CN106566236A - High temperature resistant polyamide composite having biocompatibility, and preparation method and application of high temperature resistant polyamide composite - Google Patents
High temperature resistant polyamide composite having biocompatibility, and preparation method and application of high temperature resistant polyamide composite Download PDFInfo
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- CN106566236A CN106566236A CN201610931230.9A CN201610931230A CN106566236A CN 106566236 A CN106566236 A CN 106566236A CN 201610931230 A CN201610931230 A CN 201610931230A CN 106566236 A CN106566236 A CN 106566236A
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- 239000004952 Polyamide Substances 0.000 title claims abstract description 55
- 229920002647 polyamide Polymers 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000002131 composite material Substances 0.000 title abstract description 19
- 239000011256 inorganic filler Substances 0.000 claims abstract description 14
- 229910003475 inorganic filler Inorganic materials 0.000 claims abstract description 14
- 239000000843 powder Substances 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000001125 extrusion Methods 0.000 claims abstract description 6
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 239000003365 glass fiber Substances 0.000 claims description 11
- 239000003963 antioxidant agent Substances 0.000 claims description 9
- 230000003078 antioxidant effect Effects 0.000 claims description 9
- 239000000314 lubricant Substances 0.000 claims description 8
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 8
- 239000006057 Non-nutritive feed additive Substances 0.000 claims description 7
- 229920006122 polyamide resin Polymers 0.000 claims description 7
- -1 polytetrafluoroethylene Polymers 0.000 claims description 7
- 238000002844 melting Methods 0.000 claims description 4
- 230000008018 melting Effects 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 3
- 238000005453 pelletization Methods 0.000 claims description 3
- 229920000049 Carbon (fiber) Polymers 0.000 claims description 2
- 239000004917 carbon fiber Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 2
- 229910052882 wollastonite Inorganic materials 0.000 claims description 2
- 239000010456 wollastonite Substances 0.000 claims description 2
- 239000002689 soil Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 238000012545 processing Methods 0.000 abstract description 3
- 239000004809 Teflon Substances 0.000 abstract 1
- 229920006362 Teflon® Polymers 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 description 19
- 230000000052 comparative effect Effects 0.000 description 15
- 230000012010 growth Effects 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 7
- 229940058401 polytetrafluoroethylene Drugs 0.000 description 7
- 230000001954 sterilising effect Effects 0.000 description 7
- 238000004659 sterilization and disinfection Methods 0.000 description 7
- 238000005452 bending Methods 0.000 description 6
- 239000007769 metal material Substances 0.000 description 6
- 229920001296 polysiloxane Polymers 0.000 description 5
- 238000002701 cell growth assay Methods 0.000 description 4
- 238000000465 moulding Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241001274660 Modulus Species 0.000 description 3
- BEIOEBMXPVYLRY-UHFFFAOYSA-N [4-[4-bis(2,4-ditert-butylphenoxy)phosphanylphenyl]phenyl]-bis(2,4-ditert-butylphenoxy)phosphane Chemical compound CC(C)(C)C1=CC(C(C)(C)C)=CC=C1OP(C=1C=CC(=CC=1)C=1C=CC(=CC=1)P(OC=1C(=CC(=CC=1)C(C)(C)C)C(C)(C)C)OC=1C(=CC(=CC=1)C(C)(C)C)C(C)(C)C)OC1=CC=C(C(C)(C)C)C=C1C(C)(C)C BEIOEBMXPVYLRY-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 229920006351 engineering plastic Polymers 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 150000008301 phosphite esters Chemical class 0.000 description 2
- 229920006111 poly(hexamethylene terephthalamide) Polymers 0.000 description 2
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 239000004594 Masterbatch (MB) Substances 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 239000004696 Poly ether ether ketone Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- JUPQTSLXMOCDHR-UHFFFAOYSA-N benzene-1,4-diol;bis(4-fluorophenyl)methanone Chemical compound OC1=CC=C(O)C=C1.C1=CC(F)=CC=C1C(=O)C1=CC=C(F)C=C1 JUPQTSLXMOCDHR-UHFFFAOYSA-N 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000002324 minimally invasive surgery Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000002530 phenolic antioxidant Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 229920001596 poly (chlorostyrenes) Polymers 0.000 description 1
- 229920002530 polyetherether ketone Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
