CN106332889B - 含有苯并烯氟菌唑的农药组合物 - Google Patents
含有苯并烯氟菌唑的农药组合物 Download PDFInfo
- Publication number
- CN106332889B CN106332889B CN201610761378.2A CN201610761378A CN106332889B CN 106332889 B CN106332889 B CN 106332889B CN 201610761378 A CN201610761378 A CN 201610761378A CN 106332889 B CN106332889 B CN 106332889B
- Authority
- CN
- China
- Prior art keywords
- bacterium azoles
- ipfentrifluconazole
- composition pesticide
- benzo alkene
- fluorine bacterium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 241000894006 Bacteria Species 0.000 title claims abstract description 40
- 150000001336 alkenes Chemical class 0.000 title claims abstract description 40
- 125000005605 benzo group Chemical group 0.000 title claims abstract description 40
- 150000003851 azoles Chemical class 0.000 title claims abstract description 37
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title claims abstract description 36
- 229910052731 fluorine Inorganic materials 0.000 title claims abstract description 36
- 239000011737 fluorine Substances 0.000 title claims abstract description 36
- 239000000203 mixture Substances 0.000 title claims abstract description 29
- 239000000575 pesticide Substances 0.000 title claims abstract description 14
- SIIJJFOXEOHODQ-UHFFFAOYSA-N 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-3-methyl-1-(1,2,4-triazol-1-yl)butan-2-ol Chemical compound C=1C=C(OC=2C=CC(Cl)=CC=2)C=C(C(F)(F)F)C=1C(O)(C(C)C)CN1C=NC=N1 SIIJJFOXEOHODQ-UHFFFAOYSA-N 0.000 claims abstract description 38
- 239000000375 suspending agent Substances 0.000 claims description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 201000010099 disease Diseases 0.000 claims description 10
- 235000009754 Vitis X bourquina Nutrition 0.000 claims description 7
- 235000012333 Vitis X labruscana Nutrition 0.000 claims description 7
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 7
- 239000004562 water dispersible granule Substances 0.000 claims description 6
- 241000209140 Triticum Species 0.000 claims description 5
- 235000021307 Triticum Nutrition 0.000 claims description 5
- 206010039509 Scab Diseases 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 4
- 239000000839 emulsion Substances 0.000 claims description 4
- 206010027146 Melanoderma Diseases 0.000 claims description 3
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000000725 suspension Substances 0.000 claims description 3
- 241001530056 Athelia rolfsii Species 0.000 claims description 2
- 241000221785 Erysiphales Species 0.000 claims description 2
- 239000000470 constituent Substances 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000004530 micro-emulsion Substances 0.000 claims description 2
