CN106309409A - Tylosin tartrate premix composition and preparation method of tylosin tartrate sustained-released pellets - Google Patents
Tylosin tartrate premix composition and preparation method of tylosin tartrate sustained-released pellets Download PDFInfo
- Publication number
- CN106309409A CN106309409A CN201610862377.7A CN201610862377A CN106309409A CN 106309409 A CN106309409 A CN 106309409A CN 201610862377 A CN201610862377 A CN 201610862377A CN 106309409 A CN106309409 A CN 106309409A
- Authority
- CN
- China
- Prior art keywords
- tylosin tartrate
- enteric
- tylosin
- tartrate
- release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ICVKYYINQHWDLM-KBEWXLTPSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;2-[(4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-[(2r,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2r,3r,4r,5r,6r)-5-hydroxy-3,4 Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 ICVKYYINQHWDLM-KBEWXLTPSA-N 0.000 title claims abstract description 111
- 229960001717 tylosin tartrate Drugs 0.000 title claims abstract description 111
- 239000000203 mixture Substances 0.000 title claims abstract description 68
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000008188 pellet Substances 0.000 title abstract 3
- 238000002156 mixing Methods 0.000 claims abstract description 51
- 239000000945 filler Substances 0.000 claims abstract description 26
- 239000002702 enteric coating Substances 0.000 claims abstract description 19
- 238000009505 enteric coating Methods 0.000 claims abstract description 19
- 239000007787 solid Substances 0.000 claims abstract description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 39
- 239000007788 liquid Substances 0.000 claims description 22
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 20
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 18
- 235000002906 tartaric acid Nutrition 0.000 claims description 17
- 239000011975 tartaric acid Substances 0.000 claims description 17
- 239000006187 pill Substances 0.000 claims description 15
- 239000004014 plasticizer Substances 0.000 claims description 14
- 238000005422 blasting Methods 0.000 claims description 12
- 230000002572 peristaltic effect Effects 0.000 claims description 12
- 239000002002 slurry Substances 0.000 claims description 12
- 239000007779 soft material Substances 0.000 claims description 12
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 10
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 10
- 239000011230 binding agent Substances 0.000 claims description 8
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims description 8
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims description 8
- 239000011347 resin Substances 0.000 claims description 8
- 229920005989 resin Polymers 0.000 claims description 8
- 239000007921 spray Substances 0.000 claims description 8
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 7
- AJXBTRZGLDTSST-UHFFFAOYSA-N amino 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)ON AJXBTRZGLDTSST-UHFFFAOYSA-N 0.000 claims description 7
- 239000011248 coating agent Substances 0.000 claims description 7
- 238000000576 coating method Methods 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 239000001069 triethyl citrate Substances 0.000 claims description 7
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 7
- 235000013769 triethyl citrate Nutrition 0.000 claims description 7
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 6
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 6
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 238000013268 sustained release Methods 0.000 claims description 4
- 239000012730 sustained-release form Substances 0.000 claims description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 238000004132 cross linking Methods 0.000 claims description 3
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 238000010008 shearing Methods 0.000 claims description 2
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 229960003943 hypromellose Drugs 0.000 claims 1
- 239000011806 microball Substances 0.000 claims 1
- LGRFSURHDFAFJT-UHFFFAOYSA-N phthalic anhydride Chemical compound C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 claims 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims 1
- 238000010298 pulverizing process Methods 0.000 claims 1
- 239000013049 sediment Substances 0.000 claims 1
- 235000019629 palatability Nutrition 0.000 abstract description 5
- 238000005538 encapsulation Methods 0.000 abstract description 3
- 239000010410 layer Substances 0.000 abstract description 3
- 238000009776 industrial production Methods 0.000 abstract 2
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- 229930194936 Tylosin Natural products 0.000 description 8
- 239000004182 Tylosin Substances 0.000 description 8
- 229960004059 tylosin Drugs 0.000 description 8
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 8
- 235000019375 tylosin Nutrition 0.000 description 8
- 239000002253 acid Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 4
- 238000005507 spraying Methods 0.000 description 4
- PQCLJXVUAWLNSV-UHFFFAOYSA-N 5-Methyl-2,3-hexanedione Chemical group CC(C)CC(=O)C(C)=O PQCLJXVUAWLNSV-UHFFFAOYSA-N 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 238000000889 atomisation Methods 0.000 description 2
- 229960000935 dehydrated alcohol Drugs 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012055 enteric layer Substances 0.000 description 2
- 210000004211 gastric acid Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000004005 microsphere Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- FEWJPZIEWOKRBE-XIXRPRMCSA-N Mesotartaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-XIXRPRMCSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940113115 polyethylene glycol 200 Drugs 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a tylosin tartrate premix composition and a preparation method of tylosin tartrate sustained-released pellets, aiming at solving the problems in the prior art that the encapsulation efficiency of tylosin tartrate is low, the light-shielding property and the palatability are poor, the releasing efficiency of the tylosin tartrate cannot be effectively controlled and industrial production is not easy to realize and the like. The preparation method comprises: firstly crushing a solid component and sieving; mixing the tylosin tartrate and a filling agent; adding an adhesive and covering an enteric coating layer and a sustained-released layer on the tylosin tartrate through a granulator. According to the tylosin tartrate premix composition and the preparation method of the tylosin tartrate sustained-released pellets, provided by the invention, whole encapsulation is realized and the palatability is good; the releasing efficiency of the tylosin tartrate can be effectively controlled and the industrial production can be realized.