- C08L77/06—Polyamides derived from polyamines and polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2201/00—Properties
- C08L2201/08—Stabilised against heat, light or radiation or oxydation
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
The invention discloses a high temperature resistant polyamide composite having biocompatibility, and a preparation method and an application of the high temperature resistant polyamide composite. The high temperature resistant polyamide composite consists of the following components by weight percent, 48-74% of high temperature resistant polyamide, 25-45% of inorganic filler, 1-10% of teflon powder and 0.1-2% of processing agent. The preparation method of the high temperature resistant polyamide composite can be realized by adopting a double screw extrusion machine. The preparation method is simple and facilities industrial mass production. The high temperature resistant polyamide composite is high in cost performance and can be processed and formed easily, can be sterilized in high temperature and high pressure methods, is good in chemical stability, has excellent biocompatibility, can not release substances harmful to a human body, and can be used in the field of surgical operation medical devices.
Description
Technical field
The present invention relates to polyamide material field, and in particular to a kind of combination of the heat resistant polyamide with biocompatibility
Thing and its preparation method and application.
Background technology
With social development, the aged tendency of population trend of China is increasingly serious, and the aged is to health care, nursing, guarantor
The rigid demand of the resource such as strong is that this country is just actively increasing input to fields such as health care, health cares increasing, and lifts doctor
Service level is treated, health management system is improved, so the health care relevant market of following China has a high potential.
In medicine and hygiene fieldses, traditional metal materials such as rustless steel, titanium alloy etc. are because its is corrosion-resistant, satisfactory mechanical property,
Good biocompatibility and enjoy favor, but metal material there is also deficiency, such as some Minimally Invasive Surgerys, the apparatus meeting of metal material
Cause image to produce artifact, metal material easily causes human allergy, also need to perform the operation from taking-up etc. in vivo after metal parts rehabilitation.
In recent years, with technological innovation, the alternative metal material of some medical polymers is used for medical field, such as polychlorostyrene second
Alkene is used for conduit, bags of blood, and functional modification polypropylene is thin for blood storage (Chinese patent CN101831132A), dialysis
Film, polyurethane material is used for interposing catheter, et al. Ke product (Chinese patent CN101831132A), and poly-lactic acid material is used for can
The interference screw (CN102940908A) for implanting, while the material can slowly be degraded by human body, absorbed.Resistant to elevated temperatures special type
PEEK adapts to high temperature, the method for high pressure and carries out disinfection sterilizing, while with biocompatibility, alternative metal
Material is used for surgical medical equipment parts.But such special engineering plastics is expensive, processing conditionss are harsh, should to its popularization
With causing resistance.
The content of the invention
It is an object of the invention to provide a kind of heat resistant polyamide compositionss with biocompatibility and preparation method thereof
And application, said composition cost performance is high, be easily worked molding, adapt to high temperature and high pressure method carries out disinfection sterilizing, chemically stable
Property it is good, while with excellent biocompatibility, harmful material will not be discharged, can be used for surgical medical equipment neck
Domain.
For achieving the above object, the technical scheme that the present invention takes is as follows：
A kind of heat resistant polyamide compositionss with biocompatibility, are made up of the component of following percetage by weight：
In the present invention, polytetrafluoroethylene powder as biocompatibility function ingredients, and using based on heat resistant polyamide
Material is wanted, and adds inorganic filler and processing aid so that heat resistant polyamide compositionss of the present invention with biocompatibility
With excellent mechanical property and heat resistance, adapt to high temperature and high pressure method and carry out disinfection sterilizing, meanwhile, with excellent life
The thing compatibility, is conducive to biological cell in the growth on heat resistant polyamide composite material surface.