- 239000003094 microcapsule Substances 0.000 claims description 2
- 208000031968 Cadaver Diseases 0.000 claims 2
- 240000006365 Vitis vinifera Species 0.000 claims 1
- 230000035613 defoliation Effects 0.000 claims 1
- 239000003090 pesticide formulation Substances 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 5
- 230000000855 fungicidal effect Effects 0.000 abstract description 5
- 239000000417 fungicide Substances 0.000 abstract description 5
- 230000002195 synergetic effect Effects 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000012752 auxiliary agent Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 description 29
- 238000002360 preparation method Methods 0.000 description 10
- 238000002156 mixing Methods 0.000 description 9
- 231100000419 toxicity Toxicity 0.000 description 8
- 230000001988 toxicity Effects 0.000 description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 7
- 239000002270 dispersing agent Substances 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 241000219095 Vitis Species 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000002265 prevention Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- -1 liquor Substances 0.000 description 5
- 239000004576 sand Substances 0.000 description 5
- 239000004563 wettable powder Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 4
- 239000005858 Triflumizole Substances 0.000 description 4
- 244000052769 pathogen Species 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- HSMVPDGQOIQYSR-KGENOOAVSA-N triflumizole Chemical compound C1=CN=CN1C(/COCCC)=N/C1=CC=C(Cl)C=C1C(F)(F)F HSMVPDGQOIQYSR-KGENOOAVSA-N 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 235000013339 cereals Nutrition 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 230000001804 emulsifying effect Effects 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- 229940051841 polyoxyethylene ether Drugs 0.000 description 3
- 229920000056 polyoxyethylene ether Polymers 0.000 description 3
- 230000003449 preventive effect Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000012797 qualification Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 150000003852 triazoles Chemical class 0.000 description 3
- 239000005995 Aluminium silicate Substances 0.000 description 2
- SRGHCTFUBDUEEJ-UHFFFAOYSA-N C1(=CC=CC=C1)O.C(C)C1=CC=CC=C1.C1=CC=CC=C1 Chemical compound C1(=CC=CC=C1)O.C(C)C1=CC=CC=C1.C1=CC=CC=C1 SRGHCTFUBDUEEJ-UHFFFAOYSA-N 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- 102000011687 Electron Transport Complex II Human genes 0.000 description 2
