CN1063610C - Broad-spectrum fungicide - Google Patents
Broad-spectrum fungicide Download PDFInfo
- Publication number
- CN1063610C CN1063610C CN96100896A CN96100896A CN1063610C CN 1063610 C CN1063610 C CN 1063610C CN 96100896 A CN96100896 A CN 96100896A CN 96100896 A CN96100896 A CN 96100896A CN 1063610 C CN1063610 C CN 1063610C
- Authority
- CN
- China
- Prior art keywords
- broad
- spectrum
- spectrum bactericidal
- preparation
- bactericidal preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000000855 fungicidal effect Effects 0.000 title abstract description 8
- 239000000417 fungicide Substances 0.000 title abstract description 8
- 238000002360 preparation method Methods 0.000 claims abstract description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 8
- 239000004094 surface-active agent Substances 0.000 claims abstract description 6
- 241000894006 Bacteria Species 0.000 claims abstract description 5
- 239000012153 distilled water Substances 0.000 claims abstract description 5
- 230000002195 synergetic effect Effects 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 230000000844 anti-bacterial effect Effects 0.000 claims description 19
- 238000004659 sterilization and disinfection Methods 0.000 claims description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- 241000233866 Fungi Species 0.000 claims description 3
- 241000700605 Viruses Species 0.000 claims description 3
- 238000001764 infiltration Methods 0.000 claims description 3
- 230000008595 infiltration Effects 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920005862 polyol Polymers 0.000 claims 4
- 150000003077 polyols Chemical class 0.000 claims 4
- IPBRZLMGGXHHMS-UHFFFAOYSA-N 1-chloro-2-phenoxybenzene Chemical compound ClC1=CC=CC=C1OC1=CC=CC=C1 IPBRZLMGGXHHMS-UHFFFAOYSA-N 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 claims 1
- 230000002421 anti-septic effect Effects 0.000 claims 1
- 239000003595 mist Substances 0.000 claims 1
- 229920000847 nonoxynol Polymers 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 abstract description 12
- ISPYQTSUDJAMAB-UHFFFAOYSA-N 2-chlorophenol Chemical compound OC1=CC=CC=C1Cl ISPYQTSUDJAMAB-UHFFFAOYSA-N 0.000 abstract description 8
- 210000004400 mucous membrane Anatomy 0.000 abstract description 3
- 206010002198 Anaphylactic reaction Diseases 0.000 abstract 1
- 230000036783 anaphylactic response Effects 0.000 abstract 1
- 208000003455 anaphylaxis Diseases 0.000 abstract 1
- 230000000249 desinfective effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 description 9
- 239000003139 biocide Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000003213 activating effect Effects 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 2
- 244000144987 brood Species 0.000 description 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
- 230000005180 public health Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000009967 tasteless effect Effects 0.000 description 2
- KUXGUCNZFCVULO-UHFFFAOYSA-N 2-(4-nonylphenoxy)ethanol Chemical compound CCCCCCCCCC1=CC=C(OCCO)C=C1 KUXGUCNZFCVULO-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241001062472 Stokellia anisodon Species 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- 229950003169 nonoxinol Drugs 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a broad-spectrum fungicide prepared by mixing chlorophenol phenylate, a non-basic surface active agent with certain bacterium resisting properties, polyalcohol with synergistic action and monobasic alcohol with distilled water. The broad-spectrum fungicide in a working concentration simultaneously has the superior characteristics of no toxicity, no irritation to skin and mucous membrane, no anaphylaxis, no color, no taste, no smell, no pollution to application objects and high stability, and is a superior effective sterilizing and disinfecting preparation for preventing disease contagion and protecting the health of human bodies in people's life.
Description
The invention belongs to the hygiene field, relate in particular to a kind of broad-spectrum fungicide.
In existing numerous external sterilizing biocide preparation, a lot of effectively bactericide are arranged, fruit is fine, but it is colourless that they all do not possess simultaneously, nothing is smelt, tasteless, do not pollute subject, good stability, the working concentration of its preparation is nontoxic, not chafe and mucous membrane, there are not advantages such as irritated effect, as, all commercially available phenols biocide preparations, pair cell is killed very capable, can be all toxic, and strong peculiar smell arranged, it is also very strong that all chloride biocide preparations, pair cell are killed ability, but have the excitant of the unacceptable poisonous chlorine of people to smell flavor, metronidazole, bactericidal actions such as hibitane are also all good, unfortunately extremely strong bitter taste is all arranged,, very dark color is arranged though sterilizing powers such as P.V iodine are stronger, and pollute subject when using, these drawbacks limit they being extensive use of in people's sphere of life.