It is following as the preferred technical solution of the present invention：
Described heat resistant polyamide, refers to p-phthalic acid and semiaromatic that fats diamidogen is main polymerized monomer
Type polyamide, fusing point is 305-320 DEG C, preferred copolymerization PA6T.
Described inorganic filler, including fibrous inorganic filler, powdered inorganic filler and combinations thereof, described is inorganic
Filler is fibrous inorganic matters, diameter at 1-50 μm, described fibrous inorganic matters be glass fibre, carbon fiber, attapulgite,
More than the one or two kinds of in wollastonite, whisker (including two kinds).Still more preferably, described inorganic filler is diameter 1-
15 μm of glass fibre.The fibrous inorganic matters of addition can improve the mechanical property and thermostability of heat resistant polyamide composite material
Energy.
Polytetrafluoroethylene powder as biocompatibility function ingredients, using the excellent polymer of biocompatibility, polytetrafluoro
Ethylene micropowder.Polytetrafluoroethylene powder is introduced and is conducive to biological cell in the growth on heat resistant polyamide composite material surface, is improved
Its biocompatibility, and can also ensure that the excellent mechanical property of material.
Described processing aid is one or two in antioxidant, lubricant.
Described antioxidant, selected from phenols, one or several mixture of phosphite ester apoplexy due to endogenous wind, phenolic antioxidant is excellent
Select H161,1010,1098, phosphite ester kind antioxidant preferably 168, PEPQ.Antioxidant energy and peroxide reactions, prevent polymerization
Thing molecule chain break, delays the aging hydraulic performance decline for causing of heat resistant polyamide composite material, extends its service life.
Described lubricant, one or several the mixture in silicone powder, silicone master batch, zinc stearate is excellent
Select silicone powder.Lubricant can form lubricating layer in polymer and metal die surface, improve processing, the molding of heat resistant polyamide
Performance.
Further preferably, the described heat resistant polyamide compositionss with biocompatibility, by following percetage by weight
Component composition：
Still more preferably, the described heat resistant polyamide compositionss with biocompatibility, by following weight percent
Several component compositions：
Most preferably, the described heat resistant polyamide compositionss with biocompatibility, by the group of following percetage by weight
It is grouped into：
Described heat resistant polyamide adopts the A-6000 types of Su Wei companies, and fusing point is 308 DEG C；
Described inorganic filler adopts the 568H short glass fibers of Jushi Group Co., Ltd., 10 μm of diameter；
Polytetrafluoroethylene powder adopts the ptfe micropowder Polymist F-5A-EX of Su Wei companies；
Described processing aid is made up of the antioxidant of percetage by weight 0.4% and the lubricant of percetage by weight 0.5%, described
Lubricant be silicone powder.
The preparation method of the described heat resistant polyamide compositionss with biocompatibility, comprises the following steps：
1) it is, that heat resistant polyamide resin is predrying；
2), by through the heat resistant polyamide resin of pre-dried, polytetrafluoroethylene powder and processing aid, fed by main
Material mouth enters double screw extruder；And inorganic filler enters double screw extruder by side spout；
3) the high temperature resistant polyamides with biocompatibility is obtained after double screw extruder melting extrusion, cooling, pelletizing
Amine composition.
Preparation process keeps whole production scene cleaning, without obvious dust.
Step 1) in, described pre-dried condition is：In being positioned over 100 DEG C～120 DEG C of air dry oven, 3- is dried
8 hours；Further preferably, described pre-dried condition is：In being positioned over 110 DEG C of air dry oven, 4-6 is dried individual little
When.
Step 3) in, in described double screw extruder, 300 DEG C -340 DEG C of the temperature of melting extrusion, engine speed：
200rpm/min-500rpm/min。
The heat resistant polyamide compositionss with biocompatibility of the present invention, said composition is easily worked molding, adapts to
High temperature and high pressure method carries out disinfection sterilizing, chemical stability well, while with excellent biocompatibility, it is right to discharge
The harmful material of human body, is highly suitable for preparing surgical medical equipment or inserts internal medical apparatus and instruments.