- 108010076322 Electron Transport Complex II Proteins 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 102000019259 Succinate Dehydrogenase Human genes 0.000 description 2
- 108010012901 Succinate Dehydrogenase Proteins 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 239000002518 antifoaming agent Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229920005551 calcium lignosulfonate Polymers 0.000 description 2
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 229940099112 cornstarch Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 description 2
- 229940073769 methyl oleate Drugs 0.000 description 2
- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 229920005646 polycarboxylate Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 235000012424 soybean oil Nutrition 0.000 description 2
- 239000003549 soybean oil Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 1
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
- 241000223600 Alternaria Species 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 239000005737 Benzovindiflupyr Substances 0.000 description 1
- YDNVHHQVOKUSRZ-UHFFFAOYSA-N CC=CC1=CC=CC=C1.[F] Chemical compound CC=CC1=CC=CC=C1.[F] YDNVHHQVOKUSRZ-UHFFFAOYSA-N 0.000 description 1
- 241001157813 Cercospora Species 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 208000035240 Disease Resistance Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- 102000007474 Multiprotein Complexes Human genes 0.000 description 1
- 108010085220 Multiprotein Complexes Proteins 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- CCCGEKHKTPTUHJ-UHFFFAOYSA-N N-[9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methylpyrazole-4-carboxamide Chemical compound FC(F)C1=NN(C)C=C1C(=O)NC1=CC=CC2=C1C1CCC2C1=C(Cl)Cl CCCGEKHKTPTUHJ-UHFFFAOYSA-N 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 125000004772 dichloromethyl group Chemical group [H]C(Cl)(Cl)* 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000035806 respiratory chain Effects 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- CCCGEKHKTPTUHJ-ZJUUUORDSA-N solatenol Chemical compound C1([C@]2([H])CC[C@]3(C2=C(Cl)Cl)[H])=C3C=CC=C1NC(=O)C1=CN(C)N=C1C(F)F CCCGEKHKTPTUHJ-ZJUUUORDSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
本发明涉及一种包含Ipfentrifluconazole和苯并烯氟菌唑的杀菌组合物，两种有效成分的重量比为20:1‑1:20，杀菌剂中有效成分的重量百分含量为2‑80%，优选为5‑70%，其余为农药中允许的助剂和载体。本发明的组合物具有明显的增效作用，可以降低农药使用量，对环境友好安全。
Description
技术领域
本发明属于农药技术领域，具体涉及的是一种含有苯并烯氟菌唑和Ipfentrifluconazole的农药组合物。
背景技术
Ipfentrifluconazole是巴斯夫公司新开发的三唑类杀菌剂，其作用机理是抑制病菌麦角甾醇的生物合成使菌体细胞膜功能受到破坏，因而抑制或干扰菌体附着胞及吸器的发育、菌丝和孢子的形成。主要用于一系列较难防治的病害具有显著的生物活性，是具有划时代意义的新产品。防治效果优异。新型三唑类杀菌剂 Ipfentrifluconazole的化学结构式为：