The object of the present invention is to provide a kind of broad-spectrum fungicide, it can kill Gram-positive Tong, gram-negative bacteria, multiple virus, brood cell and fungi etc. widely, and have simultaneously colourless, do not have smell, tasteless, do not pollute subject, good stability, its preparation working concentration is nontoxic, do not stimulate characteristics such as human body skin, mucous membrane, the irritated effect of nothing, to overcome the defective of present commercially available biocide preparation.
The present invention adopts following technical scheme:
Broad-spectrum fungicide of the present invention is characterized in, it is by the chlorophenol phenylate
Form with in surfactant, polyalcohol, the unit alcohol 1 to 3 kind mixed preparing in distilled water, surfactant is the non-basic surface activating agent with certain antibacterial action, polyalcohol is the polyalcohol with synergistic effect, it can be polyethylene glycol, it also can be the polyalcohol that contains 2～3 carbon atoms and have 2～3 hydroxyls, unit alcohol is ethanol, content with non-basic surface activating agent of certain antibacterial action is 0.1～2%, content with polyalcohol of synergistic effect is 3～30%, the content of unit alcohol is 15～60%, the chlorophenol phenylate
Content be 0.1ppm to 5%, this broad-spectrum sterilization preparation can be used for killing grampostive bacteria, gram-negative bacteria, brood cell, fungi and multiple virus widely, the preparation of this broad-spectrum sterilization preparation institute working concentration is nontoxic, can be directly used in air-atomizing and imitate poison, the infiltration of body surface, tableware and various body surfaces is sterilized or is embrocated sterilization.
The antibacterial tests result of the present invention in the research process for preparation shows, the mutual synergy of each component is apparent in view in the said preparation, the antibiotic minimal effective concentration (according to the bacterial classification of the Ministry of Public Health to the antibacterial tests appointment) of the former powder of chlorophenol phenylate (commodity are called Wei Jieling--100) is 1PPM (seeing Appendix), the antibiotic minimal effective concentration of broad-spectrum fungicide of the present invention is that 0.5PPM is (with the cubage of chlorophenol phenylate in preparation to identical appointment bacterial classification, see Appendix), some material of proof can suppress the antibacterial ability of chlorophenol phenylate in the experiment, and other materials can be strengthened the antibacterial ability of chlorophenol phenylate, have the non-basic surface activating agent and the polyalcohol with synergistic effect of certain antibacterial action as used in the present invention.
Following mask body narration embodiment:
Embodiment one:
Get 0.1 gram chlorobenzene phenolic ether biocide agent (content 〉=99%), join in the mixed solution of 5 gram propane diols and 38 gram ethanol, add 0.5 gram nonoxinol then, at room temperature stir after molten Jie mixes, add distilled water to 100 again and restrain, can use.
Embodiment two:
Get 0.1 gram chlorophenol phenylate bactericide (content 〉=99%), join in the mixed solution of 5 gram propane diols and 38 gram ethanol, at room temperature stir after molten Jie mixes, add distilled water to 100 again and restrain, can use.
Get above-mentioned preparation respectively, " defend clean clever high effect disinfectants " with trade name and carry out antibacterial tests by Ministry of Public Health's disinfectant for external use test specification, its result is as follows: bacterial classification embodiment one embodiment two
MIC (PPM) MIC (PPM) Escherichia coli (8099) 0.5 0.5 bacillus subtilis black variety bud cells
(ATCC 9372) 2.0 2.0 diplococcuses (29106) 3.0 3.0
HBsAg 250.0 250.0 staphylococcus aureuses (ATCC 6538) 0.1 0.1
(detailed results is seen Appendix)
This preparation is respectively applied for the air-atomizing sterilization, sterilization is cleaned on surface such as furniture, apparatus, the infiltration sterilization of body surface, hand, the shower sterilization, and the spraying of outer suit, clean sterilization after, show through assay, be sterilized object and need only contact 2～5 minutes with this preparation, promptly reach the purpose of sterilizing.
Facts have proved, broad spectrum activity antibiotic preparation of the present invention, its prescription rationally, and creative and novelty, have practicality simultaneously, overcome the problem that existing biocide preparation exists, can widely be used in people's the sphere of life, be a kind of have high safety and biocide preparation efficiently, reach design purpose.