Compared with prior art, the invention has the advantages that：
Heat resistant polyamide compositionss with biocompatibility of the present invention, polytetrafluoroethylene powder is used as biofacies
Capacitive function ingredients, and heat resistant polyamide is adopted for main material, and add inorganic filler and processing aid so that this
The bright heat resistant polyamide compositionss with biocompatibility have excellent mechanical property and heat resistance, adapt to high temperature and height
Pressure method carries out disinfection sterilizing, meanwhile, with excellent biocompatibility, be conducive to biological cell compound in heat resistant polyamide
The growth of material surface.
The heat resistant polyamide compositionss with biocompatibility of the present invention, said composition is easily worked molding, adapts to
High temperature and high pressure method carries out disinfection sterilizing, chemical stability well, while with excellent biocompatibility, it is right to discharge
The harmful material of human body, is highly suitable for preparing surgical medical equipment or inserts internal medical apparatus and instruments.
Heat resistant polyamide preparation method of composition of the present invention with biocompatibility is simple, it is easy to which industrialization is extensive
Production, and its cost only has the 18%-25% of special engineering plastics, therefore with wide market application foreground.
Description of the drawings
Fig. 1 is heat resistant polyamide composite material cell growth assay result schematic diagram.
Specific embodiment
Below in conjunction with specific embodiment and experimental data, the invention will be further described, but should not be construed as limiting this
Bright protection domain.
The raw material adopted in embodiment：
The A-6000 types of heat resistant polyamide PA6T Shi Su prestige company, fusing point is 308 DEG C；
Inorganic filler glass fibre is the 568H short glass fibers of Jushi Group Co., Ltd., 10 μm of diameter；
The ptfe micropowder Polymist F-5A-EX of biocompatibility function ingredients Shi Su prestige company；
Antioxidant is the PEPQ of the Thanox 1010 of Li Anlong Chemical Co., Ltd.s and Clariant companies；
Lubricant is silicone powder GM-100 of Zhonglan Chenguang Chemical Inst.
Embodiment 1
First by heat resistant polyamide Resin A -6000 in 110 DEG C of air dry oven, 5 hours, moisture content weight are dried
Percentage composition is less than 0.15%.By through the heat resistant polyamide resin of pre-dried, biocompatibility function ingredients poly- four
Fluorothene micropowder Polymist F-5A-EX, antioxidant Thanox1010, antioxidant PEPQ and lubricant GM-100, are separately added into
During corresponding independent feeding weightlessness claims, double screw extruder is entered eventually through main spout, short glass fiber 568H is added
In the weightless title of side feeding, double screw extruder is entered by side spout.According still further to component shown in the embodiment 1 shown in table 1
Proportioning, sets each weightless feeding capacity parameter for claiming, and each section temperature of the double screw extruder from feed zone to head is set as：340
DEG C, 340 DEG C, 330 DEG C, 320 DEG C, 320 DEG C, 310 DEG C, 300 DEG C, 300 DEG C, 300 DEG C, 330 DEG C, the main frame of double screw extruder turns
Speed is 400rpm/min, and screw slenderness ratio is 40 in double screw extruder：1, through melt blending extrusion, cooling and pelletizing work
Sequence, is obtained heat resistant polyamide composite material (heat resistant polyamide compositionss i.e. of the present invention).
Embodiment 2
Step is with embodiment 1, and constituent content is different from embodiment 1, according to matching somebody with somebody for component shown in the embodiment 2 shown in table 1
Than.
Comparative example 1
Step does not add biocompatibility function ingredients ptfe micropowder, according to shown in table 1 with embodiment 1
The proportioning of component shown in comparative example 1.