苯并烯氟菌唑，英文名：benzovindiflupyr，商品名Solatenol,分子式为:N-[9-(二氯甲基)-1,2,3,4-四氢-1,4-亚甲基萘-5-基]-3-3（二氟甲基）-1-甲基-1H-吡唑-4-羧酰胺。结构式如下：
苯并烯氟菌唑是广谱叶用杀菌剂，是琥珀酸脱氢酶抑制剂，作用于病原菌线粒体呼吸电子传递链上的蛋白复合体Ⅱ，即琥珀酸脱氢酶（sunccinate dehydrogenase,SDH）或琥珀酸泛醌还原酶（succinate ubiquinone reductase,SQR），影响病原菌的呼吸链电子传递系统，阻碍其能量的代谢，抑制病原菌的生长，导致其死亡，从而达到防治病害的目的。该杀菌剂主要用于谷物作物，对小麦、玉米和特种作物等多种作物的主要病害有杰出防效，可很好地防治小麦叶枯病、花生黑斑病、小麦全蚀病及小麦基腐病，特别对葡萄穗轴褐枯病、玉米小斑病及灰霉病有特效，对亚洲大豆锈病防效优异。其与甲氧基丙烯酸酯类及三唑类杀菌剂无交互抗性，可以和多种杀菌剂复配使用。
目前植物病菌的防治难度越来越大，一方面，随着种植结构的改变，瓜果、蔬菜等经济作物种植面积逐年扩大，病害发生程度、发生数量均有所提高，在防治上难度加大；另一方面，病原菌的抗性在持续的药剂选择压力下逐年上升，单剂的防治效果大打折扣，植物病害防治面临着重大挑战。
发明内容
本发明的目的在于针对现有技术的不足，提供一种适用范围广、成本低、效果好、能解决植物病害抗性问题的Ipfentrifluconazole与苯并烯氟菌唑的杀菌剂组合。
为解决上述技术问题，本发明采用如下技术方案：
一种含有Ipfentrifluconazole和苯并烯氟菌唑的杀菌组合物，所述的Ipfentrifluconazole与苯并烯氟菌唑重量比为1:50-50:1，优选为1:20-20：1。
进一步的，所述Ipfentrifluconazole和苯并烯氟菌唑二者占组合物的重量百分比2~80%，优选10~50%。
进一步的，所述杀菌组合物可以通过常规的制备方法制备成农药剂型加工中的任意一种剂型，所述剂型可以为乳油、可湿性粉剂、悬浮剂、水乳剂、微乳剂、水分散粒剂、可分散油悬浮剂、可分散油剂、可分散液剂、可溶粉剂、可溶粒剂、微囊悬浮剂、悬乳剂、液剂、油剂。
本发明的另一目的在于提供杀菌组合物作为制备防治植物真菌引起真菌病害药物的应用，尤其是作为制备防治锈病、白粉病、纹枯病、叶斑病、黑斑病、菌核病、网斑病、褐斑病、云纹病、灰霉病、黑胫病、葡萄穗轴褐枯病、苹果斑点落叶病、黑星病、散黑穗病、丝黑穗病、疮痂病、小麦赤霉病和小麦全蚀病药物的应用。
与现有技术相比，本发明的有益效果为：（1）与单剂相比，本发明杀菌组合物对上述所述病害有明显增效作用，克服和延缓了抗药性，扩大防治谱，明显提高了防治效果；（2）减少防治用工，用药成本；（3）可替代常规和易产生抗性的农药；（4）与单剂相比，生产和使用成本降低。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白，本发明用以下具体实施例进行说明，但本发明绝非限于这些例子。以下所述仅为本发明较好的实施例，仅仅用于解释本发明，但不能因此理解为对本发明专利范围的限制。应当指出的时，凡在本发明的精神和原则之内所作的任何修改、等同替换或改进等，均应包含在本发明的保护范围之内，因此，本发明专利的保护范围应以所附权利要求为准。
一、制剂实施例
1、实施例1: 20% Ipfentrifluconazole•苯并烯氟菌唑可分散油悬浮剂
Ipfentrifluconazole 8%
苯丙烯氟菌唑 12%
囊心溶剂 13%
壁材 12%
乳化剂 8%
分散剂 16%
去离子水 补足至100%
所述可分散油悬浮剂的制备方法为：将上述物料(有机膨润土除外)一起加入到反应釜混合机中，搅拌半小时，打开釜底入料阀，将物料注入多级砂磨机中研磨，研磨后的物料细度合格后出料，物料再与有机膨润土一起放入高剪切乳化釜中，充分分散混合后即得相应重量百分比的Ipfentrifluconazole·苯并烯氟菌唑可分散油悬浮剂。
2、实施例2: 70% Ipfentrifluconazole•苯并烯氟菌唑悬浮剂
Ipfentrifluconazole 21%
苯并烯氟菌唑 49%
木质素磺酸盐 4%
十二烷基苯磺酸钙 3%
黄原胶 0.5%
脂肪醇聚氧乙烯醚 7%
丙三醇 5%
硅酸镁铝 0.2%
消泡剂 0.5%
去离子水补足至 100%
所述悬浮剂的制备方法为：按照上述配方，依次称取所述重量比的活性成分、分散剂、防冻剂、去离子水等进行预先混合，充分混合后再经过砂磨机中进行研磨，砂磨后得所需合格粒径的悬浮液，加入增稠剂和消泡剂经高效剪切机混合剪切后即得到70%Ipfentrifluconazole•苯并烯氟菌唑悬浮剂。
3、实施例3:60% Ipfentrifluconazole•苯并烯氟菌唑可湿性粉剂
Ipfentrifluconazole 50%
苯并烯氟菌唑 10%
十二烷基硫酸钠 5%
分散剂NNO 8%
木质素磺酸钙 4%
白炭黑 10%
高岭土 余量
所述可湿性粉剂的制备方法为：依本发明的技术方案，将上述各物料一起加入锥形混合机中混合均匀，后经气流粉碎机粉碎，粉碎后的物料再经锥形混合机混合，混合后的物料细度98%通过600目标准筛，即得相应重量百分比的Ipfentrifluconazole·苯并烯氟菌唑可湿性粉剂。
4、实施例4: 22%Ipfentrifluconazole·苯并烯氟菌唑可分散油悬浮剂
Ipfentrifluconazole 20%
苯并烯氟菌唑 2%
苯乙苯酚聚氧乙烯醚 8%
烷基酚聚氧乙烯醚 8%
大豆油 20%
有机膨润土 10%
十二烷基磺酸钙盐 11%
油酸甲酯 余量
所述可分散油悬浮剂的制备方法为：将上述物料(有机膨润土除外)一起加入到反应釜混合机中，搅拌半小时，打开釜底入料阀，将物料注入多级砂磨机中研磨，研磨后的物料细度合格后出料，物料再与有机膨润土一起放入高剪切乳化釜中，充分分散混合后即得相应重量百分比的Ipfentrifluconazole·苯并烯氟菌唑可分散油悬浮剂。