Description
Technical field
The present invention relates to a kind of tylosin tartrate pre-mixing agent compositions and slow-release micro-pill preparation method thereof, belong to veterinary drug
Preparing technical field.
Background technology
Tylosin tartrate belongs to macrolide antibiotic, for the antibiotic that birds is special, is that treatment birds and beasts are former
The ideal medicament that body is sick.The common using method of tylosin tartrate is the drinking-water admixed and be administered or put into animal in feedstuff
In, but tartaric acid tylosin crude drug abnormal smells from the patient is relatively big, bitter in the mouth, and easily disperse so that it is palatability is poor, affects feed intake,
Needing to increase administration number of times, be unfavorable for reaching efficient therapeutic effect, prior art CN103301144B discloses a kind of for animals
Tartaric acid acetylisovaleryl tylosin pre-mixing agent preparation method, uses tartaric acid acetylisovaleryl tylosin to be combined with carrier
Thing mixing acquisition is coated carrier mixture, adds carboxymethyl cellulose, D-glucitol and dehydrated alcohol mixing and obtains half inclusion
Medicine, add polyethylene glycol 200 mixing improve envelop rate, vacuum drying make dehydrated alcohol volatilize, add Pulvis Talci mix, so
After be diluted to the 20% of percentage by weight, it is thus achieved that tartaric acid acetylisovaleryl tylosin pre-mixing agent, this preparation method uses nothing
The organic solvents such as water-ethanol, and preparation technology is loaded down with trivial details, is not suitable for industrialized production.
Summary of the invention
The present invention provides a kind of tylosin tartrate pre-mixing agent compositions and slow-release micro-pill preparation method thereof, solves existing
Technology mesotartaric acid tylosin envelop rate is low, and lucifuge, palatability are poor, it is impossible to effectively control tylosin tartrate release effect
Rate, and it is difficult to the problems such as industrialized production.
In order to realize the purpose of the present invention, technical scheme discloses a kind of tylosin tartrate pre-mixing agent compositions, presses
Percentage by weight said composition is composed of the following components:
Tylosin tartrate: 2%～10%；
Filler: 74%～84.7%；
Binding agent: 1%～4.5%；
Enteric material: 5%～15%；
Enteric antitackiness agent: 3.5%～6.5%；
Enteric plasticizer: 0.5%～1.5%；
Slow-release material: 2%～8%；
Slow release antitackiness agent: 0.5%～5%；
Slow release plasticizer: 0.3%～2%.
In the present invention, described filler is in starch, sucrose, lactose, microcrystalline Cellulose, cross-linking sodium carboxymethyl cellulose one
Plant or multiple.
In the present invention, described binding agent be mass concentration be polyvidon aqueous solution, the mass concentration of 2%～10%
Be 2%～10% hydroxypropyl cellulose aqueous solution, mass concentration be 2%～10% hydroxypropylcellulose in one or more.
In the present invention, described enteric material is methacrylic acid copolymer A type, methacrylic acid copolymer Type B, methyl-prop
In olefin(e) acid copolymer c-type, HP-55 one or more.
In the present invention, described enteric antitackiness agent and described slow release antitackiness agent are a kind of in glyceryl monostearate, Pulvis Talci
Or two kinds.
In the present invention, described enteric plasticizer and described slow release plasticizer are propylene glycol, triethyl citrate, Polyethylene Glycol
In 6000 one or more.
In the present invention, described slow-release material be season ammonio methacrylate resin copolymer Type B with A type mixture, season amino
In the aqueous dispersion mixture of methacrylic acid resin copolymer Type B and A type one or both.