Comparative example 2
Step does not add biocompatibility function ingredients ptfe micropowder and short glass fiber with embodiment 1,
According to the proportioning of component shown in the comparative example 2 shown in table 1.
Table 1 is the composition and composite property of each component weight percent of embodiment 1-2 and comparative example 1-2.
Table 1
Embodiment 1-2 and comparative example 1～2 are obtained into heat resistant polyamide composite material particle, in 120 DEG C of forced air drying
It is dried in case after 4 hours, the standard size batten needed for properties test, injection temperature 330 is molded into by injection machine
DEG C, 130 DEG C of mold temperature.Then according to the national standard shown in table 2 carries out properties detection, testing result is as shown in table 1.
The national standard that the detection of the properties of table 2 is followed
| Test event | Testing standard |
| Tensile strength | GB/T 1040.2-2006 |
| Bending strength | GB/T 9341-2008 |
| Bending moduluses | GB/T 9341-2008 |
| Simply supported beam unnotched impact strength | GB/T 1043.1-2008 |
| 1.8MPa heat distortion temperature | GB/T 1634.2-2004 |
| Water absorption rate | GB/T 1034-2008 |
As shown in table 1, the tensile strength of the heat resistant polyamide resin of comparative example 2, bending strength, bending moduluses and thermal deformation
Temperature all than relatively low, it is difficult to meet practical application request.Relative to comparative example 2, comparative example 1, embodiment 1 and embodiment 2 are used
Heat resistant polyamide composite material mechanical property after 35% glass fiber reinforcement increases obvious, and embodiment 1 and embodiment 2 are brighter
Aobvious, tensile strength improves 160%, bending strength and improves 130%, bending moduluses and improves 280%, and thermostability is also improved very
Many, heat distortion temperature improves 150% under 1.8MPa load, increases to 280 DEG C or so, the notable drop while water absorption rate has been got back
It is low, have dropped more than 50%, it can be ensured that the dimensional stability of compression molding parts.
Compare the ptfe micropowder addition as can be seen that certain content by embodiment 1,2 and comparative example 1, not only
Can cooperate with and improve the mechanical property of composite, and make its water absorption rate lower.The high temperature resistant of this high comprehensive performance is gathered
Amide composite adapts to completely the method for high temperature and high pressure and carries out disinfection sterilizing, can be used for zero of surgical machinery
Part.
Growth experiment of the biocompatibility of heat resistant polyamide composite material by cell attachment after sheet surface come
Judge, experimental result is as shown in Figure 1.Cell type used is the stronger HeLa cells of adherence quality, and sheet material used is by resistance to height
Warm polyamide compoiste material is molded into the thick lamellars of 1.2mm by injection machine.Experimental technique：By 4 × 104Individual HeLa cells inoculation
To sheet surface growth, liquid is changed daily, the cell quantity on sheet material is counted after three days.
It will be seen from figure 1 that being not changed in before and after the cell quantity experiment of the sheet surface of comparative example 2, it may be possible to due to
HeLa cells are weaker to sticking for the sheet material of comparative example 2, are lost during liquid is changed, or the sheet material of comparative example 2 is inhibited
The division of cell, growth.And the cell quantity of sheet surface rises substantially after embodiment 1,2 and the cell growth assay of comparative example 1,
Illustrate that these three materials can maintain the normal growth of cell, the addition of glass fibre to improve HeLa cells and stick to sheet material
Property.The cell quantity of sheet surface rises more than 1 times than comparative example 1 after embodiment 1 and the cell growth assay of embodiment 2, says
Bright HeLa cells are easier in the division of the sheet surface containing ptfe micropowder, growth.The cell growth assay of embodiment 1
As a result illustrate that its biocompatibility is more preferable.