5、实施例5: 21% Ipfentrifluconazole·苯并烯氟菌唑水分散粒剂
Ipfentrifluconazole 20%
苯并烯氟菌唑 1%
十二烷基硫酸钠 5%
分散剂聚羧酸盐 8%
萘磺酸盐 7%
硫酸铵 20%
玉米淀粉 余量
所述水分散粒剂的制备方法为：将上述各物料按配比一起加入锥形混合机中混合均匀，后经气流粉碎机粉碎，粉碎后的物料再经锥形混合机混合，混合后的物料细度98%通过400目标准筛，加入捏合机中捏合成可塑性物料，最后将此物料放入挤压造粒机中挤压造粒，造粒后经干燥、筛分后即制得相应重量百分比的 Ipfentrifluconazole·苯并烯氟菌唑水分散粒剂。
6、实施例6:36% Ipfentrifluconazole•苯并烯氟菌唑可湿性粉剂
Ipfentrifluconazole 6%
苯并烯氟菌唑 30%
十二烷基硫酸钠 5%
分散剂NNO 8%
木质素磺酸钙 4%
白炭黑 10%
高岭土 余量
所述可湿性粉剂的制备方法为：依本发明的技术方案，将上述各物料一起加入锥形混合机中混合均匀，后经气流粉碎机粉碎，粉碎后的物料再经锥形混合机混合，混合后的物料细度98%通过600目标准筛，即得相应重量百分比的Ipfentrifluconazole·苯并烯氟菌唑可湿性粉剂。
7、实施例7: 22% Ipfentrifluconazole·苯并烯氟菌唑可分散油悬浮剂
Ipfentrifluconazole 2%
苯并烯氟菌唑 20%
苯乙苯酚聚氧乙烯醚 10%
烷基酚聚氧乙烯醚 10%
大豆油 20%
有机膨润土 10%
十二烷基磺酸钙盐 11%
油酸甲酯 余量
所述可分散油悬浮剂的制备方法为：将上述物料(有机膨润土除外)一起加入到反应釜混合机中，搅拌半小时，打开釜底入料阀，将物料注入多级砂磨机中研磨，研磨后的物料细度合格后出料，物料再与有机膨润土一起放入高剪切乳化釜中，充分分散混合后即得相应重量百分比的Ipfentrifluconazole·苯并烯氟菌唑可分散油悬浮剂。
8、实施例8：42% Ipfentrifluconazole·苯并烯氟菌唑水分散粒剂
Ipfentrifluconazole 2%
苯并烯氟菌唑 40%
十二烷基硫酸钠 5%
分散剂聚羧酸盐 8%
萘磺酸盐 7%
硫酸铵 20%
玉米淀粉 余量
所述水分散粒剂的制备方法为：将上述各物料按配比一起加入锥形混合机中混合均匀，后经气流粉碎机粉碎，粉碎后的物料再经锥形混合机混合，混合后的物料细度98%通过400目标准筛，加入捏合机中捏合成可塑性物料，最后将此物料放入挤压造粒机中挤压造粒，造粒后经干燥、筛分后即制得相应重量百分比的 Ipfentrifluconazole•苯并烯氟菌唑水分散粒剂。
二、生测实施例
1、室内毒力测定
为了了解苯并烯氟菌唑与 Ipfentrifluconazole组合混配对葡萄穗轴褐枯病的确切毒力，本发明对于其配比进行了筛选。
葡萄穗轴褐枯病(分离自辽宁大石桥周边地区)，纯化培养后经柯赫氏法则验证其致病
性后将菌种接种于PDA培养基中，在250C ,90%湿度条件下培养7d，菌丝长满培养皿后用0. 4cm打孔器打成菌饼用。
采用菌丝生长速率法测定苯并烯氟菌唑与 Ipfentrifluconazole以及二者组合物对葡萄穗轴褐枯病菌菌丝生长的影响，设定二者重量配比为2:3,3:7,5:1,10:1,20:1,1:5,1:10,1:20，,以及各单剂共10种药剂处理，各处理设定0. 125, 0. 25, 0. 5,1, 2, 4,8,16, 32mg/L共9个浓度梯度制成PDA平板，设置无药剂为对照，每浓度重复3次，在无菌条件下将打好的菌饼倒置于各个处理PDA平板中央后，将平板置于250C, 90%湿度条件下培养，待菌丝生长直径达到培养皿直径50%左右时(10d左右)调查结果，按照下述公式计算抑制率，并借助DPS数据统计软件推算各个药剂处理至毒力回归方程、相关系数、EC50以及复配共毒系数。在室内采用菌丝生长速率法，测定不同药剂对菌株的EC50，采用共毒系数计算方法，计算出混剂的共毒系数（CTC），确定混剂的增效性，具体计算方法如下：
以混剂中某一单剂为标准药剂（通常选择EC50较低者），进行计算：
单剂毒力指数=标准药剂EC50/某单剂EC50×100
理论毒力指数=A单剂的毒力指数×A单剂在混剂中所占比列+B单剂的毒力指数×B单剂在混剂所占比列
实测毒力指数=标准单剂的EC50值/混剂的EC50值×100
共毒系数=实测毒力指数/理论毒力指数×100
共毒系数分级：CTC大于120时混剂具有协同增效性，CTC小于80时为拮抗，CTC在80~120之间为相加作用。
由表1可以看出，采用Ipfentrifluconazole(A)和苯并烯氟菌唑 (B)以不同配比对葡萄穗轴褐枯病的室内生测试验，由表1可知，本发明的组合物共毒系数均大于120，即本发明组合物具有较好的协同增效性，其效果均好于单剂品种。
三、田间药效试验
试验处理:本试验根据各个成分的不同分别设两个药剂用量，药剂用量是有效成分新产品(A)和苯并烯氟菌唑(B)的质量和。对照药剂分别是25%Ipfentrifluconazole悬浮剂和10%苯并烯氟菌唑悬浮剂及空白清水试验。
试验方法：每个小区面积为66.7m2，重复3次; 施药前调查及防治后的调查药效方法为:在试验处理区内随机取样5点，按照国家田间试验相关标准进行病情分级，计算防效。试验结果如表2所示:
通过田间药效结果表明，由表2可知，本发明组合物具有明显的协同增效作用，组合物的防治效果优良，防治效果均好于单剂品种，在农业应用中具有应用价值。
Claims (5)
1.一种农药组合物，其特征在于，活性成分为Ipfentrifluconazole和苯并烯氟菌唑，其中，Ipfentrifluconazole和苯并烯氟菌唑的重量比为1:20-20：1。
2.根据权利要求1所述的农药组合物，其特征在于，所述农药组合物辅以农药制剂加工辅助成分加工成适合农业上使用的任意一种剂型。