Based on tylosin tartrate pre-mixing agent compositions, in order to realize the purpose of the present invention, technical scheme also discloses that
A kind of tylosin tartrate slow-release micro-pill preparation method, the method is made up of following processing step:
(1) each component of tylosin tartrate pre-mixing agent compositions is weighed by weight percentage, by solid in each component
Component is pulverized, and makes powder body be sieved through 60 mesh～100 mesh sieve subnettings respectively, and each component individually stores, and then takes tartaric acid Thailand happy
Rhzomorph adds in wet granulator with filler, and wet granulator rotating speed is 500r/min～1000r/min, and mixing time is
1min～3min, makes tylosin tartrate mix homogeneously with filler, it is thus achieved that tylosin tartrate filler mixture；
(2) in step (1) obtains tylosin tartrate filler mixture, binding agent is added, in wet granulator
Mix homogeneously, speed of agitator is 800r/min～1800r/min, and shearing rotating speed is 1200r/min～2500r/min, during stirring
Between be 2min～3min, it is thus achieved that tylosin tartrate soft material；
(3) tylosin tartrate soft material step (2) made, prepares strip material, hole diameter of sieve (perforated) plate with extruder
0.4mm～0.6mm, by shot-blasting machine, shot-blasting machine rotating speed is 1200r/min～2500r/min, it is thus achieved that tylosin tartrate is wet
Micropill；
(4) being placed in fluid bed dry by obtaining the wet micropill of tylosin tartrate in step (3), temperature of charge is 40 DEG C
～48 DEG C, blower fan frequency 25HZ～40HZ, at 60 DEG C～80 DEG C, it is dried 15min～30min, it is thus achieved that tylosin tartrate is done
Micropill；
(5) by enteric material, enteric antitackiness agent and enteric plasticizer mix homogeneously in slurry commanding tank, speed of agitator is
500r/min～600r/min, mixing time is 0.5h～1.5h, it is thus achieved that enteric coating liquid, will obtain tartaric acid in step (4)
Tylosin micropill adds in Multifunction granulating machine, controls temperature of charge 40 DEG C～48 DEG C, blower fan frequency 25HZ～40HZ, atomization
Pressure is 0.1MPa～0.3MPa, and peristaltic pump frequency is 2HZ～16HZ, sprays into enteric coating liquid, and hydrojet completes, at 60 DEG C～80
15min～30min it is dried so that it is moisture Control is within 3%, it is thus achieved that enteric tylosin tartrate micropill at DEG C；
(6) by slow-release material, slow release antitackiness agent, slow release plasticizer mix homogeneously in slurry commanding tank, speed of agitator is 500r/
Min～600r/min, mixing time is 0.5h～1.5h, it is thus achieved that sustained release coating liquid, safe by obtaining enteric tartaric acid in step (5)
Happy rhzomorph micropill adds in Multifunction granulating machine, controls temperature of charge 40 DEG C～48 DEG C, blower fan frequency 25HZ～40HZ, atomization pressure
Power is 0.1MPa～0.3MPa, and peristaltic pump frequency is 2HZ～16HZ, sprays into enteric coating liquid, and hydrojet completes, at 60 DEG C～80 DEG C
Under be dried 15min～30min so that it is moisture Control is within 3%, it is thus achieved that tylosin tartrate slow-release micro-pill.
Beneficial effects of the present invention:
1, tylosin tartrate is made the micropill of easily release by the present invention, i.e. at the tartaric acid tylosin of uniform particle sizes
Element surface first covers binding agent, adds fluidizer, the most again with granulator coating enteric layer and slow release layer, thus realizes winestone
The total incapsulation rate of acid tylosin, encapsulation ratio is high, good palatability, effectively controls tylosin tartrate rate of release and efficiency,
Reach the release effect of stable release；
2, the tylosin tartrate slow-release micro-pill that prepared by the present invention, can be divided by 40 mesh～50 mesh sieves, releasing of pre-mixing agent
Overall preparation drug release behavior generation will not be had a strong impact on, therefore in preparation defect by the summation of medicine behavior because of indivedual pre-mixing agent microspheres
Repeatability and the concordance aspect of release are better than existing slow releasing preparation；
3, the tylosin tartrate slow-release micro-pill that prepared by the present invention, has lucifuge, taste masking, is destroyed in gastric acid environment
Amount is less than 10%, and i.e. by the protection of sustained-release coating layer in gastric acid, the destroyed amount of pre-mixing agent microsphere is few, enters intestinal
Time, enteric layer dissolves, and blood levels is fluctuated little, and the difference between product is little, steady quality.
Detailed description of the invention
Hereinafter with reference to example, the present invention is described in further detail, but the invention is not restricted to these instantiations.
Tylosin tartrate pre-mixing agent compositions, said composition by weight percentage is composed of the following components:
Tylosin tartrate: 2%～10%；
Filler: 74%～84.7%；
Binding agent: 1%～4.5%；
Enteric material: 5%～15%；
Enteric antitackiness agent: 3.5%～6.5%；
Enteric plasticizer: 0.5%～1.5%；
Slow-release material: 2%～8%；
Slow release antitackiness agent: 0.5%～5%；
Slow release plasticizer: 0.3%～2%.
The tylosin tartrate slow-release micro-pill prepared based on said components, embodiment 1:
(1) each component of tylosin tartrate pre-mixing agent compositions is weighed by weight percentage, by solid in each component
Component is pulverized, and makes powder body be sieved through 60 mesh～100 mesh sieve subnettings respectively, and each component individually stores, and then takes tartaric acid Thailand happy
Rhzomorph adds in wet granulator with microcrystalline Cellulose, and speed of agitator is 500r/min～1000r/min, and mixing time is 1min
～3min, make tylosin tartrate mix homogeneously with filler, it is thus achieved that tylosin tartrate filler mixture；
(2) adding mass concentration in step (1) obtains tylosin tartrate filler mixture is 2%～10%
Hydroxypropyl cellulose aqueous solution, mix homogeneously in wet granulator, speed of agitator is 800r/min～1800r/min, shears
Rotating speed is 1200r/min～2500r/min, and mixing time is 2min～3min, it is thus achieved that tylosin tartrate soft material；
(3) tylosin tartrate soft material step (2) made, prepares strip material, hole diameter of sieve (perforated) plate with extruder
0.4mm～0.6mm, by shot-blasting machine, shot-blasting machine rotating speed is 1200r/min～2500r/min, it is thus achieved that tylosin tartrate is wet
Micropill；
(4) being placed in fluid bed dry by obtaining the wet micropill of tylosin tartrate in step (3), temperature of charge is 40 DEG C
～48 DEG C, blower fan frequency 25HZ～40HZ, at 60 DEG C～80 DEG C, it is dried 15min～30min, it is thus achieved that tylosin tartrate is done
Micropill；
(5) methacrylic acid copolymer A type, glyceryl monostearate and triethyl citrate are mixed in slurry commanding tank all
Even, speed of agitator is 500r/min～600r/min, and mixing time is 0.5h～1.5h, it is thus achieved that enteric coating liquid, by step (4)
Middle acquisition tylosin tartrate micropill adds in Multifunction granulating machine, controls temperature of charge 40 DEG C～48 DEG C, blower fan frequency
25HZ～40HZ, atomizing pressure is 0.1MPa～0.3MPa, and peristaltic pump frequency is 2HZ～16HZ, sprays into enteric coating liquid, hydrojet
Complete, at 60 DEG C～80 DEG C, be dried 15min～30min so that it is moisture Control is within 3%, it is thus achieved that enteric tartaric acid Thailand is happy
Rhzomorph micropill；
(6) by season ammonio methacrylate resin copolymer Type B and A type mixture, glyceryl monostearate, Fructus Citri Limoniae triethylenetetraminehexaacetic acid
Ester is mix homogeneously in slurry commanding tank, and speed of agitator is 500r/min～600r/min, and mixing time is 0.5h～1.5h, it is thus achieved that slow
Release coating solution, add in Multifunction granulating machine by step (5) obtains enteric tylosin tartrate micropill, control temperature of charge
40 DEG C～48 DEG C, blower fan frequency 25HZ～40HZ, atomizing pressure is 0.1MPa～0.3MPa, and peristaltic pump frequency is 2HZ～16HZ,
Spraying into enteric coating liquid, hydrojet completes, at 60 DEG C～80 DEG C be dried 15min～30min so that it is moisture Control within 3%,
Obtain tylosin tartrate slow-release micro-pill.
Embodiment 2:
(1) each component of tylosin tartrate pre-mixing agent compositions is weighed by weight percentage, by solid in each component
Component is pulverized, and makes powder body be sieved through 60 mesh～100 mesh sieve subnettings respectively, and each component individually stores, and then takes tartaric acid Thailand happy
Rhzomorph adds in wet granulator with cross-linking sodium carboxymethyl cellulose, and speed of agitator is 500r/min～1000r/min, during stirring
Between be 1min～3min, make tylosin tartrate mix homogeneously with filler, it is thus achieved that tylosin tartrate filler mix
Thing；
(2) adding mass concentration in step (1) obtains tylosin tartrate filler mixture is 2%～10%
Polyvidon aqueous solution, mix homogeneously in wet granulator, speed of agitator is 800r/min～1800r/min, shears
Rotating speed 1200r/min～2500r/min, mixing time is 2min～3min, it is thus achieved that tylosin tartrate soft material；
(3) tylosin tartrate soft material step (2) made, prepares strip material, hole diameter of sieve (perforated) plate with extruder
0.4mm～0.6mm, by shot-blasting machine, shot-blasting machine rotating speed is 1200r/min～2500r/min, it is thus achieved that tylosin tartrate is wet
Micropill；
(4) being placed in fluid bed dry by obtaining the wet micropill of tylosin tartrate in step (3), temperature of charge is 40 DEG C
～48 DEG C, blower fan frequency 25HZ～40HZ, at 60 DEG C～80 DEG C, it is dried 15min～30min, it is thus achieved that tylosin tartrate is done
Micropill；
(5) methacrylic acid copolymer c-type, glyceryl monostearate and triethyl citrate are mixed in slurry commanding tank all
Even, speed of agitator is 500r/min～600r/min, and mixing time is 0.5h～1.5h, it is thus achieved that enteric coating liquid, by step (4)
Middle acquisition tylosin tartrate micropill adds in Multifunction granulating machine, controls temperature of charge 40 DEG C～48 DEG C, blower fan frequency
25HZ～40HZ, atomizing pressure is 0.1MPa～0.3MPa, and peristaltic pump frequency is 2HZ～16HZ, sprays into enteric coating liquid, hydrojet
Complete, at 60 DEG C～80 DEG C, be dried 15min～30min so that it is moisture Control is within 3%, it is thus achieved that enteric tartaric acid Thailand is happy
Rhzomorph micropill；
(6) by season ammonio methacrylate resin copolymer Type B and A type mixture, glyceryl monostearate, Fructus Citri Limoniae triethylenetetraminehexaacetic acid
Ester is mix homogeneously in slurry commanding tank, and speed of agitator is 500r/min～600r/min, and mixing time is 0.5h～1.5h, it is thus achieved that slow
Release coating solution, add in Multifunction granulating machine by step (5) obtains enteric tylosin tartrate micropill, control temperature of charge
40 DEG C～48 DEG C, blower fan frequency 25HZ～40HZ, atomizing pressure is 0.1MPa～0.3MPa, and peristaltic pump frequency is 2HZ～16HZ,
Spraying into enteric coating liquid, hydrojet completes, at 60 DEG C～80 DEG C be dried 15min～30min so that it is moisture Control within 3%,
Obtain tylosin tartrate slow-release micro-pill.
Embodiment 3:
(1) each component of tylosin tartrate pre-mixing agent compositions is weighed by weight percentage, by solid in each component
Component is pulverized, and makes powder body be sieved through 60 mesh～100 mesh sieve subnettings respectively, and each component individually stores, and then takes tartaric acid Thailand happy
Rhzomorph and lactose add in wet granulator, and speed of agitator is 500r/min～1000r/min, mixing time be 1min～
3min, makes tylosin tartrate mix homogeneously with filler, it is thus achieved that tylosin tartrate filler mixture；
(2) adding mass concentration in step (1) obtains tylosin tartrate filler mixture is 2%～10%
Hydroxypropylcellulose, mix homogeneously in wet granulator, speed of agitator is 800r/min～1800r/min, shears rotating speed
1200r/min～2500r/min, mixing time is 2min～3min, it is thus achieved that tylosin tartrate soft material；
(3) tylosin tartrate soft material step (2) made, prepares strip material, hole diameter of sieve (perforated) plate with extruder
0.4mm～0.6mm, by shot-blasting machine, shot-blasting machine rotating speed is 1200r/min～2500r/min, it is thus achieved that tylosin tartrate is wet
Micropill；
(4) being placed in fluid bed dry by obtaining the wet micropill of tylosin tartrate in step (3), temperature of charge is 40 DEG C
～48 DEG C, blower fan frequency 25HZ～40HZ, at 60 DEG C～80 DEG C, it is dried 15min～30min, it is thus achieved that tylosin tartrate is done
Micropill；
(5) methacrylic acid copolymer A type, glyceryl monostearate and triethyl citrate are mixed in slurry commanding tank all
Even, speed of agitator is 500r/min～600r/min, and mixing time is 0.5h～1.5h, it is thus achieved that enteric coating liquid, by step (4)
Middle acquisition tylosin tartrate micropill adds in Multifunction granulating machine, controls temperature of charge 40 DEG C～48 DEG C, blower fan frequency
25HZ～40HZ, atomizing pressure is 0.1MPa～0.3MPa, and peristaltic pump frequency is 2HZ～16HZ, sprays into enteric coating liquid, hydrojet
Complete, at 60 DEG C～80 DEG C, be dried 15min～30min so that it is moisture Control is within 3%, it is thus achieved that enteric tartaric acid Thailand is happy
Rhzomorph micropill；
(6) by season ammonio methacrylate resin copolymer Type B and A type mixture, glyceryl monostearate, Fructus Citri Limoniae triethylenetetraminehexaacetic acid
Ester is mix homogeneously in slurry commanding tank, and speed of agitator is 500r/min～600r/min, and mixing time is 0.5h～1.5h, it is thus achieved that slow
Release coating solution, add in Multifunction granulating machine by step (5) obtains enteric tylosin tartrate micropill, control temperature of charge
40 DEG C～48 DEG C, blower fan frequency 25HZ～40HZ, atomizing pressure is 0.1MPa～0.3MPa, and peristaltic pump frequency is 2HZ～16HZ,
Spraying into enteric coating liquid, hydrojet completes, at 60 DEG C～80 DEG C be dried 15min～30min so that it is moisture Control within 3%,
Obtain tylosin tartrate slow-release micro-pill.
Embodiment 4:
(1) each component of tylosin tartrate pre-mixing agent compositions is weighed by weight percentage, by solid in each component
Component is pulverized, and makes powder body be sieved through 60 mesh～100 mesh sieve subnettings respectively, and each component individually stores, and then takes tartaric acid Thailand happy
Rhzomorph and sucrose add in wet granulator, and speed of agitator is 500r/min～1000r/min, mixing time be 1min～
3min, makes tylosin tartrate mix homogeneously with filler, it is thus achieved that tylosin tartrate filler mixture；
(2) adding mass concentration in step (1) obtains tylosin tartrate filler mixture is 2%～10%
Polyvidon aqueous solution, mix homogeneously in wet granulator, speed of agitator is 800r/min～1800r/min, shears
Rotating speed 1200r/min～2500r/min, mixing time is 2min～3min, it is thus achieved that tylosin tartrate soft material；
(3) tylosin tartrate soft material step (2) made, prepares strip material, hole diameter of sieve (perforated) plate with extruder
0.4mm～0.6mm, by shot-blasting machine, shot-blasting machine rotating speed is 1200r/min～2500r/min, it is thus achieved that tylosin tartrate is wet
Micropill；
(4) being placed in fluid bed dry by obtaining the wet micropill of tylosin tartrate in step (3), temperature of charge is 40 DEG C
～48 DEG C, blower fan frequency 25HZ～40HZ, at 60 DEG C～80 DEG C, it is dried 15min～30min, it is thus achieved that tylosin tartrate is done
Micropill；
(5) HP-55, glyceryl monostearate and triethyl citrate are mixed in slurry commanding tank all
Even, speed of agitator is 500r/min～600r/min, and mixing time is 0.5h～1.5h, it is thus achieved that enteric coating liquid, by step (4)
Middle acquisition tylosin tartrate micropill adds in Multifunction granulating machine, controls temperature of charge 40 DEG C～48 DEG C, blower fan frequency
25HZ～40HZ, atomizing pressure is 0.1MPa～0.3MPa, and peristaltic pump frequency is 2HZ～16HZ, sprays into enteric coating liquid, hydrojet
Complete, at 60 DEG C～80 DEG C, be dried 15min～30min so that it is moisture Control is within 3%, it is thus achieved that enteric tartaric acid Thailand is happy
Rhzomorph micropill；
(6) by season ammonio methacrylate resin copolymer Type B with the aqueous dispersion mixture of A type, glyceryl monostearate,
Triethyl citrate is mix homogeneously in slurry commanding tank, and speed of agitator is 500r/min～600r/min, mixing time be 0.5h～
1.5h, it is thus achieved that sustained release coating liquid, adds in Multifunction granulating machine by obtaining enteric tylosin tartrate micropill in step (5),
Controlling temperature of charge 40 DEG C～48 DEG C, blower fan frequency 25HZ～40HZ, atomizing pressure is 0.1MPa～0.3MPa, peristaltic pump frequency
For 2HZ～16HZ, spraying into enteric coating liquid, hydrojet completes, and is dried 15min～30min so that it is moisture control at 60 DEG C～80 DEG C
System is within 3%, it is thus achieved that tylosin tartrate slow-release micro-pill.
The tylosin tartrate slow-release micro-pill that will obtain in embodiment 1～4, is respectively put into the hydrochloric acid solution of 0.1mol/L
In, in 37 DEG C of thermostat water baths, place 2 hours and as follows with dissolution analyzer detection dissolution results:
| Embodiment | Dissolution |
| Embodiment 1 | 5% |
| Embodiment 2 | 7% |
| Embodiment 3 | 5% |
| Embodiment 4 | 8% |
Claims (8)
1. a tylosin tartrate pre-mixing agent compositions, by weight percentage said composition are composed of the following components:
Tylosin tartrate: 2%～10%；
Filler: 74%～84.7%；
Binding agent: 1%～4.5%；
Enteric material: 5%～15%；
Enteric antitackiness agent: 3.5%～6.5%；
Enteric plasticizer: 0.5%～1.5%；
Slow-release material: 2%～8%；
Slow release antitackiness agent: 0.5%～5%；
Slow release plasticizer: 0.3%～2%.
Tylosin tartrate pre-mixing agent compositions the most according to claim 1, it is characterised in that: described filler is for forming sediment
In powder, sucrose, lactose, microcrystalline Cellulose, cross-linking sodium carboxymethyl cellulose one or more.
Tylosin tartrate pre-mixing agent compositions the most according to claim 1, it is characterised in that: described binding agent is matter
Amount concentration be 2%～10% polyvidon aqueous solution, mass concentration be 2%～10% hydroxypropyl cellulose water-soluble
Liquid, mass concentration be 2%～10% hydroxypropylcellulose in one or more.
Tylosin tartrate pre-mixing agent compositions the most according to claim 1, it is characterised in that: described enteric material is
Methacrylic acid copolymer A type, methacrylic acid copolymer Type B, methacrylic acid copolymer c-type, hypromellose phthalandione
In ester one or more.
Tylosin tartrate pre-mixing agent compositions the most according to claim 1, it is characterised in that: described enteric antitackiness agent
With described slow release antitackiness agent be in glyceryl monostearate, Pulvis Talci one or both.
Tylosin tartrate pre-mixing agent compositions the most according to claim 1, it is characterised in that: described enteric plasticizer
It is one or more in propylene glycol, triethyl citrate, polyethylene glycol 6000 with described slow release plasticizer.
Tylosin tartrate pre-mixing agent compositions the most according to claim 1, it is characterised in that: described slow-release material is
Season ammonio methacrylate resin copolymer Type B with A type mixture, season ammonio methacrylate resin copolymer Type B with the moisture of A type
In prose style free from parallelism mixture one or both.
8. the tylosin tartrate slow-release micro-pill system of preparation tylosin tartrate pre-mixing agent compositions described in claim 1
Preparation Method, it is characterised in that: the method is made up of following processing step:
(1) each component of tylosin tartrate pre-mixing agent compositions is weighed by weight percentage, by solid constituent in each component
Pulverizing, make powder body be sieved through 60 mesh～100 mesh sieve subnettings respectively, each component individually stores, and then takes tylosin tartrate
Adding in wet granulator with filler, wet granulator rotating speed is 500r/min～1000r/min, mixing time be 1min～
3min, makes tylosin tartrate mix homogeneously with filler, it is thus achieved that tylosin tartrate filler mixture；
(2) in step (1) obtains tylosin tartrate filler mixture, add binding agent, mix in wet granulator
Uniformly, speed of agitator is 800r/min～1800r/min, and shearing rotating speed is 1200r/min～2500r/min, and mixing time is
2min～3min, it is thus achieved that tylosin tartrate soft material；
(3) tylosin tartrate soft material step (2) made, prepares strip material, hole diameter of sieve (perforated) plate 0.4mm with extruder
～0.6mm, by shot-blasting machine, shot-blasting machine rotating speed is 1200r/min～2500r/min, it is thus achieved that the wet micropill of tylosin tartrate；
(4) being placed in fluid bed dry by obtaining the wet micropill of tylosin tartrate in step (3), temperature of charge is 40 DEG C～48
DEG C, blower fan frequency 25HZ～40HZ, at 60 DEG C～80 DEG C, it is dried 15min～30min, it is thus achieved that tylosin tartrate is done micro-
Ball；
(5) by enteric material, enteric antitackiness agent and enteric plasticizer mix homogeneously in slurry commanding tank, speed of agitator is 500r/min
～600r/min, mixing time is 0.5h～1.5h, it is thus achieved that enteric coating liquid, will obtain tylosin tartrate in step (4)
Micropill adds in Multifunction granulating machine, controls temperature of charge 40 DEG C～48 DEG C, and blower fan frequency 25HZ～40HZ, atomizing pressure is
0.1MPa～0.3MPa, peristaltic pump frequency is 2HZ～16HZ, sprays into enteric coating liquid, and hydrojet completes, dry at 60 DEG C～80 DEG C
Dry 15min～30min so that it is moisture Control is within 3%, it is thus achieved that enteric tylosin tartrate micropill；
(6) by slow-release material, slow release antitackiness agent, slow release plasticizer mix homogeneously in slurry commanding tank, speed of agitator is 500r/min
～600r/min, mixing time is 0.5h～1.5h, it is thus achieved that sustained release coating liquid, by happy for acquisition enteric tartaric acid Thailand in step (5)
Rhzomorph micropill adds in Multifunction granulating machine, controls temperature of charge 40 DEG C～48 DEG C, blower fan frequency 25HZ～40HZ, atomizing pressure
For 0.1MPa～0.3MPa, peristaltic pump frequency is 2HZ～16HZ, sprays into enteric coating liquid, and hydrojet completes, at 60 DEG C～80 DEG C
It is dried 15min～30min so that it is moisture Control is within 3%, it is thus achieved that tylosin tartrate slow-release micro-pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610862377.7A CN106309409B (en) | 2016-09-29 | 2016-09-29 | A kind of sustained release pellet preparation method of Tylosin Tartrate pre-mixing agent composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610862377.7A CN106309409B (en) | 2016-09-29 | 2016-09-29 | A kind of sustained release pellet preparation method of Tylosin Tartrate pre-mixing agent composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106309409A true CN106309409A (en) | 2017-01-11 |
| CN106309409B CN106309409B (en) | 2019-05-24 |
Family
ID=57820882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610862377.7A Expired - Fee Related CN106309409B (en) | 2016-09-29 | 2016-09-29 | A kind of sustained release pellet preparation method of Tylosin Tartrate pre-mixing agent composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106309409B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107496436A (en) * | 2017-10-19 | 2017-12-22 | 洛阳瑞华动物保健品有限公司 | A kind of Tylosin Tartrate sulfadimidine sustained release pellet and preparation method thereof |
| CN107595785A (en) * | 2017-10-31 | 2018-01-19 | 成都乾坤动物药业股份有限公司 | A kind of new tylosin pre-mixing agent and its preparation technology and application |
| CN111419823A (en) * | 2020-04-30 | 2020-07-17 | 上海公谊药业有限公司 | Tiamulin fumarate enteric-coated pellet as well as preparation method and application thereof |
| CN115475150A (en) * | 2022-10-14 | 2022-12-16 | 江西高胜动物保健品有限公司 | Novel enteric coated tylosin tartrate product and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4048268A (en) * | 1975-02-19 | 1977-09-13 | Eli Lilly And Company | Stabilization method |
| CN1089098A (en) * | 1992-12-21 | 1994-07-13 | 伊莱利利公司 | Tylosin animal feed premix |
| EP0872232A1 (en) * | 1997-04-10 | 1998-10-21 | BASF Labiana S.A. | Pharmaceutical preparation with delayed release of active ingredient |
| CN105616383A (en) * | 2015-12-30 | 2016-06-01 | 中国药科大学 | Acetylisovaleryl tylosion tartrate enteric pellet and preparation method thereof |
| CN105853363A (en) * | 2016-03-30 | 2016-08-17 | 成都中牧生物药业有限公司 | Preparation method of tylosin tartrate premix |
-
2016
- 2016-09-29 CN CN201610862377.7A patent/CN106309409B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4048268A (en) * | 1975-02-19 | 1977-09-13 | Eli Lilly And Company | Stabilization method |
| CN1089098A (en) * | 1992-12-21 | 1994-07-13 | 伊莱利利公司 | Tylosin animal feed premix |
| EP0872232A1 (en) * | 1997-04-10 | 1998-10-21 | BASF Labiana S.A. | Pharmaceutical preparation with delayed release of active ingredient |
| CN105616383A (en) * | 2015-12-30 | 2016-06-01 | 中国药科大学 | Acetylisovaleryl tylosion tartrate enteric pellet and preparation method thereof |
| CN105853363A (en) * | 2016-03-30 | 2016-08-17 | 成都中牧生物药业有限公司 | Preparation method of tylosin tartrate premix |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107496436A (en) * | 2017-10-19 | 2017-12-22 | 洛阳瑞华动物保健品有限公司 | A kind of Tylosin Tartrate sulfadimidine sustained release pellet and preparation method thereof |
| CN107595785A (en) * | 2017-10-31 | 2018-01-19 | 成都乾坤动物药业股份有限公司 | A kind of new tylosin pre-mixing agent and its preparation technology and application |
| CN107595785B (en) * | 2017-10-31 | 2019-10-22 | 成都乾坤动物药业股份有限公司 | A kind of tylosin pre-mixing agent and the preparation method and application thereof |
| CN111419823A (en) * | 2020-04-30 | 2020-07-17 | 上海公谊药业有限公司 | Tiamulin fumarate enteric-coated pellet as well as preparation method and application thereof |
| CN111419823B (en) * | 2020-04-30 | 2022-03-29 | 上海公谊药业有限公司 | Tiamulin fumarate enteric-coated pellet as well as preparation method and application thereof |
| CN115475150A (en) * | 2022-10-14 | 2022-12-16 | 江西高胜动物保健品有限公司 | Novel enteric coated tylosin tartrate product and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106309409B (en) | 2019-05-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106309409A (en) | Tylosin tartrate premix composition and preparation method of tylosin tartrate sustained-released pellets | |
| CN107484878B (en) | A kind of preparation method of microbial microcapsule and its application in feed | |
| CN101006829B (en) | Feed additive for aquaculture covered by high-molecular material | |
| CN104958764A (en) | Tilmicosin smell masking preparation and preparing method thereof | |
| CN102525990A (en) | Ilaprazole enteric-coated tablets and preparation method thereof | |
| CN111972551B (en) | A rumen-passing preparation and its preparation method and device | |
| CN103228268A (en) | Sustained-release tablet and process for preparing the same | |
| CN106420629B (en) | Branched-amino acid supplement and its preparation method and application | |
| CN101601663A (en) | Multi-unit sustained-release preparation of levetiracetam and preparation method thereof | |
| CN103040774B (en) | Granulating and coating process of esomeprazole magnesium contained in esomeprazole magnesium enteric-coated tablet | |
| CN110973369A (en) | Slow-release sodium butyrate suitable for aquatic animals and preparation method thereof | |
| CN102908317B (en) | Macrolide antibiotics enteric-coated pellets and coating solution thereof | |
| CN102068412A (en) | Enteric targeted tilmicosin particles and preparation method thereof | |
| CN103622919A (en) | Tilmicosin phosphate enteric granules and preparation method thereof | |
| CN101390840B (en) | A production method of high-content calcium ascorbate granules capable of direct compression | |
| CN104686808A (en) | 50% enteric package zinc oxide nanoparticle preparation method | |
| CN104606141A (en) | Tilmicosin enteric micro pellet | |
| CN105534950A (en) | Production method for kitasamycin solid micro-capsules for feed | |
| CN106619572A (en) | Quinocetone sustained-release pellet and preparation method thereof | |
| CN104304681B (en) | A kind of feeding slow-releasing granules type phosphoric acid and preparation method thereof | |
| CN103705482A (en) | Preparation method of tiopronin tablets | |
| CN100438879C (en) | New process for making animal medicine madumycin ammonium, ivermection or dikezhuli premixed agent | |
| KR102258769B1 (en) | Delayed release enzyme preparations and the preparation method for the same | |
| CN101543526A (en) | Kudzu root total aglycone sustained-release pellet as well as preparation method and application thereof | |
| CN118178356A (en) | Slow-release capsule containing fenofibrate acid choline and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20200511 Address after: No. 578, shigu village, Shuikou Town, Shizhong District, Leshan City, Sichuan Province Patentee after: Leshan baierte bioengineering partnership (L.P.) Address before: 614000, Shuikou Industrial Park, Shizhong District, Sichuan, Leshan Patentee before: LESHAN RECONDEX ANIMAL HEALTH CARE PHARMACEUTICAL Co.,Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190524 Termination date: 20210929 |