Claims (10)
1. a kind of heat resistant polyamide compositionss with biocompatibility, it is characterised in that by the group of following percetage by weight
It is grouped into：
2. heat resistant polyamide compositionss with biocompatibility according to claim 1, it is characterised in that by following
The component composition of percetage by weight：
3. heat resistant polyamide compositionss with biocompatibility according to claim 2, it is characterised in that by following
The component composition of percetage by weight：
4. heat resistant polyamide compositionss with biocompatibility according to claim 1, it is characterised in that described
The fusing point of heat resistant polyamide is 305-320 DEG C.
5. heat resistant polyamide compositionss with biocompatibility according to claim 1, it is characterised in that described
Inorganic filler is fibrous inorganic matters, and at 1-50 μm, described fibrous inorganic matters are glass fibre, carbon fiber, concavo-convex to diameter
It is more than the one or two kinds of in rod soil, wollastonite, whisker；
Described processing aid is one or two in antioxidant, lubricant.
6. heat resistant polyamide compositionss with biocompatibility according to claim 1, it is characterised in that described
Inorganic filler is the glass fibre of 1-15 μm of diameter.
7. the preparation side of the heat resistant polyamide compositionss with biocompatibility according to any one of claim 1～6
Method, it is characterised in that comprise the following steps：
1) it is, that heat resistant polyamide resin is predrying；
2), by through the heat resistant polyamide resin of pre-dried, polytetrafluoroethylene powder and processing aid, by main spout
Into double screw extruder；And inorganic filler enters double screw extruder by side spout；
3) the heat resistant polyamide group with biocompatibility is obtained after double screw extruder melting extrusion, cooling, pelletizing
Compound.
8. the preparation method of the heat resistant polyamide compositionss with biocompatibility according to claim 7, its feature
It is, step 1) in, described pre-dried condition is：In being positioned over 100 DEG C～120 DEG C of air dry oven, 3-8 is dried
Hour.
9. the preparation method of the heat resistant polyamide compositionss with biocompatibility according to claim 7, its feature
It is, step 3) in, in described double screw extruder, 300 DEG C -340 DEG C of the temperature of melting extrusion, engine speed：200rpm/
min-500rpm/min。
10. the heat resistant polyamide compositionss with biocompatibility according to any one of claim 1～6 are outside preparing
Application in section's surgical medical apparatus.
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| CN107815100A (en) * | 2017-11-02 | 2018-03-20 | 雪龙集团股份有限公司 | A kind of preparation method of Nylon for Automobile fan material |
| CN111117231A (en) * | 2019-12-31 | 2020-05-08 | 会通新材料(上海)有限公司 | Halogen-free polyamide 56 composition capable of resisting long-term aging of hot air and application thereof |
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| CN101550272A (en) * | 2008-04-03 | 2009-10-07 | 惠州市华聚塑化科技有限公司 | High strength wear resistant nylon resin and method for preparing same |
| US20110196080A1 (en) * | 2007-08-01 | 2011-08-11 | Kuraray Co., Ltd. | Polyamide composition |
| CN103450673A (en) * | 2013-09-10 | 2013-12-18 | 南京鸿瑞塑料制品有限公司 | Pumping rod centralizer reinforcement material with high wear resistance and preparation method thereof |
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| US20110196080A1 (en) * | 2007-08-01 | 2011-08-11 | Kuraray Co., Ltd. | Polyamide composition |
| CN101550272A (en) * | 2008-04-03 | 2009-10-07 | 惠州市华聚塑化科技有限公司 | High strength wear resistant nylon resin and method for preparing same |
| CN101343409A (en) * | 2008-08-27 | 2009-01-14 | 毛惠敏 | Carbon fiber reinforced composite and preparation thereof |
| CN103450673A (en) * | 2013-09-10 | 2013-12-18 | 南京鸿瑞塑料制品有限公司 | Pumping rod centralizer reinforcement material with high wear resistance and preparation method thereof |
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| CN107815100A (en) * | 2017-11-02 | 2018-03-20 | 雪龙集团股份有限公司 | A kind of preparation method of Nylon for Automobile fan material |
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Application publication date: 20170419 |