3.根据权利要求2所述的农药组合物，其特征在于，所述农药组合物的剂型为乳油、可湿性粉剂、悬浮剂、水乳剂、微乳剂、水分散粒剂、可分散油悬浮剂、可分散油剂、可分散液剂、可溶粉剂、可溶粒剂、微囊悬浮剂、悬乳剂、液剂、油剂中任一中。
4.根据权利要求1-3中任一项权利要求所述的农药组合物用于防除农作物病害的用途。
5.根据权利要求4所述的用途，其特征在于，所述农作物病害为锈病、白粉病、纹枯病、叶斑病、黑斑病、菌核病、网斑病、褐斑病、云纹病、灰霉病、黑胫病、葡萄穗轴褐枯病、苹果斑点落叶病、黑星病、散黑穗病、丝黑穗病、疮痂病、小麦赤霉病和小麦全蚀病中任意一种。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610761378.2A CN106332889B (zh) | 2016-08-30 | 2016-08-30 | 含有苯并烯氟菌唑的农药组合物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610761378.2A CN106332889B (zh) | 2016-08-30 | 2016-08-30 | 含有苯并烯氟菌唑的农药组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106332889A CN106332889A (zh) | 2017-01-18 |
| CN106332889B true CN106332889B (zh) | 2018-09-25 |
Family
ID=57823277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610761378.2A Active CN106332889B (zh) | 2016-08-30 | 2016-08-30 | 含有苯并烯氟菌唑的农药组合物 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106332889B (zh) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2934146A1 (en) * | 2012-12-20 | 2015-10-28 | Basf Se | Compositions comprising a triazole compound |
| BR112016000299B8 (pt) * | 2013-07-08 | 2021-04-20 | Basf Agro Bv | composições, uso de uma composição, método para o combate dos fungos fitopatogênicos e uso dos componentes |
| PL3169157T3 (pl) * | 2014-07-14 | 2022-01-31 | Basf Se | Kompozycje szkodnikobójcze |
-
2016
- 2016-08-30 CN CN201610761378.2A patent/CN106332889B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN106332889A (zh) | 2017-01-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106359395A (zh) | 一种含有苯并烯氟菌唑的杀菌组合物 | |
| CN102578126B (zh) | 一种含吡唑醚菌酯的农用杀菌复配组合物 | |
| CN102630679B (zh) | 一种含肟醚菌胺的农药组合物 | |
| CN102696622A (zh) | 一种防治植物病害的农药组合物 | |
| CN101861866B (zh) | 一种含有噻呋酰胺和己唑醇的农药组合物及其应用 | |
| CN101810181A (zh) | 杀菌农药组合物及其制备方法和用途 | |
| CN106332889B (zh) | 含有苯并烯氟菌唑的农药组合物 | |
| CN104115841A (zh) | 一种含有咯菌腈的杀菌组合物及其应用 | |
| CN103355303A (zh) | 含有啶氧菌酯和氨基寡糖素的杀菌组合物、使用方法及应用 | |
| CN104872158B (zh) | 含有中生菌素和氟菌唑的农药组合物及其应用 | |
| CN107279157A (zh) | 一种含氟嘧菌酯和丙硫菌唑的杀菌组合物及其应用 | |
| CN105519540A (zh) | 含有苯并烯氟菌唑和四氟醚唑的农药组合物 | |
| CN110521728A (zh) | 一种用于小麦白粉病防治的杀菌剂组合物 | |
| CN105432622A (zh) | 含有苯并烯氟菌唑和丙硫菌唑的农药组合物 | |
| CN105746523B (zh) | 一种含吡丙醚的杀虫组合物 | |
| CN109730075A (zh) | 一种可湿性杀菌剂及其制备方法 | |
| CN101849545A (zh) | 含有粉唑醇和井冈霉素a的杀菌组合物及其制备方法 | |
| CN108450473A (zh) | 一种杀菌组合物 | |
| CN107467038A (zh) | 一种含有异噻菌胺和中生菌素的杀菌组合物 | |
| CN104872137A (zh) | 含有嘧菌环胺与环氟菌胺的农药组合物及其应用 | |
| CN107041369A (zh) | 一种防治马铃薯晚疫病的杀菌组合物 | |
| CN104872134B (zh) | 含有氟啶胺与环氟菌胺的农药组合物及其应用 | |
| CN104137832A (zh) | 含有肟菌酯和氨基寡糖素的杀菌组合物及其应用 | |
| CN105532677B (zh) | 含苯并烯氟菌唑与四氟醚唑的复配杀菌剂 | |
| CN105248421B (zh) | 一种含螺甲螨酯与双酰肼类的农药组合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |