏板,激光发生器发出波长为1064nm的激光,激光笔照射人体牙齿2min,所述踏板在受到向上的作用力后,激光发生器关闭发射1064nm的激光;第三次脚踏所述踏板,激光发生器发出波长为808nm的激光,激光笔照射人体牙齿2min,所述踏板在受到向上的作用力后,激光发生器关闭发射808nm的激光。早晚各一次,观察效果。防治效果:如图3中的曲线8,患者经采用多波长激光治疗仪治疗后,疼痛程度值降为轻度疼痛,并保持不变,因此可知,激光治疗仪对患者具有长期疗效。The method of treatment group 6: the laser wavelength of the laser therapy instrument is 980nm, 1064nm and 808nm, and the terminal output power is not more than 300 milliwatts. The generator emits a laser with a wavelength of 980nm, and the laser pointer irradiates the teeth of the human body for 2 minutes. After the pedal receives an upward force, the laser generator turns off and emits a 980nm laser; step on the pedal again, and the laser generator emits a laser with a wavelength of 1064nm The laser pointer irradiates the human teeth for 2 minutes. After the pedal is subjected to an upward force, the laser generator turns off and emits a 1064nm laser; the third time the pedal is stepped on, the laser generator emits a laser with a wavelength of 808nm. The pen irradiates the teeth of the human body for 2 minutes. After the pedal is subjected to an upward force, the laser generator turns off and emits 808nm laser light. Once in the morning and evening, observe the effect. Prevention and treatment effect: as shown in curve 8 in Figure 3, after the patient is treated with the multi-wavelength laser therapy device, the pain level value is reduced to mild pain and remains unchanged. Therefore, it can be seen that the laser therapy device has a long-term curative effect on the patient.
经过多位患者的治疗试验,证明本脱敏牙刷对于牙齿敏感者有治疗作用,总有效率为100%,治愈率为100%。Through the treatment test of many patients, it is proved that the desensitizing toothbrush has a therapeutic effect on those with sensitive teeth, the total effective rate is 100%, and the cure rate is 100%.
本发明还征集了25例牙周炎患者作为试验的志愿者,于2015年12月-2016年12月间进行了试验,40例患者中,年龄在27-88岁之间,平均年龄60.16岁。随机分为:对比组为5例,治疗组20例。其中治疗组分为4组,各组性别、年龄、病情等资料均无显著性差异,具有可比性。The present invention also recruited 25 periodontitis patients as volunteers for the test, and conducted the test between December 2015 and December 2016. Among the 40 patients, the age was between 27 and 88 years old, and the average age was 60.16 years old. . Randomly divided into: 5 cases in the control group and 20 cases in the treatment group. Among them, the treatment group was divided into 4 groups, and there were no significant differences in gender, age, disease condition and other data among the groups, which were comparable.
对照组:未采用激光治疗仪治疗;Control group: no treatment with laser therapy instrument;
治疗组1-3分别采用波长为540nm、415nm、808nm的激光治疗仪治疗,具体方法:每次照射6min,早晚各一次,3个月后观察效果。Treatment groups 1-3 were treated with laser therapy devices with wavelengths of 540nm, 415nm, and 808nm respectively. The specific method: each time irradiated for 6 minutes, once in the morning and once in the evening, and observed the effect after 3 months.
治疗组4采用三波长(540nm、415nm和808nm)的激光治疗仪治疗,具体方法:每个波长照射2min,早晚各一次,3个月后观察效果。Treatment group 4 was treated with a laser therapy device with three wavelengths (540nm, 415nm and 808nm). The specific method: each wavelength was irradiated for 2 minutes, once in the morning and once in the evening, and the effect was observed after 3 months.
PD为牙周探诊深度,指用探针可以无痛性插入牙龈的深度,为临床评价牙周破坏的重要标志。采用△PD表征牙周炎疾病为本领域技术人员所熟知。PD is the periodontal probing depth, which refers to the depth at which the probe can be painlessly inserted into the gingiva, and is an important sign for clinical evaluation of periodontal destruction. The use of ΔPD to characterize periodontitis disease is well known to those skilled in the art.
如图4所示,纵坐标△PD指的是3个月后牙周探诊深度的变化值。从图中可以看出,在未采用任何波长的激光照射治疗牙周炎,△PD为负值,说明在未干预的情况下牙周炎越发严重;分别采用540nm、415nm和808nm激光照射后,△PD均小于4,可见采用不同波长的激光照射后,牙周炎得到一定的控制;当采用540nm、415nm和808nm三波长的激光治疗仪治疗后,△PD大于4,说明采用三波长的激光治疗仪治疗牙周炎效果最佳。As shown in Figure 4, the ordinate △PD refers to the change value of periodontal probing depth after 3 months. It can be seen from the figure that △PD is a negative value when no laser irradiation of any wavelength is used to treat periodontitis, indicating that periodontitis is more serious without intervention; after 540nm, 415nm and 808nm laser irradiation, respectively, △PD is less than 4, it can be seen that periodontitis can be controlled after laser irradiation with different wavelengths; when 540nm, 415nm and 808nm three-wavelength laser treatment equipment is used for treatment, △PD is greater than 4, indicating that three-wavelength lasers are used The therapeutic instrument has the best effect in treating periodontitis.
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| WO2018232484A1 (en) * | 2017-06-22 | 2018-12-27 | Da Silva Rafael Figueiredo | LASER DIODE DEVICE FOR BIOMODULATION OF TISSUES AND PAIN IN DENTINARY HYPERSENSITIVITY WITHOUT USE OF CHEMICAL AGENTS AND / OR HEAT |
| CN112105418A (en) * | 2018-05-24 | 2020-12-18 | 亥伯龙医疗有限公司 | Apparatus for biophotonic tissue treatment |
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| CN101193605A (en) * | 2005-03-09 | 2008-06-04 | 宝洁公司 | Sensor-responsive electric toothbrush and method of use |
| CN202146047U (en) * | 2010-03-25 | 2012-02-22 | 阿卜杜拉·库尔卡耶夫 | Multifunctional toothbrush |
| CN103239293A (en) * | 2013-05-16 | 2013-08-14 | 顶信光电(上海)有限公司 | Dental semi-conductor laser therapeutic apparatus |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101193605A (en) * | 2005-03-09 | 2008-06-04 | 宝洁公司 | Sensor-responsive electric toothbrush and method of use |
| CN202146047U (en) * | 2010-03-25 | 2012-02-22 | 阿卜杜拉·库尔卡耶夫 | Multifunctional toothbrush |
| CN103239293A (en) * | 2013-05-16 | 2013-08-14 | 顶信光电(上海)有限公司 | Dental semi-conductor laser therapeutic apparatus |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2018232484A1 (en) * | 2017-06-22 | 2018-12-27 | Da Silva Rafael Figueiredo | LASER DIODE DEVICE FOR BIOMODULATION OF TISSUES AND PAIN IN DENTINARY HYPERSENSITIVITY WITHOUT USE OF CHEMICAL AGENTS AND / OR HEAT |
| CN112105418A (en) * | 2018-05-24 | 2020-12-18 | 亥伯龙医疗有限公司 | Apparatus for biophotonic tissue treatment |
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