Claims (6)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96100896A CN1063610C (en) | 1996-02-06 | 1996-02-06 | Broad-spectrum fungicide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96100896A CN1063610C (en) | 1996-02-06 | 1996-02-06 | Broad-spectrum fungicide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1156535A CN1156535A (en) | 1997-08-13 |
| CN1063610C true CN1063610C (en) | 2001-03-28 |
Family
ID=5116796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96100896A Expired - Fee Related CN1063610C (en) | 1996-02-06 | 1996-02-06 | Broad-spectrum fungicide |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1063610C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100523222C (en) * | 2002-12-06 | 2009-08-05 | Tfl皮革技术有限责任公司 | Process for tanning and tanning agent |
| CN112616836A (en) * | 2020-12-18 | 2021-04-09 | 湖南幻影三陆零科技有限公司 | Compound disinfectant, disinfection composition and application thereof |
| CN112586502A (en) * | 2020-12-18 | 2021-04-02 | 湖南幻影三陆零科技有限公司 | Disinfectant suitable for high-temperature and high-pressure spray disinfection pipeline and disinfection composition containing disinfectant |
| CN112450217A (en) * | 2020-12-18 | 2021-03-09 | 湖南幻影三陆零科技有限公司 | Disinfectant and disinfectant composition containing same |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3784694A (en) * | 1963-02-22 | 1974-01-08 | Ciba Geigy Corp | Halogenated 2-acyloxy-diphenylethers as bactericides and fungicides |
| US4467117A (en) * | 1983-02-07 | 1984-08-21 | Ciba-Geigy Corporation | Process for the production and purification of 2,4,4'-trichloro-2'-hydroxydiphenylether |
| WO1986005391A1 (en) * | 1985-03-13 | 1986-09-25 | Gluck Bruno A | Antiseptic fluids |
| GB2218617A (en) * | 1988-04-23 | 1989-11-22 | Smith & Nephew | Medical gloves |
| WO1991013608A1 (en) * | 1990-03-05 | 1991-09-19 | Roella Gunnar | Dentifrice inhibiting dental plaque |
| JPH0474102A (en) * | 1990-07-12 | 1992-03-09 | Kao Corp | External bactericide composition and cutaneous detergent composition |
| CA2111523A1 (en) * | 1992-12-16 | 1994-06-17 | Karen Mccue | Infection control agents |
| US5403864A (en) * | 1993-04-01 | 1995-04-04 | John A. Manfuso, Jr. | Rapidly-acting topical antimicrobial composition |
-
1996
- 1996-02-06 CN CN96100896A patent/CN1063610C/en not_active Expired - Fee Related
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3784694A (en) * | 1963-02-22 | 1974-01-08 | Ciba Geigy Corp | Halogenated 2-acyloxy-diphenylethers as bactericides and fungicides |
| US4467117A (en) * | 1983-02-07 | 1984-08-21 | Ciba-Geigy Corporation | Process for the production and purification of 2,4,4'-trichloro-2'-hydroxydiphenylether |
| WO1986005391A1 (en) * | 1985-03-13 | 1986-09-25 | Gluck Bruno A | Antiseptic fluids |
| GB2218617A (en) * | 1988-04-23 | 1989-11-22 | Smith & Nephew | Medical gloves |
| WO1991013608A1 (en) * | 1990-03-05 | 1991-09-19 | Roella Gunnar | Dentifrice inhibiting dental plaque |
| JPH0474102A (en) * | 1990-07-12 | 1992-03-09 | Kao Corp | External bactericide composition and cutaneous detergent composition |
| CA2111523A1 (en) * | 1992-12-16 | 1994-06-17 | Karen Mccue | Infection control agents |
| US5403864A (en) * | 1993-04-01 | 1995-04-04 | John A. Manfuso, Jr. | Rapidly-acting topical antimicrobial composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1156535A (en) | 1997-08-13 |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: TIANJIN WANGRI CHEMICAL TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: TIANJIN INST. OF MEDICAL INDUSTRIAL TECHNOLOGY Effective date: 20030214 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20030214 Address after: 300040 No. 10, Taierzhuang Road, Heping District, Tianjin Patentee after: Tianjin net Chemical Technology Co., Ltd. Address before: 300110 No. 102, Jiang Lu, Tianjin, Nankai District Patentee before: Tianjin Inst. of Medical Industrial Technology |
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| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |